🎥 Highlights from yesterday's VPD-HLRI Monthly Seminar! Great talks by Prof. Jason Gill from @uofglasgow.bsky.social and our very own Prof. Murray Clarke.
Thanks to our speakers and attendees!
#HLRI #MetabolicHealth #VascularInflammation @cambridgeuni.bsky.social
@murrayclarkelab.bsky.social

#Colchicine stabilizes #SmoothMuscleCell contractile phenotype & alleviates🐭#AbdominalAorticAneurysm (local elastase + BAPN in water)
ep.1

⏬collagen
↔️elastin
⏬#VascularInflammation
⏬immune cell infiltr
⏬vascular wall #Pyroptosis SMC or immune cells?🤔

#ClinSci 2023
portlandpress.com/clinsci/arti...

Hyperglycemia-YAP cascade in diabetic #VascularInflammation, likely both arterial #EndothelialCell & #SmoothMuscleCell

db/db mice

This time, TAZ seems not to be responding to #HighGlucose/#DisturbedFlow

Marco Meloni lab #FrontPhysiol 2021
www.frontiersin.org/journals/phy...

An #OscillatoryShearStress -α5β1 integrin-ABL1-YAP cascade in #EndothelialCell promotes #VascularInflammation & Apoe-/-🐭#Atherosclerosis

Elevated p-ABL1 Tyr412 & p-YAP Tyr357 on athero-prone🐭aortic endothelium &👤athero-lesional endothelium

#JCI 2019
www.jci.org/articles/vie...

My continued biomedical education

Specialized Pro-resolving Mediators in #VascularInflammation & #AtheroscleroticCardiovascularDisease

Resolvin
Protectin
Maresin

#EndothelialCell + #Neutrophil in SPM synthesis

⏫Mφ #efferocytosis #MERTK #FAO

#NatRevCardiol 2024
www.nature.com/articles/s41...

#GasderminD/GSDME, mainly detected in CD163+CD68+ Mɸ (& some fibroblasts in scRNAseq, too), mediates Mɸ motility, cytokine, #Pyroptosis & atherogenesis (#VascularInflammation + lesional burden)

GSDME under control of oxLDL-STAT3 axis

#NatureComms 2023
www.nature.com/articles/s41...

ApoB #AntiSenseOligo + low-fat diet for 12 wks alleviates #VascularInflammation in established🐭#Atherosclerosis

EC invagination+focal loss in regressing plaque😎 (#EndMT at sub-cap level)
⏫contractile #FibrousCap SMC; ⏬Fibromyocyte & Chondromyocyte

#NatureCVR 2024
www.nature.com/articles/s44...

Enhancer-associated #LongNonCodingRNA #Atherosclerosis

PSMB8-AS1⏫promixal gene transcription of PSMB9 in #EndothelialCell->
Zeb1->
VCAM1/ICAM1->
#VascularInflammation #Atherosclerosis

Serum lipids also regulated by PSMB8-AS1

#CircRes 2023
www.ahajournals.org/doi/10.1161/...

Sox10, a central hub for Mφ-like transdifferentiation of #SmoothMuscleCell #VascularInflammation #Pyropotosis

PI3K-Akt->
phospho-Sox10->
TNFα-dependent Sox10 lactylation->
pro-inflam; pro-death

RGS5⏬PI3K-Sox10 axis

F Zhang, M Han lab Cell Reports 2023
www.sciencedirect.com/science/arti...