#WernerSyndrome
#WernerSyndrome hiPSC engineered vessel

Aligned #SmoothMuscleCell in Collagen hydrogel➡️
Roll-up as helical tube
+PLA mold
+Luminal #EndothelialCell

#SpatialTranscriptomics
#Metabolomics

Vessels with Werner EC are Hypercontractile even with healthy SMC

bioRxiv 2025
www.biorxiv.org/content/10.1...
October 4, 2025 at 7:06 PM Everybody can reply
5 likes
🧬 Longevity & Aging Series (S3, E2):
Dr. Julia Sidorova discusses, “Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells.”

🎥 www.youtube.com/watch?v=3yn8...

#aging #oa #wernersyndrome #longevity
Longevity & Aging Series (S3, E2): Dr. Julia Sidorova | Aging-US
YouTube video by Aging-US
www.youtube.com
September 24, 2025 at 12:21 PM Everybody can reply
👀 Abstract #video about this #research paper #published as the #cover for Volume 17, Issue 4, titled "Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation."

www.youtube.com/watch?v=WpRp...

#aging #wernersyndrome #prematureaging #oa #peerreview #publishing
WRN Deficiency and Mitochondrial NAD+ Depletion Impair Cell Proliferation | Aging-US
YouTube video by Aging (Aging-US)
www.youtube.com
April 30, 2025 at 6:46 PM Everybody can reply
#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH
April 24, 2025 at 5:31 PM Everybody can reply
1 reposts 3 likes
#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH
April 24, 2025 at 1:54 PM Everybody can reply
2 reposts 4 likes
#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH
April 24, 2025 at 8:50 AM Everybody can reply
2 likes