#WestSyndrome
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plosbiology.org
PLOS Biology
@plosbiology.org
#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv
3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.
October 14, 2025 at 7:57 AM Everybody can reply
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plosbiology.org
PLOS Biology
@plosbiology.org
#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv
3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.
October 13, 2025 at 4:50 PM Everybody can reply
2 reposts 2 quotes 12 likes
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epilepsia-open.bsky.social
Epilepsia Open
@epilepsia-open.bsky.social
Key point: Racial disparities: Non-Hispanic Black children with IESS had significantly lower odds of undergoing genetic sequencing.
doi.org/10.1002/epi4...

#epilepsy #ILAE #geneticsequencing #healthequity #inequities #infantilespasms #westsyndrome
February 20, 2025 at 3:54 PM Everybody can reply
plosbiology.org
PLOS Biology
@plosbiology.org
#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv
3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.
October 13, 2025 at 1:22 PM Everybody can reply
1 reposts 1 likes
1 1
epilepsiajournal.bsky.social
Epilepsia Journal
@epilepsiajournal.bsky.social
Key point: Thalamic electroencephalography (EEG) showed slow-wave complex with or without low-voltage fast activity during epileptic spasms.
onlinelibrary.wiley.com/doi/full/10....

#epilepsy #ILAE #corticothalamicnetwork #infantileepilepticspasmssyndrome #thalamus #westsyndrome
March 19, 2025 at 2:16 PM Everybody can reply
2 likes
2
epilepsiajournal.bsky.social
Epilepsia Journal
@epilepsiajournal.bsky.social
Key point: We hypothesized that the time course of the BASED score after ES remission is associated with ES relapse.
doi.org/10.1111/epi....

#epilepsy #ilae #antiseizuremedication #electroencephalography #hypsarrhythmia #interraterreliability #Westsyndrome
April 3, 2025 at 7:09 PM Everybody can reply
1 reposts 1 likes
1 1