#activin
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drvergaro.bsky.social
WO2026006740 describes fully human bispecific antibodies that selectively neutralize myostatin (GDF8) and Activin A to enhance skeletal muscle mass, matching ActRIIB-Fc efficacy while avoiding vascular, hematologic, and endocrine toxicities from non-selective receptor blockade.
[Credit: Regeneron]
January 15, 2026 at 12:21 PM
albertsc79.bsky.social
Quan inclemències meterològiques, pandèmies, desastres naturals.. posen en risc la vida de les persones, s'han d'activar recursos d'emergència de protecció civil. Amb pressupostos específics, protocols clars i consensuats i que activin tots els serveis necessaris
January 15, 2026 at 9:18 AM
arula-ratnakar.bsky.social
Oh yes I wasn't trying to say there would be a universal definition of phases in bio--just that phases are helpful. Like for morphogens in the case below (these are slides I saved from my biology advisor Prof Cynthia Bradham's class) defining phases (fates) along an activin gradient seems useful.
slide showing how morphogens work, including an explanatory graph for a hypothetical morphogen with three different cell fates induced by different areas along a gradient of the morphogen. Text reads "Morphogens are a specific type of signal whose gradients induce a range of cell fates" and "Not all inductive signals are morphogens, but all morphogens are inductive signals" Text reads "Activin functions as a morphogen: a Substance that Produces different effects with Differing Doses" And the diagram shows an experiment where presumptive ectoderm cells are taken from the animal hemisphere of a blastula, and dosed with different concentrations of the morphogen activin. 0.1ng/ml activin leads to bloodlike cells, 1ng/l leads to muscle cells, 10ng/ml leads to notochord cells, 100ng/ml leads to heart cells diagram showing that different genes are induced with the differing doses, not just differing levels of the same genes. when there is 1nM activin, a region of brachyury expression is created and when there is a 4nm activin there is a region of goosecoid expression surrounded by a region of brachyury expression
January 11, 2026 at 7:18 PM
qkine.bsky.social
Cell therapy grade animal origin-free activin A protein (Qk001-CTG) for regenerative cell therapy applications > zurl.co/cfATJ

All of our 120+ recombinant proteins are available as cell therapy grade on request > zurl.co/0JBo8
January 7, 2026 at 8:50 AM
planarian-brain.bsky.social
Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea | bioRxiv
www.biorxiv.org/content/10.6...
Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea
Highly regenerative animals often have a seemingly limitless capacity for tissue growth and stem cell proliferation, which often requires molecular and organismal capacities associated with pre-malign...
www.biorxiv.org
January 1, 2026 at 10:24 AM
prepub-singlecell.bsky.social
Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2025.12.29.696926v1
December 30, 2025 at 8:00 AM
biorxivpreprint.bsky.social
Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea https://www.biorxiv.org/content/10.64898/2025.12.29.696926v1
December 30, 2025 at 5:30 AM
biorxiv-devbio.bsky.social
Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea https://www.biorxiv.org/content/10.64898/2025.12.29.696926v1
December 30, 2025 at 5:30 AM
scienceofpd.bsky.social
Researchers report knockdown of Activin receptor-like kinase 5 (ALK5) & Mothers against decapentaplegic homolog 2 (SMAD2) - 2 genes of the TGFb pathway, protected dopaminergic neurons from a-Synuclein-induced toxicity; ⬆️TGFb signaling exacerbated a-Synuclein toxicity
www.nature.com/articles/s41...
December 14, 2025 at 11:19 PM
grazianomartello.bsky.social
9/ Key discovery #3:
🔥 Activin A is a potent inducer of primitive streak in 3D epiblast epithelium.
After epithelialisation (day 2), treatment with Activin A (alone!) produces:
– >60% MIXL1-GFP+ cells
– strong TBXT induction
– full mesenchymal morphology
December 11, 2025 at 1:32 PM
medru.bsky.social
and the activin E-targeting antibody IBIO-610, which are aimed at promoting quality weight loss (preserving muscle mass) and preventing weight regain. gemin
December 8, 2025 at 1:56 PM
orittle.bsky.social
胚発生における細胞運命の決定は、さまざまなシグナルにより制御される。
この研究では、ヒトの原腸形成においてactivinと BMP4が協調して細胞運命を制御する仕組みの数理モデルを示した。
表紙絵では、細胞系譜の分岐や収束を迷路で表している。
December 8, 2025 at 8:52 AM
biorxivpreprint.bsky.social
Gradient-Based Regulation of Activin A Directs Multilineage Liver Organoid Development from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2025.11.27.690974v1
December 2, 2025 at 7:01 AM
biorxiv-bioeng.bsky.social
Gradient-Based Regulation of Activin A Directs Multilineage Liver Organoid Development from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2025.11.27.690974v1
December 2, 2025 at 7:01 AM
eurekamag.com
ICYMI: The disturbance of oral-aboral axis formation in starfish embryo by activin A
The disturbance of oral-aboral axis formation in starfish embryo by activin A
It was likely that the mesenchyme cells were not affected in their differentiation. We will also discuss a relationship between the shape formation and cell differentiation in the starfish embryo treated with activin A.
eurekamag.com
November 26, 2025 at 7:34 AM
eurekamag.com
The disturbance of oral-aboral axis formation in starfish embryo by activin A
The disturbance of oral-aboral axis formation in starfish embryo by activin A
It was likely that the mesenchyme cells were not affected in their differentiation. We will also discuss a relationship between the shape formation and cell differentiation in the starfish embryo treated with activin A.
eurekamag.com
November 25, 2025 at 7:33 AM
davidrafols.bsky.social
Si us plau, que activin JA el pla rellisCAT!!!!!!
November 16, 2025 at 11:14 AM
biorxivpreprint.bsky.social
The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin https://www.biorxiv.org/content/10.1101/2025.11.14.688564v1
November 16, 2025 at 3:18 AM
biorxiv-molbio.bsky.social
The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin https://www.biorxiv.org/content/10.1101/2025.11.14.688564v1
November 16, 2025 at 3:18 AM
joan.ayma.cat
Esperarem a que activin alarmes/despertadors
November 12, 2025 at 8:12 PM
osteoporosis-nl.bsky.social
Discovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase‑2(ALK2) for the Treatment of Fibrodysplasia Ossificans Progressiva. T Ullrichet al. ACSMed.Chem. Lett. 31Oct 2025 shorturl.at/UCzDT …mouse model …start clinical trial
November 8, 2025 at 7:33 AM
helixbrief.bsky.social
These findings highlight the importance of stromal cell metabolism in MM progression and provide a promising therapeutic strategy by targeting the PYCR1-activin A axis to enhance bortezomib efficacy.
November 6, 2025 at 12:11 PM
helixbrief.bsky.social
Combination therapy of a PYCR1 inhibitor and bortezomib demonstrated reduced tumor load in a 3D model and lowered serum activin A levels in mice.
November 6, 2025 at 12:11 PM
helixbrief.bsky.social
Silencing PYCR1 in BMSCs reduced the secretion of activin A, impairing oxidative phosphorylation in MM cells and sensitizing them to bortezomib.
November 6, 2025 at 12:11 PM