#alveolarepithelium
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MedSky🧪#IDSky @cellpress #Viralimmunology There are the reason to #MaskUp 😷 and #Getboosted #COVID kills
#Viralimmunology #Molecularmedicine identify a spectrum of pathway dysregulations in #alveolarepithelium, #bronchialepithelium & #bloodvessels in severe #COVID patients vs non-#COVID19 controls,
A) Schematic workflow including cohort design, autopsy specimen collection, pathology-guided LMD, integrated sample preparation, MS-based deep proteome profiling, and bioinformatic analysis to analyze the ten regions of pulmonary tissues of severe COVID-19 patients and non-COVID-19 control individuals. (B) Representative H&E images of selected regions for spatial proteome profiling (scale bar represents 100 μm). Region names and their abbreviations are labeled above images. (C) Schematic human pulmonary structure. Case counts for each region are labeled including BE (n = 11), BMP (n = 7), AE (n = 10), HAT2 (n = 3), PF (n = 11), ASI (n = 10), VE (n = 11), N-BE (n = 2), N-AE (n = 3), and N-VE (n = 3). (D) Total number (as bar graph) and average number (as black dot) of identified protein groups for each region and project-specific spectral library. (E) Dynamic range of the proteome within ten regions based on average protein LFQ intensity. (F) Box-whisker plot of Pearson correlation coef
January 19, 2024 at 1:09 PM