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Reposted by TRAstonDrs

quhl @quhl.bsky.social · 43m

My autumn walk this morning.
#NaturePhotography #quhl5

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TRAstonDrs @castltrastondrs.bsky.social · 7h

Currently, no specific medication exists for #denguefever, so clinical trials test promising antiviral compounds.

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TRAstonDrs @castltrastondrs.bsky.social · 7h

#Medsky🧪 #Drugdevelopment #publichealth The experience of a participant in a #clinicaltrial for dengue would reflect the general phases of a drug trial, though specific procedures vary by the trial & the drug being tested.

Thiago Carvalho @cyrilpedia.bsky.social · 7h

'The next day, I went back to the facilities, where a nurse injected my arm with a genetically modified version of the DENV-3 serotype of the dengue virus designed to give only mild illness rather than full-blown “break-bone fever,” as the illness is known colloquially.'
cen.acs.org/pharmaceutic...

I was injected with dengue virus to learn about clinical trials

I became a test subject in a clinical trial for a new dengue treatment. Here’s what I discovered

cen.acs.org

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TRAstonDrs @castltrastondrs.bsky.social · 7h

A little consideration,
a little thought for others, makes all the difference…
A. A. Milne

A climbing rose pushed through the iron gate.

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TRAstonDrs @castltrastondrs.bsky.social · 7h

The world is full of detail
if you have the light to see it.

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Reposted by TRAstonDrs

ProdigalHoosier @prodigalhoosier.medsky.social · 9h

Sending my PCP the @batemanhornecenter.bsky.social Clinical Care Guide for #LongCovid. 🤞

batemanhornecenter.org/wp-content/u...

batemanhornecenter.org

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TRAstonDrs @castltrastondrs.bsky.social · 9h

such as human fungal pathogens, to understand how they develop drug resistance
@robertarkowitz.bsky.social

www.charite.de/en/service/p...

Press reports: Charité – Universitätsmedizin Berlin

Press release of the Charité – Universitätsmedizin Berlin

https://www.charite.de/en/service/press_reports/artikel/detail/tracking_the_impact_of_mutations#:~:text=Proteome%20reveals%20molecular%20basis&text=“And%20to%20check%20whether%20the,resistant%20to%20the%20antimycotic%20agent.”

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TRAstonDrs @castltrastondrs.bsky.social · 9h

Researchers can better predict how mutations will influence a cell's health, its response to drugs, or its ability to adapt to new environments.
The study provides a framework for researchers to forecast the molecular and phenotypic consequences of genetic variation in other organisms

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TRAstonDrs @castltrastondrs.bsky.social · 9h

providing insight into the molecular principles that determine how an organism's genes influence its traits
By understanding how #geneticvariants affect #proteinexpression

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TRAstonDrs @castltrastondrs.bsky.social · 9h

The map helped identify "hidden" causal variants. I.e , a variant in the IRA2 gene was found to strongly influence fitness, but this effect was only revealed through its impact on the proteome.
The map reveals how natural selection operates on variants throughout the genome to remodel the proteome,

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TRAstonDrs @castltrastondrs.bsky.social · 9h

often combined to have a more significant influence on overall protein expression. By connecting genomic & proteomic data, the researchers could use the map to predict how genetic variants would affect an organism's fitness under various stressful conditions, like exposure to #antifungaldrugs.

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TRAstonDrs @castltrastondrs.bsky.social · 9h

The study revealed that many of these influential Trans-regulatory are not traditional regulatory genes but are instead common proteins like enzymes or transporters. While cis variants had strong individual impacts, the study found that the collective, smaller effects of trans regulatory variants

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TRAstonDrs @castltrastondrs.bsky.social · 9h

There are 2 types of regulatory variants
- 𝐶𝑖𝑠 regulatory variants: These are genetic changes near a gene that have a strong, localized effect on the protein it produces
- 𝑇𝑟𝑎𝑛𝑠-regulatory variants: These are variants that have an effect on proteins produced from distant genes.

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TRAstonDrs @castltrastondrs.bsky.social · 9h

which more directly determines an organism's function & fitness.
Despite the modest genetic differences between the parent strains, their offspring displayed "remarkable proteomic diversity," highlighting the genome's latent potential for creating protein variation.

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TRAstonDrs @castltrastondrs.bsky.social · 9h

The study provides a crucial bridge between an organism's genetic makeup ( #genotype) & its observable characteristics ( #phenotype). While the genome is the instruction manual, the proteome is what is actually being built at any given moment,

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TRAstonDrs @castltrastondrs.bsky.social · 9h

A 🔑 study published @science.org created a genome-to-proteome map using nearly 1,000 hybrid yeast strains derived from 2 parent strains, which had adapted to different environments.
PDF www.science.org/doi/epdf/10....

A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness

Understanding how genetic variation translates into complex phenotypes remains a fundamental challenge. In this work, we address this by mapping genome-to-proteome relationships in 800 progeny of a cr...

www.science.org

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TRAstonDrs @castltrastondrs.bsky.social · 9h

This type of map reveals how natural genetic variation drives protein diversity & ultimately shapes an organism's fitness
@eurekalert.bsky.social

www.eurekalert.org/news-release...

proteomecentral.proteomexchange.org/cgi/GetDatas....

Tracking the impact of mutations

Every organism’s genome contains mutations that often have unknown biological effects. In partnership with Stanford University (USA), researchers at Charité – Universitätsmediz...

www.eurekalert.org

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TRAstonDrs @castltrastondrs.bsky.social · 9h

#Medsky🧪 #microsky A " #genome -to- #proteome map" is a molecular atlas that links specific genetic variants (in the genome) to their effects on the abundance & characteristics of proteins (the proteome).

Robert Arkowitz @robertarkowitz.bsky.social · 9h

www.science.org/doi/10.1126/...

A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness

Understanding how genetic variation translates into complex phenotypes remains a fundamental challenge. In this work, we address this by mapping genome-to-proteome relationships in 800 progeny of a cr...

www.science.org

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Chris Sundling @chrissundling.bsky.social · 1d

From the now published pan-disease blood atlas, we used the proteomic data together with clinical and single-cell data to describe immune cross-talk linked with disease severity in malaria @cp-immunity.bsky.social

Check it out!

www.sciencedirect.com/science/arti...

#Immunology #malaria @ki.se

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The Sick Times @thesicktimes.org · 21h

A group of 53 people with #LongCOVID joined a clinical trial for Vyvgart. For many of them, the treatment changed everything.

Then, without warning, Argenx canceled the trial.

Most of them have now relapsed.

They're calling on the NIH and HHS to study the drug: bit.ly/48l1Qp5

A photo Nicole Barrick, a woman in a pink KN95 mask, receives an infusion of Vyvgart. The text reads, "The Sick Times. Vyvgart brought us back to life, but the Long COVID trial was canceled. We are calling on the NIH and HHS to study the drug. By Clare Banaszewski, Nicole Barrick, Mike Bilik, Addie Davis, Mia Delli Gatti, Ellie Hayes, Roman White."

"For those living with Long COVID, every ounce of hope is hard-won. This isn’t just about physical symptoms. It’s about the emotional toll of being given hope — and then having it taken away." - Vyvgart clinical trial participants
Clare Banaszewski, Nicole Barrick, Mike Bilik, Addie Davis, Mia Delli Gatti, Ellie Hayes, Roman White

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Reposted by TRAstonDrs

Denise Wheeler @denisedwheeler.bsky.social · 17d

Epidemiologist Erin McCanlies spent much of the past two decades studying how parents’ exposure to toxic chemicals affects the chances that they will have an autistic child.

RFK Jr. has now cut her entire division.

RFK Jr. Vowed to Find the Environmental Causes of Autism. Then He Shut Down Research Trying to Do Just That.

While touting a $50 million initiative to identify the causes of autism, Robert F. Kennedy Jr. is helping lead an administration that is rolling back protections against pollution and toxic chemicals,...

www.propublica.org

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TRAstonDrs @castltrastondrs.bsky.social · 18h

In the slow creaking of time, searching for oneself there, where nothingness shatters
- Quotation from the character V. in the video game Cyberpunk 2077

Photos taken by @billydeee.bsky.social in Midtown, NYC

Photos taken by @billydeee.bsky.social in Midtown, NYC

TRAstonDrs @castltrastondrs.bsky.social · 18h

regarding vaccine timing & selection, especially as new variants emerge & evolve
biz.chosun.com/en/en-scienc...

pmc.ncbi.nlm.nih.gov/articles/PMC...

pmc.ncbi.nlm.nih.gov/articles/PMC...

Booster shot strengthens B-cell immunity against variants in Korea and US

Booster shot strengthens B-cell immunity against variants in Korea and US Booster prompts memory B cells to mature again, producing antibodies that neutralize multiple variants

biz.chosun.com

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TRAstonDrs @castltrastondrs.bsky.social · 18h

that actively promote the development of broadly neutralizing #Bcells. This could lead to more durable #immunity against a wider range of current & future variants.
- The superior ability of booster 💉 to broaden #Bcell #immunity can inform #publichealth strategies

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TRAstonDrs @castltrastondrs.bsky.social · 18h

That’s why booster vaccinations are effective against new variants, even if they are not perfectly
@ebiomedicine.bsky.social
www.thelancet.com/journals/ebi...
An improved understanding of germinal center dynamics can help in designing next-generation vaccines

Bivalent Omicron BA.1 vaccine booster increases memory B cell breadth and neutralising antibodies against emerging SARS-CoV-2 variants

These results suggest that the bivalent vaccine confers an advantage against future novel variants due to increased frequency of broadly reactive RBD-specific B cells.

www.thelancet.com

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