TRAstonDrs
@castltrastondrs.bsky.social
"Not all those who wander are lost" JR Tolkien
#Clinicalresearcher #DrugDevelopment
#Clinicaltrials & Registration
🧬🔬📚🔎🦠🧫 📌
Melbourne 🇦🇺 Oxford 🇬🇧& 🏴 #MedSky🧪
#Clinicalresearcher #DrugDevelopment
#Clinicaltrials & Registration
🧬🔬📚🔎🦠🧫 📌
Melbourne 🇦🇺 Oxford 🇬🇧& 🏴 #MedSky🧪
Pinned
Our greatest strength lies in the gentleness and tenderness of our heart.
Rumi
Rumi
#Medsky🧪 #IDsky #immunosky #publichealth #LongCOVID pathophysiology is a complex & not fully established process. One prevailing theory is that the formation of fibrin amyloid microclots ( #fibrinaloids), due to #Covid infection, can induce persistent inflammation & capillary blockage .
November 27, 2025 at 5:15 AM
#Medsky🧪 #IDsky #immunosky #publichealth #LongCOVID pathophysiology is a complex & not fully established process. One prevailing theory is that the formation of fibrin amyloid microclots ( #fibrinaloids), due to #Covid infection, can induce persistent inflammation & capillary blockage .
Reposted by TRAstonDrs
Another US BA.3.2 wastewater detection.
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
November 26, 2025 at 11:01 PM
Another US BA.3.2 wastewater detection.
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
#Medsky🧪 #IDsky #Covid19Vaccine worked #immunosky #publichealth The study @systemsvirology.bsky.social shows immune boosting by the LP.8.1-based vaccine is effective in achieving cross neutralization against a broad range of JN.1 sublineages in a JN.1-naïve population
November 27, 2025 at 4:43 AM
#Medsky🧪 #IDsky #Covid19Vaccine worked #immunosky #publichealth The study @systemsvirology.bsky.social shows immune boosting by the LP.8.1-based vaccine is effective in achieving cross neutralization against a broad range of JN.1 sublineages in a JN.1-naïve population
#Medsky🧪 #IDsky #immunosky #publichealth
@thjournal.bsky.social
Outpatient LMWH ( low-molecular weight heparin) given pre-admission for high-risk #Covid patients was associated with improved outcome following diagnosis:
@thjournal.bsky.social
Outpatient LMWH ( low-molecular weight heparin) given pre-admission for high-risk #Covid patients was associated with improved outcome following diagnosis:
November 26, 2025 at 7:37 PM
#Medsky🧪 #IDsky #immunosky #publichealth
@thjournal.bsky.social
Outpatient LMWH ( low-molecular weight heparin) given pre-admission for high-risk #Covid patients was associated with improved outcome following diagnosis:
@thjournal.bsky.social
Outpatient LMWH ( low-molecular weight heparin) given pre-admission for high-risk #Covid patients was associated with improved outcome following diagnosis:
Reposted by TRAstonDrs
Thanksgiving reminder… ⚖️
November 26, 2025 at 4:12 PM
Thanksgiving reminder… ⚖️
#Medsky🧪 #IDsky #pedsky #episky #publichealth Multisystem Inflammatory Syndrome in Children (MIS-C) a rare, severe & potentially life threatening condition that occurs in children & adolescents following post covid with manifesting 2–6 wks post infection , often asymptomatic or mild disease
November 26, 2025 at 5:43 PM
#Medsky🧪 #IDsky #pedsky #episky #publichealth Multisystem Inflammatory Syndrome in Children (MIS-C) a rare, severe & potentially life threatening condition that occurs in children & adolescents following post covid with manifesting 2–6 wks post infection , often asymptomatic or mild disease
#Medsky🧪 #IDsky #microsky #pharmsky #immunosky #publichealth
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
November 26, 2025 at 3:56 PM
#Medsky🧪 #IDsky #microsky #pharmsky #immunosky #publichealth
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
I don't like those who know, I like those who love…
#ChristianBobin
#ChristianBobin
November 26, 2025 at 11:50 AM
I don't like those who know, I like those who love…
#ChristianBobin
#ChristianBobin
Reposted by TRAstonDrs
Mornings on the beach be like...
Sunrise and enjoying the view, but not the wind.
#photography #nature #landscapephotography
Sunrise and enjoying the view, but not the wind.
#photography #nature #landscapephotography
November 20, 2025 at 3:41 AM
Mornings on the beach be like...
Sunrise and enjoying the view, but not the wind.
#photography #nature #landscapephotography
Sunrise and enjoying the view, but not the wind.
#photography #nature #landscapephotography
#Mesky🧪 #IDsky #endosky #immunosky #publichealth This review highlights the need to consider #obesity in general & adipose tissue in particular as an active disease modifier of viral infection with implications for future pandemics.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
#Medsky🧪 #IDsky #endosky #cardiosky #publichealth In this large, prospective, population-based study of 15,516 participants from the MDCS cohort, the study observed that familial burden of diabetes was independently associated with increased relative risk of a hospital diagnosis of #COVID
November 26, 2025 at 8:36 AM
#Mesky🧪 #IDsky #endosky #immunosky #publichealth This review highlights the need to consider #obesity in general & adipose tissue in particular as an active disease modifier of viral infection with implications for future pandemics.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
i sense the fleetness of the earthly mirage more sure than anything
A hiraeth - There's a long ago lost distant home
on the passageway's other side
A hiraeth - There's a long ago lost distant home
on the passageway's other side
November 26, 2025 at 8:18 AM
i sense the fleetness of the earthly mirage more sure than anything
A hiraeth - There's a long ago lost distant home
on the passageway's other side
A hiraeth - There's a long ago lost distant home
on the passageway's other side
#Medsky🧪#IDsky #immunosky #publichealth in This review of 25 studies on the relationship between pre-COVID & post-COVID vaccination on #longCOVID.
🔑 findings :
- 2 dose preCOVID vaccination was associated with a 24% reduced odds of #longCOVID
🔑 findings :
- 2 dose preCOVID vaccination was associated with a 24% reduced odds of #longCOVID
November 26, 2025 at 6:08 AM
#Medsky🧪#IDsky #immunosky #publichealth in This review of 25 studies on the relationship between pre-COVID & post-COVID vaccination on #longCOVID.
🔑 findings :
- 2 dose preCOVID vaccination was associated with a 24% reduced odds of #longCOVID
🔑 findings :
- 2 dose preCOVID vaccination was associated with a 24% reduced odds of #longCOVID
Reposted by TRAstonDrs
📣 Heavy Menstrual Bleeding in Women Treated with DOACs: Results of the HEMBLED Registry ⬇️
📌 Lindhoff-Last report differences among DOACs and their influence on the intensity of sponteneous menstrual bleeding
🆓 on TH: www.thieme-connect.de/products/ejo...
#Thrombosis #DOAC #VTE #HemeSky
📌 Lindhoff-Last report differences among DOACs and their influence on the intensity of sponteneous menstrual bleeding
🆓 on TH: www.thieme-connect.de/products/ejo...
#Thrombosis #DOAC #VTE #HemeSky
November 21, 2025 at 7:31 PM
📣 Heavy Menstrual Bleeding in Women Treated with DOACs: Results of the HEMBLED Registry ⬇️
📌 Lindhoff-Last report differences among DOACs and their influence on the intensity of sponteneous menstrual bleeding
🆓 on TH: www.thieme-connect.de/products/ejo...
#Thrombosis #DOAC #VTE #HemeSky
📌 Lindhoff-Last report differences among DOACs and their influence on the intensity of sponteneous menstrual bleeding
🆓 on TH: www.thieme-connect.de/products/ejo...
#Thrombosis #DOAC #VTE #HemeSky
Reposted by TRAstonDrs
Patient came in with sore throat. While waiting for rapid Strep test result we glanced back at the Covid-19 RAT result: positive. Reminder that masking in health care makes sense, if you don’t want everyone in your waiting room to go home sick, your staff to get sick, and physicians to get sick.
November 25, 2025 at 4:35 PM
Patient came in with sore throat. While waiting for rapid Strep test result we glanced back at the Covid-19 RAT result: positive. Reminder that masking in health care makes sense, if you don’t want everyone in your waiting room to go home sick, your staff to get sick, and physicians to get sick.
#Medsky🧪 #virosk #idsky #immunosky #publichealth Structural and functional characterizations of infectivity & immune evasion of #SARSCoV2 Omicron revival
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
(Cell 185, 860–871.e1–e4; March 3, 2022)
www.cell.com
November 25, 2025 at 1:50 PM
#Medsky🧪 #virosk #idsky #immunosky #publichealth Structural and functional characterizations of infectivity & immune evasion of #SARSCoV2 Omicron revival
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
#Medsky🧪 #IDsky #Drugrepurpose #pharmsky #publichealth Current Evidences for #Sirolimus in #LongCOVID
Clinical Trials & Research Activity
Clinical Trials & Research Activity
Low-Dose Rapamycin for ME/CFS and Long COVID: New Clinical Data, Promising Hints, and Ongoing Caution
danilobuonsenso.substack.com/p/low-dose-r...
danilobuonsenso.substack.com/p/low-dose-r...
Low-Dose Rapamycin for ME/CFS and Long COVID: New Clinical Data, Promising Hints, and Ongoing Caution
Over the past months, I have written several posts exploring the potential role of low-dose rapamycin in Long COVID and ME/CFS (Part 1, Part 2, Part 3).
danilobuonsenso.substack.com
November 25, 2025 at 11:56 AM
#Medsky🧪 #IDsky #Drugrepurpose #pharmsky #publichealth Current Evidences for #Sirolimus in #LongCOVID
Clinical Trials & Research Activity
Clinical Trials & Research Activity
Reposted by TRAstonDrs
🫁🧬 Preclinical signal: can lung clots protect? Moderate thrombosis in sepsis ARDS limited endothelial injury via ALOX15-driven lipids.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
New Clues to Protecting Lungs in Sepsis Lung Injury
Mouse and human data suggest endothelial ALOX15 and its lipids may help turn some lung clots into protection in sepsis lung injury, highlighting future therapeutic opportunities.
www.emjreviews.com
November 25, 2025 at 11:43 AM
🫁🧬 Preclinical signal: can lung clots protect? Moderate thrombosis in sepsis ARDS limited endothelial injury via ALOX15-driven lipids.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
Reposted by TRAstonDrs
My work on SARS-CoV-2 variants informed a recent piece in The Lancet: "Epidemiological and virological update on the emerging SARS-CoV-2 variant BA.3.2".
The authors were kind enough to mention me and the Variant Hunters Ryan Hisner and Federico Gueli.
www.thelancet.com/journals/lan...
🧵
The authors were kind enough to mention me and the Variant Hunters Ryan Hisner and Federico Gueli.
www.thelancet.com/journals/lan...
🧵
Epidemiological and virological update on the emerging SARS-CoV-2 variant BA.3.2
The constant emergence of novel SARS-CoV-2 variants has driven the COVID-19 pandemic
and sustains the current endemic. Saltation variants, such as BA.2.86,1 encode highly
mutated spike (S) proteins th...
www.thelancet.com
November 25, 2025 at 1:30 AM
My work on SARS-CoV-2 variants informed a recent piece in The Lancet: "Epidemiological and virological update on the emerging SARS-CoV-2 variant BA.3.2".
The authors were kind enough to mention me and the Variant Hunters Ryan Hisner and Federico Gueli.
www.thelancet.com/journals/lan...
🧵
The authors were kind enough to mention me and the Variant Hunters Ryan Hisner and Federico Gueli.
www.thelancet.com/journals/lan...
🧵
The texture of life…
November 25, 2025 at 10:27 AM
The texture of life…
We all need something to start the day …
November 25, 2025 at 8:32 AM
We all need something to start the day …
Growing old is deeply sweet & tragic
November 25, 2025 at 8:23 AM
Growing old is deeply sweet & tragic
#Medsky🧪#IDsky #publichealth @plosone.org In the cohort, 59% of #PostCovid patients could not return to their previous level of independence or employment due to symptoms, & 81% reported fatigue on the WEIMuS questionnaire.
November 25, 2025 at 6:57 AM
#Medsky🧪#IDsky #publichealth @plosone.org In the cohort, 59% of #PostCovid patients could not return to their previous level of independence or employment due to symptoms, & 81% reported fatigue on the WEIMuS questionnaire.
Perfect is boring.
Imperfect is where the story lives.
Peter Falk
Imperfect is where the story lives.
Peter Falk
November 25, 2025 at 6:29 AM
Perfect is boring.
Imperfect is where the story lives.
Peter Falk
Imperfect is where the story lives.
Peter Falk
The truth never
harmed anyone What harms us is to
persist in ignorance
Marcus Aurelius
harmed anyone What harms us is to
persist in ignorance
Marcus Aurelius
November 25, 2025 at 6:00 AM
The truth never
harmed anyone What harms us is to
persist in ignorance
Marcus Aurelius
harmed anyone What harms us is to
persist in ignorance
Marcus Aurelius
#Mesky🧪 #IDsky #immunosky #publichealth
Vaccination are still reduced diseases severity & 😷 has also an effective layer of protection . 🇺🇸 flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries
Vaccination are still reduced diseases severity & 😷 has also an effective layer of protection . 🇺🇸 flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries
U.S. flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries
A New Flu Variant May Make Cold Season Brutal This Year
U.S. flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries
www.scientificamerican.com
November 25, 2025 at 5:52 AM
#Mesky🧪 #IDsky #immunosky #publichealth
Vaccination are still reduced diseases severity & 😷 has also an effective layer of protection . 🇺🇸 flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries
Vaccination are still reduced diseases severity & 😷 has also an effective layer of protection . 🇺🇸 flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries