Dr. Veronica Chiang shares updates on three #clinicaltrials she is leading that target brain metastases. #brainmets
medicine.yale.edu/news-article...
medicine.yale.edu/news-article...
Clinical Trials Target Brain Metastases
Veronica Chiang, MD, professor of neurosurgery, is currently leading several clinical trials seeking to improve treatments for brain metastases, or cancers that
medicine.yale.edu
January 16, 2026 at 3:01 PM
Dr. Veronica Chiang shares updates on three #clinicaltrials she is leading that target brain metastases. #brainmets
medicine.yale.edu/news-article...
medicine.yale.edu/news-article...
Thrilled to be part of the upcoming Brain & Spine Metastases Conference! Join me and colleagues to explore the latest in brain and spine mets. Use code Ahmed for a discounted rate! Register here: www.gotoper.com/brainspinemets #BMC25 #BrainMets #SpineMets
CME / CE - Physicians' Education Resource
Physicians' Education Resource - Newest Continuing Medical Education Live Events, Webcasts & Online Activities
www.gotoper.com
January 8, 2026 at 2:42 AM
Thrilled to be part of the upcoming Brain & Spine Metastases Conference! Join me and colleagues to explore the latest in brain and spine mets. Use code Ahmed for a discounted rate! Register here: www.gotoper.com/brainspinemets #BMC25 #BrainMets #SpineMets
💡 Clinical Tip: In MBC (esp. HER2+ & TNBC), discuss brain metastasis risk proactively — patient-centered dialogue is key while awaiting trial evidence.
#BreastCancer #BrainMets #MetastaticBC #OncoTwitter #MedicalWatch
#BreastCancer #BrainMets #MetastaticBC #OncoTwitter #MedicalWatch
August 26, 2025 at 2:44 PM
💡 Clinical Tip: In MBC (esp. HER2+ & TNBC), discuss brain metastasis risk proactively — patient-centered dialogue is key while awaiting trial evidence.
#BreastCancer #BrainMets #MetastaticBC #OncoTwitter #MedicalWatch
#BreastCancer #BrainMets #MetastaticBC #OncoTwitter #MedicalWatch
👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky
July 11, 2025 at 8:18 AM
👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky
CIMARa has 4 goals:
1) Establish an infrastructure to enhance discovery & development of #brainmetstherapies
2) Provide a network of experts to advance & implement clinical trials for patients with #brainmets
3) Harmonize study end-points
4) Develop a common forum for discussion
1) Establish an infrastructure to enhance discovery & development of #brainmetstherapies
2) Provide a network of experts to advance & implement clinical trials for patients with #brainmets
3) Harmonize study end-points
4) Develop a common forum for discussion
June 6, 2025 at 2:00 PM
CIMARa has 4 goals:
1) Establish an infrastructure to enhance discovery & development of #brainmetstherapies
2) Provide a network of experts to advance & implement clinical trials for patients with #brainmets
3) Harmonize study end-points
4) Develop a common forum for discussion
1) Establish an infrastructure to enhance discovery & development of #brainmetstherapies
2) Provide a network of experts to advance & implement clinical trials for patients with #brainmets
3) Harmonize study end-points
4) Develop a common forum for discussion
Hello! Formally introducing CIMARa. Led by CareyAnders
(@dukemets.bsky.social) and @HTawbi_MD
(@mdanderson.bsky.social), we are physicians, scientists, non-profits & advocates who share the goal of improving outcomes for patients with #brainmets through awareness & coordination of research.
(@dukemets.bsky.social) and @HTawbi_MD
(@mdanderson.bsky.social), we are physicians, scientists, non-profits & advocates who share the goal of improving outcomes for patients with #brainmets through awareness & coordination of research.
June 6, 2025 at 1:57 PM
Hello! Formally introducing CIMARa. Led by CareyAnders
(@dukemets.bsky.social) and @HTawbi_MD
(@mdanderson.bsky.social), we are physicians, scientists, non-profits & advocates who share the goal of improving outcomes for patients with #brainmets through awareness & coordination of research.
(@dukemets.bsky.social) and @HTawbi_MD
(@mdanderson.bsky.social), we are physicians, scientists, non-profits & advocates who share the goal of improving outcomes for patients with #brainmets through awareness & coordination of research.
Happening now! Join us to learn from this great group of speakers. #CNS #pediatricbraintumor #braintumor #glioma #gbm #neurosurgery #brainmets #brainmetastasis
April 11, 2025 at 12:45 PM
Happening now! Join us to learn from this great group of speakers. #CNS #pediatricbraintumor #braintumor #glioma #gbm #neurosurgery #brainmets #brainmetastasis
Fine-tune your strategies for using #HER2 targeting tx in HER2+ #MBC with and without #BrainMets: Get expert insight in this video from @PeerView & @graspcancer.bsky.social featuring Sara A. Hurvitz, MD, FACP, and colleagues. bit.ly/4fk0wD5
MDADI
MDADI
bit.ly
March 17, 2025 at 11:37 PM
Fine-tune your strategies for using #HER2 targeting tx in HER2+ #MBC with and without #BrainMets: Get expert insight in this video from @PeerView & @graspcancer.bsky.social featuring Sara A. Hurvitz, MD, FACP, and colleagues. bit.ly/4fk0wD5
Why are our findings significant?
Routine ERBB2 testing in EAC patients could guide early HER2-targeted therapy - and can identify high-risk patients for brain metastasis.
JAK2 alterations may help stratify patients for immunotherapy.
Thanks for reading!
#brainmets #oncology
Routine ERBB2 testing in EAC patients could guide early HER2-targeted therapy - and can identify high-risk patients for brain metastasis.
JAK2 alterations may help stratify patients for immunotherapy.
Thanks for reading!
#brainmets #oncology
February 28, 2025 at 2:27 PM
Why are our findings significant?
Routine ERBB2 testing in EAC patients could guide early HER2-targeted therapy - and can identify high-risk patients for brain metastasis.
JAK2 alterations may help stratify patients for immunotherapy.
Thanks for reading!
#brainmets #oncology
Routine ERBB2 testing in EAC patients could guide early HER2-targeted therapy - and can identify high-risk patients for brain metastasis.
JAK2 alterations may help stratify patients for immunotherapy.
Thanks for reading!
#brainmets #oncology
Really excited to share our lab's first manuscript! I cant be more proud of our team, especially @nora-mae.bsky.social who diligently worked on this project.
It will be a long thread but I promise it's worth it!
#Oncology #BrainMets
It will be a long thread but I promise it's worth it!
#Oncology #BrainMets
February 28, 2025 at 2:27 PM
Really excited to share our lab's first manuscript! I cant be more proud of our team, especially @nora-mae.bsky.social who diligently worked on this project.
It will be a long thread but I promise it's worth it!
#Oncology #BrainMets
It will be a long thread but I promise it's worth it!
#Oncology #BrainMets
[email protected] provides a clear overview of treatments for HER2+ MBC with a lot of discussion around those living with #brainmets. ADCs are now indicated for patients with active CNS disease #OncoAlertColloquium #BreastCancer
February 5, 2025 at 5:50 PM
[email protected] provides a clear overview of treatments for HER2+ MBC with a lot of discussion around those living with #brainmets. ADCs are now indicated for patients with active CNS disease #OncoAlertColloquium #BreastCancer
The late, great Laura Greco had 8 brain surgeries because of #BrainMets. Lung Cancer spreads to the brain more often than any other cancer.
We deserve better.
#LMD #lcsm
We deserve better.
#LMD #lcsm
For Emma, losing her licence after a #LungCancer diagnosis with #BrainMets felt like losing her independence.
70% of #ALK+ pts get 🧠 mets, yet many don't get clear guidance on driving.
That’s why our DVLA Advisory Panel created this @pifonline.bsky.social certified guide #LCSM
📌 shorturl.at/k20oo
70% of #ALK+ pts get 🧠 mets, yet many don't get clear guidance on driving.
That’s why our DVLA Advisory Panel created this @pifonline.bsky.social certified guide #LCSM
📌 shorturl.at/k20oo
February 5, 2025 at 5:30 PM
The late, great Laura Greco had 8 brain surgeries because of #BrainMets. Lung Cancer spreads to the brain more often than any other cancer.
We deserve better.
#LMD #lcsm
We deserve better.
#LMD #lcsm
For Emma, losing her licence after a #LungCancer diagnosis with #BrainMets felt like losing her independence.
70% of #ALK+ pts get 🧠 mets, yet many don't get clear guidance on driving.
That’s why our DVLA Advisory Panel created this @pifonline.bsky.social certified guide #LCSM
📌 shorturl.at/k20oo
70% of #ALK+ pts get 🧠 mets, yet many don't get clear guidance on driving.
That’s why our DVLA Advisory Panel created this @pifonline.bsky.social certified guide #LCSM
📌 shorturl.at/k20oo
January 22, 2025 at 11:58 AM
For Emma, losing her licence after a #LungCancer diagnosis with #BrainMets felt like losing her independence.
70% of #ALK+ pts get 🧠 mets, yet many don't get clear guidance on driving.
That’s why our DVLA Advisory Panel created this @pifonline.bsky.social certified guide #LCSM
📌 shorturl.at/k20oo
70% of #ALK+ pts get 🧠 mets, yet many don't get clear guidance on driving.
That’s why our DVLA Advisory Panel created this @pifonline.bsky.social certified guide #LCSM
📌 shorturl.at/k20oo
…or develop ways to deliver non-CNS-penetrant drugs to the central nervous system.
🔑 #OncSky #MedSky
We MUST include people w/ #brainmets, & as appropriate active untreated brain mets, in #Oncology #clinicaltrials. Preventing/treating CNS mets will be the final frontier in #bcsm.
/END
🔑 #OncSky #MedSky
We MUST include people w/ #brainmets, & as appropriate active untreated brain mets, in #Oncology #clinicaltrials. Preventing/treating CNS mets will be the final frontier in #bcsm.
/END
December 23, 2024 at 9:56 PM
…or develop ways to deliver non-CNS-penetrant drugs to the central nervous system.
🔑 #OncSky #MedSky
We MUST include people w/ #brainmets, & as appropriate active untreated brain mets, in #Oncology #clinicaltrials. Preventing/treating CNS mets will be the final frontier in #bcsm.
/END
🔑 #OncSky #MedSky
We MUST include people w/ #brainmets, & as appropriate active untreated brain mets, in #Oncology #clinicaltrials. Preventing/treating CNS mets will be the final frontier in #bcsm.
/END
#OncSky #bcsm
👉Remember this, esp in isolated #brainmets or isolated CNS progression
👉Determine if we can reliably detect same alterations in CSF (or innovate to make 🧠 biopsy ⬇️ invasive)
👉Prioritize CNS penetrant agents w/ 👌 safety for #drugdevelopment
/3
www.nature.com/articles/s41...
👉Remember this, esp in isolated #brainmets or isolated CNS progression
👉Determine if we can reliably detect same alterations in CSF (or innovate to make 🧠 biopsy ⬇️ invasive)
👉Prioritize CNS penetrant agents w/ 👌 safety for #drugdevelopment
/3
www.nature.com/articles/s41...
Breast cancer brain metastases genomic profiling identifies alterations targetable by immune-checkpoint and PARP inhibitors - npj Precision Oncology
npj Precision Oncology - Breast cancer brain metastases genomic profiling identifies alterations targetable by immune-checkpoint and PARP inhibitors
www.nature.com
December 23, 2024 at 9:54 PM
#OncSky #bcsm
👉Remember this, esp in isolated #brainmets or isolated CNS progression
👉Determine if we can reliably detect same alterations in CSF (or innovate to make 🧠 biopsy ⬇️ invasive)
👉Prioritize CNS penetrant agents w/ 👌 safety for #drugdevelopment
/3
www.nature.com/articles/s41...
👉Remember this, esp in isolated #brainmets or isolated CNS progression
👉Determine if we can reliably detect same alterations in CSF (or innovate to make 🧠 biopsy ⬇️ invasive)
👉Prioritize CNS penetrant agents w/ 👌 safety for #drugdevelopment
/3
www.nature.com/articles/s41...
#MedSky #OncSky
NEW & IMPORTANT Genomic profiling performed on 822 #breastcancer #brainmets (BCBM) + thousands of local breast tumors & non-brain mets (unpaired).
🔑 HRD & #ImmunoOnc-predictive biomarkers are significantly more common in BCBM.
🔑 There were some diffs by #bcsm subtype.
/1
NEW & IMPORTANT Genomic profiling performed on 822 #breastcancer #brainmets (BCBM) + thousands of local breast tumors & non-brain mets (unpaired).
🔑 HRD & #ImmunoOnc-predictive biomarkers are significantly more common in BCBM.
🔑 There were some diffs by #bcsm subtype.
/1
December 23, 2024 at 9:42 PM
#MedSky #OncSky
NEW & IMPORTANT Genomic profiling performed on 822 #breastcancer #brainmets (BCBM) + thousands of local breast tumors & non-brain mets (unpaired).
🔑 HRD & #ImmunoOnc-predictive biomarkers are significantly more common in BCBM.
🔑 There were some diffs by #bcsm subtype.
/1
NEW & IMPORTANT Genomic profiling performed on 822 #breastcancer #brainmets (BCBM) + thousands of local breast tumors & non-brain mets (unpaired).
🔑 HRD & #ImmunoOnc-predictive biomarkers are significantly more common in BCBM.
🔑 There were some diffs by #bcsm subtype.
/1
Now at #esmobreast24 it’s #BrainMets. Should we routinely screen? I know most MBC patients would say 👍🏻. Dr Emilie Le Rhun provides @myESMO guidelines. Brain mets are more common in HER2+ & TNBC, but can also occur in ER+. Brain mets also tend to occur sooner in TNBC.
November 16, 2024 at 11:52 PM
Now at #esmobreast24 it’s #BrainMets. Should we routinely screen? I know most MBC patients would say 👍🏻. Dr Emilie Le Rhun provides @myESMO guidelines. Brain mets are more common in HER2+ & TNBC, but can also occur in ER+. Brain mets also tend to occur sooner in TNBC.
via @NYTimes
watching a fascinating story on @60Minutes about Dr Ali Razai and the use of focused ultrasound to open the blood brain barrier to improved delivery of drugs to people with Alzheimer’s- this could be so impactful in #BrainMets...
watching a fascinating story on @60Minutes about Dr Ali Razai and the use of focused ultrasound to open the blood brain barrier to improved delivery of drugs to people with Alzheimer’s- this could be so impactful in #BrainMets...
November 17, 2024 at 12:51 AM
via @NYTimes
watching a fascinating story on @60Minutes about Dr Ali Razai and the use of focused ultrasound to open the blood brain barrier to improved delivery of drugs to people with Alzheimer’s- this could be so impactful in #BrainMets...
watching a fascinating story on @60Minutes about Dr Ali Razai and the use of focused ultrasound to open the blood brain barrier to improved delivery of drugs to people with Alzheimer’s- this could be so impactful in #BrainMets...
.@MalladiLab talking about his lab’s work on #brainmets, in mouse models #MBCRC22
November 17, 2024 at 11:26 AM
.@MalladiLab talking about his lab’s work on #brainmets, in mouse models #MBCRC22
Tucatinib (Tukysa) in the HER2 Climb trial really changed the paradigm by allowing people with active #BrainMets to enroll. This is so important due to the high incidence of brain mets in HER2+ #MetastaticBreastCancer @cure_today #bcsm
November 17, 2024 at 12:45 PM
Tucatinib (Tukysa) in the HER2 Climb trial really changed the paradigm by allowing people with active #BrainMets to enroll. This is so important due to the high incidence of brain mets in HER2+ #MetastaticBreastCancer @cure_today #bcsm
Dr @AyalAizer should we be screening people with MBC for #brainmets routinely? There is trial in progress (will look later and add link to head later) #bcsm
November 17, 2024 at 10:04 PM
Dr @AyalAizer should we be screening people with MBC for #brainmets routinely? There is trial in progress (will look later and add link to head later) #bcsm
what about drugs other than tucatinib for #brainmets in HER2+ MBC? Lots of encouraging data, and ongoing trials. #bcsm
November 17, 2024 at 10:04 PM
what about drugs other than tucatinib for #brainmets in HER2+ MBC? Lots of encouraging data, and ongoing trials. #bcsm
Tucatinib is tyrosine kinase inhibitor that is super exciting, especially for those with active #brainmets. #bcsm
November 17, 2024 at 10:50 PM
Tucatinib is tyrosine kinase inhibitor that is super exciting, especially for those with active #brainmets. #bcsm
very interesting @UCSFBreastForum talk by Dr Claire Robertson, a materials scientist, on brain mets. Different subtypes of #breastcancer metastasize to different areas of the brain (white/yellow are more frequent sites) #brainmets #metastatic #bcsm
November 18, 2024 at 3:02 AM
very interesting @UCSFBreastForum talk by Dr Claire Robertson, a materials scientist, on brain mets. Different subtypes of #breastcancer metastasize to different areas of the brain (white/yellow are more frequent sites) #brainmets #metastatic #bcsm