Thank you so much for this research highlight!! Beautifully done!
Reposted by: Adrienne Boire, Mikala Egeblad
I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...
Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature
Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...
www.nature.com
I am so very proud of our collective work, and of our message: understanding fundamental biology is essential to the understanding of human disease. Basic science matters!
We found that anti-tumor immunity operates differently within the leptomeningeal space. Surprisingly, this is independent of antigen presentation: Interferon gamma drives maturation of dendritic cells into supporters of NK cell-mediated tumor killing.
This truly massive undertaking was led by an extraordinary postdoc in my laboratory, Jan Remsik, now a PI at the VIB. Our led to analysis of a great many patient samples, transgenic models, and a rich collaboration with my friend and colleague Dana Pe’er.
I am delighted to share that our work focused on anti-tumor immunity in the leptomeningeal space was published today:
www.nature.com/articles/s41...
@meningojan.bsky.social
www.nature.com/articles/s41...
@meningojan.bsky.social
Hello Bluesky! I wanted to start with pure science LOVE: some pics from my wonderful laboratory that capture the total joy in discovery that we all share.
