Scholar

Elena Grassi

Videos
H-index: 22
Biology 86%
Medicine 10%
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Reposted by: Elena Grassi

elizsmckenna.bsky.social
Now online in Cancer Discovery @aacrjournals.bsky.social: The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer - by Marco Avolio, Simonetta Leto, Andrea Bertotti, Livio Trusolino, and colleagues doi.org/10.1158/2159...
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Reposted by: Elena Grassi, Simon Roux

jbonfield.bsky.social
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.

Ie: it's not us (Samtools team)! Be warned
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by Elena Grassi

vodkatad.bsky.social
Proud of Sofia who is presenting our fight vs scRNA with GNN and GRN at CIBB2025.

Reposted by: Elena Grassi

ciriellolab.bsky.social
🚀 WE'RE BACK! "The Many Faces of Cancer Evolution" is coming back to Rimini on May 27-29, 2026! meetings.embo.org/event/26-can... Join me, Luca @magnanilab.bsky.social , Celine Vallot, and Samra @turajliclab.bsky.social for 3 days of amazing science on the beach! @embo.org meeting #cancer 👇👇
The Many Faces of Cancer Evolution
Cancer evolution is a multi-faceted process and a major clinical challenge. Indeed, tumors constantly change as they progress through multiple mechanisms, the understanding of which is critical to an…
meetings.embo.org
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Reposted by: Elena Grassi

magnanilab.bsky.social
Finally, we are OPEN! meetings.embo.org/event/26-can.... You dont' want to miss this one. Capped at 180 partecipants, so register super early to avoid disappointment. Amazing speakers, incredible location and the best vibe. Come to learn, share, discuss and enjoy some of the most exciting ideas.
The Many Faces of Cancer Evolution
Cancer evolution is a multi-faceted process and a major clinical challenge. Indeed, tumors constantly change as they progress through multiple mechanisms, the understanding of which is critical to an…
meetings.embo.org
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Reposted by: Elena Grassi

bits-bioinf.bsky.social
Stay connected during #BITS2025!
Use the hashtag and tag us in your posts 🧬

We’re on:
🔹 X → x.com/BITS_bioinf
🔹 LinkedIn → linkedin.com/company/bioinformatics-italian-society-bits
🔹 BlueSky → bsky.app/profile/bits-bioinf.bsky.social
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by Elena Grassi

vodkatad.bsky.social
(7/7) If you want to know more about how we measured MRs, compared them with computationally inferred ones and validated our results thanks to the Genomics England Research Network: www.science.org/doi/10.1126/...
@sottoriva.bsky.social @genomicsengland.bsky.social
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer
Tumors with chromosomal instability accrue DNA sequence mutations at highly variable rates, which increase during metastatic progression.
www.science.org

by Elena Grassi

vodkatad.bsky.social
(6/7) Our data suggest tumors evolve toward higher mutation rates over time - this will impact how drug response and resistance are modelled. Moreover shifts in mutational signatures before vs after tumor initiation may offer a way to 'carbon-date' tumors.
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by Elena Grassi

vodkatad.bsky.social
(5/7) We also discovered that the mutational processes at play during cancer growth are different from the ones in normal cells - the mutational signatures detected during the accumulation period are different from the ones seen in bulk tumors.

by Elena Grassi

vodkatad.bsky.social
(4/7) It turned out each tumor has its own specific MR and the differences in MRs among MSS tumors are as large as the ones between MSS and MSI. Moreover, earlier lesions have lower mutation rates than later ones of the same patient.

by Elena Grassi

vodkatad.bsky.social
(3/7) Using colorectal cancer clonal organoids we set up a Mutation Accumulation experiment, where we performed a WGS at the beginning and the end of six months of growth and identified the newly accumulated mutations.

by Elena Grassi

vodkatad.bsky.social
(2/7) We decided to directly measure the Mutation Rate (MR) in colorectal tumors, to understand if MSS tumors really do accumulate few SNVs at homogeneous rates and check whether in silico models that estimate MR are trustworthy.

by Elena Grassi

vodkatad.bsky.social
(1/7) Our paper on how fast colorectal tumors accumulate mutations is finally out (and on the STM cover! @science.org )
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Reposted by: Elena Grassi

ultanmcd.bsky.social
This is pretty depressing - why OpenSNP, a company with a data-centric belief that genetic data would be a key driver for improving human health and medicine, will close (and delete all of its data) opensnp.wordpress.com. Turns out the biggest users were law enforcement and govt, not labs or pharma.
openSNP
crowdsourcing genome wide association studies
opensnp.wordpress.com
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Reposted by: Elena Grassi

odedrechavi.bsky.social
The Woodstock of Biology 2 + Nightscience conference is going to be out of this world.
#theconferencetoendallconferences - Register NOW while it's still possible: woodstock.img.cas.cz
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by Elena Grassi

vodkatad.bsky.social
Weekly read: www.nature.com/articles/s41... lessons on phenotypic evolution, genetically or environmentally driven, from E.Coli.
Genetic properties underlying transcriptional variability across different perturbations - Nature Communications
Organisms display non-uniform transcriptional variability in response to genetic and environmental perturbations. This study on Escherichia coli reveals how gene regulatory networks shape transcriptio...
www.nature.com
1

Reposted by: Elena Grassi

helloeacr.bsky.social
What a fantastic conference we’ve had this week in Lyon, shining the spotlight on the rapidly evolving area of research that is cancer persister cells. Thank you to all participants, speakers and our wonderful Scientific Programme Committee 🤩
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Reposted by: Elena Grassi

odedrechavi.bsky.social
I really enjoy reading "Evolution Evolving", really mind-opening and beautifully written
press.princeton.edu/books/hardco...
@kevinlala.bsky.social
Evolution Evolving
A new account of the central role developmental processes play in evolution
press.princeton.edu
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by Elena Grassi

vodkatad.bsky.social
Weekly read: www.nature.com/articles/s41... - about the role of EMT in PDAC het-evol and (another) evidence of cell-state-specific mutational processes.
Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature
Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...
www.nature.com

by Elena Grassi

vodkatad.bsky.social
Before (beer to fuel the body) and after (climb to destroy it) a super intensive conference on cancer/bacterial persisters. Lots of interesting talks, interactive sessions and fruitful posters discussions. @helloeacr.bsky.social
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Reposted by: Elena Grassi

odedrechavi.bsky.social
Friends! The science that we love is under threat. World-wide, there're forces seeking to make it corporate-like, focused on deliverables, or even the enemy of society. Take a stand & celebrate science & music! #theconferencetoendallconferences - Registration starts NOW!
woodstock.img.cas.cz
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References

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