Lightnews — Scholar-powered news

Reposted by Anjali Hinch

Inigo Martincorena @imartincorena.bsky.social · 2d

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

Inigo Martincorena @imartincorena.bsky.social · 3d

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

www.nature.com

3 11 32

Anjali Hinch @anjalihinch.bsky.social · 5d

Emily passed her transfer viva with flying colours! Thanks to her awesome examiners Simon Myers and Nicky Whiffin #ProudPI

1 9

Reposted by Anjali Hinch

Society for Molecular Biology and Evolution @official-smbe.bsky.social · 10d

🔁 Please share - we remind the SMBE community that the Call for Symposia for SMBE2026 in Copenhagen is open.

We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting.

🗓️ Deadline: October 15th

More information: smbe2026.org/symposia

#SMBE2026

15 7

Reposted by Anjali Hinch

Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

4 46 110

Reposted by Anjali Hinch

Matthew Freeman @mjafreeman.bsky.social · Sep 10

Another exciting opportunity @dunnschool.bsky.social !

Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health

Please help us find great applicants

The Dunn School, Oxford @dunnschool.bsky.social · Sep 10

We're hiring (again)!

We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)

If you have a great record and exciting plans, consider joining our thriving and welcoming department

www.path.ox.ac.uk/vacancy/asso...

19 24

Reposted by Anjali Hinch

The Dunn School, Oxford @dunnschool.bsky.social · Sep 8

Our PhD studentship programme is officially open; pass it on

If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...

Great science and a great environment!

www.path.ox.ac.uk/news-article...

Applications now open for our PhD studentship programme - Dunn School

Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

www.path.ox.ac.uk

1 20 21

Reposted by Anjali Hinch

Lino Ferreira @linoafferreira.bsky.social · Sep 10

Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics!
academic.oup.com/genetics/adv...

We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵

Phantom epistasis through the lens of genealogies

Abstract. Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive ef

academic.oup.com

2 13 21

Reposted by Anjali Hinch

Yun S. Song @yun-s-song.bsky.social · Sep 11

SINGER, our ARG inference method, is finally published and freely available online:

doi.org/10.1038/s415...

It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...

Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes - Nature Genetics

SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.

doi.org

1 52 99

Reposted by Anjali Hinch

Scott Keeney @spo11rulz.bsky.social · Aug 16

New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...

Insight into Meiotic DNA End Resection: Mechanisms and Regulation

Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic ch…

www.sciencedirect.com

13 23

Reposted by Anjali Hinch

The Dunn School, Oxford @dunnschool.bsky.social · Jul 30

📣 Applications now open 📣

We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!

Please share!

www.path.ox.ac.uk/work-with-us...

10 13

Reposted by Anjali Hinch

Yun S. Song @yun-s-song.bsky.social · Jun 6

The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io

Please help spread the news.

Home - ProbGen 2026

Your Site Description

probgen2026.github.io

2 36 68

Reposted by Anjali Hinch

Andrew Blackford @andrewblackford.bsky.social · May 29

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

35 23

Reposted by Anjali Hinch

Ian Henderson @hendersi.bsky.social · May 30

A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social
www.jobs.cam.ac.uk/job/51488/

Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge

Research Assistant / Research Associate (Fixed Term) in the Department of Plant Sciences at the University of Cambridge.

www.jobs.cam.ac.uk

60 50

Anjali Hinch @anjalihinch.bsky.social · May 30

Wonderful talk by Yun today on the present and future of protein and DNA large language models. Spectacular!

Yun S. Song @yun-s-song.bsky.social · Apr 7

Thrilled to see my digital art on the cover of Trends Genet. The two binary strings represent reverse-complementary DNA sequences (00=A, 01=C, 10=G, 11=T) and the connecting rectangles represent “embeddings” learned by DNA language models. Pls check out our article as well: doi.org/10.1016/j.ti...

1 1 2

Reposted by Anjali Hinch

Caroline Wright @carolinefwright.bsky.social · May 29

Both translational and fundamental curiosity-driven research are needed to fuel the incredible progress we're seeing in genomic medicine; an important message in this article and and some lovely quotes from @sarahlwynn.bsky.social
www.ft.com/content/25dd...

Curiosity underlies a breakthrough in rare disease

We must recognise and protect the pipelines that lead from research to real-world benefit

www.ft.com

9 18

Reposted by Anjali Hinch

The Dunn School, Oxford @dunnschool.bsky.social · May 20

Delighted to announce that Prof. Kevin Foster has been elected Fellow of @royalsociety.org!

This honour recognises the unique way he combines maths, ecology, evolution and microbiology to study microbial communities

Many congratulations Kevin!

Find out more: www.path.ox.ac.uk/news-article...

Kevin Foster elected Fellow of the Royal Society - Dunn School

Many congratulations to Kevin for this prestigious honour, recognising his contribution to integrate ecological and evolutionary principles into microbiology to understand the human microbiome and oth...

www.path.ox.ac.uk

3 30

Reposted by Anjali Hinch

Molly Przeworski @mollyprz.bsky.social · Apr 29

Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!

3 15 87

Reposted by Anjali Hinch

Nature @nature.com · Apr 21

Nature research paper: Towards multimodal foundation models in molecular cell biology

https://go.nature.com/3YvGcbJ

Towards multimodal foundation models in molecular cell biology - Nature

The development of multimodal foundation models, pretrained on diverse omics datasets, to unravel the intricate complexities of molecular cell biology is envisioned.

go.nature.com

8 43

Reposted by Anjali Hinch

The Dunn School, Oxford @dunnschool.bsky.social · Mar 5

Tonight at 5.30pm on the BBC! 📺

The Foster group here at the the Dunn School will bring the science of the microbiome to ‘Operation Ouch!’, a popular children programme presented by Doctors Chris and Xand Van Tulleken. One to watch with your little ones! 👣🦠

www.path.ox.ac.uk/news-article...

3 10

Reposted by Anjali Hinch

Cat Vicente @catcvicente.bsky.social · Feb 18

Come work with me! Great opportunity for an enthusiastic Comms or events professional!

The Dunn School, Oxford @dunnschool.bsky.social · Feb 6

We are recruiting a centenary communications and events officer!

We have a spectacular history and our research has saved millions of lives. But we think the best is still to come. Help us mark this special occasion!

Deadline is the 17th of March. Please share!

my.corehr.com/pls/uoxrecru...

2 2

Reposted by Anjali Hinch

Oded Rechavi @odedrechavi.bsky.social · Feb 18

What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX

https://www.biorxiv.org/content/10.1101/2025.02.14.638102v1?ct=

t.co

1 47 100

Reposted by Anjali Hinch

Federico Teloni @fedeteloni.bsky.social · Feb 12

New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!

How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!

Read more 👉 https://doi.org/10.1101/2025.02.10

Follow along for key insights! 🧵

3 18 55

Reposted by Anjali Hinch

DNA Topology Lab @dnatopologylab.bsky.social · Feb 7

Why do different DNA molecules occupy different places in the nucleus? What drives chromatin compartmentalisation? Read this amazing paper to find out www.science.org/doi/10.1126/...
Many congratulations to all the authors of this brilliant work! @rkoszul.bsky.social

5 16

Reposted by Anjali Hinch

Matthew Freeman @mjafreeman.bsky.social · Feb 6

This is a great opportunity for someone interested in comms, event planning, science history, or just working @dunnschool.bsky.social in Oxford.

The Dunn School, Oxford @dunnschool.bsky.social · Feb 6

We are recruiting a centenary communications and events officer!

We have a spectacular history and our research has saved millions of lives. But we think the best is still to come. Help us mark this special occasion!

Deadline is the 17th of March. Please share!

my.corehr.com/pls/uoxrecru...

7 4