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Ben Engel @cellarchlab.com · 11h

Let’s stare into the far red 🏮. A stunning tour-de-force of high-resolution #CryoEM by Gio, Bill, & company reveals how the machinery of photosynthesis redshifts itself so cyanobacteria can live on far red light, deep in the cracks of rocks or under microbial mats. #PlantScience 🧪 🧶🧬 🌾 🔬 🌍

giovanniconsoli.bsky.social @giovanniconsoli.bsky.social · 2d

Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠

Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org

www.science.org/doi/10.1126/...

Locating the missing chlorophylls f in far-red photosystem I

The discovery of chlorophyll f-containing photosystems, with their long-wavelength photochemistry, represented a distinct, low-energy paradigm for oxygenic photosynthesis. Structural studies on chloro...

www.science.org

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Ben Engel @cellarchlab.com · 1d

The KEY🔑 to regulating Rubisco phase separation in the Chlamydomonas algal pyrenoid. Beautiful work by Shan He, @mjonikas.bsky.social, and friends. #PhaseSeparation #CO2 #PlantScience 🧪 🧶🧬 🌾 🌍

Martin Jonikas @mjonikas.bsky.social · 1d

Algal pyrenoids—condensates that mediate ~1/3 of Earth’s CO2 fixation—change size and number as cells divide. Our data suggest a simple control mechanism: a kinase that continuously ejects material from the condensate! ☀️🌍🔬💧 #Biophysics #Photosynthesis
www.biorxiv.org/content/10.1...

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Ben Engel @cellarchlab.com · 1d

Hey, you’re up in my hills. I love it around here 🌳🍂🍁

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Ben Engel @cellarchlab.com · 4d

What happens when the cell's powerhouse gets stressed out? 💪🥵 Great visualization in this #Mitochondria #TeamTomo study! Congrats @denkenny.bsky.social @ruferbus.bsky.social & crew 🧪 🧶🧬 🔬

Kenneth Ehses @denkenny.bsky.social · 5d

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...

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Ben Engel @cellarchlab.com · 7d

Hellooooo beautiful!😍 #CryoEM #ArchaeaSky 🧪

The Daum Lab @daumlab.bsky.social · 7d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Ben Engel @cellarchlab.com · 8d

#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪

Jakob Meier-Credo @meiercredo.bsky.social · 24d

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

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Ben Engel @cellarchlab.com · 8d

This is rad! It gets me excited for the potential with mixed environmental samples. Congrats to you, @andschwarz.bsky.social and the crew!

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Ben Engel @cellarchlab.com · 9d

Delightful to finally meet you @edwardmarcotte.bsky.social and hear about your crazy cool science exploring the proteomes of all the diverse beasties on the planet to reconstruct LECA 🧪🌎. Now I see where Caitie gets it from 👨‍🔬👩‍🔬

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Reposted by Ben Engel

Caitie McCafferty @computingcaitie.bsky.social · 10d

So much fun to host @edwardmarcotte.bsky.social at the @biozentrum.unibas.ch and introduce him to the @cellarchlab.com, thanks for a wonderful Discovery Seminar!!

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Ben Engel @cellarchlab.com · 12d

Can they make eggs from male skin cells? Or sperm from female skin cells? Now that would be interesting….

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Reposted by Ben Engel

Alicia Michael @aliciakmichael.bsky.social · 13d

A place with fantastic colleagues, excellent facilities, a stimulating scientific environment, and a very international and vibrant city - it's got it all!

Ben Engel @cellarchlab.com · 13d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Reposted by Ben Engel

Karolin Luger @nucleosomepolice.bsky.social · 13d

Biocenter is THE BEST!

Biozentrum, University of Basel @biozentrum.unibas.ch · 14d

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

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Reposted by Ben Engel

David Brückner @davidbrueckner.bsky.social · 14d

Come join us in Basel! @biozentrum.unibas.ch is an amazing place to start your group.

Biozentrum, University of Basel @biozentrum.unibas.ch · 14d

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

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Ben Engel @cellarchlab.com · 13d

Yay @centriolelab.bsky.social !! 🙌

Ali Shaib @alishaib.bsky.social · 13d

#GEF25 Concluding Plenary Lecture with the wonderful Virginie Hamel.

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Ben Engel @cellarchlab.com · 13d

I think it has something to do with conservative lawmakers taking aim at liberal-leaning social media. See this announcement that my friend got. Did you get something similar? X is not affected by this law, and that place is swarming with misinformation and porn bots. No free speech = Hot Garbage 🔥🗑️

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Ben Engel @cellarchlab.com · 13d

What's it like to live in Basel and do basic science 🧪 at the @biozentrum.unibas.ch?

Take a look 👀👇
www.biozentrum.unibas.ch/about/biozen...

International Researchers - Biozentrum

www.biozentrum.unibas.ch

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Ben Engel @cellarchlab.com · 13d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Ben Engel @cellarchlab.com · 14d

The former supervisor of @computingcaitie.bsky.social is coming to visit and tell us all about structural proteomics. Looking forward to this #DiscoverySeminar from @edwardmarcotte.bsky.social !! 😃

#ProteinCosmos 🧶🧬

Biozentrum, University of Basel @biozentrum.unibas.ch · 17d

On Friday, October 3, we will welcome our next #DiscoverySeminar speaker, Prof. @edwardmarcotte.bsky.social @utaustin.bsky.social. Join his lecture on "Modern Cells, Ancient Proteins: Proteomics Across Deep Evolutionary Time to Decode Human Genetics" @biozentrum.unibas.ch @unibas.ch

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Ben Engel @cellarchlab.com · 15d

Thanks for highlighting our work! Here's a thread 🧵 diving into our findings and how they fit into those long-standing debates. #TeamTomo #PlantScience 🧪 🌾 🔬

bsky.app/profile/cell...

Ben Engel @cellarchlab.com · 18d

Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!

#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵

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Reposted by Ben Engel

Ricardo D. Righetto @lifeonthewedge.bsky.social · 16d

The case for studying proteins inside the cell 😉

#CryoET #TeamTomo

Ben Engel @cellarchlab.com · 18d

But there’s a curious loose end to this story. Scientists have been looking at PSII organization in thylakoids for over 50 years (including some really stunning freeze fracture 🔬😍). Sometimes PSII looks randomly oriented, and other times it forms extended 2D crystalline arrays in the membrane 💠

9/🧵

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Reposted by Ben Engel

Ben Engel @cellarchlab.com · 16d

Love it! 🧪🤓 Ya know, thylakoids can also play this paracrystalline lattice game. In plants, they emerge from the prolamellar body during de-etiolation 🟡➡️🟢

Little piece by @wojwie.bsky.social & me:
www.nature.com/articles/s41...

Lovely review by Andrew Staehelin💚:
link.springer.com/article/10.1...

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Ben Engel @cellarchlab.com · 16d

Love it! 🧪🤓 Ya know, thylakoids can also play this paracrystalline lattice game. In plants, they emerge from the prolamellar body during de-etiolation 🟡➡️🟢

Little piece by @wojwie.bsky.social & me:
www.nature.com/articles/s41...

Lovely review by Andrew Staehelin💚:
link.springer.com/article/10.1...

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Ben Engel @cellarchlab.com · 16d

An interesting parallel: Rod outer-segment disk membranes are highly packed with a membrane protein (rhodopsin) 👁️, similar to the stacked domains of thylakoids (PSII-LHCII) 🌱. And isolation of disk membranes may cause rhodopsin to crystallize into 2D arrays 💠

www.nature.com/articles/421... 🧪 🧶🧬🌾🔬

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Ben Engel @cellarchlab.com · 17d

Thanks Marcel! But don’t you mean the prettiest membranes on Earth? 😉. Golgi tried hard…. but thylakoids are the best 🌱🏆

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Ben Engel @cellarchlab.com · 18d

Thanks Harry! Now back to work on the figure🎨 for our collab paper. Almost done… ⏰😅

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