Caitie McCafferty
@computingcaitie.bsky.social
Postdoc in the @cellarchlab.com at the @biozentrum.unibas.ch. Find out more at ciliagirl.com.
Pinned
Hi! My interests include structure prediction, proteomics, cryo-EM, and citizen science. Many of which are summarized in this review I wrote with @cellarchlab.com @svenklumpe.bsky.social @rommieamaro.bsky.social Wanda and Lucy earlier this year tinyurl.com/CellreviewEM
Tomorrow!!
#Cilia and #Centrosome friends- tomorrow is the big day!! 🎉 🎉
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
November 24, 2025 at 3:52 PM
Tomorrow!!
Reposted by Caitie McCafferty
While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.
And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News
focalplane.biologists.com
November 13, 2025 at 11:26 AM
While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.
And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
Reposted by Caitie McCafferty
Super happy this work is out and included in the really interesting cilia and flagella focused issue!
Abigail Moye @abimoye.bsky.social @iobswiss.bsky.social, Theodore Wensel @bcmhouston.bsky.social and colleagues examine the sub-ciliary localisation of CEP290 and dissect the effects of its loss in mouse photoreceptors during development.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
October 31, 2025 at 2:53 PM
Super happy this work is out and included in the really interesting cilia and flagella focused issue!
Halloween card?!
October 31, 2025 at 7:18 PM
Halloween card?!
Reposted by Caitie McCafferty
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
Reposted by Caitie McCafferty
Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by @cilialab.bsky.social and @lottepedersen.bsky.social, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at #JCSciliaSI.
journals.biologists.com/jcs/issue/13...
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
journals.biologists.com
October 27, 2025 at 10:30 AM
Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by @cilialab.bsky.social and @lottepedersen.bsky.social, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at #JCSciliaSI.
journals.biologists.com/jcs/issue/13...
journals.biologists.com/jcs/issue/13...
Reposted by Caitie McCafferty
A class like no other!! From #AI structure hallucination 🤖 to #CryoEM structure reality 🔬 by @biozentrum.unibas.ch @unibas.ch undergraduate students👩🔬👩🎓 in just a few weeks!
One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the #ProteinCosmos 🧶🧬 🧪
One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the #ProteinCosmos 🧶🧬 🧪
October 26, 2025 at 1:48 PM
A class like no other!! From #AI structure hallucination 🤖 to #CryoEM structure reality 🔬 by @biozentrum.unibas.ch @unibas.ch undergraduate students👩🔬👩🎓 in just a few weeks!
One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the #ProteinCosmos 🧶🧬 🧪
One of their creations is this beautiful flower-shaped tetrameric pore 🌼, a brand new member of the #ProteinCosmos 🧶🧬 🧪
And the INCREDIBLE biophysics and bioEM facilities and protein production facility (Niko and Roman)
October 25, 2025 at 1:51 PM
And the INCREDIBLE biophysics and bioEM facilities and protein production facility (Niko and Roman)
This production was the result of a huge team effort from the members of @cellarchlab.com, Maier lab, Lim lab, Hiller lab and our neighbor Basile Wicky!
October 25, 2025 at 1:01 PM
This production was the result of a huge team effort from the members of @cellarchlab.com, Maier lab, Lim lab, Hiller lab and our neighbor Basile Wicky!
That’s a wrap of the 2nd edition of our one of a kind structural biology block course at the @biozentrum.unibas.ch! In just 6 short weeks students designed protein oligomers; rotated in cryo-ET, cryo-EM SPA, AFM, and NMR labs; and expressed, purified, and structurally characterized their designs
October 25, 2025 at 12:57 PM
That’s a wrap of the 2nd edition of our one of a kind structural biology block course at the @biozentrum.unibas.ch! In just 6 short weeks students designed protein oligomers; rotated in cryo-ET, cryo-EM SPA, AFM, and NMR labs; and expressed, purified, and structurally characterized their designs
Mark your calendars for some cilia science!!!
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
October 21, 2025 at 9:40 PM
Mark your calendars for some cilia science!!!
Reposted by Caitie McCafferty
Last Friday (17th), we had an amazing first Young Swiss Tomo meeting in Bern, organized with Elda Bauda, Zanetta Kechagia, and @leonieanton.bsky.social!
Over 70 people from 🇨🇭 gathered to talk about cryo-electron tomography 🔬.
Huge thanks to the DCI for making the event possible! See you next year! 👋
Over 70 people from 🇨🇭 gathered to talk about cryo-electron tomography 🔬.
Huge thanks to the DCI for making the event possible! See you next year! 👋
October 19, 2025 at 9:16 AM
Last Friday (17th), we had an amazing first Young Swiss Tomo meeting in Bern, organized with Elda Bauda, Zanetta Kechagia, and @leonieanton.bsky.social!
Over 70 people from 🇨🇭 gathered to talk about cryo-electron tomography 🔬.
Huge thanks to the DCI for making the event possible! See you next year! 👋
Over 70 people from 🇨🇭 gathered to talk about cryo-electron tomography 🔬.
Huge thanks to the DCI for making the event possible! See you next year! 👋
Reposted by Caitie McCafferty
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
October 5, 2025 at 10:35 AM
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
So much fun to host @edwardmarcotte.bsky.social at the @biozentrum.unibas.ch and introduce him to the @cellarchlab.com, thanks for a wonderful Discovery Seminar!!
October 4, 2025 at 8:56 AM
So much fun to host @edwardmarcotte.bsky.social at the @biozentrum.unibas.ch and introduce him to the @cellarchlab.com, thanks for a wonderful Discovery Seminar!!
Reposted by Caitie McCafferty
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
September 29, 2025 at 2:58 PM
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
You don’t want to miss this one!
The former supervisor of @computingcaitie.bsky.social is coming to visit and tell us all about structural proteomics. Looking forward to this #DiscoverySeminar from @edwardmarcotte.bsky.social !! 😃
#ProteinCosmos 🧶🧬
#ProteinCosmos 🧶🧬
On Friday, October 3, we will welcome our next #DiscoverySeminar speaker, Prof. @edwardmarcotte.bsky.social @utaustin.bsky.social. Join his lecture on "Modern Cells, Ancient Proteins: Proteomics Across Deep Evolutionary Time to Decode Human Genetics" @biozentrum.unibas.ch @unibas.ch
September 30, 2025 at 7:56 AM
You don’t want to miss this one!
Reposted by Caitie McCafferty
Meet the CAGE: a newly-discovered protein nanocapsule💊, conserved from bacteria to eukaryotes! Looks more like an eclair🍩 than a prezel🥨. This protein pastry now makes us wonder- what's the filling!? Huge congrats to the ever-amazing @computingcaitie.bsky.social, now at the @biozentrum.unibas.ch 🧪🧶🧬
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 24, 2025 at 12:03 PM
Meet the CAGE: a newly-discovered protein nanocapsule💊, conserved from bacteria to eukaryotes! Looks more like an eclair🍩 than a prezel🥨. This protein pastry now makes us wonder- what's the filling!? Huge congrats to the ever-amazing @computingcaitie.bsky.social, now at the @biozentrum.unibas.ch 🧪🧶🧬
Thanks Oli! And yes the resemblance is uncanny 🔮
September 24, 2025 at 8:05 AM
Thanks Oli! And yes the resemblance is uncanny 🔮
Yes it’s a midi shell, I’ll think about how to rephrase/present it better before submitting :)
September 24, 2025 at 8:02 AM
Yes it’s a midi shell, I’ll think about how to rephrase/present it better before submitting :)
I am in a cryo-ET lab now so hoping to figure it out!
September 24, 2025 at 8:01 AM
I am in a cryo-ET lab now so hoping to figure it out!
Next step U-ExM!!
September 23, 2025 at 5:38 PM
Next step U-ExM!!
Shout out to the amazing team working on this @ghooger.bsky.social, Ophelia, Evan, Simone, Axel and my PhD advisors David Taylor and @edwardmarcotte.bsky.social for always encouraging me to explore!!!
September 23, 2025 at 5:08 PM
Shout out to the amazing team working on this @ghooger.bsky.social, Ophelia, Evan, Simone, Axel and my PhD advisors David Taylor and @edwardmarcotte.bsky.social for always encouraging me to explore!!!
We have renamed it to CAGE: Conserved Assembly in Gram-negative bacteria and Eukaryotes; because in addition to shape, it has crazy phylogeny!! And to quote the paper: “The CAGE complex stands as both a new structural archetype and a reminder that the molecular universe is far from fully charted.”
September 23, 2025 at 5:08 PM
We have renamed it to CAGE: Conserved Assembly in Gram-negative bacteria and Eukaryotes; because in addition to shape, it has crazy phylogeny!! And to quote the paper: “The CAGE complex stands as both a new structural archetype and a reminder that the molecular universe is far from fully charted.”
When I first saw it in my micrographs, I thought it looked like a Philadelphia pretzel. After years of explaining a Philly pretzel and receiving endless pretzel pictures (s/o Jamie) and pretzel swag (s/o @sofie-dot-rec.bsky.social)….
September 23, 2025 at 5:08 PM
When I first saw it in my micrographs, I thought it looked like a Philadelphia pretzel. After years of explaining a Philly pretzel and receiving endless pretzel pictures (s/o Jamie) and pretzel swag (s/o @sofie-dot-rec.bsky.social)….
The early days looking at this complex were spent with @ghooger.bsky.social on the JEOL 2010F in the basement of UT Austin during the pandemic (while watching Real Housewives)
September 23, 2025 at 5:08 PM
The early days looking at this complex were spent with @ghooger.bsky.social on the JEOL 2010F in the basement of UT Austin during the pandemic (while watching Real Housewives)