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Reposted by Mattia Frontini

Mikhail Spivakov @mspivakov.bsky.social · 5d

A quick heads-up that we will have two PhD positions available to start in October 2026. One as part of MRC LMS PhD programme, and one as a transdisciplinary studentship with @srinjan.bsky.social and Thomas Ouldridge at Imperial.

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Mattia Frontini @ciavenasc.bsky.social · 6d

mark all as read

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Reposted by Mattia Frontini

Exeter City FC @officialecfc.bsky.social · 8d

🗣️ "You can get test kits sent to you - it's discreet and quick and easy."

Jack Fitzwater is supporting Royal Devon NHS's RAPID-IBD study 👊

FREE testing kits are available for EX postcode volunteers aged 16–49 ➡️ bit.ly/IBDKit

#ECFC #SemperFidelis

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Stefan Schoenfelder @stefanschoenfelder.bsky.social · 12d

Very much looking forward to @axelvisel.bsky.social's talk "From Nucleotide to Megabase Scale: Enhancer Function in Development and Disease" in our @enhancedgenomics.bsky.social seminar series "The 3D Regulatory Genome"

📅 02 October 2025 (today!)
⏰ 4 pm GMT

Join:
us02web.zoom.us/webinar/regi...

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Mattia Frontini @ciavenasc.bsky.social · 14d

nice to see this coming together with previous work on RNA pol II factories

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Reposted by Mattia Frontini

Carmelo Ferrai @carmeloferrai.bsky.social · 20d

As we wait for the final version in the journal, I leave here the last version that we uploaded on bioarchive.
I hope you like it!

www.biorxiv.org/content/10.1...

Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells

Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi...

www.biorxiv.org

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · Sep 3

Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (‪@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.

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kasitc.bsky.social @kasitc.bsky.social · Aug 18

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

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Reposted by Mattia Frontini

James Bonfield @jbonfield.bsky.social · 29d

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.

Ie: it's not us (Samtools team)! Be warned

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GW4 BioMed MRC DTP @gw4biomeddtp.bsky.social · Sep 9

Are you interested in applying for a studentship with us? Come along to our first online Candidate Support Webinar for tips on preparing your application. Thursday 11th September at 4pm (UK time). Click here to register: events.teams.microsoft.com/event/83d5eb...

Microsoft Virtual Events Powered by Teams

events.teams.microsoft.com

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Mattia Frontini @ciavenasc.bsky.social · Sep 8

www.exeter.ac.uk/study/fundin...

PhD:GW4 BioMed2 MRC DTP Studentship | University of Exeter

  The GW4 BioMed2 MRC DTP is offering up to 17 funded studentships across a range of biomedical disciplines, with a start date of October 2026.

www.exeter.ac.uk

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Mattia Frontini @ciavenasc.bsky.social · Sep 8

Interested in a PhD to study the genetic determinants of protein abundance using paired RNA-seq and proteomic data? Join us with a @gw4biomeddtp.bsky.social funded project available in my group together with Nick Bray (Cardiff) and Kate Burley (Bristol)

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FragileNucleosome @fnucleosome.bsky.social · Sep 1

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

Fragile Nucleosome Fall Seminars:
September 10 Grace Bower, Kvon Lab @ UC Irvine, USA
Jennifer Phillips-Cremins, UPenn, USA

September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA
Juanma Schvartzman, Columbia University, USA

October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA
Alex Federation, Talus Bio, USA

October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland
Seungsoo Kim, UC Irvine, USA

November 5 Hannah Long, University of Edinburgh, UK
Jeff Vierstra, Altius Institute, USA

November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada
Sarah Teichmann, University of Cambridge, UK

December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain
Jonathan Henninger, Carnegie Mellon, USA

December 17 Rebecca Berrens, Oxford University, UK
Jean-Benoit Lalanne, University of Montreal, Canada

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Romain Koszul @rkoszul.bsky.social · Aug 11

New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries
www.sciencedirect.com/science/arti...

RNA Pol II-based regulations of chromosome folding

The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation. St…

www.sciencedirect.com

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Yamuna Krishnan @krishnanyamuna.bsky.social · Aug 11

A big blow to All of Science, not just Harvard, not just the Fly community, not just Genetics. All of Science. Turbocharge was just switched off. Flies gave us so many insights.

Dr Sian Gramates @drglam.bsky.social · Aug 11

I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.

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Rada-Iglesias Lab @radaiglesiaslab.bsky.social · Aug 11

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression

www.biorxiv.org/content/10.1...

Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts

Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...

www.biorxiv.org

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Reposted by Mattia Frontini

Denis Wirtz @deniswirtz.bsky.social · Aug 10

My team has updated our free database of POSTDOC fellowships.

This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.

Download this updated and expanded database here: research.jhu.edu/rdt/funding-...

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Maurizio Scaltriti @scaltritilab.bsky.social · Jul 27

Per chi volesse, presenterò il mio libro a Palmi (RC) il prossimo 2 agosto.

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EMBL-EBI @ebi.embl.org · Jul 23

The Perturbation Catalogue is here!

A new platform unifying perturbation data from CRISPR screens, multiplexed variant effect assays and gene expression data in one place.

The beta version is now live. Find out more and try the platform:

www.ebi.ac.uk/about/news/u...
🧬🖥️

New platform integrates gene perturbation data

The Perturbation Catalogue provides user-friendly access to human gene perturbation, variant analysis, and expression data.

www.ebi.ac.uk

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Doug Fowler @dougfowler.bsky.social · Jul 21

Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU

Multiplexed assays of variant effect for clinical variant interpretation

Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...

www.nature.com

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Claudio Cantù @claudiocantu81.bsky.social · Jul 15

A 6-year long study from the Lab is finally out @genomeresearch.bsky.social

Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social

Why is our work Important? Discover it in the quick Bluetorial 👇

genome.cshlp.org/content/earl...

Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

genome.cshlp.org

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EMBL-EBI @ebi.embl.org · Jul 14

🚨Our user survey is closing on 24 July.

Only a few days left to share your views. Please take 10 minutes to help us demonstrate the value of the data resources we manage with our collaborators.

Complete survey 👇 www.surveymonkey.com/r/QGFMBH8?ch...

🖥️🧬 #FAIRdata

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Reposted by Mattia Frontini

David K Smith @professor-dave.bsky.social · Jun 30

Tw-Eat Sweet
Currently available FREE as an eBook - anyone can read it with the free Kindle App.
www.amazon.co.uk/dp/B094J9ZS8X

#cookbooks #CookSky #FoodSky #BookSky #KindleDeal #BookGiveaway #FreeBook #Kindle #eBook #Foodie #SimpleRecipes

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Pradeepa Madapura @pradeepmadapura.bsky.social · Jun 26

Registration for Transcription and Chromatin UK is OPEN! Taking place from September 17 to 19, 2025, this conference will showcase cutting-edge research and is a ‘must-attend’ event for the UK transcription and chromatin community & both at home and abroad.
Pl register ow.ly/7QQb50W9Alo & share

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Mary Lyon Centre at MRC Harwell @mrcharwell.bsky.social · Jun 25

"People don't do actual training in how to do animal experiments and there's such a lot that you need to think about that you just wouldn't realise unless somebody tells you."

Apply by 31st August.

Find out more about our Mouse Models for Human Disease Workshop:

www.har.mrc.ac.uk/training/cou...

Mouse Models for Human Disease Workshop

This course brings together a team of experienced mouse geneticists who guide you through the process of designing and implementing a mouse research project plan and the subsequent data analysis.

www.har.mrc.ac.uk

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