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Reposted by Courtney Hanna

Julien Richard Albert @jrichardalbert.bsky.social · 9d

I didn't think I could admire Azim Surani more than I already did
journals.biologists.com/dev/article/...

Professor Azim Surani is the Director of Epigenomics and Germline Imprinting at the Gurdon Institute in Cambridge, UK. He is this year's recipient of both the prestigious Kyoto Prize and the Paul Ehrl...

journals.biologists.com

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Reposted by Courtney Hanna

Naomi McGovern @mcgovernlab.bsky.social · 18d

An insight into advances in the field of placental biology and their importance: www.nature.com/articles/d41...

The mini placentas and ovaries revealing the basics of women’s health

Lab-made organoids that mimic reproductive tissues could point to treatments for common conditions such as pre-eclampsia and endometriosis.

www.nature.com

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Reposted by Courtney Hanna

Maxim Greenberg @maxvcg.bsky.social · 26d

Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...

Epigenetic relay: Polycomb-directed DNA methylation in mammalian development

In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...

journals.plos.org

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Courtney Hanna @cwhanna.bsky.social · Aug 22

Congrats! Looking forward to read it!

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Reposted by Courtney Hanna

Richard Sever @richardsever.bsky.social · Aug 15

"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "?

One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...

Why would anyone want to be a scientist?

It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...

journals.biologists.com

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Courtney Hanna @cwhanna.bsky.social · Aug 14

Congrats to @clairesimon.bsky.social and @niakanlab.bsky.social! We were happy to contribute to this great project investigating FGF/ERK signalling in human embryogenesis. @georgiaplea.bsky.social

Niakan Lab @niakanlab.bsky.social · Aug 13

Delighted to see this out! Human embryos depend on FGF/ERK signalling to specify epiblast versus primitive endoderm cells. Well done Claire Simon and the lab for their contributions! Many thanks to Mary Herbert @josh-brickman.bsky.social @cwhanna.bsky.social labs for brilliant contributions!

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

Nature Communications - The authors show human embryo lineage specification in the blastocyst is driven by differential FGF/ERK signaling, which segregates yolk sac-fated hypoblast and embryonic...

rdcu.be

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Courtney Hanna @cwhanna.bsky.social · Jul 17

Congrats Rebecca!

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Courtney Hanna @cwhanna.bsky.social · Jul 16

Looking forward to it!! 😀

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Courtney Hanna @cwhanna.bsky.social · May 15

Congrats! Really looking forward to reading this!

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Reposted by Courtney Hanna

Turner Lab @lab-turner.bsky.social · May 14

We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵

Divergent DNA methylation dynamics in marsupial and eutherian embryos - Nature

A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.

www.nature.com

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Courtney Hanna @cwhanna.bsky.social · Feb 10

@c-jake-harris.bsky.social looking forward to reading this!

Peter Andersen @germline.bsky.social · Feb 10

Very interesting epigenome editing work on the effect of K4me3 on both gene expression and recombination in plants!

Well done @c-jake-harris.bsky.social & co!

bioRxiv Plant Bio @biorxiv-plants.bsky.social · Feb 9

CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.02.07.636860v1

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Reposted by Courtney Hanna

James Briscoe @jamesbriscoe.bsky.social · Feb 3

Registration open for this year's Young Embryologist Network meeting

19 May, The Francis Crick Institute, London

thenode.biologists.com/yen-2025-con...

YEN 2025 Conference: Registration is open! - the Node

Register now for the Young Embryologist Network meeting - Monday 19 May 2025 at the Francis Crick Institute. Are you an early career researcher in

thenode.biologists.com

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Reposted by Courtney Hanna

Miguel Branco @brancolab.bsky.social · Jan 21

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.

Postdoctoral Research Associate - QMUL Jobs

ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:

qmul-jobs.tal.net

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Courtney Hanna @cwhanna.bsky.social · Jan 8

Compared to early human trophoblast, hTSCs lack DNMT3L expression, which is necessary for PMDs in mouse trophoblast. When we ectopically express DNMT3L in hTSCs, we find placental PMDs are restored, supporting a conserved role for DNMT3L in de novo methylation in trophoblast.

Courtney Hanna @cwhanna.bsky.social · Jan 8

The placental DNA methylation landscape is unique compared to all other cells of the body, with widespread partially methylated domains (PMDs). hTSCs exhibit widespread loss of PMDs and this pattern is persistent, regardless of cell origin, oxygen levels or culture conditions.

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Courtney Hanna @cwhanna.bsky.social · Jan 8

Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social.
tinyurl.com/93mchcd2

@loke-ctr.bsky.social @cam-repro.bsky.social

Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome

The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental “methylome” is conserved across …

tinyurl.com

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Courtney Hanna @cwhanna.bsky.social · Dec 6

Shifaan Thowfeequ @shifaant.bsky.social · Dec 4

Nice to see our latest review published in
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social

www.nature.com/articles/s41...

Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology

During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...

www.nature.com

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