Communications Chemistry, Published online: 30 July 2025; doi:10.1038/s42004-025-01611-1Structure and function in mitochondrial cristae are shaped by interactions between ATP synthase dimers and cardiolipin lipids, but the underlying mechanisms remain unclear. Here, using molecular dynamics simulations, the authors show that the altered lipid environment in Barth syndrome disrupts cardiolipin interactions at the dimer interface, leading to a reduced wedge angle of the ATP synthase dimer that may compromise crista architecture and OXPHOS efficiency.

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Martin Shipton Cardiff University has released to Nation.Cymru the breakdown by School of the 1,807 academics who have been told their jobs are “in scope” to be cut. The university announced in Januar...

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