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Reposted by Dr Emma S Chambers

Eric Topol @erictopol.bsky.social · 2d

Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...

Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...

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Reposted by Dr Emma S Chambers

Roel De Maeyer @roeldemaeyer.bsky.social · 2d

New paper alert #immunosky 🚨
What happens to our immune systems as we get older? What happens after the menopause? Turns out monocytes are actually quite important in their own right!

Check out our paper in Aging Cell now:
onlinelibrary.wiley.com/doi/10.1111/...

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy

Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace...

onlinelibrary.wiley.com

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Dr Emma S Chambers @emmaschambers.bsky.social · 2d

I am very grateful to my funders the @vivensa.bsky.social and @bartscharity.bsky.social for funding this research through seed awards. More research is desperately needed to understand the impact of menopause on immunity and I hope more funders consider this as an important research area. #immunosky

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Dr Emma S Chambers @emmaschambers.bsky.social · 2d

This study was an amazing Early Career researcher effort with Roel de Maeyer performing the functional monocyte assays, @oliviabracken.bsky.social performing the bioinformatic analysis, and my lovely lab member Justyna performing the Menopause analysis. I am very grateful for all their hard work.

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Dr Emma S Chambers @emmaschambers.bsky.social · 2d

Importantly the use of Hormone Replacement Therapy (HRT) in menopausal females kept their monocytes looking ‘young’ and they had improved phagocytosis as compared to age matched controls. Highlighting the potential immune benefits of HRT.

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Dr Emma S Chambers @emmaschambers.bsky.social · 2d

In this paper we demonstrate that there is an increase in inflammatory monocytes with altered proteome in post-menopausal females, which is not observed with age in males. Phagocytosis is significantly decreased in post-menopausal as compared to pre-menopausal females.

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Dr Emma S Chambers @emmaschambers.bsky.social · 2d

I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy

Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....

onlinelibrary.wiley.com

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Dr Emma S Chambers @emmaschambers.bsky.social · 25d

This afternoon I am speaking at @emds2025.bsky.social. Chatting monocytes, ageing and menopause :) Looking forward to an exciting meeting

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Reposted by Dr Emma S Chambers

British Society for Immunology @britsocimm.bsky.social · Sep 1

📣 Abstract submissions for #BSI25 are CLOSING SOON!

Don't miss your chance to share your research — submit today.

🗓️Deadline: Midnight, Weds 3 Sept
🔗Submit here: bit.ly/3UfF6i5

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Reposted by Dr Emma S Chambers

tovah-shaw-lab.bsky.social @tovah-shaw-lab.bsky.social · Aug 12

I am recruiting for a postdoc that wants to work on an exciting project on gut macrophages, TGFb signalling, and colon cancer! Please see the link for details - elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Postdoctoral Research Associate

We are looking for a talented and enthusiastic postdoctoral researcher to join the Shaw lab to investigate identify the regulatory function of NRROS/LRRC33 in gastrointestinal macrophage development a...

elxw.fa.em3.oraclecloud.com

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Reposted by Dr Emma S Chambers

Prof Sian Henson @drsianh.bsky.social · Jun 23

New output from the CELLO Network. Article highlighting how metabolic dysfunction underpins ageing and disease.
Read the full open-access article 👉 link.springer.com/article/10.1...
#Ageing #Metabolism #CellBiology #SystemsBiology

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Dr Emma S Chambers @emmaschambers.bsky.social · Jun 23

You get to listen to me talk about menopause and immunity :)

London Immunology Group @london-immuno.bsky.social · Jun 23

🚨 Early bird registration for our annual meeting ends this Wednesday - grab your tickets NOW! 🐦🎟️

Join us for: 'Diversity in Immunology'
🗓️ 11th July
📍Holiday Inn - Brentford Lock (new venue!)

Link to register: www.immunology.org/events/diver...

& check out our final speakers line-up! 🤩

#LIG2025

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Reposted by Dr Emma S Chambers

Lizzy Rosser @bcellsrosser.bsky.social · Jun 20

GET YOUR APPLICATION IN NOW! Couldn’t recommend this lab more #sciencebffs ♥️

Madhvi Menon @madhvimenon.bsky.social · Jun 20

🚨 The Menon lab is hiring a postdoc!

Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social

Please help spread the word #ImmunoSky

www.jobs.manchester.ac.uk/Job/JobDetai...

Research Associate in Mucosal Immunology :Manchester

www.jobs.manchester.ac.uk

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Reposted by Dr Emma S Chambers

Immune Sex Differences @sexdiffimmunity.bsky.social · May 13

Come join us this fall in Paris

Milieu Intérieur Consortium @milieuinterieur.bsky.social · May 12

Join the 1st EFIS Sex Differences in Immunity Congress – October 23, 2025 @pasteur.fr @sexdiffimmunity.bsky.social Registration link lnkd.in/emerimQc abstracts welcome from all researchers, scientists, clinicians #immunosky

Poster for EFIS sex Differences in Immunity Congress on 23 October at Institut Pasteur Paris

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Reposted by Dr Emma S Chambers

Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · Apr 24

Who's ready for another @thestemvillage.bsky.social Immunology Seminar Series? If you haven't seen these before, we invite LGBTQ+ immunologists to present online to the wider immunology community. If you'd like to present or attend, please drop a mention below #immunosky 🧪 #academicsky

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Dr Emma S Chambers @emmaschambers.bsky.social · Apr 3

Thanks :). Good question, my collaborators at UCL including @bcellsrosser.bsky.social have been working with samples from transgender individuals who are undergoing gender reaffirming hormone therapy. I am not sure what data they have on monocytes, but it probably won't be functional.

Dr Emma S Chambers @emmaschambers.bsky.social · Apr 2

If you have wondered how age, sex and even the menopause influences monocyte phenotype and function. Then our new preprint is for you www.biorxiv.org/content/10.1...

Age-associated inflammatory monocytes are increased in menopausal females and reversed by Hormone Replacement Therapy

Biological sex is a crucial, but poorly understood variable in age-related susceptibility to infections and chronic inflammation, inflammageing. Monocytes are important immune cells responsible for in...

www.biorxiv.org

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Reposted by Dr Emma S Chambers

Journal of Experimental Medicine @jem.org · Mar 26

Great coverage of the recent JEM paper by @hlpeks.bsky.social, @emmaschambers.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin, and colleagues. See the original paper here: rupress.org/jem/article/...

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Dr Emma S Chambers @emmaschambers.bsky.social · Mar 25

Thank you to @bartscharity.bsky.social who funded my menopause and HRT research. I am super excited for the next dataset on menopause and HRT so keep your eyes peeled 🤓

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Dr Emma S Chambers @emmaschambers.bsky.social · Mar 25

Finally in middle-aged cis-female donors. Those who were taking Hormone Replacement Therapy (HRT) had similar class switch B cell numbers to younger females. rupress.org/view-large/f...

rupress.org

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Dr Emma S Chambers @emmaschambers.bsky.social · Mar 25

My favourite bits about the paper come from studying old and young donors. We found that post-menopausal women had similar class switched B cells to men. rupress.org/view-large/f...

rupress.org

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Dr Emma S Chambers @emmaschambers.bsky.social · Mar 25

Super excited to have contributed to this great paper led by @bcellsrosser.bsky.social @arrdept-ucldom.bsky.social showing that Oestrogen influences B cell class switching. rupress.org/jem/article/...

Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes | Journal of Experimental Medicine | Rockefeller University Press

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in ind

rupress.org

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Dr Emma S Chambers @emmaschambers.bsky.social · Mar 19

Her true love is monocytes 😄

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Reposted by Dr Emma S Chambers

John Connelly @connellybioeng.bsky.social · Mar 18

We have a new PhD position open in the lab! Interested in the intersection between cell mechanics and protein metabolism in scar formation, then have a look. tinyurl.com/4s7wduhu

Dissecting the role of lysosomal exocytosis in keloid scar pathogenesis at Queen Mary University of London on FindAPhD.com

PhD Project - Dissecting the role of lysosomal exocytosis in keloid scar pathogenesis at Queen Mary University of London, listed on FindAPhD.com

tinyurl.com

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Dr Emma S Chambers @emmaschambers.bsky.social · Mar 14

I had a lovely trip to my daughter's class today, to tell them all about our biological army, the immune system, for science week. I got such lovely thank you cards from the class :)

Text saying "thank you for teaching me about phagocytosis"

Thank you cards with immune cells drawn on by children

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