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Piotr Ziolkowski @piotraz.bsky.social · 19d

Fantastic work coming out of Neil Hunter’s lab! www.nature.com/articles/s41...

Protecting double Holliday junctions ensures crossing over during meiosis - Nature

Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

www.nature.com

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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 19d

Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu

@univie.ac.at
@meduniwien.ac.at

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Adam Phillippy @aphillippy.bsky.social · 20d

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...

How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse

YouTube video by Stowers Institute for Medical Research

youtu.be

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Adam Phillippy @aphillippy.bsky.social · 22d

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

A complete diploid human genome benchmark for personalized genomics

Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...

www.biorxiv.org

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Aurele Piazza @aurelepiazza.bsky.social · Aug 27

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

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Florencia Pratto @florpratto.bsky.social · May 6

Woohoo! That's great news! Congratulations!!! 🎉🎉🎉🎉

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Adam Phillippy @aphillippy.bsky.social · Apr 9

A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...

A phylogeny of the 7 ape genomes that have now been completed from "T2T", with Homer Simpson representing mankind.

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Florencia Pratto @florpratto.bsky.social · Apr 8

Check this out if you ever wondered what intercellular bridges might be doing during meiosis! Happy to have played a small role! Congrats!!! @thejainlab.bsky.social

Devanshi Jain @thejainlab.bsky.social · Apr 8

For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁

Done with some awesome colleagues @florpratto.bsky.social

www.nature.com/articles/s41...

Intercellular bridges are essential for transposon repression and meiosis in the male germline - Nature Communications

A conserved feature of metazoan meiosis is that it occurs in a syncytium. Here, the authors show that intercellular bridges that connect germ cells in a syncytium are critical for ensuring proper meio...

www.nature.com

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Ewan Birney @ewanbirney.bsky.social · Jan 14

This is an important shift - the long awaited new Ensembl web site is ready for beta testing - is smooth, scrollable genome loveliness +clean views of the complex information - but @ensembl.bsky.social needs your help to get all the use cases out. Come to the webinar, and check out beta.ensembl.org

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Kate Miroshnikova @katemiro.bsky.social · Jan 8

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin

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Cohen Lab @Cornell @cohenlab.bsky.social · Jan 1

Happy new year to all! I am delighted to say that our new preprint went on @biorxiv-genetic.bsky.social today! The work was a labor of love for Mercedes Carro from my lab and Alexis Dzuibek from Andrew Grimson's lab - congrats to all! #meiosis #meiosis4eva #RNA

biorxiv.org/cgi/content/...

Argonaute proteins regulate the timing of the spermatogenic transcriptional program

Argonaute proteins are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we show that AGO3 and AGO4, but not AGO2, localize to the sex chromatin of pachytene sp...

biorxiv.org

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Florencia Pratto @florpratto.bsky.social · Dec 31

Sii, fracias! Por dónde andan ustedes? Besos!

Florencia Pratto @florpratto.bsky.social · Dec 31

Home sweet home... New Year in the summer! #puntadeleste #uruguay

View of the Playa Mansa in Punta del Este, crystal clear water with Isla Gorriti in the background

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John Weir @jweir.bsky.social · Dec 22

New preprint! How does meiosis work in non-model organisms? Together with Susana Coelho at the MPI for Biology Tübingen @mpi-bio-fml.bsky.social , we took a look at the proteins of the meiotic axis in the brown alga Ectocarpus www.biorxiv.org/content/10.1...

Exploring Meiosis in Brown Algae: Meiotic Axis Proteins in the model brown alga Ectocarpus

Most extant eukaryotic systems share core meiosis-specific genes, suggesting meiosis evolved only once in the last eukaryotic common ancestor (LECA). These genes have been characterized as master regu...

www.biorxiv.org

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Florencia Pratto @florpratto.bsky.social · Dec 15

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Florencia Pratto @florpratto.bsky.social · Nov 30

Uff Botafogo! 1 player down, 2 goals up!
#CopaLibertadores

Pic of the game showing Botafogo up by two goals, playing with 10 players since minute 1

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Florencia Pratto @florpratto.bsky.social · Nov 23

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Takashi Akera Lab @takashiakeralab.bsky.social · Nov 16

2024 Mid-Atlantic Meiosis Mini-Symposium!! 🐭🪱🪰🧬🦠Co-organized with @scienceleah.bsky.social and @florpratto.bsky.social at NIH. Amazing talks from trainees and new PIs🎉 #meiosis4eva

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Florencia Pratto @florpratto.bsky.social · Nov 14

Congratulations! Happy to have you around!

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Javier Santoyo @jsantoyo.bsky.social · Nov 13

Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries. #CrossoverRecombination #Chromosomes #Meiosis #TrendsInGenetics
www.cell.com/trends/genet...

Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries

Crossing over between homologous chromosomes in meiosis is essential in most eukaryotes to produce gametes with the correct ploidy. Meiotic crossovers are typically evenly spaced, with each homolog pa...

www.cell.com

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Marc Somssich @somssich.bsky.social · Nov 5

The Chromosome Biology Department of @raphmercier.bsky.social here at the Max Planck Institute for Plant Breeding Research Cologne (@maxplanck.bsky.social) is looking for a new group leader!

jobs.mpipz.mpg.de/jobposting/8...

#PlantScience #PlantSciJobs #GroupLeader #NewPI #PlantChromosomalBiology

Group Leader Position in Plant Chromosome Biology (m/f/d)

jobs.mpipz.mpg.de

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Tobias Lenz @biotobi.bsky.social · Oct 29

Fantastic resource for bio icons: NIH Bioart Source

Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov

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Compound Interest | Chemistry infographics @compoundchem.com · Oct 21

It's #InternationalNachoDay!

This graphic on kitchen chemistry hacks in @cenmag.bsky.social features tips on making a creamy nacho sauce as well as a guac that doesn't brown: cen.acs.org/food/food-sc...

Infographic detailing the chemistry behind four kitchen chemistry hacks. The first is slowing fruit browning. Fruits brown due to oxidation and polymerization of phenols. Adding acids, such as lemon juice, wrapping fruit in cling film or otherwise blocking oxygen slows browning, reducing the activity of the polyphenol oxidase enzyme.
You can brown onions more quickly by increasing the pH with baking soda, deprotonating amines so they react with sugars faster.
Onions make your eyes water when chopped due to the production of propanethial S-oxide. A sharp knife damages onion cells less, reducing eye-watering reactions. Chilling onions before chopping reduces the rate of the reaction and the volatility of propanethial S-oxide.
Warming cheese, water, milk, and sodium citrate makes a stable, smooth cheese sauce. Sodium ions replace calcium ions that hold casein proteins in cheese together. This allows the casein proteins to separate and act as emulsifiers, binding fat and water together

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Elena Shekhova, PhD @lumipie.com · Oct 17

🧪What a beautiful work has just been published.

This study reveals the mechanisms behind egg release during ovulation.

Looking at those images and videos is like visiting a museum. Pure art!
🔗 www.nature.com/articles/s41...

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Florencia Pratto @florpratto.bsky.social · Oct 19

Picaña al gancho! Not many grilling days left this year...

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