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Harlan M. Krumholz

@hmkyale.bsky.social

1.9K followers 7 following 68 posts

Committed to my family, friends, and colleagues - working to make the future better than the past.

Harlan M. Krumholz, MD, SM is an American cardiologist, a leading research scientist, and the Harold H. Hines, Jr. Professor of Medicine at Yale School of Medicine, where he has been on faculty since 1992. A pioneer in the development of the field of outcomes research, Krumholz is an international expert in the science to evaluate and improve the quality and efficiency of care, reduce disparities, improve integrity in medical research, promote better health policies and regulations, and promote patient-centeredness in research and clinical care. He is the founder and director of the Yale New Haven Hospital Center for Outcomes Research and Evaluation. .. more

Medicine 68%

Economics 22%

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Harlan M. Krumholz @hmkyale.bsky.social · 4d

Physician certification should not be an ordeal; it is in vast need of improvement.
My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective.
🔗 www.jacc.org/doi/10.1016/...

Rethinking Physician Certification: A Call for a Modern, Meaningful Standard

www.jacc.org

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Harlan M. Krumholz @hmkyale.bsky.social · 11d

In this Editor’s Page, I outline why we believe authors can use AI tools to improve scientific writing—if they fully own what they submit.

At JACC, we won’t stigmatize responsible use of AI. But we will insist on accountability.

jacc.org/doi/10.1016/...

@jaccjournals.bsky.social

Tools, Not Ghosts: Artificial Intelligence, Writing, and Responsibility

Download article citation: If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

jacc.org

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Harlan M. Krumholz @hmkyale.bsky.social · 11d

In this Editor’s Page, I outline why we believe authors can use AI tools to improve scientific writing if they fully own what they submit.
At JACC,we won’t stigmatize responsible use of AI. We will insist on accountability.
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @yalemed.bsky.social

Tools, Not Ghosts: Artificial Intelligence, Writing, and Responsibility

www.jacc.org

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Harlan M. Krumholz @hmkyale.bsky.social · 11d

For anyone who has wanted a clear, authoritative summary of inflammation and cardiovascular disease, and where the science is heading, here it is.
The 2025 ACC Scientific Statement on Inflammation and Cardiovascular Disease. @jaccjournals.bsky.social www.jacc.org/doi/10.1016/...

Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology

www.jacc.org

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Harlan M. Krumholz @hmkyale.bsky.social · 13d

This is an extraordinary report from @ihmeuw.bsky.social and published in @jaccjournals.bsky.social; it demonstrates that cardiovascular disease is a global scourge. And we are failing to leverage what we know to save lives. www.jacc.org/doi/10.1016/...

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Reposted by Harlan M. Krumholz

Tim Plante, MD MHS @tbplante.bsky.social · 15d

Congratulations to @uvmlarnermed.bsky.social medical student, Sarah Krumholz, for winning the Outstanding Research Publication award for her study in REGARDS investigating risk of hypertension by sRAGE level! Very well deserved!

Her paper: pubmed.ncbi.nlm.nih.gov/40708351/

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Harlan M. Krumholz @hmkyale.bsky.social · 17d

The next leap is computable quality.

Living, real-time intelligence from routine clinical data that will:

-Support accountability
-Fuel improvement
-Accelerate discovery

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Harlan M. Krumholz @hmkyale.bsky.social · 17d

But most current measures fail this test.

Registries = richer than claims but costly, delayed, and not built for improvement

Claims = coarser, even more delayed

Neither delivers what clinicians need at the point of care.

Harlan M. Krumholz @hmkyale.bsky.social · 17d

Door-to-balloon time proved what’s possible.

When hospitals had real-time feedback, mortality for STEMI dropped—without new drugs or devices.
The lesson?

👉 Quality improves when data are timely, trusted, and actionable.

Harlan M. Krumholz @hmkyale.bsky.social · 17d

Quality measurement was once a breakthrough.
But today it’s too slow, too costly, and too disconnected from daily care.

It’s time to reinvent it.

🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10....

@jaccjournals.bsky.social @yalemed.bsky.social

Computable Quality

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www.jacc.org

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Harlan M. Krumholz @hmkyale.bsky.social · 24d

New @JACCJournals: Guiding the AI Revolution in CV Medicine
I lay out 5 operational principles—from rigorous validation to bias reduction—to make AI safe, equitable & impactful in cardiology.
➡️ www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @yalemed.bsky.social @yaleschoolofmed.bsky.social

Guiding the AI Revolution in Cardiovascular Medicine:

www.jacc.org

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Reposted by Harlan M. Krumholz

Eric Topol @erictopol.bsky.social · 28d

A conversation on Healthy Aging with @hmkyale.bsky.social and @thehowie.bsky.social @yaleschoolofmed.bsky.social
insights.som.yale.edu/podcasts/hea...

Eric Topol: The Keys to Healthy Aging

Howie and Harlan are joined by physician, scientist, and author Eric Topol to discuss his new book, Super Agers: An Evidence-Based Approach to Longevity; the potential of individualized polygenic risk...

insights.som.yale.edu

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Reposted by Harlan M. Krumholz, Eric J. Topol

Miranda Shafer @mirandashafer.bsky.social · 29d

“Everyone thinks their genes are the cause for them getting an age-related disease, it’s actually your immune system.” - @erictopol.bsky.social the author of Super Agers on #HealthandVeritas podcast
pod.link/1588414491/e... @thehowie.bsky.social @hmkyale.bsky.social

pod.link

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Harlan M. Krumholz @hmkyale.bsky.social · Sep 1

Biology, not blame.
That’s the message from #ESCCongress.
Fat is not just storage, it’s an organ.
Its signals may drive heart failure and more.
Read my take: Fat, Reframed: A Turning Point in Heart Disease.
substack.com/home/post/p-... @jaccjournals.bsky.social @yaleschoolofmed.bsky.social

Fat, Reframed

A Turning Point in Heart Disease

substack.com

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Reposted by Harlan M. Krumholz

snigdhajain.bsky.social @snigdhajain.bsky.social · Aug 27

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Rehabilitation can ⬆️ Functional Independence and ⬇️ Long-term Cognitive Impairment among #ICU survivors. But how often do hospitals deliver it?

Led by @yalemedicine.bsky.social resident Jose Victor, our paper bit.ly/41p9fPT in @accpchest.bsky.social provides insights

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Reposted by Nicholas A. Christakis

Harlan M. Krumholz @hmkyale.bsky.social · Aug 25

New @JACCJournals Editor’s Page: A Disquieting Plateau
🫀 Cardiovascular mortality progress has stalled
📉 In some areas, it’s reversing
💡 We must confront what’s happening on our watch—and what comes next
👉 authors.elsevier.com/a/1lfjn2d9GI...
#CardioTwitter #HealthEquity @jaccjournals.bsky.social

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Harlan M. Krumholz @hmkyale.bsky.social · Aug 20

In my new Substack post...

Did you know air pollution can raise blood pressure?

I break down a just-published JACC trial testing HEPA filters in homes near highways—and what it means for heart health.

@jaccjournals.bsky.social

👉 neverdelegateunderstanding.substack.com/p/00314b6f-e...

Never Delegate Understanding

Making health and science understandable. Click to read Never Delegate Understanding, by Harlan Krumholz, a Substack publication. Launched 3 days ago.

neverdelegateunderstanding.substack.com

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Harlan M. Krumholz @hmkyale.bsky.social · Aug 20

Can a HEPA filter protect the heart?
My latest JACC #DeepDive explores a new trial of in-home air filtration—what it found, why the effect size matters, and how it fits into decades of research on air pollution and CVD risk.
🎧 www.jacc.org/digital-cont...
@jaccjournals.bsky.social

Podcast Episode: Environmental Exposure as Intervention: HEPA Filtration and Blood Pressure Near Traffic Corridors | JACC Deep Dive

In this Deep Dive, Editor-in-Chief Dr. Harlan Krumholz explores a pragmatic, randomized crossover trial testing whether in-home HEPA filtration can reduce blood pressure in adults living near high-traffic roadways. The findings offer early insights into how targeted environmental interventions may influence cardiovascular risk—especially among individuals with elevated baseline systolic blood pressure.

www.jacc.org

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Harlan M. Krumholz @hmkyale.bsky.social · Aug 19

🎙️ New JACC This Week podcast!
This issue features:
🔹 CSPACE RCT — CSP vs RV pacing in AV block
🔹 HEPA filtration & blood pressure
🔹 FLAVOUR 6-year follow-up—FFR vs IVUS
🔹 Editor’s Page: excess CV mortality in Black Americans

🎧 Listen: www.jacc.org/digital-cont...
@jaccjournals.bsky.social

Podcast Episode: Pacing Strategies, Air Quality, and the Path to Equity | JACC This Week

In this week's JACC Deep Dive podcast, Dr. Harlan Krumholz highlights new science with direct clinical implications: a randomized trial showing conduction system pacing outperforms RV pacing in AV block, a pragmatic study suggesting HEPA filtration may modestly lower blood pressure, and long-term data from FLAVOR comparing FFR and IVUS-guided PCI. Also featured are a state-of-the-art review on heart failure therapy implementation, a brief report refining NT-proBNP thresholds for pre–heart failure, and an updated JACC Report Card revealing persistent cardiovascular mortality disparities among Black Americans.

www.jacc.org

Harlan M. Krumholz @hmkyale.bsky.social · Aug 19

Did COVID-19 really age our arteries?

A major new study says yes—esp in women. But is it true?

I take a deeper look to see if the evidence matches the headlines.

Read it here → neverdelegateunderstanding.substack.com/p/did-covid-...

#COVID19 @virusesimmunity.bsky.social @yalemed.bsky.social

Did COVID Age Our Arteries?

A Closer Look at the Evidence

neverdelegateunderstanding.substack.com

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Reposted by Cary P. Gross, Ruairidh Milne

Harlan M. Krumholz @hmkyale.bsky.social · Aug 19

“Never delegate understanding.”

That quote stuck with me—and it’s now the title of my new Substack.

I’ll be writing about health, science, & how these things can be understandable.

Subscribe here → neverdelegateunderstanding.substack.com/subscribe

#health #science #medicine @yalemed.bsky.social

Subscribe to Never Delegate Understanding

Making health and science understandable. Click to read Never Delegate Understanding, by Harlan Krumholz, a Substack publication. Launched 2 days ago.

neverdelegateunderstanding.substack.com

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Harlan M. Krumholz @hmkyale.bsky.social · Aug 11

🎙️ New #JACC Deep Dive
MASTER DAPT recurrent events analysis goes beyond the first event, revealing total burden of ischemia & bleeding in PCI patients.
Why we published it, what we learned, & how it changes the view.
🎧 Listen: www.jacc.org/digital-cont...
#CardioTwitter #DAPT #HBR #PCI

Podcast Episode: Master DAPT | JACC Deep Dive

In this episode of JACC Deep Dive, Dr. Harlan Krumholz explores new insights from a post hoc analysis of the MASTER DAPT trial, highlighting the real-world burden of ischemic and bleeding events in high bleeding risk patients after PCI. By examining recurrent—not just first—events, the study sheds light on how abbreviated dual antiplatelet therapy (DAPT) impacts total clinical outcomes. Key findings include reduced bleeding without increased ischemic risk and a notable clustering of ischemic events following bleeding. This analysis advances the conversation around patient-centered endpoints and the evolving science of recurrent event modeling in cardiology.

www.jacc.org

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Harlan M. Krumholz @hmkyale.bsky.social · Aug 11

From device safety to novel valve design—the new JACC This Week podcast covers:
🔹 Clinician-led device safety
🔹 MASTER DAPT recurrent events
🔹 Drug-coated balloons for complex ISR
🔹 Polymer surgical mitral valve
Listen: bit.ly/4ove0Bn
#JACCPodcast #Cardiology @jaccjournals.bsky.social

Podcast Episode: Device Safety, DAPT Strategy & Structural Innovation | JACC This Week

In this episode of JACC This Week, Editor-in-Chief Dr. Harlan Krumholz explores device safety, abbreviated DAPT, drug-coated balloons, and a novel surgical polymer valve. Plus: expert insights on car...

bit.ly

Harlan M. Krumholz @hmkyale.bsky.social · Aug 5

🎙️ New JACC This Week:
🧬 Mini-Focus on Amyloid Heart Disease
🫀 Vutrisiran echo + biomarker insights
✍️ Editor’s Page on access + innovation
🩼 Bonus: VVS trial + DOACs in frailty
Listen now ⤵️
🔗 www.jacc.org/digital-cont...
@jaccjournals.bsky.social #cardiotwitter #amyloidosis

Podcast Episode: Amyloidosis in Focus: Biomarkers, Structural Insights & Therapeutic Strategy | JACC This Week

In this mini focus issue of JACC This Week, Editor-in-Chief Dr. Harlan Krumholz explores the evolving landscape of cardiac amyloidosis care. From structural and biomarker findings in the HELIOS-B subs...

www.jacc.org

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Harlan M. Krumholz @hmkyale.bsky.social · Jul 31

🎧 New JACC This Week podcast:

• SOGALDI-PEF: Dual therapy in HFpEF—worth it?
• HFimpEF: Big data, big risk
• Finerenone withdrawal
• LMNA stroke risk
• DSP & sex-specific risk
• Rethinking ICDs

🎙️ Listen: www.jacc.org/digital-cont...

#CardioTwitter @jaccjournals.bsky.social

Podcast Episode: Heart Failure in Practice: Dual Therapy Insights, Digital Innovation & the Future of Risk Models | JACC This Week

In this focus issue on Heart Failure in Practice, JACC Editor-in-Chief Dr. Harlan Krumholz examines how contemporary research continues to refine and at times challenge our understanding of heart fail...

www.jacc.org

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Reposted by Harlan M. Krumholz

JACC Journals @jaccjournals.bsky.social · Jul 30

We’re drowning in data, but are we helping patients? In this #JACC Editor’s Page, Dr. @hmkyale.bsky.social challenges us to ask better questions in #HeartFailure care. If you think you know HF, read this: www.jacc.org/doi/10.1016/... #CardioSky #MedSky

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Harlan M. Krumholz @hmkyale.bsky.social · Jul 25

🎙️ New JACC Deep Dive:
Why did ACURATE neo2 fail in the IDE trial?

Post hoc analysis suggests valve underexpansion may be part of the answer.
Even with normal gradients.
Even with a good echo.
We explore what happened—and what’s next.

🔗 www.jacc.org/digital-cont... @jaccjournals.bsky.social

Podcast Episode: ACURATE neo2 Under-Expansion | JACC Deep Dive

JACC's July 29 issue explores why the ACURATE neo2 valve failed in its IDE trial, with a post-hoc analysis pointing to under-expansion in heavily calcified anatomies as a potential culprit. Though the...

www.jacc.org

Harlan M. Krumholz @hmkyale.bsky.social · Jul 24

🎧 New #JACC This Week podcast

🔬 Valve underexpansion & outcomes in ACURATE IDE
💉 Body composition & tirzepatide in HFpEF
🏥 Private equity & heart failure care
🫀 Multivalve disease challenges
🧾 Brief reports+more

▶️ Listen: www.jacc.org/digital-cont...
#cardiotwitter @jaccjournals.bsky.social

Podcast Episode: Structural Heart Disease, Obesity-Related Heart Failure, Private Equity Ownership in Hospitals | JACC This Week

In this episode of JACC This Week, Editor-in-Chief Dr. Harlan Krumholz introduces the journal’s new design and highlights key studies from the July 29, 2025 issue. Topics include the under-expansion a...

www.jacc.org

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Reposted by Katelyn K. Jetelina

Harlan M. Krumholz @hmkyale.bsky.social · Jul 24

“...my biggest goal is to not turn people off that are curious… that means leading with a lot of empathy.” —
@kkjetelina.bsky.social

A powerful conversation on science, trust, and public health on Health & Veritas

🔗 insights.som.yale.edu/podcasts/hea...
#PublicHealth #ScienceCommunication

Katelyn Jetelina: A Visit from Your Local Epidemiologist

Howie and Harlan are joined by public health communicator Katelyn Jetelina for updates on COVID-19 and other issues, and to discuss how her emails to students and colleagues in the early days of the p...

insights.som.yale.edu

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Harlan M. Krumholz @hmkyale.bsky.social · Jul 24

🎙️New Health & Veritas:
A Visit from Your Local Epidemiologist

We talk w/@kkjetelina.bsky.social about:
• Building trust in public health
• Making science clear—not scary
• What’s next for COVID, H5N1, measles & more

@yalesph.bsky.social
@yalesom.bsky.social
@thehowie.bsky.social

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