Harlan M. Krumholz
@hmkyale.bsky.social
Committed to my family, friends, and colleagues - working to make the future better than the past.
Harlan M. Krumholz, MD, SM is an American cardiologist, a leading research scientist, and the Harold H. Hines, Jr. Professor of Medicine at Yale School of Medicine, where he has been on faculty since 1992. A pioneer in the development of the field of outcomes research, Krumholz is an international expert in the science to evaluate and improve the quality and efficiency of care, reduce disparities, improve integrity in medical research, promote better health policies and regulations, and promote patient-centeredness in research and clinical care. He is the founder and director of the Yale New Haven Hospital Center for Outcomes Research and Evaluation. .. more
Medicine
68%
Economics
22%
Ania Jastreboff: Treating Obesity Without Shame
In this bonus episode, Howie and Harlan are joined by Ania Jastreboff, a Yale School of Medicine endocrinologist and an expert on the science of obesity. They discuss her new book, co-authored with Op...
insights.som.yale.edu
New Health & Veritas bonus episode with Ania Jastreboff, coinciding with the release of Enough: Your Health, Your Weight, and What It’s Like to Be Free (with Oprah Winfrey).
“Having obesity is not a choice. It’s driven by biology.”
@thehowie.bsky.social
🎧 insights.som.yale.edu/podcasts/hea...
“Having obesity is not a choice. It’s driven by biology.”
@thehowie.bsky.social
🎧 insights.som.yale.edu/podcasts/hea...
Older Patients and Cardiovascular Disease: At the Center of Care, on the Margins of Science
www.jacc.org
“Older adults were, and still are, at the center of cardiovascular care, but they remain on the margins of cardiovascular science.”
My Editor’s Page in the new @JACCJournals issue reflects on why this gap persists, and what must change.
www.jacc.org/doi/10.1016/...
My Editor’s Page in the new @JACCJournals issue reflects on why this gap persists, and what must change.
www.jacc.org/doi/10.1016/...
JACC Journals Exploring the Impact on Cardiovascular Medicine
Stay informed with JACC Family of Journals, published by the ACC | Providing updates in cardiovascular medicine for clinicians, specialists, and researchers.
JACC.org
New JACC issue centers on cardiovascular care for older adults:
• Frailty and BP control
• Frailty as a prognostic tool in HF
• Loss of Y chromosome and CV risk
• Vascular cognitive impairment and dementia
Age is not the whole story.
👉 JACC.org @jaccjournals.bsky.social
• Frailty and BP control
• Frailty as a prognostic tool in HF
• Loss of Y chromosome and CV risk
• Vascular cognitive impairment and dementia
Age is not the whole story.
👉 JACC.org @jaccjournals.bsky.social
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
insights.som.yale.edu
“The goal isn’t just to live longer, it’s to live better.”
— Ezekiel Emanuel
New Health & Veritas bonus episode 🎙️
insights.som.yale.edu/podcasts/hea...
— Ezekiel Emanuel
New Health & Veritas bonus episode 🎙️
insights.som.yale.edu/podcasts/hea...
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
insights.som.yale.edu
“If wellness requires constant self-denial, it won’t last.”
— Ezekiel Emanuel
Why eating your ice cream might actually be part of a healthy life.
🎧 Health & Veritas bonus episode
insights.som.yale.edu/podcasts/hea...
— Ezekiel Emanuel
Why eating your ice cream might actually be part of a healthy life.
🎧 Health & Veritas bonus episode
insights.som.yale.edu/podcasts/hea...
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
insights.som.yale.edu
“Having friends is better for your immune system and your heart than most people realize.”
— Ezekiel Emanuel
Bonus episode of Health & Veritas 🎙️
🎧 insights.som.yale.edu/podcasts/hea...
— Ezekiel Emanuel
Bonus episode of Health & Veritas 🎙️
🎧 insights.som.yale.edu/podcasts/hea...
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
insights.som.yale.edu
“Wellness shouldn’t feel like self-denial.”
— Ezekiel Emanuel
A bonus episode of Health & Veritas on longevity, joy, and what the evidence really says.
🎧 insights.som.yale.edu/podcasts/hea...
— Ezekiel Emanuel
A bonus episode of Health & Veritas on longevity, joy, and what the evidence really says.
🎧 insights.som.yale.edu/podcasts/hea...
Ezekiel Emanuel: Ice Cream and Other Keys to a Long Life
In a bonus episode, Howie and Harlan welcome oncologist, bioethicist, and public health expert Ezekiel Emanuel to discuss his new book, which counters the wellness industry by offering simple, evidenc...
insights.som.yale.edu
🎙️Bonus episode of Health & Veritas
In this special episode, we talk w/Ezekiel Emanuel about his new book Eat Your Ice Cream, why wellness should not feel like punishment, and how evidence can support a life that includes joy. @thehowie.bsky.social
Listen here 👉 insights.som.yale.edu/podcasts/hea...
In this special episode, we talk w/Ezekiel Emanuel about his new book Eat Your Ice Cream, why wellness should not feel like punishment, and how evidence can support a life that includes joy. @thehowie.bsky.social
Listen here 👉 insights.som.yale.edu/podcasts/hea...
The Dry January Experiment
What Happens to Your Blood Pressure After Just One Less Drink?
neverdelegateunderstanding.substack.com
The Dry January Experiment: What happens to your blood pressure after just one less drink? Evidence from @jaccjournals.bsky.social suggests even light drinking affects your heart health. @yaleschoolofmed.bsky.social @yalesph.bsky.social
👉 neverdelegateunderstanding.substack.com/p/the-dry-ja...
👉 neverdelegateunderstanding.substack.com/p/the-dry-ja...
Reposted by Ruairidh Milne
Harlan M. Krumholz
@hmkyale.bsky.social
· Dec 11
Do Clinical Trials Expire?
What Beta Blockers Teach Us About How Medicine Learns
neverdelegateunderstanding.substack.com
Do clinical trials expire?
New heart attack studies show that evidence from 1980s may not apply to patients in 2025.
Beta blockers are a case study in how medicine evolves, and how slowly our evidence base often keeps up.
My latest Substack:
neverdelegateunderstanding.substack.com/p/do-clinica...
New heart attack studies show that evidence from 1980s may not apply to patients in 2025.
Beta blockers are a case study in how medicine evolves, and how slowly our evidence base often keeps up.
My latest Substack:
neverdelegateunderstanding.substack.com/p/do-clinica...
Harlan M. Krumholz
@hmkyale.bsky.social
· Nov 11
After two years and thousands of manuscripts, I’ve learned that the real work of an editor isn’t gatekeeping — it’s partnership.
My latest JACC Editor’s Page: The Partnership
🔗 www.jacc.org/doi/10.1016/...
#MedTwitter #AcademicMedicine #Cardiology
My latest JACC Editor’s Page: The Partnership
🔗 www.jacc.org/doi/10.1016/...
#MedTwitter #AcademicMedicine #Cardiology
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
Fat, Reframed
A Turning Point in Heart Disease
neverdelegateunderstanding.substack.com
Here is my substack on the topic: Fat, Reframed.
neverdelegateunderstanding.substack.com/p/fat-reframed
neverdelegateunderstanding.substack.com/p/fat-reframed
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
@jaccjournals.bsky.social is the place for ideas that may change our thinking; spark dialogue; and contribute to progress in advancing global cardiovascular health.
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
JACC: Vol 86, No 16
JACC. 2025 Oct, 86 (16) 1231–1233.
www.jacc.org
HFpEF is one of medicine’s biggest puzzles.
Maybe the answers lie not in the heart alone, but in the cross-talk between fat and myocardium.
Read the full JACC Adipokine Spotlight and join the conversation.
🔗 www.jacc.org/toc/jacc/cur...
#JACC #HFpEF #Cardiology #AdipokineHypothesis
Maybe the answers lie not in the heart alone, but in the cross-talk between fat and myocardium.
Read the full JACC Adipokine Spotlight and join the conversation.
🔗 www.jacc.org/toc/jacc/cur...
#JACC #HFpEF #Cardiology #AdipokineHypothesis
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
The issue invites disagreement and testing.
Some cases of HFpEF may not fit the model.
But frameworks like this push the field forward—helping us ask sharper questions and design better studies.
Some cases of HFpEF may not fit the model.
But frameworks like this push the field forward—helping us ask sharper questions and design better studies.
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
Themes emerge:
• It’s about fat distribution, not just BMI.
• Adipokines act through endocrine-paracrine signaling.
• Sex, race, and metabolic context all shape expression and risk.
• New therapies (GLP-1RA, SGLT2i) may restore adipokine balance.
• It’s about fat distribution, not just BMI.
• Adipokines act through endocrine-paracrine signaling.
• Sex, race, and metabolic context all shape expression and risk.
• New therapies (GLP-1RA, SGLT2i) may restore adipokine balance.
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
To deepen the discussion, we invited experts across cardiology and metabolism to weigh in:
• Erica Spatz: A Turning Point
• Carolyn Lam & Dalane Kitzman: From Pariah to Paradigm
• Subodh Verma & Deepak Bhatt: Parsing the Adipokine Axis
• Faiez Zannad, Jennifer Ho, Robert Mentz, and others.
• Erica Spatz: A Turning Point
• Carolyn Lam & Dalane Kitzman: From Pariah to Paradigm
• Subodh Verma & Deepak Bhatt: Parsing the Adipokine Axis
• Faiez Zannad, Jennifer Ho, Robert Mentz, and others.
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
Ideas Worth Testing: The Adipokine Hypothesis
www.jacc.org
As Editor-in-Chief, I wrote about why JACC published it:
Because progress in medicine requires ideas that connect disciplines and challenge assumptions.
🧠 “Ideas Worth Testing: The Adipokine Hypothesis.”
www.jacc.org/doi/10.1016/...
Because progress in medicine requires ideas that connect disciplines and challenge assumptions.
🧠 “Ideas Worth Testing: The Adipokine Hypothesis.”
www.jacc.org/doi/10.1016/...
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
In this 25,000-word State-of-the-Art Review, Packer unites >1,800 references to build a testable framework explaining how dysfunctional adipose tissue could underlie HFpEF.
It’s bold, ambitious—and worth debating.
It’s bold, ambitious—and worth debating.
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
Dr. Milton Packer proposes that hypertrophied, inflamed fat cells secrete molecules—adipokines—that drive cardiac remodeling, inflammation, and fibrosis.
In other words: HFpEF may begin in fat, not the heart.
In other words: HFpEF may begin in fat, not the heart.
Harlan M. Krumholz
@hmkyale.bsky.social
· Oct 13
After decades of disappointment in HFpEF, a new idea is shaking things up.
Could heart failure with preserved EF actually be an adipose-driven disease?
JACC’s latest issue explores “The Adipokine Hypothesis.”
@jaccjournals.bsky.social
🔗 www.jacc.org/toc/jacc/cur...
Could heart failure with preserved EF actually be an adipose-driven disease?
JACC’s latest issue explores “The Adipokine Hypothesis.”
@jaccjournals.bsky.social
🔗 www.jacc.org/toc/jacc/cur...
Rethinking Physician Certification: A Call for a Modern, Meaningful Standard
www.jacc.org
Physician certification should not be an ordeal; it is in vast need of improvement.
My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective.
🔗 www.jacc.org/doi/10.1016/...
My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective.
🔗 www.jacc.org/doi/10.1016/...
Harlan M. Krumholz
@hmkyale.bsky.social
· Sep 29
Tools, Not Ghosts: Artificial Intelligence, Writing, and Responsibility
Download article citation: If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.
jacc.org
In this Editor’s Page, I outline why we believe authors can use AI tools to improve scientific writing—if they fully own what they submit.
At JACC, we won’t stigmatize responsible use of AI. But we will insist on accountability.
jacc.org/doi/10.1016/...
@jaccjournals.bsky.social
At JACC, we won’t stigmatize responsible use of AI. But we will insist on accountability.
jacc.org/doi/10.1016/...
@jaccjournals.bsky.social
Harlan M. Krumholz
@hmkyale.bsky.social
· Sep 29
Tools, Not Ghosts: Artificial Intelligence, Writing, and Responsibility
Download article citation: If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.
www.jacc.org
In this Editor’s Page, I outline why we believe authors can use AI tools to improve scientific writing if they fully own what they submit.
At JACC,we won’t stigmatize responsible use of AI. We will insist on accountability.
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @yalemed.bsky.social
At JACC,we won’t stigmatize responsible use of AI. We will insist on accountability.
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @yalemed.bsky.social
Harlan M. Krumholz
@hmkyale.bsky.social
· Sep 29
Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology
www.jacc.org
For anyone who has wanted a clear, authoritative summary of inflammation and cardiovascular disease, and where the science is heading, here it is.
The 2025 ACC Scientific Statement on Inflammation and Cardiovascular Disease. @jaccjournals.bsky.social www.jacc.org/doi/10.1016/...
The 2025 ACC Scientific Statement on Inflammation and Cardiovascular Disease. @jaccjournals.bsky.social www.jacc.org/doi/10.1016/...
Harlan M. Krumholz
@hmkyale.bsky.social
· Sep 28
This is an extraordinary report from @ihmeuw.bsky.social and published in @jaccjournals.bsky.social; it demonstrates that cardiovascular disease is a global scourge. And we are failing to leverage what we know to save lives. www.jacc.org/doi/10.1016/...
Reposted by Harlan M. Krumholz
Tim Plante, MD MHS
@tbplante.bsky.social
· Sep 25
Congratulations to @uvmlarnermed.bsky.social medical student, Sarah Krumholz, for winning the Outstanding Research Publication award for her study in REGARDS investigating risk of hypertension by sRAGE level! Very well deserved!
Her paper: pubmed.ncbi.nlm.nih.gov/40708351/
Her paper: pubmed.ncbi.nlm.nih.gov/40708351/
Harlan M. Krumholz
@hmkyale.bsky.social
· Sep 23
The next leap is computable quality.
Living, real-time intelligence from routine clinical data that will:
-Support accountability
-Fuel improvement
-Accelerate discovery
Living, real-time intelligence from routine clinical data that will:
-Support accountability
-Fuel improvement
-Accelerate discovery
Harlan M. Krumholz
@hmkyale.bsky.social
· Sep 23
But most current measures fail this test.
Registries = richer than claims but costly, delayed, and not built for improvement
Claims = coarser, even more delayed
Neither delivers what clinicians need at the point of care.
Registries = richer than claims but costly, delayed, and not built for improvement
Claims = coarser, even more delayed
Neither delivers what clinicians need at the point of care.