banner
LightNews
jdhl18.bsky.social
Jon Humphries
@jdhl18.bsky.social
870 followers 520 following 450 posts
Cell Biologist. Manchester Metropolitan University. Cell-ECM adhesion and proteomics, often in the context of cancer. Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en Orcid: https://orcid.org/0000-0002-8953-7079
scholar.google.com
Posts Media Videos Starter Packs
Reposted by Jon Humphries
drannecarpenter.bsky.social
Anne Carpenter @drannecarpenter.bsky.social · 22h
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further
16 120 340
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 4h
A human pan-disease blood atlas of the circulating proteome | Science www.science.org/doi/10.1126/...
A human pan-disease blood atlas of the circulating proteome
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of divers...
www.science.org
3
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 1d
Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice
www.jci.org/articles/vie...
JCI - Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice
www.jci.org
1
Reposted by Jon Humphries
protaiomics.bsky.social
protaiomics.bsky.social @protaiomics.bsky.social · 3d
🌟Ready to apply?
16 fully funded PhD positions are open in ProtAIomics Doctoral Network!
Join 16 labs across Europe to advance AI-powered proteomics and drive discoveries in health & biotechnology.
👉 Apply here: www.protaiomics.eu
#Proteomics #ArtificialIntelligence #MSCA #PhDOpportunities
1 2
Reposted by Jon Humphries
pedrobeltrao.bsky.social
Pedro Beltrao @pedrobeltrao.bsky.social · 3d
Our group has a PhD position open in this Doctoral network. Our topic is around combining proteomics AI and protein structures. Look through the website below to look at all of the projects/groups and apply.
protaiomics.bsky.social
protaiomics.bsky.social @protaiomics.bsky.social · 3d
🌟Ready to apply?
16 fully funded PhD positions are open in ProtAIomics Doctoral Network!
Join 16 labs across Europe to advance AI-powered proteomics and drive discoveries in health & biotechnology.
👉 Apply here: www.protaiomics.eu
#Proteomics #ArtificialIntelligence #MSCA #PhDOpportunities
6 8
Reposted by Jon Humphries
mrclmb.bsky.social
MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 3d
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Black and white portrait of John Gurdon, 1971
3 32 99
Reposted by Jon Humphries
carmeloferrai.bsky.social
Carmelo Ferrai @carmeloferrai.bsky.social · 3d
Epithelial-mesenchymal transition

www.cell.com/cell/fulltex...
Epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) is a conserved multi-step cellular program that plays an essential role across a range of biological processes. This review covers the roles and states of EMT i...
www.cell.com
5 9
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 5d
www.theguardian.com/science/2025...
Nobel prize in medicine awarded to scientists for immune system research
Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi win for work on preventing immune system harming body
www.theguardian.com
1
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 6d
Mechanobiological engineering strategies for organoid culture
pubs.aip.org/aip/apb/arti...
Mechanobiological engineering strategies for organoid culture
Organoid culture systems have emerged as powerful platforms for studying development, disease modeling, and regenerative medicine. However, current models prima
pubs.aip.org
5
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 6d
Therapeutic Use of Integrin Signaling in Melanoma Cells: Physical Link with the Extracellular Matrix (ECM)
www.mdpi.com/2072-6694/17...
www.mdpi.com
1 1
Reposted by Jon Humphries
amsterdammed.bsky.social
Marnie Chesterton @amsterdammed.bsky.social · 9d
Just discovered that Jane Goodall like this! We discuss her life and legacy on Inside Science tomorrow. #RIPJaneGoodall
1 8
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 7d
@amsterdammed.bsky.social low hanging koalas. Perfect 👏
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 14d
Rider Cup bunkers giving me white blood cell vibes
6
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 15d
Focusing on the complex and dynamic interplay between ageing and cancer
www.nature.com/articles/s41...
Focusing on the complex and dynamic interplay between ageing and cancer - Nature Reviews Cancer
This Focus issue highlights current research at the intersection of ageing and cancer, and explores how insights gained from this may lead to better cancer prevention strategies and diagnostics, enhanced therapeutic efficacy and improvements to both patient quality of life and outcomes.
www.nature.com
1 2
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 16d
SPP1 = osteopontin
CD61 = integrin β3
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 16d
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
www.nature.com/articles/s41...
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
www.nature.com
1 3
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 16d
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
www.nature.com/articles/s41...
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
www.nature.com
1
Reposted by Jon Humphries
emboreports.org
EMBO Reports @emboreports.org · 22d
Sandra Iden @sandraiden.bsky.social @idenlab.bsky.social @uni-saarland.de @pharmascihub.bsky.social and co-workers show that #melanocyte #differentiation and #mechanosensation are differentially modulated by distinct extracellular matrix proteins. #ECM #MITF

www.embopress.org/doi/full/10....
3 8
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 23d
Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism
doi.org/10.1093/brai...
Validate User
doi.org
1
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 23d
The bidirectional interplay between RNA processing and mechanotransduction
www.sciencedirect.com/science/arti...
The bidirectional interplay between RNA processing and mechanotransduction
Through mechanotransduction, cells sense and respond to mechanical stimuli from their environment. A mechanical stimulus is first detected by a mechan…
www.sciencedirect.com
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 26d
Molecular exaptation by the integrin αI domain
www.science.org/doi/10.1126/...
Molecular exaptation by the integrin αI domain
An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.
www.science.org
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 26d
Defining the Role of Integrins in Melanoblast Migration In Vivo
www.molbiolcell.org/doi/10.1091/...
Defining the Role of Integrins in Melanoblast Migration In Vivo | Molecular Biology of the Cell
During embryonic development, neural crest-derived melanoblasts, which are precursors of pigment-producing melanocytes, disperse throughout the skin by long-range cell migration that requires adhesion...
www.molbiolcell.org
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 26d
Talin autoinhibition is required for normal hemostasis
www.tandfonline.com/doi/full/10....
Talin autoinhibition is required for normal hemostasis
The integrin family of extracellular matrix (ECM) adhesion receptors plays a central role in platelet function, including adhesion and aggregation. In resting platelets, integrins exist in a low-af...
www.tandfonline.com
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 28d
Wearing that jumper too 🤣
1 1
jdhl18.bsky.social
Jon Humphries @jdhl18.bsky.social · 28d
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer
www.nature.com/articles/s41...
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer - Nature Cell Biology
Al-Hilal, Chrysovergi et al. identify a role for durotaxis in lung fibrosis and metastatic pancreatic cancer, mediated by the FAK–paxillin mechanosensor complex, and demonstrate therapeutic targeting ...
www.nature.com
1
Reposted by Jon Humphries
bugsinyourguts.bsky.social
Professor Lesley Hoyles @bugsinyourguts.bsky.social · 28d
If you are UK-based and working on any aspect of microbiomes (human, plant, insect, soil, animal, ...), please do sign up to Microbiome-Net for details of networking, funding and training opportunities.

forms.office.com/pages/respon...
4 39 34