Professor Lesley Hoyles
@bugsinyourguts.bsky.social
And all this science I don't understand, it's just my job five days a week.
Professor of Microbiome and Systems Biology @ Nottingham Trent University. 🏳️🌈
Working predominantly on the human gut microbiota.
All views my own.
Professor of Microbiome and Systems Biology @ Nottingham Trent University. 🏳️🌈
Working predominantly on the human gut microbiota.
All views my own.
Reposted by Professor Lesley Hoyles
Participate in the EUP OHAMR survey to strengthen AMR research capacity #AntibioticResistance #MicroSky ohamr.eu/2025/11/18/o...
Participate in the EUP OHAMR survey to strengthen AMR research capacity! - EUP OHAMR
We are launching a survey to identify gaps in strengthening research capacity in the field of AMR. Your input is valuable!
ohamr.eu
November 28, 2025 at 12:54 PM
Participate in the EUP OHAMR survey to strengthen AMR research capacity #AntibioticResistance #MicroSky ohamr.eu/2025/11/18/o...
Reposted by Professor Lesley Hoyles
Want to learn about #klebsiella genomics?
Check out our free online resource, developed as part of the @klebnet.bsky.social project and in collaboration with ECDC Gen-Epi Bio train.
#genomics #amr #sero-epi #hypervirulence #LINcodes
Check out our free online resource, developed as part of the @klebnet.bsky.social project and in collaboration with ECDC Gen-Epi Bio train.
#genomics #amr #sero-epi #hypervirulence #LINcodes
The @klebnet.bsky.social team are pleased to share slides from our “Klebsiella pneumoniae Genomic Epidemiology & Antimicrobial Resistance” lecture series!
Topics include Kleb diversity, lineages, AMR, hypervirulence, how to use Kaptive & Kleborate for typing, and more!
klebnet.org/2025/11/18/k...
Topics include Kleb diversity, lineages, AMR, hypervirulence, how to use Kaptive & Kleborate for typing, and more!
klebnet.org/2025/11/18/k...
Klebsiella pneumoniae genomics tutorials – KlebNET-GSP
klebnet.org
November 28, 2025 at 10:12 AM
Want to learn about #klebsiella genomics?
Check out our free online resource, developed as part of the @klebnet.bsky.social project and in collaboration with ECDC Gen-Epi Bio train.
#genomics #amr #sero-epi #hypervirulence #LINcodes
Check out our free online resource, developed as part of the @klebnet.bsky.social project and in collaboration with ECDC Gen-Epi Bio train.
#genomics #amr #sero-epi #hypervirulence #LINcodes
Reposted by Professor Lesley Hoyles
Another £1k sent to AKT from pin badge sales.
[over £46k in total]
24% or young homeless people are LGBTQ+ and AKT offers dedicated and informed support. So valuable, especially in winter.
🥰Thanks for continued support 🥰
AKT: www.akt.org.uk
Pin badges: www.jamiebgall.co.uk/shop
Recent purchases:
[over £46k in total]
24% or young homeless people are LGBTQ+ and AKT offers dedicated and informed support. So valuable, especially in winter.
🥰Thanks for continued support 🥰
AKT: www.akt.org.uk
Pin badges: www.jamiebgall.co.uk/shop
Recent purchases:
November 28, 2025 at 11:05 AM
Another £1k sent to AKT from pin badge sales.
[over £46k in total]
24% or young homeless people are LGBTQ+ and AKT offers dedicated and informed support. So valuable, especially in winter.
🥰Thanks for continued support 🥰
AKT: www.akt.org.uk
Pin badges: www.jamiebgall.co.uk/shop
Recent purchases:
[over £46k in total]
24% or young homeless people are LGBTQ+ and AKT offers dedicated and informed support. So valuable, especially in winter.
🥰Thanks for continued support 🥰
AKT: www.akt.org.uk
Pin badges: www.jamiebgall.co.uk/shop
Recent purchases:
Reposted by Professor Lesley Hoyles
Seriously we need to hear from @natureportfolio.nature.com @magdalenaskipper.bsky.social on this.
Wow. What on earth is going on @natureportfolio.nature.com?
Imagine being an author who had a paper rejected by this journal, only to see this AI slop published…
Unless of course nothing is ever rejected by Sci Reports, which it seems must be the case 🤦🏻♀️
Imagine being an author who had a paper rejected by this journal, only to see this AI slop published…
Unless of course nothing is ever rejected by Sci Reports, which it seems must be the case 🤦🏻♀️
"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se
November 27, 2025 at 10:16 PM
Seriously we need to hear from @natureportfolio.nature.com @magdalenaskipper.bsky.social on this.
Reposted by Professor Lesley Hoyles
📢 New preprint on bioRxiv!
We introduce V4-EXT, a revised 16S rRNA V4 primer set that dramatically improves detection of Patescibacteria and other undersampled lineages
✅ 938 samples
✅ More novel ASVs
Primer choice matters 👀
www.biorxiv.org/content/10.1...
@ppjevac.bsky.social #HuifengHu
We introduce V4-EXT, a revised 16S rRNA V4 primer set that dramatically improves detection of Patescibacteria and other undersampled lineages
✅ 938 samples
✅ More novel ASVs
Primer choice matters 👀
www.biorxiv.org/content/10.1...
@ppjevac.bsky.social #HuifengHu
November 27, 2025 at 5:38 PM
📢 New preprint on bioRxiv!
We introduce V4-EXT, a revised 16S rRNA V4 primer set that dramatically improves detection of Patescibacteria and other undersampled lineages
✅ 938 samples
✅ More novel ASVs
Primer choice matters 👀
www.biorxiv.org/content/10.1...
@ppjevac.bsky.social #HuifengHu
We introduce V4-EXT, a revised 16S rRNA V4 primer set that dramatically improves detection of Patescibacteria and other undersampled lineages
✅ 938 samples
✅ More novel ASVs
Primer choice matters 👀
www.biorxiv.org/content/10.1...
@ppjevac.bsky.social #HuifengHu
Reposted by Professor Lesley Hoyles
🚨 Research Fellow Opportunity 🚨
Join @uniofeastanglia.bsky.social & @quadraminstitute.bsky.social to explore the Brain-Gut Axis.
📍 Norwich Medical School
✅ £48,822–£56,535
📅 Apply by 1 Dec
Lead pioneering research at the neuroscience–microbiome interface.
👉 vacancies.uea.ac.uk/vacancies/18...
Join @uniofeastanglia.bsky.social & @quadraminstitute.bsky.social to explore the Brain-Gut Axis.
📍 Norwich Medical School
✅ £48,822–£56,535
📅 Apply by 1 Dec
Lead pioneering research at the neuroscience–microbiome interface.
👉 vacancies.uea.ac.uk/vacancies/18...
November 25, 2025 at 4:09 PM
🚨 Research Fellow Opportunity 🚨
Join @uniofeastanglia.bsky.social & @quadraminstitute.bsky.social to explore the Brain-Gut Axis.
📍 Norwich Medical School
✅ £48,822–£56,535
📅 Apply by 1 Dec
Lead pioneering research at the neuroscience–microbiome interface.
👉 vacancies.uea.ac.uk/vacancies/18...
Join @uniofeastanglia.bsky.social & @quadraminstitute.bsky.social to explore the Brain-Gut Axis.
📍 Norwich Medical School
✅ £48,822–£56,535
📅 Apply by 1 Dec
Lead pioneering research at the neuroscience–microbiome interface.
👉 vacancies.uea.ac.uk/vacancies/18...
Reposted by Professor Lesley Hoyles
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
High frequency body site translocation of nosocomial Pseudomonas aeruginosa - Nature Communications
Here, the authors report within-host diversity and body site translocation dynamics in hospital samples of Pseudomonas aeruginosa and reveal that body site sharing was likely due to within-patient tra...
www.nature.com
November 25, 2025 at 10:40 AM
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
After a week off with COVID I very much don't want to open my work email account this morning.
a little girl in a red jacket is laying on a brick sidewalk covered in leaves
ALT: a little girl in a red jacket is laying on a brick sidewalk covered in leaves
media.tenor.com
November 27, 2025 at 9:55 AM
After a week off with COVID I very much don't want to open my work email account this morning.
Reposted by Professor Lesley Hoyles
We're at 735 registrants and counting! 🎉🦠
If you haven't registered yet, don't miss out on this exciting (free) symposium on gut microbial metabolites and their impacts on host health.
Please share with your networks. 🔗👇
isbscience.org/events/2025-...
If you haven't registered yet, don't miss out on this exciting (free) symposium on gut microbial metabolites and their impacts on host health.
Please share with your networks. 🔗👇
isbscience.org/events/2025-...
November 26, 2025 at 5:19 PM
We're at 735 registrants and counting! 🎉🦠
If you haven't registered yet, don't miss out on this exciting (free) symposium on gut microbial metabolites and their impacts on host health.
Please share with your networks. 🔗👇
isbscience.org/events/2025-...
If you haven't registered yet, don't miss out on this exciting (free) symposium on gut microbial metabolites and their impacts on host health.
Please share with your networks. 🔗👇
isbscience.org/events/2025-...
Reposted by Professor Lesley Hoyles
Reposted by Professor Lesley Hoyles
When one of the most respected organisations in the world directly spreads disinformation we have truly reached a dark place.
It's going to take years to rebuild trust in anything the CDC leadership says.
Meanwhile millions of people will suffer from misguided decisions about their health.
It's going to take years to rebuild trust in anything the CDC leadership says.
Meanwhile millions of people will suffer from misguided decisions about their health.
November 21, 2025 at 7:38 AM
When one of the most respected organisations in the world directly spreads disinformation we have truly reached a dark place.
It's going to take years to rebuild trust in anything the CDC leadership says.
Meanwhile millions of people will suffer from misguided decisions about their health.
It's going to take years to rebuild trust in anything the CDC leadership says.
Meanwhile millions of people will suffer from misguided decisions about their health.
Reposted by Professor Lesley Hoyles
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 20, 2025 at 8:40 PM
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Reposted by Professor Lesley Hoyles
Another PhD!!
Are you, or someone you know, looking for a PhD, starting in Oct 2026?
Do you like phages, genomes & public health impact?🦠🧬🧩
Wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?
Please apply or share by 6 Jan🗓️
#PhDposition #academicsky
Are you, or someone you know, looking for a PhD, starting in Oct 2026?
Do you like phages, genomes & public health impact?🦠🧬🧩
Wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?
Please apply or share by 6 Jan🗓️
#PhDposition #academicsky
PhD Carrying a toxic burden: the continuing spread of “Shiga toxin stx2a”-harbouring phage in E. coli (LANGRIDGE_Q26MMB) 2026/27 | UEA
PhD Carrying a toxic burden: the continuing spread of “Shiga toxin stx2a”-harbouring phage in E. coli (LANGRIDGE_Q26MMB) 2026/27 | UEA
www.uea.ac.uk
November 20, 2025 at 3:47 PM
Another PhD!!
Are you, or someone you know, looking for a PhD, starting in Oct 2026?
Do you like phages, genomes & public health impact?🦠🧬🧩
Wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?
Please apply or share by 6 Jan🗓️
#PhDposition #academicsky
Are you, or someone you know, looking for a PhD, starting in Oct 2026?
Do you like phages, genomes & public health impact?🦠🧬🧩
Wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?
Please apply or share by 6 Jan🗓️
#PhDposition #academicsky
Change the y axis on that graph to "Microbiome articles published on the gut-brain axis (%)" and the split of research articles to reviews wouldn't be far off (there would be more reviews in an accurate comparison).
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
The Autism-Microbiome Hypothesis Is Falling Apart
Why this new review paper should be required reading for every microbiome researcher
open.substack.com
November 20, 2025 at 6:05 PM
Change the y axis on that graph to "Microbiome articles published on the gut-brain axis (%)" and the split of research articles to reviews wouldn't be far off (there would be more reviews in an accurate comparison).
Reposted by Professor Lesley Hoyles
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
The Autism-Microbiome Hypothesis Is Falling Apart
Why this new review paper should be required reading for every microbiome researcher
open.substack.com
November 19, 2025 at 5:12 PM
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
Reposted by Professor Lesley Hoyles
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
November 19, 2025 at 9:48 PM
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
Reposted by Professor Lesley Hoyles
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates
-in @natcomms.nature.com
www.nature.com/articles/s41...
-in @natcomms.nature.com
www.nature.com/articles/s41...
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates - Nature Communications
Ghatbale et al. adapted a co-evolutionary technique to develop Klebsiella pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates, including drug resistant isolate...
www.nature.com
November 20, 2025 at 11:23 AM
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates
-in @natcomms.nature.com
www.nature.com/articles/s41...
-in @natcomms.nature.com
www.nature.com/articles/s41...
Reposted by Professor Lesley Hoyles
My new favorite kind of meme is "here are detailed instructions on how to turn off AI". 🔨
November 19, 2025 at 3:00 PM
My new favorite kind of meme is "here are detailed instructions on how to turn off AI". 🔨
Reposted by Professor Lesley Hoyles
#AMR #Klebsiella cause >100,000 neonatal deaths globally each year.
Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW
doi.org/10.1101/2025...
Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW
doi.org/10.1101/2025...
![figure showing estimated proportion of cases in clusters, for each site. range from 0.04 to 0.93, mean estimate in random effects model is 0.57 [0.46,0.68]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:q5nky4heg5sfix4get4zh2pw/bafkreibshmuvkuafxwd2uk3r42ss6ma2dhmaidbysgvufnbkbv5cn4guai@jpeg)
November 19, 2025 at 3:43 PM
#AMR #Klebsiella cause >100,000 neonatal deaths globally each year.
Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW
doi.org/10.1101/2025...
Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW
doi.org/10.1101/2025...
Reposted by Professor Lesley Hoyles
I’ve released a tool to sketch and edit phylogenetic trees!
yawak.jp/PhyloWeaver/
Load a Newick file and intuitively add/remove/resize branches.
Useful for quick conceptual trees, extracting subtrees, or turning ideas into Newick.
yawak.jp/PhyloWeaver/
Load a Newick file and intuitively add/remove/resize branches.
Useful for quick conceptual trees, extracting subtrees, or turning ideas into Newick.
PhyloWeaver – Interactive phylogenetic tree editor
Edit and visualize phylogenetic trees directly in your browser. PhyloWeaver lets you interactively rearrange tree topologies and export high-quality figures for publications and presentations.
yawak.jp
November 18, 2025 at 1:59 AM
I’ve released a tool to sketch and edit phylogenetic trees!
yawak.jp/PhyloWeaver/
Load a Newick file and intuitively add/remove/resize branches.
Useful for quick conceptual trees, extracting subtrees, or turning ideas into Newick.
yawak.jp/PhyloWeaver/
Load a Newick file and intuitively add/remove/resize branches.
Useful for quick conceptual trees, extracting subtrees, or turning ideas into Newick.
Reposted by Professor Lesley Hoyles
🚨#PhD studentship opportunity! Plasmids provide bacteria with antimicrobial resistance, but do they have more fundamental effects on behaviour? 🧫🦠💫🧟♂️
Apply for a 4y funded MRC DiMeN position with me and Jamie Wheeler @livuni-ives.bsky.social www.findaphd.com/phds/project...
Apply for a 4y funded MRC DiMeN position with me and Jamie Wheeler @livuni-ives.bsky.social www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Resistant zombies: how drug-resistance plasmids manipulate the behaviour of the opportunistic pathogen Pseudomonas aeruginosa at University of Liverpool on Fin...
PhD Project - MRC DiMeN Doctoral Training Partnership: Resistant zombies: how drug-resistance plasmids manipulate the behaviour of the opportunistic pathogen Pseudomonas aeruginosa at University of Li...
www.findaphd.com
November 18, 2025 at 9:38 AM
🚨#PhD studentship opportunity! Plasmids provide bacteria with antimicrobial resistance, but do they have more fundamental effects on behaviour? 🧫🦠💫🧟♂️
Apply for a 4y funded MRC DiMeN position with me and Jamie Wheeler @livuni-ives.bsky.social www.findaphd.com/phds/project...
Apply for a 4y funded MRC DiMeN position with me and Jamie Wheeler @livuni-ives.bsky.social www.findaphd.com/phds/project...
Reposted by Professor Lesley Hoyles
There's just over 2 weeks left to apply for a fully funded PhD studentship with us working on C. difficile vancomycin resistance. Two more studentships - linked in the thread below - close in early January
November 19, 2025 at 1:45 PM
There's just over 2 weeks left to apply for a fully funded PhD studentship with us working on C. difficile vancomycin resistance. Two more studentships - linked in the thread below - close in early January
Reposted by Professor Lesley Hoyles
🚨Job claxon 🚨
University College Cork is looking to appoint a lecturer in Medical Microbiology into a permanent, non-clinical post
A great opportunity in a microbiology powerhouse
For details go to my.corehr.com/pls/uccrecru... and enter reference number 092153
University College Cork is looking to appoint a lecturer in Medical Microbiology into a permanent, non-clinical post
A great opportunity in a microbiology powerhouse
For details go to my.corehr.com/pls/uccrecru... and enter reference number 092153
University College Cork Vacancies
my.corehr.com
November 18, 2025 at 10:55 PM
🚨Job claxon 🚨
University College Cork is looking to appoint a lecturer in Medical Microbiology into a permanent, non-clinical post
A great opportunity in a microbiology powerhouse
For details go to my.corehr.com/pls/uccrecru... and enter reference number 092153
University College Cork is looking to appoint a lecturer in Medical Microbiology into a permanent, non-clinical post
A great opportunity in a microbiology powerhouse
For details go to my.corehr.com/pls/uccrecru... and enter reference number 092153
Reposted by Professor Lesley Hoyles
Going blue for AMR Awareness Week at HIS! 💙
Why does it matter? Antimicrobial resistance (AMR) makes infections harder to treat, putting lives at risk worldwide.
Raising awareness is the first step toward action!
#WAAW2025 #GoingBlueforAMR #AMRWeek
Why does it matter? Antimicrobial resistance (AMR) makes infections harder to treat, putting lives at risk worldwide.
Raising awareness is the first step toward action!
#WAAW2025 #GoingBlueforAMR #AMRWeek
November 19, 2025 at 10:05 AM
Going blue for AMR Awareness Week at HIS! 💙
Why does it matter? Antimicrobial resistance (AMR) makes infections harder to treat, putting lives at risk worldwide.
Raising awareness is the first step toward action!
#WAAW2025 #GoingBlueforAMR #AMRWeek
Why does it matter? Antimicrobial resistance (AMR) makes infections harder to treat, putting lives at risk worldwide.
Raising awareness is the first step toward action!
#WAAW2025 #GoingBlueforAMR #AMRWeek
Reposted by Professor Lesley Hoyles
Hard to believe it’s already that time of year!
Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more!
@lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.
Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more!
@lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.
November 18, 2025 at 10:43 PM
Hard to believe it’s already that time of year!
Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more!
@lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.
Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more!
@lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.