Kat Holt
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katholt.bsky.social
Kat Holt
@katholt.bsky.social
Scientist… pathogen genomics & antimicrobial resistance, computational biology & infectious disease epidemiology.
Co-Director LSHTM AMR Centre @lshtmamrcentre.bsky.social
holtlab.net | klebnet.org | typhoidgenomics.org | amr.lshtm.ac.uk
Pinned
#AMR #Klebsiella cause >100,000 neonatal deaths globally each year.

Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW

doi.org/10.1101/2025...
Reposted by Kat Holt
Our study of neonatal sepsis in a NICU in Botswana underscores the value of integrating colonization surveillance, environmental investigation, and genomics to uncover hidden reservoirs and strengthen infection prevention and control (IPC) practices in resource-limited settings.
November 25, 2025 at 7:36 PM
Reposted by Kat Holt
We have an amazing opportunity for Early-Career Researchers to join our Board of Directors!

We're looking for someone with experience in leading #OpenScience projects to support and lead eLife in our mission to change research communication.

🔗 buff.ly/SZgtgVv
November 24, 2025 at 9:02 PM
Reposted by Kat Holt
If you're about to push these last manuscripts before wrapping up 2025, remider that our MGen Eukaryotic collection @microbiologysociety.org is open & growing; #Protists #Parasites #Fungi; friend or foe; all welcome 😊
#MicroSky #IDSky #Protistsonsky 🧬💻
www.microbiologyresearch.org/content/micr...
Microbial Genomics of Eukaryotes | Microbiology Society
With technological advances like single-cell sequencing and long-read sequence techniques continually improving, allowing the full resolution of increasingly complex highly repetitive genomes, and wit...
www.microbiologyresearch.org
November 24, 2025 at 6:54 AM
Reposted by Kat Holt
Join us on 26 Nov 2025 for the NeoNET AFRICA & KlebNET-GSP seminar on Klebsiella genomics and neonatal sepsis.

Our Co-Director @katholt.bsky.social will speak on serotype prevalence & vaccine coverage

⏰ 15:00–16:00 SAST

🔗 bit.ly/klebs_seminar
November 21, 2025 at 2:03 PM
Reposted by Kat Holt
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Reposted by Kat Holt
If you use GMail, AI (Gemini) was turned on yesterday by default and now scans all of your content for machine learning. To turn off, go to Settings>General and scroll down. Uncheck the box for "Smart features."

There's other "Smart" add-ons as well, but that's the one that reads your content.
November 20, 2025 at 5:32 PM
Reposted by Kat Holt
💉 Our annual lecture will be given by Prof Caroline Trotter, who will explore work estimating the #PublicHealth impact of vaccination of Gavi & discuss its implications for #vaccine policy

🗓️ Thursday 27 November, 17:30 GMT
📍 LSHTM | Online

Details ⬇️
www.lshtm.ac.uk/newsevents/e...
November 4, 2025 at 12:14 PM
Reposted by Kat Holt
Our sister journal has joined the Bluesky party!
Give them a follow if you are interested in clinical research and the open science space
We are thrilled to now be on BlueSky!

We prioritize studies addressing critical health challenges—from major diseases to health equity—that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health 🧬🧪

#OpenScience #MedSky
November 20, 2025 at 3:09 PM
Reposted by Kat Holt
We are thrilled to now be on BlueSky!

We prioritize studies addressing critical health challenges—from major diseases to health equity—that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health 🧬🧪

#OpenScience #MedSky
November 20, 2025 at 2:31 PM
Reposted by Kat Holt
Don't forget to register for the #1st ever @shigellameeting.bsky.social at Pasteur next year! Apr 20 - 24 www.shigella2026.conferences-pasteur.org/home
Home - EMBO Workshop Shigella: from biology to prevention
EMBO Workshop Shigella: from biology to prevention
www.shigella2026.conferences-pasteur.org
November 20, 2025 at 3:37 PM
Reposted by Kat Holt
KlebPhaCol: a community-driven resource for Klebsiella research identified a novel phage family
https://doi.org/10.1093/nar/gkaf1122
November 20, 2025 at 4:30 PM
Reposted by Kat Holt
Another PhD!!

Are you, or someone you know, looking for a PhD, starting in Oct 2026?

Do you like phages, genomes & public health impact?🦠🧬🧩

Wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?

Please apply or share by 6 Jan🗓️

#PhDposition #academicsky
PhD Carrying a toxic burden: the continuing spread of “Shiga toxin stx2a”-harbouring phage in E. coli (LANGRIDGE_Q26MMB) 2026/27 | UEA
PhD Carrying a toxic burden: the continuing spread of “Shiga toxin stx2a”-harbouring phage in E. coli (LANGRIDGE_Q26MMB) 2026/27 | UEA
www.uea.ac.uk
November 20, 2025 at 3:47 PM
#AMR #Klebsiella cause >100,000 neonatal deaths globally each year.

Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW

doi.org/10.1101/2025...
November 19, 2025 at 3:43 PM
Reposted by Kat Holt
Happy to share our new AMR resource which has phenotypic AMR (usually MIC data) collected from publications and databases. This is paired with assemblies and annotations

We're excited for users who might train new models, find phenotype/genotype mismatches, or any other use
Antimicrobial resistance (AMR) is a growing health threat, making infections harder to treat and complicating routine medical care.

EMBL-EBI’s new AMR portal brings together laboratory resistance data and bacterial genomes in one open platform.

#WAAW2025 #ActOnAMR

www.ebi.ac.uk/about/news/t...
🧬💻
A new gateway to global antimicrobial resistance data
New online portal connects bacterial genomes with experimental resistance data to support antimicrobial resistance research.
www.ebi.ac.uk
November 19, 2025 at 12:27 PM
Reposted by Kat Holt
Every test result tells a story - of a life supported, a treatment informed, a community protected. Behind those stories lies an invisible network - the supply chain - connecting suppliers, ministries, laboratories, health programs, and the people they serve 🌐

#WorldAMRWeek2025 #AMR
November 18, 2025 at 12:45 PM
Reposted by Kat Holt
Antimicrobial Resistance Awareness Week starts today.

Our research themes show how we tackle AMR from every angle, from biological and clinical sciences to modelling, social science, and more.

Learn more: 👉 bit.ly/4i5Uf0v
November 18, 2025 at 2:40 PM
The @klebnet.bsky.social team are pleased to share slides from our “Klebsiella pneumoniae Genomic Epidemiology & Antimicrobial Resistance” lecture series!

Topics include Kleb diversity, lineages, AMR, hypervirulence, how to use Kaptive & Kleborate for typing, and more!

klebnet.org/2025/11/18/k...
Klebsiella pneumoniae genomics tutorials – KlebNET-GSP
klebnet.org
November 18, 2025 at 8:25 AM
Reposted by Kat Holt
The Chronic and Recurrent #UTI Priority Setting Partnership supported by James Lind Alliance (funders AMR Action UK, Bladder Health UK & The Urology Foundation) needs your help! Please take our survey to help prioritise research questions for this horrible malady www.surveymonkey.com/r/UTI2 #UTISky
Shortlisting survey - chronic and recurrent UTI Priority Setting Partnership (PSP)
Take this survey powered by surveymonkey.com. Create your own surveys for free.
www.surveymonkey.com
November 17, 2025 at 2:08 PM
Reposted by Kat Holt
Hey Labour

Remember the majority of voters who believe in treating people decently and not stealing from those who've endured months and years of hardship fleeing war and persecution to seek a place of safety?

We're still over here 👋
November 17, 2025 at 7:49 AM
Reposted by Kat Holt
📢 Save the Date!
✨We’re thrilled to announce the first TARGetAMR Annual Conference!
🗓 Thursday 14 – Friday 15 May 2026
📍The Studio, Birmingham
🔎Theme: Building the Future of AMR Genomics
🔗Registration opens soon – stay tuned! www.targetamr.org.uk/hdrevents/sa...
#TARGetAMR26
November 14, 2025 at 12:50 PM
Reposted by Kat Holt
London interdisciplinary #PhD position now open with myself, @sergemostowylab.bsky.social, & @gmknght.bsky.social on #phage -bacteria-host immune dynamics for WHO priority bacterial pathogens #Klebsiella, #Shigella, and #Staph. Combines cellular microbiology, genomics, & mathematical modelling.
2026-27 Project (Dyson & Mostowy & Knight) - MRC London Intercollegiate Doctoral Training Partnership Studentships
PHACTS: Unravelling PHAge-baCTeria-host immune dynamicS to inform phage therapy SUPERVISORY TEAM Supervisor Dr Zoe Dyson...
mrc-lid.lshtm.ac.uk
November 13, 2025 at 11:11 AM
Reposted by Kat Holt
MHRA-led study reveals major inconsistencies in global microbiome research www.gov.uk/government/n...
MHRA-led study reveals major inconsistencies in global microbiome research
International collaboration establishes new quality standards to improve reliability of gut health studies – improving accuracy to provide better diagnosis and treatment.
www.gov.uk
November 15, 2025 at 1:53 PM
Reposted by Kat Holt
Honoured and quite blown-over to receive this award. I have been, and continue to be, very lucky - first with great mentors, and then really prodigious students, postdocs and collaborators. Working with them has been a joy.
Congratulations to @zaminiqbal.bsky.social from @milnerevolution.bsky.social on being awarded the 2026 Mary Lyon Medal!
November 14, 2025 at 12:55 PM
Reposted by Kat Holt
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
www.findaphd.com
November 12, 2025 at 1:20 PM