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Reposted by Professor Lesley Hoyles

James McDonald @jamesemcdonald.bsky.social · 2d

MMEG is coming to @unibirmingham.bsky.social in December - look out for some exciting announcements about the programme in the next few weeks! Abstract submission and registration is open 👇🏻

Applied Microbiology International @amiposts.bsky.social · Sep 1

Save the Date: #MMEG2025 is coming to Birmingham!

Join us on 15–16 December 2025 for the 31st edition of MMEG. This year's event is your chance to:
🔬 Share your research
🤝 Connect with peers
🦠 Discover the latest in molecular microbial ecology

Register now: appliedmicrobiology.org/ems-event-ca...

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Reposted by Professor Lesley Hoyles

Tung Le @tunglejic.bsky.social · 5d

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

John Innes Centre @johninnescentre.bsky.social · 5d

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...

Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre

The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…

www.jic.ac.uk

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Reposted by Professor Lesley Hoyles

Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 8d

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson

www.gla.ac.uk

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Reposted by Professor Lesley Hoyles

RuthLeyMicro @microbiome.bsky.social · 4d

Thinking about a postdoc in microbiome science?
Our lab at the MPI for Biology (Tübingen) builds on the culture I established at Cornell: collaborative, creative, and internationally diverse. Postdocs lead their own projects with secure funding. Join us!
#PostdocJobs #HostMicrobe #AcademicJobs

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Reposted by Professor Lesley Hoyles

Mya Breitbart @viromegirl.bsky.social · 6d

We're hiring for several positions (a post-bac researcher in #transcriptomics, a #phage #postdoc, a senior researcher (broad topics) and a graduate student to work on #ciliates) - find info here: www.marine.usf.edu/genomics/app...

Apply - Genomics

www.marine.usf.edu

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Reposted by Professor Lesley Hoyles

Petra Boynton @petraboynton.bsky.social · 7d

He should have been expelled. This is way more than policing opinions.

- Inciting violence at far right rallies
- Interfering in government affairs
- Destroying health and science infrastructures
- Ensuring thousands will die

Abusers, excused and enabled by craven others, always grow in power.

The Royal Society @royalsociety.org · 7d

"I am increasingly concerned over threats to the values that allow science to flourish." Read the full statement from the President of the Royal Society Sir Adrian Smith: royalsociety.org/news/2025/10...

A statement from the President of the Royal Society | Royal Society

A statement from the President of the Royal Society regarding threats to the values that allow science to flourish.

royalsociety.org

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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 6d

Nice study from Harry Sokol's lab. #microbiomesky

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon
inflammation

www.cell.com

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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 7d

Piss poor.

The Royal Society @royalsociety.org · 7d

"I am increasingly concerned over threats to the values that allow science to flourish." Read the full statement from the President of the Royal Society Sir Adrian Smith: royalsociety.org/news/2025/10...

A statement from the President of the Royal Society | Royal Society

A statement from the President of the Royal Society regarding threats to the values that allow science to flourish.

royalsociety.org

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Reposted by Professor Lesley Hoyles

James Hell Brooks @kleinman.bsky.social · 7d

RIP Jane Goodall, by all accounts a wonderful woman who loved this Far Side cartoon

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Reposted by Professor Lesley Hoyles

Philip Ball @philipcball.bsky.social · 7d

Ed's right. Again.

Science Vs @sciencevs.bsky.social · 7d

This moment from our latest episode with science writer @edyong209.bsky.social is 🔥

We asked Ed — how do we talk up the benefits of science in the face of government cuts? He told us that's the wrong approach. 🧪

Listen wherever, or watch on Spotify 👇

open.spotify.com/episode/7Evh...

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Reposted by Professor Lesley Hoyles

Wellcome Sanger Institute @sangerinstitute.bsky.social · 8d

Clinical academics are a bridge between patient care and research – ensuring discoveries translate into treatments and guiding innovation 🔎

The @acmedsci.bsky.social and other UK leaders, including the Sanger Institute, are committed to addressing the decline in these positions. Read how ⤵️

Academy of Medical Sciences @acmedsci.bsky.social · 8d

Today we’re proud to share our Clinical Academics Summit statement, signed by 40+ organisations 🤝

⚠️ Clinical academics are declining
✅ Our summit committed to action to help reverse this trend

👉 Read the full statement: bit.ly/3Ktb5JQ

Quote @rosalindsmyth.bsky.social

A quote card featuring Professor Rosalind Smyth CBC FMedSci, saying "The decline in clinical academic numbers represents a genuine threat to patient care and the UK's research leadership. This statement shows that if we act with urgency and a shared commitment, we can reverse this trend. "

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Reposted by Professor Lesley Hoyles

Tami Lieberman @contaminatedsci.bsky.social · 9d

Precisely calling mutations across hundreds of bacterial isolates has been hard, requiring manual filtering and expertise.

Until now, using AccuSNV.

Herui Liao trained an ML model based on our previous meticulously called SNVs.
www.biorxiv.org/content/10.1...

High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV

Accurate detection of mutations within bacterial species is critical for fundamental studies of microbial evolution, reconstructing transmission events, and identifying antimicrobial resistance mutati...

www.biorxiv.org

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Reposted by Professor Lesley Hoyles

Prof Christina Pagel @chrischirp.bsky.social · 9d

Just fuck off with this. How about start the conversation by highlighting how much immigrants contribute to the UK - not least by propping up the NHS and social care system!

Also - forced volunteering is not volunteering, it's unpaid labour.

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Reposted by Professor Lesley Hoyles

Stephen Curry @scurry.bsky.social · 9d

What this announcement reveals is the govt’s view on how little the public knows or cares about university finances or the health of the HE sector.

Research Professional News @resprofnews.bsky.social · 9d

Now with more details, including confirmation that the grants are to be funded by a levy on international student fees.

www.researchprofessionalnews.com/rr-news-uk-p...

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Reposted by Professor Lesley Hoyles

Lis Lowe @lislowe.bsky.social · 9d

Spending some time collecting memories of Harry today 🥺 - this is when he was elected a Fellow of the Royal Society. If anyone in the #glycotime universe has pictures or memories of Harry Gilbert they want to share please send them my way 💚

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Reposted by Professor Lesley Hoyles

Ryan Wick @rrwick.bsky.social · 9d

Happy to share that the paper describing Autocycler is now 100% up:
doi.org/10.1093/bioi...
(1/3)

Autocycler: long-read consensus assembly for bacterial genomes

AbstractMotivation. Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-l

doi.org

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Reposted by Professor Lesley Hoyles

JazzReads📚 @jazzreads.bsky.social · 10d

So exhausting..

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Reposted by Professor Lesley Hoyles

Ben Vezina @bananabenana.bsky.social · 11d

Staggering analysis here linking ciprofloxacin resistance to specific mutations in #Klebsiella.

In short, using ONLY genotype, one can reasonably predict phenotypic CIP MICs! See Fig 3 (below).

Loving the splitting of MIC and disk diffusion data as well.

#AMR #MicroSky #IDSky

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Reposted by Professor Lesley Hoyles

Zamin Iqbal @zaminiqbal.bsky.social · 12d

This is a lovely thread

Bethany Brookshire @beebrookshire.bsky.social · 12d

In reporting this piece on the new trial for a Huntington's treatment, I was struck by one thing in particular:

The joy.

One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...

Huntington's progression slowed by experimental gene therapy

An experimental gene therapy slowed Huntington’s by up to 75 percent in a small clinical trial. While not a cure, it may give patients longer lives.

www.sciencenews.org

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Reposted by Professor Lesley Hoyles

bioRxiv Genomics @biorxiv-genomic.bsky.social · 12d

Ciprofloxacin resistance in Klebsiella pneumoniae: phenotype prediction from genotype and global distribution of resistance determinants https://www.biorxiv.org/content/10.1101/2025.09.24.678318v1

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Reposted by Professor Lesley Hoyles

Craig MacLean @craigmaclean.bsky.social · Jul 29

New pre-print from my lab!
Plasmids link antibiotic resistance and phage defense.

E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!!
#microsky#AMR#phage

www.biorxiv.org/content/10.1....

Plasmids link antibiotic resistance genes and phage defense systems in E. coli

Phage therapy has been proposed as an alternative to antibiotics to treat resistant infections. However, we have a limited understanding of how antibiotic resistance genes (ARGs) associate with bacter...

www.biorxiv.org

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Reposted by Professor Lesley Hoyles

Renske van Raaphorst 🟥 @vrrenske.bsky.social · 12d

Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n

Géraldine Laloux @lalouxlab.bsky.social · 13d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Reposted by Professor Lesley Hoyles

Animalcules @bacteriophile.bsky.social · 13d

journals.plos.org/plosgenetics...

#MicroSky

Genomic profiling and experimental validation of type VI secretion system-associated proteins in Klebsiella

Klebsiella is widely distributed in nature and recognized for its dual role as a human commensal and an opportunistic pathogen capable of causing severe infections. Among its key virulence mechanisms,...

journals.plos.org

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Reposted by Professor Lesley Hoyles

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 12d

Fusobacterium nucleatum produces previously unappreciated AHR-activating metabolites and promotes CRC cell proliferation via the AHR-TERT axis https://www.biorxiv.org/content/10.1101/2025.09.25.678601v1

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Reposted by Professor Lesley Hoyles

Zamin Iqbal @zaminiqbal.bsky.social · 13d

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

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