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Reposted by Géraldine Laloux

Renske van Raaphorst 🟥 @vrrenske.bsky.social · 13d

Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n

Géraldine Laloux @lalouxlab.bsky.social · 14d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Géraldine Laloux @lalouxlab.bsky.social · 14d

Experiments and analysis led by former post-doc @vrrenske.bsky.social in collaboration with @tunglejic.bsky.social & @rkoszul.bsky.social teams

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Géraldine Laloux @lalouxlab.bsky.social · 14d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Géraldine Laloux @lalouxlab.bsky.social · 22d

🇪🇺 Smooth publishing experience with #microLife, the new @femsjournals.bsky.social journal of the European Academy for Microbiology.

🙏 @erc.europa.eu, F.R.S-FNRS & WEL-RI for support
4/4

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Géraldine Laloux @lalouxlab.bsky.social · 22d

🛠️This is the result of a long and careful work conducted by our research tech Charles de Pierpont, with help from PhD student Benoît Derneden and former lab member @remyophe.bsky.social, and validation by the whole team
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Géraldine Laloux @lalouxlab.bsky.social · 22d

🍝 Featuring the reversible spaghetti phenotype of #FtsZ -depleted Bdellovibrio: predator cell division is not required to exit the prey
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Géraldine Laloux @lalouxlab.bsky.social · 22d

🚨New paper out! #MicroSky
Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival.
We expanded its genetic toolbox:
🧬promoters to fine-tune expression
🧬IPTG-inducible system
🧬CRISPRi for rapid knockdown
bit.ly/46GUn2c
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Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference

Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.

academic.oup.com

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Géraldine Laloux @lalouxlab.bsky.social · Aug 21

#MicroSky

Géraldine Laloux @lalouxlab.bsky.social · Aug 21

Another great contribution to the “Cell Regulation” themed issue of Current Opinion in Microbiology www.sciencedirect.com/special-issu...

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Géraldine Laloux @lalouxlab.bsky.social · Aug 12

Inspiring “behind the paper” story here 👉 communities.springernature.com/posts/out-of... #MicroSky

Out Of The Blue, It Came To Me

communities.springernature.com

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Géraldine Laloux @lalouxlab.bsky.social · Jul 29

Bacterial cell wall & periplasm paradigm shift - important read #MicroSky

www.nature.com/articles/s41...

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Reposted by Géraldine Laloux

Daniela Barillà @danielabarilla.bsky.social · Jul 26

Chromosome enthusiasts, York is calling!

Join us at The Biology & Physics of Chromosomes www.eventsforce.net/biochemsoc/f...

Late breaking abstract deadline
📆 7 August

@biophychrom.bsky.social @vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social #microsky

Wild flower meadow in the foreground with York Minster in the background.

River Ouse in York and along the bank the Hospitium hall where the conference dinner will take place. The Hospitium was part of St Mary’s Abbey that was built during Medieval times.

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Géraldine Laloux @lalouxlab.bsky.social · Jul 26

Thanks, Basile! All figures were drawn manually ✏️ 🖌️ by Coralie! @coralietesseur.bsky.social

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Géraldine Laloux @lalouxlab.bsky.social · Jul 25

#MicroSky Summer read!

Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛

How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social

www.sciencedirect.com/science/arti...

Strategies and mechanisms of contact-dependent predation in bacteria

Predatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out…

www.sciencedirect.com

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Géraldine Laloux @lalouxlab.bsky.social · Jul 16

Congrats to first author of both chapters @coralietesseur.bsky.social as well as @remyophe.bsky.social and @ysantin.bsky.social

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Géraldine Laloux @lalouxlab.bsky.social · Jul 16

We wrote 2 📕 chapters with tips & tricks to identify protein-protein interactions in bacteria 🦠

1) In vivo proximity labeling with miniTurbo link.springer.com/protocol/10....

2) An adapted polar recruitment assay feat. E. coli as a test tube link.springer.com/protocol/10.....

Enjoy #MicroSky 🧪

a man wearing sunglasses and a white t-shirt is holding something in his hands .

ALT: a man wearing sunglasses and a white t-shirt is holding something in his hands .

media.tenor.com

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Reposted by Géraldine Laloux

Yves Brun lab @brunlabcaulo.bsky.social · Jul 9

Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...

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Géraldine Laloux @lalouxlab.bsky.social · Jul 7

#MicroSky

Matt Doyle @doylemt1.bsky.social · Jul 6

Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild!

www.nature.com/articles/s41...

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications

This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...

www.nature.com

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Reposted by Géraldine Laloux

Tung Le @tunglejic.bsky.social · May 9

1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below.
shorturl.at/o6S1w

A bacterial CARD-NLR immune system controls the release of gene transfer agents

Bacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are ...

shorturl.at

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Reposted by Géraldine Laloux

Martin Thanbichler @thanbichlerlab.bsky.social · Apr 2

#Postdoc position - at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"

Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages)

Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...

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Reposted by Géraldine Laloux

mosorio91.bsky.social @mosorio91.bsky.social · Mar 15

I’m very happy to share our latest work on the ParABS system. We investigated the dynamic interaction between the ATPase ParA and the CTPase ParB mediating chromosome segregation in Myxococcus xanthus. I would like to thank all the people involved.

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Mar 15

Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation https://www.biorxiv.org/content/10.1101/2025.03.14.642875v1

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Reposted by Géraldine Laloux

Yves Brun lab @brunlabcaulo.bsky.social · Mar 12

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See
lnkd.in/dVVk4N3s. #microsky

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Reposted by Géraldine Laloux

Dame lab at Leiden University @damelab.bsky.social · Feb 20

In @molecularmicro.bsky.social: two special issues on Prokaryotic Chromosome Organization. Many excellent contributions, including a vision article: 'Future directions of the Prokaryotic Chromosome Field', outcome of BioPhyChrom 2023 @biophychrom.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Future Directions of the Prokaryotic Chromosome Field

In September 2023, the Biology and Physics of Prokaryotic Chromosomes meeting ran at the Lorentz Center in Leiden, The Netherlands. As part of the workshop, those in attendance developed a series of ....

onlinelibrary.wiley.com

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Géraldine Laloux @lalouxlab.bsky.social · Dec 4

A million thanks to the ERC for the opportunity to explore bacterial predatory attacks and cell cycle switches with our VAMPIRE Consolidator grant @deDuveInstitute @UCLouvain_be @frsFNRS 🦠 🔬 🧛

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Reposted by Géraldine Laloux

Yves Brun lab @brunlabcaulo.bsky.social · Nov 13

2 days left. Asst/Assoc Prof position in bacteriology, Université de Montréal. Deadline ***Nov. 15*** come join our growing community of bacteriologists. BTW Canada is the USA’s Bluesky!

Yves Brun lab @brunlabcaulo.bsky.social · Nov 8

Please repost: Nov. 15 deadline! We are building a strong bacteriology community at Univ de Montréal, including recent hires Sven van Teeffelen, Frédérique Le Roux & myself. Moving to Montréal in 2018 is one of the best career decisions I made. Come join us! jobs.sciencecareers.org/job/664282/a...

Assistant or Associate Professor in Bacteriology - Montréal, Quebec (CA) job with University of Montreal | 664282

Université de Montréal (UdeM) is looking for an Assistant or Associate full-time professor in the field of bacteriology.

jobs.sciencecareers.org

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