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Reposted by Dame lab at Leiden University

Biochemical Society @biochemsoc.bsky.social · 19d

That’s a wrap for The Biology and Physics of Prokaryotic Chromosomes VII 2025. A big thank you to all those who attended 🧪 #BioPhyChrom2025 #BiochemEvents

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Dame lab at Leiden University @damelab.bsky.social · 23d

Tomorrow is the start of Biology and Physics of Prokaryotic Chromosomes VII. Great speakers and participants. Excellent support by the Biochem. Society. @biochemsoc.bsky.social
@danielabarilla.bsky.social @vslioy.bsky.social
@graingerlab.bsky.social
@damelab.bsky.social
#BioPhyChrom2025

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Dame lab at Leiden University @damelab.bsky.social · 23d

DNA bridging has also been established as a DNA binding mode shared by many architectural proteins across the domains of life, with DNA bridging histone proteins in archaea as latest highlight.

Dame lab at Leiden University @damelab.bsky.social · 23d

Research in many different labs has revealed that DNA bridging is key to many of its functions in vivo. 2.5 decades later novel functions of H-NS and mechanisms of functional modulation are still being discovered.

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Dame lab at Leiden University @damelab.bsky.social · 23d

Time flies .. it is today 25 years ago that we published our studies that revealed that bacterial H-NS is a DNA bridging protein:
academic.oup.com/nar/article/... @narjournal.bsky.social

H-NS mediated compaction of DNA visualised by atomic force microscopy

Abstract. The Escherichia coli H-NS protein is a nucleoid-associated protein involved in gene regulation and DNA compaction. To get more insight into the m

academic.oup.com

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Reposted by Dame lab at Leiden University

Daniela Barillà @danielabarilla.bsky.social · Sep 8

One week to go for The Biology & Physics of Chromosomes VII, but there is still time to register!
Join us! 🧬🧬🧬

@biophychrom.bsky.social @biochemsoc.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @damelab.bsky.social

River Ouse in York and the Hospitium, the conference banquet venue.

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Reposted by Dame lab at Leiden University

Tobias Warnecke @tobiaswarnecke.bsky.social · Sep 1

Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...

Supervisors and Projects

www.bioch.ox.ac.uk

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Reposted by Dame lab at Leiden University

Grainger Lab @graingerlab.bsky.social · Jul 25

Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

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Dame lab at Leiden University @damelab.bsky.social · Jul 23

Great to see it published, Daniela!

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Reposted by Dame lab at Leiden University

Daniela Barillà @danielabarilla.bsky.social · Jul 14

Just few days left to register for this chromosome biology fête! 🧬🧬🧬

⏳📆 16 July

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

Poster advertising the Biology and Physics of Prokaryotic Chromosomes conference that will be held in York, 16-19 September 2025.

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Dame lab at Leiden University @damelab.bsky.social · Jul 10

I am pleased to share our new review on the role of bacterial nucleoid-aasociated proteins in mediating responses to changes in environment. Important: some NAPs can directly ‘sense’ physico-chemical changes. www.sciencedirect.com/science/arti... @pingzhuangge.bsky.social

The role of nucleoid-associated proteins in mediating responses to environmental changes

Bacteria face diverse environmental challenges, such as changes in temperature, pH, and osmolarity, and exposure to antibiotics, which necessitate ada…

www.sciencedirect.com

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Reposted by Dame lab at Leiden University

Daniela Barillà @danielabarilla.bsky.social · Jul 2

York calling! 📣 🧬🧬🧬

Join us at www.biochemistry.org/events-and-t...

⏳⏰ Early bird deadline approaching soon, 16 July! Do not miss out! Half of the talks selected from abstracts.
@damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

View of a street in York with old houses on both sides and the towers of York Minster in the background.

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Dame lab at Leiden University @damelab.bsky.social · Jun 30

A must-read for histone afficionados: our new review on 'Histone-mediated chromatin organization in prokaryotes and viruses' www.cell.com/trends/bioch... @samuelschwab.bsky.social @vikramalva.bsky.social

Histone-mediated chromatin organization in prokaryotes and viruses

Histones are fundamental chromatin-organizing proteins in eukaryotes and archaea, where they assemble into (hyper)nucleosomes that wrap DNA. Recent studies have expanded the known repertoire of histon...

www.cell.com

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Reposted by Dame lab at Leiden University

Daniela Barillà @danielabarilla.bsky.social · Jun 11

Chromosome Enthusiasts, join us at The Biology & Physics of Prokaryotic Chromosomes 🧬! Friendly community, fantastic speakers line-up, grant writing session for ECRs. Early-bird deadline approaching soon.
@damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biophychrom.bsky.social

Flyer advertising The Biology and Physics of Prokaryotic Chromosome conference that will be held in York, 16-19 September 2025.

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Reposted by Dame lab at Leiden University

Svetlana Dodonova @dodonova-sveta.bsky.social · May 26

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM

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Dame lab at Leiden University @damelab.bsky.social · May 26

So very nice to see the pre-print online - it’s a beautiful story! We’re happy to have been involved.

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Reposted by Dame lab at Leiden University

Daniela Barillà @danielabarilla.bsky.social · May 15

Join us in York for the Biology & Physics of Prokaryotic Chromosomes! 🧬 #Microsky #Archaeasky

www.biochemistry.org/events-and-t...
@biochemsoc.bsky.social
@damelab.bsky.social @graingerlab.bsky.social @vslioy.bsky.social

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Reposted by Dame lab at Leiden University

Daniel Tamarit @danieltamarit.bsky.social · May 14

New vacancy in my team!

PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.

Please repost and share with talented MSc students in #evobio, bioinformatics or related :)

www.uu.nl/en/organisat...

#MEvoSky #MicroSky

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Dame lab at Leiden University @damelab.bsky.social · May 12

It’s great to see this online. We are very glad to have been able to contribute to this work on yet an other very interesting type of bacterial histone.

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Reposted by Dame lab at Leiden University

Vikram Alva @vikramalva.bsky.social · May 12

Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1...

@mpi-bio-fml.bsky.social

A snapshot of the HLp tetramer (purple) wrapping ~60 bp of DNA (green).

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Molecular Microbiology Editors @molecularmicro.bsky.social · Mar 11

Chromatin aficionados take note:
Second of two special issues on Prokaryotic Chromosome Organization now published!
(6 review/perspective articles and 2 research articles)
Guest edited by @damelab.bsky.social
#MicroSky #Chromatin

onlinelibrary.wiley.com/toc/13652958...

Prokaryotic Chromosome Organization: part 2: Molecular Microbiology: Vol 123, No 3

Molecular Microbiology is a broad-scope microbiology journal for basic and translational research that contributes to understanding molecular principles in microbes.

onlinelibrary.wiley.com

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Reposted by Dame lab at Leiden University

Jolien van Hooff @jvhooff.bsky.social · Mar 5

Exciting news! I'm looking for a computational biologist to join my lab at Wageningen University & Research! It's a 3-year postdoc position on Holomycota genome architecture and evolution. Spread the word! www.wur.nl/en/vacancy/p...

Postdoc Comparative genomics and genome architecture in early-diverging fungi and their protist relatives (3-year position)

www.wur.nl

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Reposted by Dame lab at Leiden University

Daniela Barillà @danielabarilla.bsky.social · Mar 4

Can I tempt some young minds to consider Old York for a PhD?

Some days left to apply.
Open to applicants WORLDWIDE 🌎.

River Ouse at sunset with some orange light on the horizon.

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Dame lab at Leiden University @damelab.bsky.social · Feb 28

Returning from a great visit to the Dodonova lab at EMBL to discuss archaeal histones and hypernucleosomes. Nice also to see a tribute to the hypernucleosome on EMBL premises !#Archaeasky

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Reposted by Dame lab at Leiden University

Molecular Microbiology Editors @molecularmicro.bsky.social · Feb 21

First of two special issues on Prokaryotic Chromosome Organization now published! Guest edited by @damelab.bsky.social

#MicroSky #Chromatin

onlinelibrary.wiley.com/toc/13652958...

Prokaryotic Chromosome Organization: part 1: Molecular Microbiology: Vol 123, No 2

Molecular Microbiology is a broad-scope microbiology journal for basic and translational research that contributes to understanding molecular principles in microbes.

onlinelibrary.wiley.com

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