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doylemt1.bsky.social
Matt Doyle
@doylemt1.bsky.social
850 followers 720 following 58 posts
🇦🇺 Senior Lecturer at @sydneyuni.bsky.social and former NIHer. Research: Bacterial outer membrane biogenesis - membrane protein folding - protein translocation across membranes - novel antibiotics. He/him.
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · Nov 21
Because I'm new here I want to share two recent papers from my students to show the science we are interested in. 🦠🧫 #Microsky

1) Sarah Hanson's work on a new homodimer found across many Gram-negatives that modifies lipids in the outer membrane:

www.nature.com/articles/s41...
The patatin-like protein PlpD forms structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane - Nature Communications
The Omp85 superfamily is a widely distributed class of outer membrane proteins found in Gram-negative bacteria, mitochondria and chloroplasts. Here the authors show that PlpD has a different structure...
www.nature.com
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · 6d
This is super
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Reposted by Matt Doyle
augustsilale.bsky.social
Augustinas Silale @augustsilale.bsky.social · 7d
Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...
Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology
Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.
doi.org
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · 7d
You guys did great organising. My folks loved the venue being UQ.
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Reposted by Matt Doyle
dr-berger.bsky.social
Michael Landsberg @dr-berger.bsky.social · 7d
Thanks for coming Doyle lab! It was great to have you here.
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Reposted by Matt Doyle
asbmbaus.bsky.social
Australian Society for Biochemistry and Molecular Biology - 2025 @asbmbaus.bsky.social · 8d
Congratulations to all our poster and speaker prize winners!! 🏆🏆🏆
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Reposted by Matt Doyle
asbmbaus.bsky.social
Australian Society for Biochemistry and Molecular Biology - 2025 @asbmbaus.bsky.social · 8d
And that's a wrap! A huge shout out goes to our conference chair Michael Landsberg @dr-berger.bsky.social and the rest of the organizing committee for putting together such a vibrant #ASBMB2025! See you all at #ComBio2026!
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · 8d
Thanking support from @asbmbaus.bsky.social for travel award to Alanah, @sydney.edu.au for travel support for Alfred, and Sydney Infectious Diseases Institute and the Centre for Drug Discovery Innovation for supporting their research.
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · 8d
Very proud of both my students @itzfredz.bsky.social (Alfred Hartojo) and @alanaheisenhuth.bsky.social (Alanah Eisenhuth) for presenting their research at ASBMB2025. Also congrats to Alfred for his poster prize! 👏🏆
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Reposted by Matt Doyle
rhyswg.bsky.social
Rhys Grinter @rhyswg.bsky.social · 18d
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
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Reposted by Matt Doyle
brettcollins.bsky.social
Brett Collins @brettcollins.bsky.social · 18d
This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
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Reposted by Matt Doyle
debnathghosal.bsky.social
Debnath Ghosal @debnathghosal.bsky.social · Aug 2
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
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Reposted by Matt Doyle
eurekaprizes.bsky.social
Australian Museum Eureka Prizes @eurekaprizes.bsky.social · Jul 31
PINK1 Parkinson's Disease Research Team @wehi-research.bsky.social is a finalist in the @unsw.edu.au Eureka Prize for Scientific Research.

Learn more: youtu.be/senXARXzO20

#EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social
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Reposted by Matt Doyle
harvardcellbio.bsky.social
Harvard Med Cell Biology @harvardcellbio.bsky.social · Jul 29
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
“Revolutionary Science Comes from Unexpected Angles”
magazine.hms.harvard.edu
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Reposted by Matt Doyle
macwiatrak.bsky.social
Maciek Wiatrak @macwiatrak.bsky.social · Jul 21
💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.

Preprint 📝: biorxiv.org/content/10.1...

🧵 1/n
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Reposted by Matt Doyle
saakohl.bsky.social
Simon Kohl @saakohl.bsky.social · Jul 22
Introducing Latent-X — our all-atom frontier AI model for protein binder design.

State-of-the-art lab performance, widely accessible via the Latent Labs Platform.

Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
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Reposted by Matt Doyle
camcdevitt.bsky.social
Christopher McDevitt @camcdevitt.bsky.social · Jul 20
The costs of #antimicrobial resistance 🦠 continue to rise 📈. The Center for Global Development reports that by 2050 #AMR could shrink the global economy by US$1.7T.
Improving treatments and funding development of new antimicrobials 💊 could save millions of lives and billions in healthcare costs.
Forecasting the Fallout from AMR: Economic Impacts of Antimicrobial Resistance in Humans
Antimicrobial resistance (AMR) is a growing global health crisis that threatens to undo decades of progress in medicine. This tool allows you to explore the potential impact of different interventions...
www.cgdev.org
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · Jul 14
Unfortunately I have to skip this one because I'm at ASM. Break a leg @rhyswg.bsky.social !
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · Jul 14
Excited to be in Adelaide for the MTPconnect Innovation in Antimicrobials event ahead of attending 2025 ASM Conference @aussocmic.bsky.social
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · Jul 6
Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild!

www.nature.com/articles/s41...
A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications
This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...
www.nature.com
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doylemt1.bsky.social
Matt Doyle @doylemt1.bsky.social · Jul 6
Lost in the labyrinth of poorly LLM written "scientific" articles. Bad science writing example excerpt:

"Initially, we delve into the intricacies of […], accentuating its indispensability in cellular physiology, the enzymatic labyrinth governing its flux, and the pivotal […] mechanisms."

...boy
robertarkowitz.bsky.social
Robert Arkowitz @robertarkowitz.bsky.social · Jul 6
Delving or anti-delving?
www.science.org/doi/10.1126/...
Delving into LLM-assisted writing in biomedical publications through excess vocabulary
Excess words track LLM usage in biomedical publications.
www.science.org
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Reposted by Matt Doyle
trevor-lithgow.bsky.social
Trevor Lithgow @trevor-lithgow.bsky.social · May 25
Great science looks at big unknowns.

In bacteria, sRNAs control gene expression but ‘how’ they do this at systems level is far from known. @MACSYS is recruiting for courageous PhD students who would learn, know and report how sRNAs deliver systems level phenotypes

macsys.org/monash-phd-s... for
PhD Scholarships at Monash University - MACSYS
Do cutting-edge research at the frontiers of Whole Cell Modelling! The MACSYS Node at Monash University has multiple PhD Scholarships available to work on some exciting projects! $41,753 p.a. stipend ...
macsys.org
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Reposted by Matt Doyle
hervecelia.bsky.social
Herve Celia @hervecelia.bsky.social · Jul 1
After an unexpectedly long editorial process, our paper describing the structures of the E coli TolAQR and TonB-ExbBD complexes is finally out. The coordinates are to be released on July 9th on the PDB.

www.nature.com/articles/s41...
Cryo-EM structures of the E. coli Ton and Tol motor complexes - Nature Communications
The Ton and Tol systems are bacterial energy-transducing complexes that use the proton motive force at the inner membrane to exert force on outer membrane proteins. Here the authors present the high-r...
www.nature.com
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Reposted by Matt Doyle
carlbergstrom.com
Carl T. Bergstrom @carlbergstrom.com · Jun 23
It is a very short list of cities in which you can visit three world class research universities on three consecutive days without switching hotels.

Tomorrow, Sydney University. Wednesday, UNSW. Thursday, Macquarie University.
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Reposted by Matt Doyle
hannjbrown.bsky.social
Hannah Brown 🧂🦠🔬 @hannjbrown.bsky.social · Jun 23
Feeling very humbled by receiving this award and equally excited to attend ASM in Adelaide this year! 🎉
asm-nswact.bsky.social
ASM NSW-ACT Branch @asm-nswact.bsky.social · Jun 23
🎉 Congratulations to the winners of the 2025 Early Career Microbiologist Award!

🏆 Winner: Dr Hannah Brown @hannjbrown.bsky.social

🏆 Runner-Up: Dr Binod Rayamajhee

We’re proud to support the next generation of microbiology leaders and can’t wait to see where their research takes them!
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Reposted by Matt Doyle
jamsorgsyd.bsky.social
JAMS Sydney @jamsorgsyd.bsky.social · Jun 18
JAMS June Monthly is next week🥳

📅 Tuesday 24th June, 2024
📍 The Rose, Chippendale (LOCATION CHANGE!)

Can't wait to see you all at this new location! Come for the microbes, stay for the mates 🍻

#microbiolgy #JAMSmicro #science #seminar #networking #biology #research

@doylemt1.bsky.social
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