Sean Gibbons 🦠💩
@gibbological.bsky.social
microbiome researcher | associate professor @isbscience.org | affiliate prof @uwbioe.bsky.social | ecology, evolution, and systems biology of 💩 🦠 | precision/personalized nutrition/medicine ⚕️ | 🏳️🌈 he/him | lab website: gibbons.isbscience.org
Pinned
Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut
Carr et al. show how microbial community-scale metabolic models (MCMMs) predict personalized
Clostridioides difficile colonization risk and probiotic efficacy. MCMMs reveal key
metabolic strategies ex...
www.cell.com
💥Personalized C. difficile colonization risk prediction and probiotic therapy assessment in the human gut💥
I'm very excited about this work, driven by Alex Carr & co-supervised by @cdiener.com
@cp-cellsystems.bsky.social @isbscience.org @nitinbaliga.bsky.social
www.cell.com/cell-systems...
🧵...
I'm very excited about this work, driven by Alex Carr & co-supervised by @cdiener.com
@cp-cellsystems.bsky.social @isbscience.org @nitinbaliga.bsky.social
www.cell.com/cell-systems...
🧵...
Reposted by Sean Gibbons 🦠💩
The stock market's gains are being overwhelmingly driven by seven Big Tech companies who have invested heavily in AI, which has made tech oligarchs even wealthier.
But when that AI bubble bursts, the rest of us will be stuck holding the bag.
Be warned.
But when that AI bubble bursts, the rest of us will be stuck holding the bag.
Be warned.
November 25, 2025 at 11:01 PM
The stock market's gains are being overwhelmingly driven by seven Big Tech companies who have invested heavily in AI, which has made tech oligarchs even wealthier.
But when that AI bubble bursts, the rest of us will be stuck holding the bag.
Be warned.
But when that AI bubble bursts, the rest of us will be stuck holding the bag.
Be warned.
Reposted by Sean Gibbons 🦠💩
Breaking News: Viola Fletcher, the oldest survivor of the Tulsa Race Massacre who testified a century later in Congress to the terror she witnessed in the hope of winning reparations, died at 111. nyti.ms/4or9B1e
November 24, 2025 at 10:21 PM
Breaking News: Viola Fletcher, the oldest survivor of the Tulsa Race Massacre who testified a century later in Congress to the terror she witnessed in the hope of winning reparations, died at 111. nyti.ms/4or9B1e
Reposted by Sean Gibbons 🦠💩
I have friends in the animal rights world who — months back — thought there would be some sort of silver lining to the RFK regime, and I want to emphasize that cancelling HIV research and euthanizing a ton of chimps is not a silver lining for anyone involved.
Exclusive: CDC to end all monkey research | Science | AAAS www.science.org/content/arti... 🧪
Exclusive: CDC to end all monkey research
Studies related to HIV and other infectious diseases will be phased out, sources say; fate of the agency's animals remains unclear
www.science.org
November 24, 2025 at 8:32 PM
I have friends in the animal rights world who — months back — thought there would be some sort of silver lining to the RFK regime, and I want to emphasize that cancelling HIV research and euthanizing a ton of chimps is not a silver lining for anyone involved.
Reposted by Sean Gibbons 🦠💩
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...
scim.ag
November 24, 2025 at 10:00 PM
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
Reposted by Sean Gibbons 🦠💩
This is absolutely f'ing horrifying.
Emmanuel, a 15-year-old with intellectual disabilities, wandered away from his mom’s fruit stand in October.
She reported him missing to Houston police. But instead of reuniting them, the city turned him over to ICE.
“They’re failing all of us,” his mom said.
thebarbedwire.com/2025/11/24/d...
She reported him missing to Houston police. But instead of reuniting them, the city turned him over to ICE.
“They’re failing all of us,” his mom said.
thebarbedwire.com/2025/11/24/d...
A Disabled Child’s Mom Reported Him Missing. He Was Locked Away by Federal Immigration Authorities for 48 Days.
Emmanuel, a 15-year-old who has an intellectual disability, walked away from his mom’s fruit stand in October. Houston Police called ICE.
thebarbedwire.com
November 24, 2025 at 3:13 PM
This is absolutely f'ing horrifying.
Reposted by Sean Gibbons 🦠💩
Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
November 24, 2025 at 7:23 PM
Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466
Reposted by Sean Gibbons 🦠💩
This is concerning.
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
November 24, 2025 at 12:29 AM
This is concerning.
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
Reposted by Sean Gibbons 🦠💩
And another thing: we're not enron. please dont put in the newspaper that we're like enron
In the memo, “Nvidia also responds to claims that the ‘current situation is analogous to historical accounting frauds (Enron, WorldCom, Lucent) that featured vendor financing and SPVs [special purpose vehicles.)’”
@barrons.com $NVDA
@firstadopter.bsky.social
www.barrons.com/articles/nvi...
@barrons.com $NVDA
@firstadopter.bsky.social
www.barrons.com/articles/nvi...
November 24, 2025 at 7:36 PM
And another thing: we're not enron. please dont put in the newspaper that we're like enron
Reposted by Sean Gibbons 🦠💩
America needs more patriots like Senator Mark Kelly and fewer miserable cowards like Donald Trump and Pete Hegseth.
Sen. Mark Kelly facing military investigation after clashing with Trump
A statement from the Pentagon said all service members have a "legal obligation" to "obey lawful orders and that orders are presumed to be lawful."
www.axios.com
November 24, 2025 at 7:36 PM
America needs more patriots like Senator Mark Kelly and fewer miserable cowards like Donald Trump and Pete Hegseth.
Reposted by Sean Gibbons 🦠💩
Due to the shutdown, NIH cancelled >370 study sections, impacting >24,000 applications
Rescheduled meetings will only discuss 30-35% of applications, have simplified summary statements (no narrative paragraph), and a new category - "competitive but not discussed"
grants.nih.gov/grants/guide...
Rescheduled meetings will only discuss 30-35% of applications, have simplified summary statements (no narrative paragraph), and a new category - "competitive but not discussed"
grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 6:55 PM
Due to the shutdown, NIH cancelled >370 study sections, impacting >24,000 applications
Rescheduled meetings will only discuss 30-35% of applications, have simplified summary statements (no narrative paragraph), and a new category - "competitive but not discussed"
grants.nih.gov/grants/guide...
Rescheduled meetings will only discuss 30-35% of applications, have simplified summary statements (no narrative paragraph), and a new category - "competitive but not discussed"
grants.nih.gov/grants/guide...
Reposted by Sean Gibbons 🦠💩
Proud to be a Fellow of the National Academy of Medicine in USA, which, along with the National Academies of Science and Engineering, have published a statement on the CDC's "updated" (aka meddled-with by RFK) vaccine guidance.
www.nationalacademies.org/news/stateme...
www.nationalacademies.org/news/stateme...
National Academies - Statement on CDC’s Updated Vaccine Guidance
National Academies respond to CDC’s updated vaccine guidance, offering scientific context and clarity on vaccine safety.
www.nationalacademies.org
November 24, 2025 at 6:48 PM
Proud to be a Fellow of the National Academy of Medicine in USA, which, along with the National Academies of Science and Engineering, have published a statement on the CDC's "updated" (aka meddled-with by RFK) vaccine guidance.
www.nationalacademies.org/news/stateme...
www.nationalacademies.org/news/stateme...
Reposted by Sean Gibbons 🦠💩
A judge dismissed cases against James Comey and Letitia James on Monday after finding that the prosecutor was illegally appointed. https://to.pbs.org/3LQJ3Jb
Judge dismisses cases against James Comey, Letitia James after finding the prosecutor was illegally appointed
A judge dismissed cases against James Comey and Letitia James on Monday after finding that the prosecutor was illegally appointed.
www.pbs.org
November 24, 2025 at 5:55 PM
A judge dismissed cases against James Comey and Letitia James on Monday after finding that the prosecutor was illegally appointed. https://to.pbs.org/3LQJ3Jb
Reposted by Sean Gibbons 🦠💩
Amazing story, state legislator and Turning Points USA leader who crusaded against bogus voter fraud claims pleads guilty to attempted election fraud. azmirror.com/briefs/turni...
Turning Point leader, former GOP Rep pleads guilty to attempted election fraud | Arizona Mirror
Austin Smith election fraud guilty plea: Former GOP Rep admits forging 100+ signatures on ballot petitions in Arizona
azmirror.com
November 23, 2025 at 8:06 PM
Amazing story, state legislator and Turning Points USA leader who crusaded against bogus voter fraud claims pleads guilty to attempted election fraud. azmirror.com/briefs/turni...
Reposted by Sean Gibbons 🦠💩
This...is exactly the kind of theory that has been needed for longer than a decade in microbiome-host evolution studies
Treating emergent traits of the microbiome like quantitative genetic traits of the host reveals how environmentally acquired symbionts can contribute to hosts' adaptation
Quantitative genetics of microbiome-mediated traits
Microbiomes, the complex communities of microorganisms associated with multicellular hosts, play a vital role in shaping host traits and fitness. But how d
buff.ly
November 24, 2025 at 3:33 PM
This...is exactly the kind of theory that has been needed for longer than a decade in microbiome-host evolution studies
Reposted by Sean Gibbons 🦠💩
Two scientists who are fast friends, one Nigerian and one American, have won the MacArthur Foundation's 100&Change competition for their network to catch the next disease with pandemic potential.
$100 million prize goes to dynamic duo aiming to stop next pandemic before it starts
Two scientists who are fast friends, one Nigerian and one American, have won the MacArthur Foundation's 100&Change competition for their network to catch the next disease with pandemic potential.
n.pr
November 22, 2025 at 8:03 PM
Two scientists who are fast friends, one Nigerian and one American, have won the MacArthur Foundation's 100&Change competition for their network to catch the next disease with pandemic potential.
A movie that takes place where you're from.
November 23, 2025 at 7:40 PM
A movie that takes place where you're from.
Reposted by Sean Gibbons 🦠💩
Geneticist and microbiologist Rita Rossi Colwell was born #OTD in 1934. She was the first researcher in the US to use computers to analyze bacteriological data, and the first woman to serve as director of the NSF. 🧪 👩🔬
November 23, 2025 at 6:32 PM
Geneticist and microbiologist Rita Rossi Colwell was born #OTD in 1934. She was the first researcher in the US to use computers to analyze bacteriological data, and the first woman to serve as director of the NSF. 🧪 👩🔬
Reposted by Sean Gibbons 🦠💩
The actions of Witkoff, Rubio and Trump in this matter are an absolute disgrace. This means that the U.S. cannot be seen as an honest broker in any international conflict.
Trump’s controversial plan given to Ukraine as a take-it-or-leave it proposition was the result of weeks of negotiations behind the scenes between Steve Witkoff and his Russian counterpart Kirill Dmitriev that excluded Ukraine, its allies and key US officials.
www.bloomberg.com/news/article...
www.bloomberg.com/news/article...
Secret US-Russia Talks Led to Peace Plan That Blindsided Ukraine
The controversial 28-point plan dropped suddenly by the Trump administration to Ukraine as a take-it-or-leave it proposition mere days ago was mostly the result of several weeks of negotiations behind...
www.bloomberg.com
November 23, 2025 at 5:21 PM
The actions of Witkoff, Rubio and Trump in this matter are an absolute disgrace. This means that the U.S. cannot be seen as an honest broker in any international conflict.
Interesting microbiome-aging study in flies: "...findings are consistent with growing evidence in D. melanogaster indicating that fecal microbiota transplants from young individuals do not consistently improve or predict age-related outcomes..."
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Host genetics and diet jointly shape the microbiome of Drosophila melanogaster but do not predict lifespan or age-related traits
The microbiome is a key determinant of organismal health, yet inter-individual variability and heterogeneous responses to environmental conditions complicates the understanding of its effects on hosts...
www.biorxiv.org
November 23, 2025 at 5:06 PM
Interesting microbiome-aging study in flies: "...findings are consistent with growing evidence in D. melanogaster indicating that fecal microbiota transplants from young individuals do not consistently improve or predict age-related outcomes..."
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sean Gibbons 🦠💩
Gift link: wapo.st/43FXQfO
detailed WashPost account of how Trump and Stephen Miller sidelined serious lawyers so they could fabricate a justification for committing murder
www.washingtonpost.com/national-sec...
www.washingtonpost.com/national-sec...
White House blew past legal concerns in deadly strikes on drug boats
The Trump administration sidestepped skeptical lawyers across national security agencies as it pursued a military campaign against alleged narcotraffickers, officials say.
www.washingtonpost.com
November 22, 2025 at 2:30 PM
Gift link: wapo.st/43FXQfO
Reposted by Sean Gibbons 🦠💩
"twin studies produce a ~2x inflated estimate of narrow-sense heritability when compared to molecular estimates that are free of environmental confounding."
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 22, 2025 at 7:13 PM
"twin studies produce a ~2x inflated estimate of narrow-sense heritability when compared to molecular estimates that are free of environmental confounding."
Reposted by Sean Gibbons 🦠💩
Not this again
'however, standard culture methods did not yield readily cultivable microbiota.'
'however, standard culture methods did not yield readily cultivable microbiota.'
The findings of a study in Nature Medicine introduce microbial elements as a component of the brain tumor microenvironment and lay the foundation for future mechanistic and translational studies. go.nature.com/44bO314 #medsky #microbiome 🧪
November 22, 2025 at 8:14 AM
Not this again
'however, standard culture methods did not yield readily cultivable microbiota.'
'however, standard culture methods did not yield readily cultivable microbiota.'
Reposted by Sean Gibbons 🦠💩
In fairness, the NIH Director was describing his own research...
The NIH director told attendees the NIH doesn't do enough innovative research.
“What puts lives at risk is doing research that’s incremental,” Bhattacharya said. “All it does is advance the careers of the researchers that do it. It results in publications that don’t get used and aren’t replicable.”
“What puts lives at risk is doing research that’s incremental,” Bhattacharya said. “All it does is advance the careers of the researchers that do it. It results in publications that don’t get used and aren’t replicable.”
November 22, 2025 at 11:48 AM
In fairness, the NIH Director was describing his own research...
Reposted by Sean Gibbons 🦠💩
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵