Michael Hoffman
michaelhoffman.bsky.social
Michael Hoffman
@michaelhoffman.bsky.social
Chair, Computational BIology and Medicine Program, Princess Margaret Cancer Centre, University Health Network.

Associate Professor, Medical Biophysics, University of Toronto.

Disclosures: https://github.com/michaelmhoffman/disclosure/
Pinned
I'm at Princess Margaret Cancer Centre and University of Toronto. We have three major interests:

1/Computational methods and #ML for gene regulation data 🧬🖥️
2/Liquid biopsy beyond simple genetic variants (epigenomic, immunogenomic)
3/Reproducibility and robustness of biomedical analysis (esp. #ML)
Reposted by Michael Hoffman
In more AI bubble news, major insurers are declining to insure risks from AI chatbots & agents, saying AI models are too unpredictable & error-prone with no one clearly liable when things go wrong. Firms & universities better consider this in their rush to adopt AI.
www.ft.com/content/abfe...
Insurers retreat from AI cover as risk of multibillion-dollar claims mounts
AIG, Great American and WR Berkley seek permission to limit liability from AI agents and chatbots
www.ft.com
November 24, 2025 at 12:56 AM
Reposted by Michael Hoffman
November 25, 2025 at 12:20 AM
Reposted by Michael Hoffman
Mel Lastman told councillor David Miller that "you will never be mayor of this city."

Of course, the next mayor of the city of Toronto was David Miller.
November 24, 2025 at 9:53 PM
I like Marit. I don't know if she can win next time, but at least she vigorously contests the corrupt Doug Ford PCs.
November 24, 2025 at 9:28 PM
When @maritstilesndp.bsky.social says "at least my lemonade stand was legal" is she referring to the Globe and Mail investigation claiming he was a drug dealer? Or something else? toronto.citynews.ca/video/2025/1...
'You'll never be premier!': Ford and Stiles have heated exchange at Queen's Park
Premier Doug Ford and Ontario NDP Leader Marit Stiles had a heated exchange at Queen's Park during question period after the opposition brought up the skills-development fund controversary.
toronto.citynews.ca
November 24, 2025 at 9:21 PM
What a juxtaposition from @citynewstoronto.bsky.social:

- 5 killed in rental home where city officials allege an absentee landlord wasn't following by-laws

- Doug Ford changes the law to make it easier for landlords to evict tenants raising health and safety issues
November 24, 2025 at 9:06 PM
And another thing: we're not enron. please dont put in the newspaper that we're like enron
In the memo, “Nvidia also responds to claims that the ‘current situation is analogous to historical accounting frauds (Enron, WorldCom, Lucent) that featured vendor financing and SPVs [special purpose vehicles.)’”

@barrons.com $NVDA
@firstadopter.bsky.social
www.barrons.com/articles/nvi...
November 24, 2025 at 7:36 PM
Reposted by Michael Hoffman
Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
November 24, 2025 at 7:23 PM
Reposted by Michael Hoffman
poisoning Adobe's AI assistant by having it summarize a 1968 cookbook that exclusively contains hot dog recipes
November 23, 2025 at 9:28 PM
Reposted by Michael Hoffman
Really important to stress that the Crown Jewels of the US higher education system were never the Ivies or elite SLACs (other countries have equivalents of these) but the well-funded, large, cheap, and excellently staffed public state university systems bringing high quality education to the masses.
One of the bragging rights that the US ed system had in the 20th century is that we didn't have education tracks. Essentially, any kid could go to a CC or state school & major in whatever they wanted to (obviously an oversimplification). I fear this aspect of the American dream is dying.
November 23, 2025 at 5:18 PM
Reposted by Michael Hoffman
KPOP Demon Hunters is a movie about the importance of effective public health communication in this essay I will...
November 23, 2025 at 1:36 PM
Reposted by Michael Hoffman
Imagine, if you will, that NASA updated its website to suggest gravity might not exist, prompting CalTech and CERN to release statements saying, "With great sadness, we can no longer recommend listening to NASA."

This is what's happening in epidemiology.
November 21, 2025 at 8:58 PM
Reposted by Michael Hoffman
Keep this in mind when people claim cars mean business — closing Central #Madrid to cars over holidays resulted in a 9.5% boost in retail spending on its main shopping street: STUDY.

There was also a 71% drop in air pollution.

Via @carltonreid.com in @forbes.com. #citymakingmath #citiesforpeople
Closing Central Madrid To Cars Resulted In 9.5% Boost To Retail Spending, Finds Bank Analysis
City of Madrid significantly boosted the takings of its shops and restaurants last Christmas by banning cars from the CBD, finds an analysis by Spain's second largest bank.
www.forbes.com
November 20, 2025 at 6:21 AM
Reposted by Michael Hoffman
"Happiness, which is Smiles minus Frowns"
Good old Woz. Good for him.
November 21, 2025 at 9:30 PM
Reposted by Michael Hoffman
Normalize admitting you don’t know what some shit means!
completely outside of politics, this is so charming
November 21, 2025 at 4:33 PM
Wicked: For Good theme packs? I feel more secure already
November 21, 2025 at 3:59 PM
Reposted by Michael Hoffman
while I’m being cranky, access journalism needs to go. When the president does his “I’m alpha because I insulted you” thing somebody needs to fall on his sword and say “what the fuck is wrong with you, old man?” on a hot mic. the hero of the wizard of Oz is Toto.
November 21, 2025 at 12:11 PM
Reposted by Michael Hoffman
Relying on ChatGPT to teach you about a topic leaves you with shallower knowledge than Googling and reading about it, according to new research that compared what more than 10,000 people knew after using one method or the other.

Shared by @gizmodo.com: buff.ly/yAAHtHq
November 21, 2025 at 11:48 AM
Reposted by Michael Hoffman
PSA to academics posting threads about your paper here: you can (and should) post the link to the paper in the first post. Your X/Twitter brain rot have have you thinking otherwise, but please free yourself of that. (Also you can call them 'blue-prints' if you want).
November 21, 2025 at 2:56 AM
Reposted by Michael Hoffman
Behind this important reversal is a member of the Coast Guard who saw what was happening and had the courage to leak it to the press. That person deserves serious praise.
November 21, 2025 at 12:23 PM
Reposted by Michael Hoffman
Elon Musk is very explicitly altering the X algorithm to show people content that aligns with his far-right worldview.

If you're still posting there and think you can win hearts and minds or something, this is what you're up against. You're never going to win a rigged game.
November 21, 2025 at 12:36 AM
Reposted by Michael Hoffman
If you're trying to convince your friends to spend time on Bluesky rather than X, maybe show them this. X is not "the public town square" or about "free speech." It's "just what Elon Musk wants you to see." If you see stuff he doesn't like he'll step in to make sure you don't see it for long.
If you scroll on X, you are only being shown what Elon wants you to see. If you create content on X, no one will see it unless Elon wants them to.
November 21, 2025 at 1:31 AM
Reposted by Michael Hoffman
Line 6 Finch West LRT planned to be open December 7 according to publicly available Metrolinx board meeting slides

Source: assets.metrolinx.com/image/upload...
November 21, 2025 at 1:59 AM