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Mike-ghoul Half-man

@michaelhoffman.bsky.social

16K followers 1.6K following 4.4K posts

Chair, Computational BIology and Medicine Program, Princess Margaret Cancer Centre, University Health Network. Associate Professor, Medical Biophysics, University of Toronto. Disclosures: https://github.com/michaelmhoffman/disclosure/

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Mike-ghoul Half-man @michaelhoffman.bsky.social · Nov 12

I'm at Princess Margaret Cancer Centre and University of Toronto. We have three major interests:

1/Computational methods and #ML for gene regulation data 🧬🖥️
2/Liquid biopsy beyond simple genetic variants (epigenomic, immunogenomic)
3/Reproducibility and robustness of biomedical analysis (esp. #ML)

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Adam Serwer @adamserwer.bsky.social · 11h

www.wweek.com/culture/2025...

Can you put into words what that purpose is? You and the frog have really become icons of this protest.

There’s been a nice overall whimsy that has shown up. The frog is amazing. We had a bunch of other inflatable people here last night, too. I saw people playing Twister the other day.

What they rely on is fear. So by coming out in an absurdist manner, it speaks to them, to some extent, that we’re actually not that afraid.

It also dismantles their narrative a little bit. When they try to describe this situation as “war-torn,” it becomes much harder to take them seriously when they have to post a video saying [U.S. Secretary of Homeland Security] Kristi Noem is up on the balcony staring over the Antifa Army and it’s, like, eight journalists and five protesters and one of them is in a chicken suit.

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 16h

Not super surprised by that, but was a little surprised that the judge could draw on precedent that was so on point.

Mike-ghoul Half-man @michaelhoffman.bsky.social · 16h

Judge underestimates Kendrick tho

Mike-ghoul Half-man @michaelhoffman.bsky.social · 16h

The amount of unhinged shit is too damn high

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 17h

My HPLC was definitely overlooked

www.nature.com/articles/d41...

Prizes must recognize machine contributions to discovery

The future of science will be written by humans and machines together. Awards should reflect that reality.

www.nature.com

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 17h

Oh crap

Jacob Shamsian @jayshams.bsky.social · 18h

I've been wondering why Dominion Voting Systems suddenly reached settlements with Rudy Giuliani, Sidney Powell, and One America News.

Turns out, it's been purchased by a Republican-owned election tech firm that insisted on it, per Axios.

www.axios.com/2025/10/09/d...

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 17h

Thank you for clarifying this Matt

Mike-ghoul Half-man @michaelhoffman.bsky.social · 21h

OK my bad if this is true. Am very surprised to see he doesn't inherently understand the need for this if he rides frequently.

Mike-ghoul Half-man @michaelhoffman.bsky.social · 21h

Maybe if we ask the people who are helped if they can rake leaves off his lawn

Mike-ghoul Half-man @michaelhoffman.bsky.social · 21h

People in crisis due to his policies on a transit system he doesn't use?

Stephen Holyday: That's not my problem.

Matt Elliott @graphicmatt.com · 21h

Holyday calls this a "terrible report." He's frustrated that there's no "business case" for expanding the crisis service on the TTC and the $1.8 million annual cost. He says he'll vote against this.

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Matt Elliott @graphicmatt.com · 22h

"Someone experiencing a mental health crisis and it's a non-violent scenario, then you don't need — and I would suggest you should not have — a police officer with a full gun belt on, a bulletproof vest on that says 'Police' across the chest, speaking to them," says police rep.

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The Francis Crick Institute @crick.ac.uk · 23h

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Kai Ryssdal @kairyssdal.bsky.social · 1d

This is the lesson of 2025

Quinta Jurecic @qjurecic.bsky.social · 1d

he's going to come after you either way, so you might as well act with integrity

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Kate Starbird @katestarbird.bsky.social · 1d

Words to live by.

Quinta Jurecic @qjurecic.bsky.social · 1d

he's going to come after you either way, so you might as well act with integrity

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

So, she's also a mom.

Case closed.

Reposted by Mike-ghoul Half-man

Prem Thakker ツ @premthakker.bsky.social · 1d

My gosh. After the US bombed multiple boats in the middle of the ocean, murdering people on grounds that they were allegedly "carrying drugs," the US Attorney General says "Just like we did with cartels, we're going to take the same approach, President Trump, with Antifa."

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Own a property but don't want to clean up your own autumn leaves?

Now that's a real problem.

Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Never seen four words that sum up Stephen Holyday better.

Can't find a place to live? That's not my problem.
Can't stop cars from killing you? That's not my problem.
Stuck on a bus forever? That's not my problem.
Children can't get food to eat? That's not my problem.

Matt Elliott @graphicmatt.com · 1d

"I've had smaller developers mention to me that, you know, what a burden the DCs are on them kicking off their project, because they'd like to see it financially viable. And my response is, 'That's not my problem,'" says Holyday

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Why do people feel like having loud, angry phone conversations on transit? Apart from bothering everyone else, do they not care about everyone else knowing their business?

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

I'm coming around to this wasp wrap thing

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Anne Applebaum @anneapplebaum.bsky.social · 1d

"We took the freedom of speech away," says the president

Aaron Rupar @atrupar.com · 1d

Trump: "We took the freedom of speech away because that's been through the courts and the courts said you have freedom of speech, but what has happened is when they burn a flag it agitates and irritates crowds."

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Wow even Holyday voted yes

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Chow is going pretty hard on this. I assume it's an electoral winner.

Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

A No-Prize