Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...

Dias et al. discover that the orphan solute carrier protein, SLC25A45, enables mitochondrial import of methylated amino acids. SLC25A45-dependent mitochondrial uptake of trimethyllysine drives carniti...

Molecular biology and omics-based approaches over the past 20 years have rapidly advanced the discipline of exercise metabolism. Here, we examine three innovative human metabolic studies that have increased our understanding of exercise’s complex molecular landscape in skeletal muscle and beyond, and highlight key future directions.

Over the past 20 years, obesity research has resulted in a better understanding of the complex disease mechanisms underlying the condition, including biological, behavioural, societal and environmental factors. Although obesity research in the past 10 years has resulted in very effective and safe obesity treatments, more research is needed to improve the lives of people with obesity.

Consumption of ultra-processed foods (UPF) is increasingly linked to the development of obesity, on both an individual and a global scale. This Review assesses the role of UPF in obesity, examining the epidemiological evidence, biological mechanisms and implications for policymakers.

Background The coupling of oxygen consumption to ATP synthesis via oxidative phosphorylation (OXPHOS) is central for cellular energy homeostasis. Some studies suggest exercise training increases the...

Reducing Ca2+ leak through mutant RYR1 prevents pathological heat production in skeletal muscle.

imageimageThe ability of cells to recover after the initiation of cell death pathways is only little understood. This study challenges the dogma of irreversible cell death by characterizing a programm...

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Mitochondria are involved in cellular metabolism, energy production, calcium homeostasis, and the synthesis of sterols and bile acids (BAs). Emerging …

imageimageAcute exogenous acyl-GIP administration promotes brown adipose tissue (BAT) lipid uptake during lipid tolerance tests, augmenting whole-body lipid handling and increases whole-body fatty aci...

Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

Dr. Joseph Gordon, Biomedical Sciences with AVC and the Memorial Regional Medical Program at UPEI, has received national recognition for his innovative use of research and groundbreaking work investig...

GLP1R-based obesity therapies can reduce lean muscle and energy expenditure via adaptive thermogenesis (also known as metabolic adaptation), leading to weight plateaus and regain. Defining the role of...

This Perspective explores recent progress and future directions in glucagon-like peptide-1 medicines.

The global rise in obesity has underscored the critical importance of body composition, particularly the balance between fat mass and lean mass, in de…