Joseph Gordon
@josephwgordon.bsky.social
Associate Professor, University of Prince Edward Island
Heart and Stroke Foundation Canada Provincial Advisory Board for PEI
Heart and Stroke Foundation Canada Provincial Advisory Board for PEI
Reposted by Joseph Gordon
Mitochondrial dynamics proteins have other functions than just regulating mito dynamics, but they are often forgotten.
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPa...
physoc.onlinelibrary.wiley.com
November 22, 2025 at 5:08 PM
Mitochondrial dynamics proteins have other functions than just regulating mito dynamics, but they are often forgotten.
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Joseph Gordon
On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Bridging the variant-to-function gap in type 2 diabetes: advances and challenges - Diabetologia
Type 2 diabetes is a polygenic, heterogeneous disease affecting over 530 million individuals worldwide, a number projected to rise to 1.3 billion by 2050. Genome-wide association studies have identifi...
link.springer.com
November 22, 2025 at 8:54 PM
On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Reposted by Joseph Gordon
Based on extensive mouse studies
demonstrating miR-432 exacerbates #obesity induced dysregulation of glucose and lipid metabolism, the authors propose miR-342 antagonist to treat cardiometabolic disorders diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...
demonstrating miR-432 exacerbates #obesity induced dysregulation of glucose and lipid metabolism, the authors propose miR-342 antagonist to treat cardiometabolic disorders diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...
November 13, 2025 at 1:37 AM
Based on extensive mouse studies
demonstrating miR-432 exacerbates #obesity induced dysregulation of glucose and lipid metabolism, the authors propose miR-342 antagonist to treat cardiometabolic disorders diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...
demonstrating miR-432 exacerbates #obesity induced dysregulation of glucose and lipid metabolism, the authors propose miR-342 antagonist to treat cardiometabolic disorders diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...
Reposted by Joseph Gordon
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Reposted by Joseph Gordon
Need a big toolkit for your next cloning project, a whole palette of biosensors or fluorescent proteins, or expression constructs spanning your favorite pathway? Addgene kits may be just what you need!
Addgene: Plasmid Kits
Addgene plasmid kits for cloning, genome engineering, fluorescent proteins & more.
twp.ai
November 4, 2025 at 2:01 PM
Need a big toolkit for your next cloning project, a whole palette of biosensors or fluorescent proteins, or expression constructs spanning your favorite pathway? Addgene kits may be just what you need!
In case you missed the ILCOR release, highlights of the new resuscitation guidelines can be found here: cpr.heartandstroke.ca/s/article/20...
Heart & Stroke Training Portal
cpr.heartandstroke.ca
October 26, 2025 at 12:46 AM
In case you missed the ILCOR release, highlights of the new resuscitation guidelines can be found here: cpr.heartandstroke.ca/s/article/20...
Reposted by Joseph Gordon
The benefit of Ozempic (semaglutide) for protection from major adverse cardiovascular events (MACE) is independent of weight loss magnitude and baseline adiposity, likely related to the GLP-1 anti-inflammatory effect
thelancet.com/journals/lan...
thelancet.com/journals/lan...
Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial
The cardioprotective effects of semaglutide were independent of baseline adiposity
and weight loss and had only a small association with waist circumference, suggesting
some mechanisms for benefit bey...
thelancet.com
October 22, 2025 at 10:43 PM
The benefit of Ozempic (semaglutide) for protection from major adverse cardiovascular events (MACE) is independent of weight loss magnitude and baseline adiposity, likely related to the GLP-1 anti-inflammatory effect
thelancet.com/journals/lan...
thelancet.com/journals/lan...
Reposted by Joseph Gordon
I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...
Empowering Diabetes Care Integrating Health Information
YouTube video by T2D Network
www.youtube.com
October 20, 2025 at 9:47 PM
I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...
Reposted by Joseph Gordon
Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...
Aged mice exhibit widespread metabolic changes but preserved major fluxes
Metabolic dysregulation is a hallmark of aging, but how metabolic pathway activity
(flux) changes with age has yet to be broadly assessed. Here, Jankowski et al. measure
metabolite concentrations and ...
www.cell.com
October 16, 2025 at 6:15 PM
Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...
