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Joseph Gordon @josephwgordon.bsky.social · 1d

www.science.org/doi/10.1126/...

Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke

Reducing Ca2+ leak through mutant RYR1 prevents pathological heat production in skeletal muscle.

www.science.org

Joseph Gordon @josephwgordon.bsky.social · 6d

www.embopress.org/doi/full/10....

Programmed cell revival from imminent cell death enhances tissue repair and regeneration | The EMBO Journal

imageimageThe ability of cells to recover after the initiation of cell death pathways is only little understood. This study challenges the dogma of irreversible cell death by characterizing a programm...

www.embopress.org

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Joseph Gordon @josephwgordon.bsky.social · 8d

www.jci.org/articles/vie...

JCI - Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes

www.jci.org

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Joseph Gordon @josephwgordon.bsky.social · 10d

www.nature.com/articles/s42...

A consensus guide to preclinical indirect calorimetry experiments - Nature Metabolism

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

www.nature.com

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Joseph Gordon @josephwgordon.bsky.social · 11d

www.frontierspartnerships.org/journals/jou...

Frontiers Publishing Partnerships | The need to redefine diabetic cardiomyopathy as a unique clinical entity that requires pharmacotherapy

www.frontierspartnerships.org

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Joseph Gordon @josephwgordon.bsky.social · 13d

www.sciencedirect.com/science/arti...

Increased mitochondrial fusion via systemic OPA1 overexpression promotes dyslipidemia and atherosclerosis in LDLR deficient mice.

Mitochondria are involved in cellular metabolism, energy production, calcium homeostasis, and the synthesis of sterols and bile acids (BAs). Emerging …

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Joseph Gordon @josephwgordon.bsky.social · 13d

A quote from the press release: “A parallel study in obese patients without diabetes remains active. Results from this trial will be available in 2026, the company spokesperson said.”

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Joseph Gordon @josephwgordon.bsky.social · 13d

Thanks Kristin!

Joseph Gordon @josephwgordon.bsky.social · 13d

Thanks DREAM!

Joseph Gordon @josephwgordon.bsky.social · 14d

www.embopress.org/doi/full/10....

Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat | EMBO reports

imageimageAcute exogenous acyl-GIP administration promotes brown adipose tissue (BAT) lipid uptake during lipid tolerance tests, augmenting whole-body lipid handling and increases whole-body fatty aci...

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Joseph Gordon @josephwgordon.bsky.social · 14d

www.nature.com/articles/s44...

Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α - Nature Cardiovascular Research

Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

www.nature.com

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Reposted by Joseph Gordon

Krista Lamb @kristalamb.bsky.social · 16d

Congratulations, @josephwgordon.bsky.social! 🧪 www.upei.ca/communicatio...

Dr. Joseph Gordon recognized with national Open Science research award | University of Prince Edward Island

Dr. Joseph Gordon, Biomedical Sciences with AVC and the Memorial Regional Medical Program at UPEI, has received national recognition for his innovative use of research and groundbreaking work investig...

www.upei.ca

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Joseph Gordon @josephwgordon.bsky.social · 16d

Thanks Krista

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Reposted by Joseph Gordon

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 17d

The ongoing global epidemic of #MASLD & its close pathogenic & predictive relationship with the non-communicable diseases of #cardiovascular disease, #cancer, #obesity & type 2 #diabetes, allow the inclusion of #MASLD as a new non-communicable disease
www.thelancet.com/journals/lan...
#OpenAccess

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Joseph Gordon @josephwgordon.bsky.social · 17d

www.jci.org/articles/vie...

JCI - MASH: the nexus of metabolism, inflammation, and fibrosis

www.jci.org

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Joseph Gordon @josephwgordon.bsky.social · 17d

www.cell.com/cell-reports...

Can muscle avert GLP1R weight plateau and regain?

GLP1R-based obesity therapies can reduce lean muscle and energy expenditure via adaptive thermogenesis (also known as metabolic adaptation), leading to weight plateaus and regain. Defining the role of...

www.cell.com

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Reposted by Joseph Gordon

Elizabeth Rideout @ejrideout.bsky.social · 18d

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

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Reposted by Joseph Gordon

Daniel Drucker @danieljdrucker.bsky.social · 18d

The first GLP-1 medicine, twice daily exenatide was approved April 28 2005. Several decades later, the pace of innovation is expanding rapidly, encompassing new medicines and receptors, unique delivery options, and expanding therapeutic indications jamanetwork.com/journals/jam...

New Molecules and Indications for GLP-1 Medicines

This Perspective explores recent progress and future directions in glucagon-like peptide-1 medicines.

jamanetwork.com

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Joseph Gordon @josephwgordon.bsky.social · 20d

www.sciencedirect.com/science/arti...

Are We Giving Too Much Weight to Lean Mass Loss?

The global rise in obesity has underscored the critical importance of body composition, particularly the balance between fat mass and lean mass, in de…

www.sciencedirect.com

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Joseph Gordon @josephwgordon.bsky.social · 20d

www.embopress.org/doi/full/10....

The muscle specific MEF2Dα2 isoform promotes muscle ketolysis and running capacity in mice | EMBO reports

imageimageThe muscle specific MEF2Dα2 isoform is produced by regulated postnatal alternative splicing. Deletion of this exon in mice causes reduced running capacity and muscle ketolytic gene expressio...

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Reposted by Joseph Gordon

Matthew Alexander, PhD @mattmuscleguy.bsky.social · 21d

Congrats to #JF_CoteLab and colleagues for their new #DevelopmentJ paper: Differentially expressed fusogens specify myocyte states to drive myogenesis. #Myoblue tinyurl.com/ykbbex8t

tinyurl.com

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Reposted by Joseph Gordon

Laboratory of Exercise and Health - ETH Zürich @debocklab.bsky.social · 23d

Great and unique resource for those who are interested in studying peripheral artery disease mechanisms 👇. Congratulations to Guillermo Turiel and huge thanks to all our collaborators @ethz.ch and Kantonsspital Baden. #PAD #endothelialcells #peripheralarterydisease
rdcu.be/eGpZI

Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1+ macrophage activation

Nature Cardiovascular Research - Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify...

rdcu.be

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Reposted by Joseph Gordon

Daniel Drucker @danieljdrucker.bsky.social · 24d

Based on studies in mice the authors propose the core clock system as a potential therapeutic target to improve cardiometabolic health. www.sciencedirect.com/science/arti...

The liver clock modulates circadian rhythms in white adipose tissue

Circadian rhythms are integral to maintaining metabolic health by temporally coordinating physiology across tissues. However, the mechanisms underlyin…

www.sciencedirect.com

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Joseph Gordon @josephwgordon.bsky.social · 24d

www.cell.com/cell-reports...

Beta-cell adaptation unveiled: The role of myokines in insulin-resistant mice

Pancreatic adaptation through increased beta-cell mass occurs when an increased insulin production is required. Liboz, Beaupere, et al. decipher the mechanisms and signals that regulate such adaptatio...

www.cell.com

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Joseph Gordon @josephwgordon.bsky.social · 27d

www.embopress.org/doi/full/10....

Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy | EMBO Molecular Medicine

imageimageMolecular profiling of failing human hearts with and without diabetes revealed that diabetes exacerbates mitochondrial dysfunction and extracellular matrix remodelling, especially in ischaem...

www.embopress.org