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Reposted by Elizabeth Rideout

The Interactive Fly @interactivefly.bsky.social · 1d

Burgmer, S., Meyer Zu Altenschildesche, F., Gyenis, A., Lee, H., Vilchez, D., Giavalisco, P., Fichant, A., Uhlirova, M., Storelli, G. (2025). Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Rep, 44(6):115811 www.cell.com/cell-reports...

Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling

Burgmer et al. show that the pattern recognition receptors (PRRs) PGRP-LC and PGRP-LE repress key metabolic functions in the Drosophila midgut. These regulations occur independently of canonical immun...

www.cell.com

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Elizabeth Rideout @ejrideout.bsky.social · 2d

Another amazing achievement from the fly community 🤩

Greg Jefferis @jefferis.bsky.social · 3d

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

Male CNS Connectome

A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

www.janelia.org

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Reposted by Elizabeth Rideout

Nature Cell Biology @natcellbio.nature.com · 4d

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology

Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

bit.ly

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Reposted by Elizabeth Rideout

Instituto de Neurociencias CSIC-UMH @neuroalc.bsky.social · 9d

🪰 More than 750 scientists from 40+ countries gathered in Alicante for the XXVIII European Drosophila Research Conference #EDRC2025.
For 4 days, the fruit fly took center stage as a model to study health, aging, and disease👏
@edrc2025.bsky.social
@csic.es @dicv.csic.es @umh.es

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Reposted by Elizabeth Rideout

European Drosophila Society @fly-eds.bsky.social · 10d

Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027

EDRC2025 @edrc2025.bsky.social · 10d

That’s a wrap! We are done with #EDRC2025 and we look forward to seeing everyone again in 2027 for #EDRC2027 in Bonn!

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Reposted by Elizabeth Rideout

Lucas Waltzer @lucaswaltzer.bsky.social · 11d

#edrc2025 European #drosophila Society meeting announces the 2029 meeting location : see you all in Szeged (and Bonn in 2027 of course)!

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Elizabeth Rideout @ejrideout.bsky.social · 10d

Beautiful location, fabulous science, and wonderful people 🤩 Thanks to the organizers for all your hard work in bringing us together!

EDRC2025 @edrc2025.bsky.social · 11d

We are on day 3 of #EDRC2025 continuing with excellent #Drosophila science

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Reposted by Elizabeth Rideout

Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 11d

Interesting episode of short wave about the origin of endometriosis. I really appreciate that they end with how uncertainty in NIH funding affects the future of their work.

www.npr.org/2025/09/26/n...

What causes endometriosis? Scientists are closer to finding out : Short Wave

Since the age of nine or ten, Katie Burns has had debilitating pain from endometriosis, a condition where tissue resembling the uterine lining grows outside the uterus. For years, Katie was in the dar...

www.npr.org

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Elizabeth Rideout @ejrideout.bsky.social · 14d

Not going to lie…I have gotten very distracted by this feature before 😂

Reposted by Elizabeth Rideout

Filippo Nicolini 🧬 @filonico.bsky.social · 16d

2nd paper outta my PhD is NOW PUBLISHED😭

🧬🖥️ 🦑Here we show how comparative #genomics 🧬 is a powerful tool to detect putative #SexDetermination genes: Dmrt1L & SoxH from #bivalves 🦪 share evolutionary patterns with Sry from #mammals 🐗 but not with genes from
#drosophila 🪰

doi.org/10.1111/mec....

Graphical summary of the paper, showin several plots from the manuscript, including a phylogenetic tree of bivalves.

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Elizabeth Rideout @ejrideout.bsky.social · 14d

Taking in my favorite part of Vancouver airport on the way to EDRC in Alicante - excited to see folks there for all things Drosophila!

Tropical fish aquarium at Vancouver airport.

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Elizabeth Rideout @ejrideout.bsky.social · 15d

Thank you!!

Elizabeth Rideout @ejrideout.bsky.social · 17d

Thank you!!

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Reposted by Elizabeth Rideout

Junior European Drosophila Investigators @fly-jedi.bsky.social · 19d

Dear JEDIs, the #EDRC meeting is coming soon! Who is joining? Looking forward to meeting everyone next week!

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Reposted by Elizabeth Rideout

Daniel Drucker @danieljdrucker.bsky.social · 18d

Studies of prohormone convertase knockouts in mouse islets reveal plasticity in proglucagon processing to support intra-islet α cell-to-β cell communication, normally dominated by glucagon secretion www.science.org/doi/10.1126/...

α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

α cells can generate and secrete both glucagon and GLP-1 with distinct processing enzymes to control metabolism.

www.science.org

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Elizabeth Rideout @ejrideout.bsky.social · 18d

Feeling fortunate to have contributed data to this effort led by Dr Soumitra Pal, Dr Teresa Przytycka, Dr Brian Oliver, along with Dr George Vogler and Dr Frank Schnorrer. Puja in the lab also produced data on fat body cell counts.

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Elizabeth Rideout @ejrideout.bsky.social · 18d

Very proud of Celena Cherian in the lab, who contributed data to www.biorxiv.org/content/10.1... Briefly, Celena showed female fat body cells have higher ribosomal protein expression and more protein synthesis than males. This difference persists even after cell size is accounted for!

Cell type specific allometry controls sex-differences in Drosophila body size

Species and sex-specific differences in organ size are fundamental features of animal biology, yet the mechanisms that drive these differences remain debated. Adult female Drosophila are larger than m...

www.biorxiv.org

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Elizabeth Rideout @ejrideout.bsky.social · 18d

Supporting and extending these data, Dr Kim Rewitz’s lab has posted a beautiful paper on this topic www.biorxiv.org/content/10.1... We were fortunate to have lots of great discussions about these data!

Gut hormone signaling drives sex differences in metabolism and behavior

Males and females have different physiological and reproductive demands, and consequently exhibit widespread differences in metabolism and behavior. One of the most consistent differences across anima...

www.biorxiv.org

Elizabeth Rideout @ejrideout.bsky.social · 18d

There are lots of interesting questions left from this work, but we were excited to report such a strong sex difference in these cells.

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Elizabeth Rideout @ejrideout.bsky.social · 18d

Puja’s data suggests that Tachykinin and Allatostatin C act on neurons to mediate this effect on fat storage. However, the subset of neurons upon which they act is unclear (but was not the insulin- or Akh-producing cells).

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Elizabeth Rideout @ejrideout.bsky.social · 18d

Because these hormones affect behavior and physiology, Puja tested whether this female biss in hormone production affected fat storage. She found Tachykinin and Allatostatin C contribute to greater fat storage in female flies with no effect in males.

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Elizabeth Rideout @ejrideout.bsky.social · 18d

Briefly, Puja saw a strong female bias in mRNA levels of hormones produced by gut enteroendocrine cells. This sex bias was not caused by sex determination gene transformer.

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Elizabeth Rideout @ejrideout.bsky.social · 18d

The next paper from @pujabiswas.bsky.social PhD has been posted! www.biorxiv.org/content/10.1... Puja found a sex difference in levels of hormones produced by gut enteroendocrine cells.

Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females

Enteroendocrine (EE) cells in the Drosophila gut produce and release multiple factors, including Allatostatin A (AstA), Allatostatin C (AstC), neuropeptide F (NPF), tachykinin (Tk), Diuretic hormone 3...

www.biorxiv.org

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Elizabeth Rideout @ejrideout.bsky.social · 18d

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

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Reposted by Elizabeth Rideout

The Company of Biologists @biologists.bsky.social · 19d

In our Forest of Biologists we fund the restoration and preservation of ancient woodland and dedicate these trees to our peer reviewers.

There are now over 10,000 trees for peer reviews!

Thank you to all our peer reviewers. Find out more:
forest.biologists.com

#PRW2025 @peerreviewweek.bsky.social

Lots of illustrated trees. A sample image taken from the Forest of Biologists website.

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