Lightnews — Scholar-powered news

Reposted by Lluis Morey

The Lewis Lab @peterlewislab.bsky.social · Jul 23

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...

1 19 47

Reposted by Lluis Morey

Sam Stein @samsteindc.bsky.social · May 13

Bernie Sanders' office has put out a report this morning on Trump's NIH cuts: "Trump officials effectively cut $2.7 billion in [NIH] funding in the first three months of 2025 – including a 31 percent cut to cancer research through March, compared to the same timeframe last year."

18 290 740

Lluis Morey @lluismorey.bsky.social · Apr 21

Congratulations Elena!

2

Reposted by Lluis Morey

Anna Gifty @itsafronomics.bsky.social · Apr 19

Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky

wgntv.com/evanston/nor...

Northwestern University to self-fund research despite Trump administration freeze

While university officials said they’ve still not received official word of such action, they acknowledged receiving about 100 stop-work orders from the federal government on roughly 100 fede…

wgntv.com

14 610 2.1K

Reposted by Lluis Morey

Nuria Lopez-Bigas @nlbigas.bsky.social · Mar 5

Seven New Cancer Grand Challenges Announced

www.cancergrandchallenges.org/new-challenges

With awards of up to £20m ($25m). Expressions of Interest are now open.

@cancergrand.bsky.social #CancerGrandChallenges

12 21

Lluis Morey @lluismorey.bsky.social · Feb 21

Very happy to see this outstanding work finally out!

1 3

Reposted by Lluis Morey

Yael David @davidlabmsk.bsky.social · Feb 21

Thank you to all the people who helped with making this work possible, inc. MSKCC Center for Epigenetic Research PJ Hamatd & Richard Koche @lluismorey.bsky.social . You all put a piece in this puzzle.

Thank you to our editor &reviewers for being scientific allies,making our work better 🙏🏻

2 1 4

Reposted by Lluis Morey

Yael David @davidlabmsk.bsky.social · Feb 21

I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social

From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵

www.cell.com/cell/fulltex...

A nucleosome switch primes hepatitis B virus infection

A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...

www.cell.com

7 35 150

Reposted by Lluis Morey

Di Jiang @dijiang319.bsky.social · Feb 16

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

4 25 48

Reposted by Lluis Morey

Marco Trizzino @marcotrizzino.bsky.social · Feb 15

New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Feb 15

CHD3 regulates BMP signalling response during cranial neural crest cell specification https://www.biorxiv.org/content/10.1101/2025.02.14.638260v1

5 17 50

Reposted by Lluis Morey

Alt NIH Bluesky 🧪 @altnih4science.bsky.social · Feb 14

Killing cancer research, Trump and Musk are killing cancer research

7 37 190

Reposted by Lluis Morey

Katie Sandlin @kmsandlin.bsky.social · Feb 14

Today, along with 2,000 other NIH employees, I had to clear out my office 😭

It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.

Office desk without any personal items or decor

350 1.2K 6.7K

Reposted by Lluis Morey

Anna Knörlein @annaknoer.bsky.social · Feb 14

Are you a postdoc or PhD student interested in Histone and DNA modifications? Join us for the GRS on Histone and DNA Modifications!

🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy

A great opportunity to present your work, engage in discussions, and network with peers.

🔗 Register now!
Register here

2025 Histone and DNA Modifications (GRS) Seminar GRC

The 2025 Gordon Research Seminar on Histone and DNA Modifications (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

www.grc.org

3 9

Reposted by Lluis Morey

George Conway 👊🇺🇸🔥 @gtconway.bsky.social · Jan 28

You can read the letter for yourself 👉

620 3K 11K

Reposted by Lluis Morey

BWJones @bwjones.bsky.social · Jan 13

Dear meeting organizers:

Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.

5 42 180

Lluis Morey @lluismorey.bsky.social · Jan 3

Congratulations Mark and team for this very important finding!

1

Lluis Morey @lluismorey.bsky.social · Dec 31

The first album of Tortoise and everything from Blossom Dearie

1 2

Lluis Morey @lluismorey.bsky.social · Dec 29

Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...

Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains

Bivalent promoters are thought to poise developmental genes for expression. Bryan et al. show that asymmetric bivalent nucleosomes recruit repressive H3K27me3 but not activating H3K4me3 readers, thereby promoting poising. Bivalency further attracts specific factors, including the acetylase KAT6B, which is required for proper activation of bivalent genes during differentiation.

www.cell.com

7 26

Reposted by Lluis Morey

Chris Hayes @chrislhayes.bsky.social · Dec 19

The world's richest man managed to take $190 million away from a *child cancer research center* with his posts yesterday. Funding now stripped in the new bill.

2.6K 19K 56K

Reposted by Lluis Morey

Davide Mazza @davidemazza.bsky.social · Dec 20

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused:

sciencedirect.com/science/arti...

A big thank you to Tom Fillot for his efforts on this and to
@hansen_lab

@marcelonollmann
for their help as editors.

4 55 140

Reposted by Lluis Morey

Eleonora Leucci @leuccilrcb.bsky.social · Dec 16

We have two fully funded #Postdoctoral
positions:
-One dark genome explorer to lead a curiosity-driven project on #lncRNA
in #cancer #therapyresistance
-One experienced researcher interested in working on #drugdevelopment in collaboration with industrial partners
The links to apply below:

1 6 8

Reposted by Lluis Morey

Benjamin Weekley, Ph.D. @benjaminweekley.bsky.social · Dec 12

Has anyone had success modeling histone peptides (with PTMs) or nuclesomes (with histone tail PTMs) with chromatin reader proteins using Alphafold or Chai1? If so, any tips? Most iterations I try have the histone tail flopping off to the side #Chromatin #Alphafold #Epigenetics

1 7 11

Reposted by Lluis Morey

Marcos Malumbres @mmalumbres.bsky.social · Dec 14

Despite the intense research, very few mutations are specific of metastatic cells. However, mew research @cellpress.bsky.social shows that most of us carry a variant in PCSK9 that promotes metastasis www.cell.com/cell/abstrac...

8 45

Reposted by Lluis Morey

Surfin' NuRD @surfinnurd.bsky.social · Dec 14

I'm quite concerned that AI will now summarise a paper or make a podcast out of it so students don't have to actually read it.

That means no looking at the data, no evaluating what was really done and how, no deciding what was really proven.

That's the opposite of what research is about.

TanentzapfLab @tanentzapflab.bsky.social · Dec 13

1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field

2 9 33

Lluis Morey @lluismorey.bsky.social · Dec 11

Thanks Rob! Greatly appreciated!