Lightnews — Scholar-powered news

Nikos Margaritelis @margaritelis.bsky.social · 9d

Big picture: better stories should follow better evidence, not the other way around.
Read the piece & join the discussion:
authors.elsevier.com/a/1lt2w5Eb1B...
#TrendsMolMed #redox #evidence

Nikos Margaritelis @margaritelis.bsky.social · 9d

The need for greater precision in redox biology has been recognized. To break free from the ‘indiscriminate antioxidant use age’ in society & from the ‘command of publicly approved science’ in research, repurposing of the oxidative stress narrative is warranted
#oxidative_stress

1 1

Nikos Margaritelis @margaritelis.bsky.social · 9d

Oxidative stress isn’t just “bad”. Reactive species can be essential signaling molecules - context, dose, timing, and location matter.
Yet we still lack clinical thresholds to define conditions like eustress vs distress.
#RedoxSignaling #antioxidants

1 1

Nikos Margaritelis @margaritelis.bsky.social · 9d

Early, catchy narratives spread fast, then resist correction, especially once industry, media, and public expectations lock them in.
This science↔society loop can stall progress.
#Narratives #MolecularMedicine #SciSoc

1

Nikos Margaritelis @margaritelis.bsky.social · 9d

Our new paper with @mg-nikolaidis.bsky.social out in
@cp-trendsmolecmed.bsky.social
“Science captured by storytelling: the oxidative stress narrative”
DOI: authors.elsevier.com/a/1lt2w5Eb1B...

1 1 4

Reposted by Nikos Margaritelis

International Journal of Sport Nutrition and Exercise Metabolism @hk-ijsnem.bsky.social · 19d

🚨LEAD FEATURE ARTICLE🚨 November 2025✨

We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.

2 4 5

Reposted by Nikos Margaritelis

Paraskevi Kritsiligkou @parikki.bsky.social · Sep 4

Metabolic dysfunction-associated steatohepatitis reduces hepatic H2S-producing enzymes altering persulfidome composition

Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive disease driven by obesity-related hepatic inflammation and oxidative stress. …

www.sciencedirect.com

1 2

Reposted by Nikos Margaritelis

Greg Atkinson @gregatki.bsky.social · Aug 28

It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...

journals.humankinetics.com

2 6 12

Reposted by Nikos Margaritelis

James Steele @jamessteeleii.bsky.social · Aug 11

Your intuitions about individual responses to training are probably wrong 😉

👇🧵 1/11

1 2 5

Reposted by Nikos Margaritelis

Greg Atkinson @gregatki.bsky.social · Aug 1

This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...

physoc.onlinelibrary.wiley.com

2 3 5

Reposted by Nikos Margaritelis

anamledo.bsky.social @anamledo.bsky.social · Jun 26

2nd Redox Medicine Workshop ... Meet the Speakers: More info: redoxmedicine2025.febsevents.org
Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track)
@sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social

1 2

Nikos Margaritelis @margaritelis.bsky.social · Jun 9

I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file!
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway

3

Reposted by Nikos Margaritelis

Michalis Nikolaidis @mg-nikolaidis.bsky.social · May 29

Vitamin C+E supplementation blunts molecular adaptations to sprint interval training but not performance gains.

Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

Abstract figure legend Sprint interval training (SIT) is a popular time-efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all-out cycling sprints) over 3...

physoc.onlinelibrary.wiley.com

1 1

Reposted by Nikos Margaritelis

Greg Atkinson @gregatki.bsky.social · May 27

After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...

OSF

osf.io

5 8

Reposted by Nikos Margaritelis

Erik van Zwet @erik-van-zwet.bsky.social · May 8

There's a nice discussion at Frank Harrell's datamethods:

discourse.datamethods.org/t/dichotomiz...

Dichotomization

I’m writing a paper about “An Empirical Assessment of the Cost of Dichotomization” together with Frank Harrell (@f2harrell) and Stephen Senn (@Stephen). In this paper, we quantify the information loss...

discourse.datamethods.org

2 7

Reposted by Nikos Margaritelis

SFRR-E_ ECRs @sfrre-ecr.bsky.social · May 5

Join us for a special ECR SFRR Webinar focused on Mental Health in Research by Amal Ibrahim.

Date: Tuesday 6th May 2025
Time: 15:00 CET
Where: Online (link in bio)

#MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity

1 4

Reposted by Nikos Margaritelis

Greg Atkinson @gregatki.bsky.social · Apr 30

Hats off to them for publishing that paper without mentioning n-of-1 trials or person-by-treatment interactions 😬. We've this paper currently under review. It's frustratingly long-winded, but that's the complex nature of the precision nutrition beast I suppose, osf.io/preprints/os...

OSF

For full functionality of this site it is necessary to enable JavaScript. Here are instructions for enabling JavaScript in your web browser.

osf.io

1 1 2

Reposted by Nikos Margaritelis

Michalis Nikolaidis @mg-nikolaidis.bsky.social · Apr 23

James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal.
onlinelibrary.wiley.com/doi/10.1111/...

The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress

Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...

onlinelibrary.wiley.com

5 10

Reposted by Nikos Margaritelis

Vanesa Cepas López @cepaslopez.bsky.social · Mar 31

📢 Exciting Webinar Alert!

Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social.
See you there!

4 8

Reposted by Nikos Margaritelis

Greg Atkinson @gregatki.bsky.social · Feb 25

Good to see this paper finally published in EJON, after a strange prior experience with another journal, "Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial" link.springer.com/article/10.1...

Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial - European Journal of Nutrition

Purpose Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been inv...

link.springer.com

2 6

Reposted by Nikos Margaritelis

Michalis Nikolaidis @mg-nikolaidis.bsky.social · Feb 12

Study shows that chronic antioxidant supplementation (VitC+VitE) blunted molecular adaptations to training, yet, no impact on any measure of exercise performance—considering that "antioxidant" is a vague term and that VitC+VitE may not always act as such.
www.biorxiv.org/content/10.1...

www.biorxiv.org

1 4

Reposted by Nikos Margaritelis

Vanesa Cepas López @cepaslopez.bsky.social · Jan 31

Great redox researcher to follow and excellent review in the redox biosensors field!

Brandán Pedre @brandanium.bsky.social · Jan 31

First Bluesky post! 👋 I work designing fluorescent indicators for redox biology. Last year, I published a review on genetically-encoded redox biosensors—DM me if you’d like a copy! Happy to connect with fluorescence enthusiasts and redox biologists. #FluorescenceFriday

doi.org/10.1016/j.ab...

1 2

Reposted by Nikos Margaritelis

Michalis Nikolaidis @mg-nikolaidis.bsky.social · Jan 31

Important study highlighting plausible molecular links between redox metabolism and exercise performance—an area notoriously difficult to dissect. The findings challenge assumptions that G6PD deficiency decreases exercise performance. A human replication study would be invaluable.

Angelo D’Alessandro @dalessandrolab.bsky.social · Jan 30

G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social

ashpublications.org/bloodadvance...

Increased exercise tolerance in humanized G6PD-deficient mice

Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu

ashpublications.org

1 2 3

Reposted by Nikos Margaritelis

Angelo D’Alessandro @dalessandrolab.bsky.social · Jan 30

G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social

ashpublications.org/bloodadvance...

Increased exercise tolerance in humanized G6PD-deficient mice

Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu

ashpublications.org

1 3 7

Nikos Margaritelis @margaritelis.bsky.social · Jan 30

Our contribution to the Special Issue "Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance" in FRBM, Guest-edited by Prof. Gomez-Cabrera & @c-handschin.bsky.social
#redox #supplements #sports #evidence

Christoph Handschin @c-handschin.bsky.social · Jan 30

“Evidence-based sports supplements: A redox analysis” by @margaritelis.bsky.social, @parikki.bsky.social, @mg-nikolaidis.bsky.social and colleagues.

www.sciencedirect.com/science/arti...

10/17

Evidence-based sports supplements: A redox analysis

Despite the overwhelming number of sports supplements on the market, only seven are currently recognized as effective. Biological functions are largel…

www.sciencedirect.com

3 4