Nikos Margaritelis
@margaritelis.bsky.social
76 followers 87 following 11 posts
Associate Professor at Aristotle University of Thessaloniki, Greece
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margaritelis.bsky.social
Personalized redox biology: Designs and concepts
#redox #biology #antioxidants #ROS #free_radicals #personalized
pubmed.ncbi.nlm.nih.gov/37541453/
margaritelis.bsky.social
Big picture: better stories should follow better evidence, not the other way around.
Read the piece & join the discussion:
authors.elsevier.com/a/1lt2w5Eb1B...
#TrendsMolMed #redox #evidence
margaritelis.bsky.social
The need for greater precision in redox biology has been recognized. To break free from the ‘indiscriminate antioxidant use age’ in society & from the ‘command of publicly approved science’ in research, repurposing of the oxidative stress narrative is warranted
#oxidative_stress
margaritelis.bsky.social
Oxidative stress isn’t just “bad”. Reactive species can be essential signaling molecules - context, dose, timing, and location matter.
Yet we still lack clinical thresholds to define conditions like eustress vs distress.
#RedoxSignaling #antioxidants
margaritelis.bsky.social
Early, catchy narratives spread fast, then resist correction, especially once industry, media, and public expectations lock them in.
This science↔society loop can stall progress.
#Narratives #MolecularMedicine #SciSoc
margaritelis.bsky.social
Our new paper with @mg-nikolaidis.bsky.social out in
@cp-trendsmolecmed.bsky.social
“Science captured by storytelling: the oxidative stress narrative”
DOI: authors.elsevier.com/a/1lt2w5Eb1B...
Reposted by Nikos Margaritelis
hk-ijsnem.bsky.social
🚨LEAD FEATURE ARTICLE🚨 November 2025✨

We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.
Reposted by Nikos Margaritelis
gregatki.bsky.social
It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...
journals.humankinetics.com
Reposted by Nikos Margaritelis
jamessteeleii.bsky.social
Your intuitions about individual responses to training are probably wrong 😉

👇🧵 1/11
Reposted by Nikos Margaritelis
gregatki.bsky.social
This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
Reposted by Nikos Margaritelis
anamledo.bsky.social
2nd Redox Medicine Workshop ... Meet the Speakers: More info: redoxmedicine2025.febsevents.org
Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track)
@sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social
margaritelis.bsky.social
I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file!
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway
Reposted by Nikos Margaritelis
gregatki.bsky.social
After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...
OSF
osf.io
Reposted by Nikos Margaritelis
sfrre-ecr.bsky.social
Join us for a special ECR SFRR Webinar focused on Mental Health in Research by Amal Ibrahim.

Date: Tuesday 6th May 2025
Time: 15:00 CET
Where: Online (link in bio)

#MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity
Reposted by Nikos Margaritelis
gregatki.bsky.social
Hats off to them for publishing that paper without mentioning n-of-1 trials or person-by-treatment interactions 😬. We've this paper currently under review. It's frustratingly long-winded, but that's the complex nature of the precision nutrition beast I suppose, osf.io/preprints/os...
OSF
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osf.io
Reposted by Nikos Margaritelis
cepaslopez.bsky.social
📢 Exciting Webinar Alert!

Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social.
See you there!
Reposted by Nikos Margaritelis
mg-nikolaidis.bsky.social
Study shows that chronic antioxidant supplementation (VitC+VitE) blunted molecular adaptations to training, yet, no impact on any measure of exercise performance—considering that "antioxidant" is a vague term and that VitC+VitE may not always act as such.
www.biorxiv.org/content/10.1...
www.biorxiv.org
Reposted by Nikos Margaritelis
cepaslopez.bsky.social
Great redox researcher to follow and excellent review in the redox biosensors field!
brandanium.bsky.social
First Bluesky post! 👋 I work designing fluorescent indicators for redox biology. Last year, I published a review on genetically-encoded redox biosensors—DM me if you’d like a copy! Happy to connect with fluorescence enthusiasts and redox biologists. #FluorescenceFriday

doi.org/10.1016/j.ab...
Reposted by Nikos Margaritelis
mg-nikolaidis.bsky.social
Important study highlighting plausible molecular links between redox metabolism and exercise performance—an area notoriously difficult to dissect. The findings challenge assumptions that G6PD deficiency decreases exercise performance. A human replication study would be invaluable.
dalessandrolab.bsky.social
G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social

ashpublications.org/bloodadvance...
Increased exercise tolerance in humanized G6PD-deficient mice
Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu
ashpublications.org
Reposted by Nikos Margaritelis
dalessandrolab.bsky.social
G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social

ashpublications.org/bloodadvance...
Increased exercise tolerance in humanized G6PD-deficient mice
Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu
ashpublications.org
margaritelis.bsky.social
Our contribution to the Special Issue "Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance" in FRBM, Guest-edited by Prof. Gomez-Cabrera & @c-handschin.bsky.social
#redox #supplements #sports #evidence