Lightnews — Scholar-powered news

Reposted by Markus Mukenhirn

Zebrafish Rock! @zebrafishrock.bsky.social · 1d

Published October 25 years ago, “Effective targeted gene ‘knockdown’ in zebrafish” by Nasevicius & Ekker detail use of antisense morpholino-modified oligonucelotides or #morpholinos that inhibit translation. This landmark spurred a revolution in targeted gene knockdown in vivo. #ZebrafishFunFacts 🧪

Structures of DNA and morpholino oligonucleotides. R and R' denote continuation of the oligomer chain in the 5' or 3' direction, respectively. Credit to Corey & Abrams (2001) Genome Biology.

2 8 25

Reposted by Markus Mukenhirn

Annika Brockschmidt @ardenthistorian.bsky.social · 1d

I truly wish all of the German Feuilleton bros who have been fawning over Thiel would read @adriandaub.bsky.social‘s piece in the Guardian and take some time to think long and hard about the fact why they believe Thiel to be a brilliant intellectual genius.

Peter Thiel’s off-the-record antichrist lectures reveal more about him than Armageddon

Silicon Valley titan desperately tries to detach self from power in amateurish talks attempting to ape his favorite philosopher

www.theguardian.com

6 70 220

Reposted by Markus Mukenhirn

Benoit Ladoux @bladoux.bsky.social · 24d

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...

Regulation of epithelial tissue homeostasis by active trans-epithelial transport

Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

www.biorxiv.org

20 35

Reposted by Markus Mukenhirn

ilastik-team.bsky.social @ilastik-team.bsky.social · 3d

Segment large images without tiling artifacts: sharing our work that should have been presented at ICCV in 2 weeks - the brilliant first author Elena can’t go because of visa issues.
The paper: arxiv.org/abs/2503.19545 1/🧵

Large images have to be broken into tiles both for training and inference with neural networks. The tile predictions then need to be merged to produce the final volume prediction.

2 16 51

Reposted by Markus Mukenhirn

Cambridge Morphogenesis Seminar Series @cammorphoseries.bsky.social · 3d

Next Monday, 13th October, at 2:30 pm (UK time), Anne Grapin-Botton will kick off the new term of the Cambridge Morphogenesis Seminar Series! Don't forget to subscribe to our mailing list to get the Zoom link!

2 3 6

Reposted by Markus Mukenhirn

André Nadler @nadlerlab.bsky.social · 3d

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

6 36 140

Reposted by Markus Mukenhirn

Miki Ebisuya @ebisuyamiki.bsky.social · 4d

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...

3 33 78

Reposted by Markus Mukenhirn

Pierre Haas @lepuslapis.bsky.social · 4d

#CellPhysics2025 @uni-saarland.de: looking forward to talking about "Mechanics of Lumina" (*) in the "Cell Collectives" session this morning.

(*) Note the use of the correct plural of "lumen".

2 1 10

Reposted by Markus Mukenhirn

University of Cambridge @cam.ac.uk · 4d

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social

Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

43 71

Reposted by Markus Mukenhirn

Seema Grewal @seemagrewal.bsky.social · 4d

So sad to hear the news - John truly was an inspiration to so many, and one of a kind.

www.cam.ac.uk/research/new...

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

25 98

Reposted by Markus Mukenhirn

Bardin Lab @bardinlab.bsky.social · 5d

The PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social

www.cell.com/developmenta...

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila

Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

www.cell.com

6 16 46

Reposted by Markus Mukenhirn

Journal of Cell Science @jcellsci.bsky.social · 9d

Mario Ledesma-Terrón, Diego Pérez-Dones, David Míguez and colleagues @cbm-csic-uam.bsky.social @ifimacuam.bsky.social present OSCAR, a framework to quantify 3D stacks with high cellular density.
journals.biologists.com/jcs/article-...

1 22 73

Reposted by Markus Mukenhirn

Katrin Göring-Eckardt @goering-eckardt.de · 9d

Der Tag der Deutschen Einheit ist ein Grund zum Feiern. Feiern wir also und vergessen nicht: Es gibt noch einiges zu tun! 35 Jahre nach der Wiedervereinigung bestehen die strukturellen Unterschiede zwischen Ost und West immer noch:

(1/2)

4 6 49

Reposted by Markus Mukenhirn

Barriga Lab @eliasbarrigalab.bsky.social · 9d

New Review! #devbiol #bioelectricity #CellBiology #tissueregeneration

In our new @annualreviews.bsky.social piece, we explore how bioelectricity is generated, sensed & translated into responses that sculpt tissues, guide growth & enable tissue regeneration.

www.annualreviews.org/content/jour...

Bioelectricity in Morphogenesis

Bioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities inf...

www.annualreviews.org

1 15 37

Reposted by Markus Mukenhirn

Freddy Frischknecht @freddyfrischknecht.bsky.social · 9d

Beautiful beasts: excited to see our first volume electron microscopy study on malaria parasites published: advanced.onlinelibrary.wiley.com/doi/10.1002/... revealing new insights into Plasmodium ookinete development. Thanks for great EMBL-Umea-Heidelberg collaboration.

1 4 16

Reposted by Markus Mukenhirn

Ulrich Schwarz @ulrichschwarz.bsky.social · 9d

Congrats Nedal @ndarif.bsky.social, Yannick, Freddy and coworkers to this beautiful project. Another great work from #SFB1129. Special congrats to first author Nedal who very recently defended his PhD at #EMBL.

1 2 4

Reposted by Markus Mukenhirn

Dr. Lutz Böhm @drlutzboehm.bsky.social · 9d

Toluoltropfen in Wasser mit Aceton als Stoffübergangskomponente. Der Tropfen steigt nicht auf, da er mittels Levitation in der kontinuierlichen Wasserphase in einem Schallknotenpunkt festgehalten wird. Konzentrationen von Aceton werden mittels Schlieren visualisiert.

1 2 23

Reposted by Markus Mukenhirn

Kate Cavanaugh @katecavanaugh.bsky.social · 10d

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

11 68 220

Reposted by Markus Mukenhirn

Pierre Haas @lepuslapis.bsky.social · Sep 8

Another #preprint: "Elasticity and plasticity of epithelial gap closure", from the #PhD work of Maryam Setoudeh:

arxiv.org/abs/2509.05110

This one required a lot of (I think) beautiful #mechanics!

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

1 8 35

Reposted by Markus Mukenhirn

Pierre Haas @lepuslapis.bsky.social · 12d

We recently submitted part of her #PhD work, "Elasticity and plasticity of epithelial gap closure" arxiv.org/abs/2509.05110: the summary of some very nice #mechanics is below. Stay tuned for more!

bsky.app/profile/lepuslapis.bsky.social/post/3lycptbyrcs2x

Pierre Haas @lepuslapis.bsky.social · Sep 8

Another #preprint: "Elasticity and plasticity of epithelial gap closure", from the #PhD work of Maryam Setoudeh:

arxiv.org/abs/2509.05110

This one required a lot of (I think) beautiful #mechanics!

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

1 3

Reposted by Markus Mukenhirn

Sara Wickstrom @sarawickstrom.bsky.social · 12d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

10 74 170

Reposted by Markus Mukenhirn

Edouard Hannezo @ehannezo.bsky.social · 15d

Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...

Edouard Hannezo @ehannezo.bsky.social · Dec 17

Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk

3 14 52

Reposted by Markus Mukenhirn

David Brückner @davidbrueckner.bsky.social · 15d

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

1 26 75

Reposted by Markus Mukenhirn

Akankshi Munjal @akankshi.bsky.social · 16d

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

4 27 73

Reposted by Markus Mukenhirn

Lori O'Brien @llobrienlab.bsky.social · 15d

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.

5 32 110