Abstract B051: Discovery of SW-3431, a first-in-class molecular glue activator with potent and selective anti-tumor activity in PPP2R1A mutant cancers url: aacrjournals.org/mct/article/...

By combining a new PP2A molecular glue (PMG) with either G12Ci or MEKi we can induce tumor regressions, significantly extend median survival, and prevent acquired resistance in mouse models. Check it out:

www.jci.org/articles/vie...

New publication from our group! We show that loss of carboxymethylation of protein phosphatase PP2A is a cellular response to MAPK pathway inhibition in NSCLC that leads to treatment resistance. Further- this resistance can be overcome with modulation of PP2A through small molecules...

What a time to have received a 9th percentile on my first MPI R01 as a new investigator...

I'm honored to have been awarded the Shields Family Research Grant for High-Grade Uterine Cancer from the Foundation for Women’s Cancer. This generous support will enable us to develop new models that more closely mimic the human disease, with the ultimate goal of benefiting patients. rb.gy/3qbh1k

“We’re fucked.” Good write-up in Nature on how the current administration has used the Federal Register as a workaround to block NIH spending without seeming to violate the injunction against the spending freeze. If it’s not rectified by September, billions of $$ for science research will be lost.

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

Our new paper describing how mutations to the PP2A gene PPP2R1A drive high-grade uterine cancers is out now in this issue of Cancer Research by @theaacr.bsky.social

aacrjournals.org/cancerres/ar...