Edwin Antony
@professorantony.bsky.social
Professor of Biochemistry at St. Louis University School of Medicine. Passionate about mechanistic & structural enzymology, electron transfer & nucleic acid binding enzymes. Fascinated by Cryo-EM, kinetics, single molecules and student training. Golf Nut!
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
ANTONY LAB SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE
Edwin Antony Lab Website
www.antonylab.org
November 18, 2025 at 7:05 PM
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
Reposted by Edwin Antony
From your friendly neighborhood SRO: thanks to everyone for their patience while we work to make these rescheduled meetings happen.
Correct guidance link: grants.nih.gov/grants/guide...
NOT-OD-26-005: Interim Guidance on Reopening of NIH Extramural Activities
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Interim Guidance on Reopening of NIH Extramural Activities NOT-OD-26-005. NIH
grants.nih.gov
November 14, 2025 at 5:51 PM
From your friendly neighborhood SRO: thanks to everyone for their patience while we work to make these rescheduled meetings happen.
Reposted by Edwin Antony
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Edwin Antony
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 27, 2025 at 1:12 PM
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This is super cool!
Congratulations on a fantastic study.
Looking forward to trying out these tricks in our ncAA incorporation setup.
Congratulations on a fantastic study.
Looking forward to trying out these tricks in our ncAA incorporation setup.
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 3:00 PM
This is super cool!
Congratulations on a fantastic study.
Looking forward to trying out these tricks in our ncAA incorporation setup.
Congratulations on a fantastic study.
Looking forward to trying out these tricks in our ncAA incorporation setup.
Reposted by Edwin Antony
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Reposted by Edwin Antony
Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Locating the missing chlorophylls f in far-red photosystem I
The discovery of chlorophyll f-containing photosystems, with their long-wavelength photochemistry, represented a distinct, low-energy paradigm for oxygenic photosynthesis. Structural studies on chloro...
www.science.org
October 11, 2025 at 10:37 AM
Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Reposted by Edwin Antony
Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
October 9, 2025 at 2:55 PM
Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Spread the word if you can.
We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!
We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!
October 8, 2025 at 3:14 PM
Spread the word if you can.
We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!
We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!
Reposted by Edwin Antony
MECC 2025 was a success at UW-Milwaukee! 153 attendees. 76 poster presenters. Talks by 4 faculty, 1 post-doc, 4 grad students, and 1 keynote.
Check out our poster prize winners on the website: mecc2025.midwestenzyme.org/photographs
See you next year in Chicago at Loyola University for MECC 2026!
Check out our poster prize winners on the website: mecc2025.midwestenzyme.org/photographs
See you next year in Chicago at Loyola University for MECC 2026!
October 6, 2025 at 12:07 AM
MECC 2025 was a success at UW-Milwaukee! 153 attendees. 76 poster presenters. Talks by 4 faculty, 1 post-doc, 4 grad students, and 1 keynote.
Check out our poster prize winners on the website: mecc2025.midwestenzyme.org/photographs
See you next year in Chicago at Loyola University for MECC 2026!
Check out our poster prize winners on the website: mecc2025.midwestenzyme.org/photographs
See you next year in Chicago at Loyola University for MECC 2026!
@midwestenzyme.bsky.social MECC 2025 was a very cool meeting this year. 160 attendees, 80 posters, and great science all around. Thanks to our sponsors @slu-biochemistry.bsky.social @uwmilwaukee.bsky.social Refeyn @ei-science.bsky.social Abbott Inc, Hampton Research, CoAla BioSci, NEB
September 30, 2025 at 1:42 AM
@midwestenzyme.bsky.social MECC 2025 was a very cool meeting this year. 160 attendees, 80 posters, and great science all around. Thanks to our sponsors @slu-biochemistry.bsky.social @uwmilwaukee.bsky.social Refeyn @ei-science.bsky.social Abbott Inc, Hampton Research, CoAla BioSci, NEB
Reposted by Edwin Antony
Folks with Christmas around the corner can I suggest a meaningful present real quick? 🎄
September 23, 2025 at 2:40 PM
Folks with Christmas around the corner can I suggest a meaningful present real quick? 🎄
...and here is the show and tell video for those of you who have a minute to spare
September 11, 2025 at 8:29 PM
...and here is the show and tell video for those of you who have a minute to spare
STRUCTURE OF A NITROGENASE-PII SUPERCOMPLEX
New work from the oxidoreductase half of the group.
www.biorxiv.org/content/10.1...
New work from the oxidoreductase half of the group.
www.biorxiv.org/content/10.1...
September 11, 2025 at 4:53 PM
STRUCTURE OF A NITROGENASE-PII SUPERCOMPLEX
New work from the oxidoreductase half of the group.
www.biorxiv.org/content/10.1...
New work from the oxidoreductase half of the group.
www.biorxiv.org/content/10.1...
We were one of the lucky ones to receive our NCI award. We have an open postdoctoral fellow or research tech position in the group. If you (or anyone you know) has strong expertise in structural biology or cell biology (genomic instability mechanisms) please reach out. www.antonylab.org
September 10, 2025 at 7:39 PM
We were one of the lucky ones to receive our NCI award. We have an open postdoctoral fellow or research tech position in the group. If you (or anyone you know) has strong expertise in structural biology or cell biology (genomic instability mechanisms) please reach out. www.antonylab.org
Reposted by Edwin Antony
Also, check the accompanying article:
Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import
Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in
human cells are imported during translation on cytosolic ribosomes. Cotranslational
import requires an N-terminal pres...
www.cell.com
August 30, 2025 at 11:44 AM
Also, check the accompanying article:
Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...
Reposted by Edwin Antony
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
August 22, 2025 at 11:48 AM
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
Reposted by Edwin Antony
My lab at BU is looking to hire a post-doc with experience in biophysics, protein engineering, and chemical (or synthetic) biology. The anticipated start date is Jan 2026. Please send a resume, cover letter, and names/emails for 3 references. We are looking to interview people during Sept/Oct 2025.
August 20, 2025 at 9:14 PM
My lab at BU is looking to hire a post-doc with experience in biophysics, protein engineering, and chemical (or synthetic) biology. The anticipated start date is Jan 2026. Please send a resume, cover letter, and names/emails for 3 references. We are looking to interview people during Sept/Oct 2025.
Reposted by Edwin Antony
Please help promote the meeting by reposting: @loizoulab.bsky.social @hopfnerlab.bsky.social @lapassmore.bsky.social @raychaudhurilab.bsky.social @hw1o9.bsky.social @westlabcrick.bsky.social @gwuite.bsky.social @dijiang319.bsky.social
August 19, 2025 at 12:07 PM
Please help promote the meeting by reposting: @loizoulab.bsky.social @hopfnerlab.bsky.social @lapassmore.bsky.social @raychaudhurilab.bsky.social @hw1o9.bsky.social @westlabcrick.bsky.social @gwuite.bsky.social @dijiang319.bsky.social
One more week for abstract deadlines for MECC-2025.
Looking forward to seeing many of you in Milwaukee!
mecc2025.midwestenzyme.org
Looking forward to seeing many of you in Milwaukee!
mecc2025.midwestenzyme.org
August 18, 2025 at 12:11 AM
One more week for abstract deadlines for MECC-2025.
Looking forward to seeing many of you in Milwaukee!
mecc2025.midwestenzyme.org
Looking forward to seeing many of you in Milwaukee!
mecc2025.midwestenzyme.org
Reposted by Edwin Antony
Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants - Nature Communications
Many protein–protein interactions depend on Short Linear Motifs (SLiMs). In this study, the authors use large-scale binding assays, deep mutational scanning, and structural analysis to map SLiMs recog...
www.nature.com
August 15, 2025 at 9:26 PM
Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Edwin Antony
Are you an undergrad thinking about grad school? Check out the St. Jude @stjuderesearch.bsky.social Symposium for Predoctoral Research! 🧪
*Reposts appreciated! 🤓
*Reposts appreciated! 🤓
August 12, 2025 at 8:40 PM
Are you an undergrad thinking about grad school? Check out the St. Jude @stjuderesearch.bsky.social Symposium for Predoctoral Research! 🧪
*Reposts appreciated! 🤓
*Reposts appreciated! 🤓
Reposted by Edwin Antony
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 5, 2025 at 10:43 AM
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Edwin Antony
BIOCHEMISTS! We are looking for a new post-doctoral colleague at BU who will be devoted to a combination of teaching Biochemistry and engaging in Research. Ask me anything! The deadline is short, but the job is awesome. #ChemJobs You can apply here: academicjobsonline.org/ajo/BU/CH/PA...
Boston University, BU Chemistry
Job #AJO30270, Postdoctoral Associate Teaching Scholar, BU Chemistry, Boston University, Boston, Massachusetts, US
academicjobsonline.org
August 4, 2025 at 8:14 PM
BIOCHEMISTS! We are looking for a new post-doctoral colleague at BU who will be devoted to a combination of teaching Biochemistry and engaging in Research. Ask me anything! The deadline is short, but the job is awesome. #ChemJobs You can apply here: academicjobsonline.org/ajo/BU/CH/PA...
Reposted by Edwin Antony
Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...
August 1, 2025 at 3:27 PM
Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...