@sfb1454.bsky.social
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News from SFB1454 Metaflammation and Cellular Programming
www.sfb1454-metaflammation.de
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sfb1454.bsky.social
@sfb1454.bsky.social
· Aug 21
🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal
imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted
adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS
induces a a cell fa...
www.embopress.org
Reposted
WachtenLab
@wachtenlab.bsky.social
· Jun 30
Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research
Abstract. Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chem
academic.oup.com
sfb1454.bsky.social
@sfb1454.bsky.social
· Jun 25
(S+) Fitness: Fifty Shades of Fett – und nicht alle sind böse
Ganz wegtrainieren lässt es sich nie. Es kann gefährlich sein, aber auch sehr vorteilhaft: Fett ist fast überall in unserem Körper und kennt drei Farbtöne. Zehn Dinge, die Sie darüber bestimmt noch ni...
www.spiegel.de
sfb1454.bsky.social
@sfb1454.bsky.social
· Jun 19
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
Reposted
sfb1454.bsky.social
@sfb1454.bsky.social
· May 25
Fantastic discussions and interactions at the Bardet-Biedl Syndrome Patient Days 2024 — huge thanks to Helen for organizing such a meaningful event! #cilia #BBS @wachtenlab.bsky.social
sfb1454.bsky.social
@sfb1454.bsky.social
· May 23
Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
Excellence Strategy Funds Bonn Cluster for Immune Research
The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…
www.immunosensation.de
sfb1454.bsky.social
@sfb1454.bsky.social
· May 22
Immunometabolism & beyond - from liver to brain.
A great success! Tx to all the speakers and participants for fantastic talks and good discussions! #immunometabolism #DFG #Universitätsmedizin Mainz
A great success! Tx to all the speakers and participants for fantastic talks and good discussions! #immunometabolism #DFG #Universitätsmedizin Mainz
sfb1454.bsky.social
@sfb1454.bsky.social
· Apr 25
Reposted
Reposted
Reposted
sfb1454.bsky.social
@sfb1454.bsky.social
· Mar 19
1/ 🚨 New preprint alert! 🚨
Micro- and nanoplastics (MNPs) are everywhere, but what happens when they get inside us? Our latest study reveals how chronic plastic exposure affects macrophages and metabolism in a size-dependent manner. 🧵👇 www.researchsquare.com/article/rs-6...
Micro- and nanoplastics (MNPs) are everywhere, but what happens when they get inside us? Our latest study reveals how chronic plastic exposure affects macrophages and metabolism in a size-dependent manner. 🧵👇 www.researchsquare.com/article/rs-6...
Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism
Plastic pollution is an emerging yet understudied environmental risk to the immune system. Once ingested, nano- and microplastic particles (MNPs) can translocate from the gut to internal organs, with ...
www.researchsquare.com
sfb1454.bsky.social
@sfb1454.bsky.social
· Mar 12
We are thrilled to present our new story on #neonatal #liver #macrophages and how they crosstalk with #hepatocytes during this early stage of life
👇
👇
Kupffer cells control neonatal hepatic metabolism via Igf1 signaling https://www.biorxiv.org/content/10.1101/2025.02.19.638983v1
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
Reposted
sfb1454.bsky.social
@sfb1454.bsky.social
· Jan 22
We would like to welcome you to our second International Conference on Brown and Beige Fat
March 31st - April 02nd 2025
Top-class speakers, cutting edge research and respected experts will come together in beautiful Bonn.
Registration is open!
www.trr333.uni-bonn.de/batenergy-sy...
Reposted
Reposted
