WachtenLab
@wachtenlab.bsky.social
Science and ideas from the lab of Dagmar Wachten
Reposted by WachtenLab
The next #DGZ Focus Workshop on #Cilia & #Centrosomes will take place November 25 (end of October is our DGZ meeting in HD). Join us for a great speaker line-up, and big thanks to David Mick @mick-lab.bsky.social & Dagmar Wachten @wachtenlab.bsky.social for organizing!
October 11, 2025 at 12:54 PM
The next #DGZ Focus Workshop on #Cilia & #Centrosomes will take place November 25 (end of October is our DGZ meeting in HD). Join us for a great speaker line-up, and big thanks to David Mick @mick-lab.bsky.social & Dagmar Wachten @wachtenlab.bsky.social for organizing!
Reposted by WachtenLab
Primary #cilia dysfunction as in Bardet-Biedl syndrome compromises normal adipogenic differentiation in favor of fibrogenic transition, predisposing to obesity
@wachtenlab.bsky.social and collaborators
www.embopress.org/doi/full/10....
@wachtenlab.bsky.social and collaborators
www.embopress.org/doi/full/10....
September 1, 2025 at 10:43 AM
Primary #cilia dysfunction as in Bardet-Biedl syndrome compromises normal adipogenic differentiation in favor of fibrogenic transition, predisposing to obesity
@wachtenlab.bsky.social and collaborators
www.embopress.org/doi/full/10....
@wachtenlab.bsky.social and collaborators
www.embopress.org/doi/full/10....
🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal
imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted
adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS
induces a a cell fa...
www.embopress.org
August 21, 2025 at 3:57 AM
🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Reposted by WachtenLab
🚨 Catching up with great news!
Our NAR paper with the @wachtenlab.bsky.social and supported by Prof. Möglich presents a powerful light-switch for gene expression in mammalian cells, with big potential for bioproduction and research.
#Optogenetics #SyntheticBiology #Bioproduction #GeneExpression
Our NAR paper with the @wachtenlab.bsky.social and supported by Prof. Möglich presents a powerful light-switch for gene expression in mammalian cells, with big potential for bioproduction and research.
#Optogenetics #SyntheticBiology #Bioproduction #GeneExpression
Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research
Abstract. Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chem
academic.oup.com
July 21, 2025 at 12:39 PM
🚨 Catching up with great news!
Our NAR paper with the @wachtenlab.bsky.social and supported by Prof. Möglich presents a powerful light-switch for gene expression in mammalian cells, with big potential for bioproduction and research.
#Optogenetics #SyntheticBiology #Bioproduction #GeneExpression
Our NAR paper with the @wachtenlab.bsky.social and supported by Prof. Möglich presents a powerful light-switch for gene expression in mammalian cells, with big potential for bioproduction and research.
#Optogenetics #SyntheticBiology #Bioproduction #GeneExpression
💡 Paper alert! We developed DEL-VPR, a potent blue-light photoswitch inducing gene expression in mammalian cells.
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research
Abstract. Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chem
academic.oup.com
June 30, 2025 at 4:54 PM
💡 Paper alert! We developed DEL-VPR, a potent blue-light photoswitch inducing gene expression in mammalian cells.
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
Reposted by WachtenLab
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
June 18, 2025 at 4:41 PM
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Looking forward to an inspiring 2-day #iii institute retreat packed with great science, collaborations, and fresh ideas. Grateful to @unibonn.bsky.social for hosting us in #IMPULSE! 🙌🔬
May 27, 2025 at 9:25 AM
Looking forward to an inspiring 2-day #iii institute retreat packed with great science, collaborations, and fresh ideas. Grateful to @unibonn.bsky.social for hosting us in #IMPULSE! 🙌🔬
Huge congratulations! 🎉
We are excellent! What a day - between hugs, applause and a lot of pride. Our rector? Jumping for joy. Our team? Overjoyed. Thank you to everyone who made this historic moment possible! @dependencybonn.de @immunosens.bsky.social @econtribute.bsky.social
© V. Lannert/G. Hübl/Uni Bonn
© V. Lannert/G. Hübl/Uni Bonn
May 23, 2025 at 8:49 AM
Huge congratulations! 🎉
Thrilled to be part of this amazing journey! 🙌 Hurray indeed! @dfg.de has just approved funding for ImmunoSensation3 🎉 Focused on Immune Diversity, we're set for 7 more years of cutting-edge #immunology in #Bonn! Let’s go! 💥 #ImmunoSensation #science
Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
Excellence Strategy Funds Bonn Cluster for Immune Research
The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…
www.immunosensation.de
May 23, 2025 at 8:46 AM
Thrilled to be part of this amazing journey! 🙌 Hurray indeed! @dfg.de has just approved funding for ImmunoSensation3 🎉 Focused on Immune Diversity, we're set for 7 more years of cutting-edge #immunology in #Bonn! Let’s go! 💥 #ImmunoSensation #science
Proud PI - congratulations to Seniz for being awarded the "Rising Star" award of the @for5547.bsky.social #cilia
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
May 14, 2025 at 9:12 PM
Proud PI - congratulations to Seniz for being awarded the "Rising Star" award of the @for5547.bsky.social #cilia
Reposted by WachtenLab
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
May 14, 2025 at 9:09 PM
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
🎉 Huge congratulations to Susan Dutcher @dutcherlab.bsky.social on her election to the National Academy of Sciences! A well-deserved recognition of her outstanding contributions to cell biology and cilia research. 👏🔬 #WomenInSTEM #Cilia
Major congratulations to our fearless leader and team captain Susan Dutcher @dutcherlab.bsky.social for being elected to the National Academy of Sciences! 🙌
Another big win for #cilia biology!!
Another big win for #cilia biology!!
May 4, 2025 at 1:16 PM
🎉 Huge congratulations to Susan Dutcher @dutcherlab.bsky.social on her election to the National Academy of Sciences! A well-deserved recognition of her outstanding contributions to cell biology and cilia research. 👏🔬 #WomenInSTEM #Cilia
Reposted by WachtenLab
Excited for an inspiring meeting in France 🇫🇷 on #cilia and #centrosomes! The German #cilia community is en route—let’s connect and share science!
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
April 15, 2025 at 5:47 AM
Excited for an inspiring meeting in France 🇫🇷 on #cilia and #centrosomes! The German #cilia community is en route—let’s connect and share science!
Reposted by WachtenLab
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
April 14, 2025 at 8:42 AM
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
Congratulations to Ronja from the @wachtenlab.bsky.social , who won the 1st poster prize at the international @batenergy.bsky.social meeting! 🎉🥳
April 2, 2025 at 12:58 PM
Congratulations to Ronja from the @wachtenlab.bsky.social , who won the 1st poster prize at the international @batenergy.bsky.social meeting! 🎉🥳
Reposted by WachtenLab
Cilia has been at the center of our discussions at the spring school of our @for5547.bsky.social cilia consortium.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
March 7, 2025 at 2:29 PM
Cilia has been at the center of our discussions at the spring school of our @for5547.bsky.social cilia consortium.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
Reposted by WachtenLab
Interested in primary #cilia, #microtubules, #protein trafficking, molecular #signaling, #GPCRs, and #ciliopathies?
We are looking for a #postdoc and a #PhDstudent to apply advanced #biochemistry and #proteomics methods to study cilia.
Check out our website and send your application until March 10.
We are looking for a #postdoc and a #PhDstudent to apply advanced #biochemistry and #proteomics methods to study cilia.
Check out our website and send your application until March 10.
February 22, 2025 at 8:59 PM
Interested in primary #cilia, #microtubules, #protein trafficking, molecular #signaling, #GPCRs, and #ciliopathies?
We are looking for a #postdoc and a #PhDstudent to apply advanced #biochemistry and #proteomics methods to study cilia.
Check out our website and send your application until March 10.
We are looking for a #postdoc and a #PhDstudent to apply advanced #biochemistry and #proteomics methods to study cilia.
Check out our website and send your application until March 10.
Thanks a lot to #FEBS and the Norwegian bioscience society for hosting me and special thanks to @nathaliejuya.bsky.social and @emreyaksi.bsky.social for your hospitality!
Decoding cilia signaling and function by the one and only @wachtenlab.bsky.social Thanks for delivering a fantastic #FEBS national lecture at the Norwegian bioscience society winter meeting.
January 25, 2025 at 3:27 PM
Thanks a lot to #FEBS and the Norwegian bioscience society for hosting me and special thanks to @nathaliejuya.bsky.social and @emreyaksi.bsky.social for your hospitality!
Looking forward to #Cilia 2027 - watch out for more information!
🚧 Work in progress for cilia 2027!
🙏 thanks to this amazing group of scientists, clinicians and patient advocates for joining the Cilia 2027 organizing committee!
🌸 Spring 2027 in Milan, more to follow
🙏 thanks to this amazing group of scientists, clinicians and patient advocates for joining the Cilia 2027 organizing committee!
🌸 Spring 2027 in Milan, more to follow
January 23, 2025 at 4:34 PM
Looking forward to #Cilia 2027 - watch out for more information!
Reposted by WachtenLab
We would like to welcome you to our second International Conference on Brown and Beige Fat
March 31st - April 02nd 2025
Top-class speakers, cutting edge research and respected experts will come together in beautiful Bonn.
Registration is open!
www.trr333.uni-bonn.de/batenergy-sy...
January 22, 2025 at 3:10 PM
We would like to welcome you to our second International Conference on Brown and Beige Fat
March 31st - April 02nd 2025
Top-class speakers, cutting edge research and respected experts will come together in beautiful Bonn.
Registration is open!
www.trr333.uni-bonn.de/batenergy-sy...
Reposted by WachtenLab
🗣️We are #hiring! Check out our the latest job opportunities!
▫️ Personnel Administration Expert
📌 Due date: 17/01/2025
▫️ Flow Cytometry Technician
📌 Due date: 19/01/2025
▫️ Postdoctoral Fellow in Innate Immune Biology (Dr. Stefanie Wculek)
📌 Due date: 28/02/2025
➡️ bit.ly/3MR4wO8
🧪
▫️ Personnel Administration Expert
📌 Due date: 17/01/2025
▫️ Flow Cytometry Technician
📌 Due date: 19/01/2025
▫️ Postdoctoral Fellow in Innate Immune Biology (Dr. Stefanie Wculek)
📌 Due date: 28/02/2025
➡️ bit.ly/3MR4wO8
🧪
January 14, 2025 at 10:11 AM
🗣️We are #hiring! Check out our the latest job opportunities!
▫️ Personnel Administration Expert
📌 Due date: 17/01/2025
▫️ Flow Cytometry Technician
📌 Due date: 19/01/2025
▫️ Postdoctoral Fellow in Innate Immune Biology (Dr. Stefanie Wculek)
📌 Due date: 28/02/2025
➡️ bit.ly/3MR4wO8
🧪
▫️ Personnel Administration Expert
📌 Due date: 17/01/2025
▫️ Flow Cytometry Technician
📌 Due date: 19/01/2025
▫️ Postdoctoral Fellow in Innate Immune Biology (Dr. Stefanie Wculek)
📌 Due date: 28/02/2025
➡️ bit.ly/3MR4wO8
🧪
Reposted by WachtenLab
Fantastic team work by our @for5547.bsky.social PIs, headed by David Mick! Check this out: www.biorxiv.org/content/10.1...
iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...
www.biorxiv.org
January 13, 2025 at 7:19 AM
Fantastic team work by our @for5547.bsky.social PIs, headed by David Mick! Check this out: www.biorxiv.org/content/10.1...
Reposted by WachtenLab
Calendars out- just over two weeks until our 🎉50th🥳 @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 14/01/2025 15:00-17:30- everything hot in #cilia #centrosomes free & open to all! Register to access this 🔥 series: www.eventbrite.co.uk/e/bscb-genso... /1
December 30, 2024 at 5:25 PM
Calendars out- just over two weeks until our 🎉50th🥳 @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 14/01/2025 15:00-17:30- everything hot in #cilia #centrosomes free & open to all! Register to access this 🔥 series: www.eventbrite.co.uk/e/bscb-genso... /1
Congratulations to Elvira and the whole team!!
We are super happy that our #FOR5775 #MagNet got funded! 🥳 Thanks to @dfgpublic.bsky.social look out for interesting #macrophage science in the coming 4 years!
www.dfg.de/de/service/p...
www.dfg.de/de/service/p...
DFG fördert acht neue Forschungsgruppen
www.dfg.de
December 12, 2024 at 10:12 AM
Congratulations to Elvira and the whole team!!