FOR5547 Primary cilia dynamics
@for5547.bsky.social
Research Unit on "Primary cilia dynamics" funded by the DFG
Great teamwork by the @wachtenlab.bsky.social @masslab.bsky.social and the May-Simera lab in our #FOR5547! Congratulations to the whole team!
🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal
imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted
adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS
induces a a cell fa...
www.embopress.org
August 21, 2025 at 10:08 AM
Great teamwork by the @wachtenlab.bsky.social @masslab.bsky.social and the May-Simera lab in our #FOR5547! Congratulations to the whole team!
Reposted by FOR5547 Primary cilia dynamics
💡 Paper alert! We developed DEL-VPR, a potent blue-light photoswitch inducing gene expression in mammalian cells.
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research
Abstract. Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chem
academic.oup.com
June 30, 2025 at 4:54 PM
💡 Paper alert! We developed DEL-VPR, a potent blue-light photoswitch inducing gene expression in mammalian cells.
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
Congratulations to our PIs @masslab.bsky.social and @wachtenlab.bsky.social - great story in @nature.com Children born to obese mothers are at higher risk of metabolic disease—even with a healthy diet.
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
June 19, 2025 at 5:18 AM
Congratulations to our PIs @masslab.bsky.social and @wachtenlab.bsky.social - great story in @nature.com Children born to obese mothers are at higher risk of metabolic disease—even with a healthy diet.
🎓 The UK Cilia Network Summer Meeting is almost here!
Our FOR students will be there — and giving talks! 🗣️
Watch out for exciting science, fresh perspectives, and future leaders in cilia research.
#Cilia2025 #UKCiliaNetwork #cilia
Our FOR students will be there — and giving talks! 🗣️
Watch out for exciting science, fresh perspectives, and future leaders in cilia research.
#Cilia2025 #UKCiliaNetwork #cilia
📢📢📢 Klaxon call for all cilia enthusiasts 📢 📢📢! Registrations still open + free. There are still spots for a few posters. Come along its London calling. Also this year we will have a special cilia imaging session organised by Kirsty Wan @micromotility.bsky.social
www.ucl.ac.uk/child-health...
www.ucl.ac.uk/child-health...
June 3, 2025 at 6:55 AM
🎓 The UK Cilia Network Summer Meeting is almost here!
Our FOR students will be there — and giving talks! 🗣️
Watch out for exciting science, fresh perspectives, and future leaders in cilia research.
#Cilia2025 #UKCiliaNetwork #cilia
Our FOR students will be there — and giving talks! 🗣️
Watch out for exciting science, fresh perspectives, and future leaders in cilia research.
#Cilia2025 #UKCiliaNetwork #cilia
Reposted by FOR5547 Primary cilia dynamics
We are hiring #postdocs and #phd students in the areas of #devbio #cellbio #Bioinformatics #mathematics #modeling.
This is the full add with details:
euraxess.de/jobs/346670
This our lab homepage:
www.uniklinik-freiburg.de/walentek-en....
This is the full add with details:
euraxess.de/jobs/346670
This our lab homepage:
www.uniklinik-freiburg.de/walentek-en....
Multiple Postdoc and PhD positions in developmental biology, genetics, bioinformatics and mathematical modeling - Walentek Lab - Freiburg, Germany
University Freiburg Medical Center is a leading institution in biomedical research in the heart of Europe with close associations to other institutions and centers in the tri-national Eucor area (Germ...
euraxess.de
May 27, 2025 at 6:38 AM
We are hiring #postdocs and #phd students in the areas of #devbio #cellbio #Bioinformatics #mathematics #modeling.
This is the full add with details:
euraxess.de/jobs/346670
This our lab homepage:
www.uniklinik-freiburg.de/walentek-en....
This is the full add with details:
euraxess.de/jobs/346670
This our lab homepage:
www.uniklinik-freiburg.de/walentek-en....
Fantastic discussions and interactions at the Bardet-Biedl Syndrome Patient Days 2024 — huge thanks to Helen for organizing such a meaningful event! #cilia #BBS @wachtenlab.bsky.social
May 25, 2025 at 2:08 PM
Fantastic discussions and interactions at the Bardet-Biedl Syndrome Patient Days 2024 — huge thanks to Helen for organizing such a meaningful event! #cilia #BBS @wachtenlab.bsky.social
Congratulations to the whole team and our PIs involved 🎉 @masslab.bsky.social @wachtenlab.bsky.social
Awesome news about #ImmunoSensation3 getting @dfg.de funding!
Awesome news about #ImmunoSensation3 getting @dfg.de funding!
Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
Excellence Strategy Funds Bonn Cluster for Immune Research
The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…
www.immunosensation.de
May 23, 2025 at 8:48 AM
Congratulations to the whole team and our PIs involved 🎉 @masslab.bsky.social @wachtenlab.bsky.social
Awesome news about #ImmunoSensation3 getting @dfg.de funding!
Awesome news about #ImmunoSensation3 getting @dfg.de funding!
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
May 14, 2025 at 9:09 PM
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
Reposted by FOR5547 Primary cilia dynamics
🎉 Huge congratulations to Susan Dutcher @dutcherlab.bsky.social on her election to the National Academy of Sciences! A well-deserved recognition of her outstanding contributions to cell biology and cilia research. 👏🔬 #WomenInSTEM #Cilia
Major congratulations to our fearless leader and team captain Susan Dutcher @dutcherlab.bsky.social for being elected to the National Academy of Sciences! 🙌
Another big win for #cilia biology!!
Another big win for #cilia biology!!
May 4, 2025 at 1:16 PM
🎉 Huge congratulations to Susan Dutcher @dutcherlab.bsky.social on her election to the National Academy of Sciences! A well-deserved recognition of her outstanding contributions to cell biology and cilia research. 👏🔬 #WomenInSTEM #Cilia
Excited for an inspiring meeting in France 🇫🇷 on #cilia and #centrosomes! The German #cilia community is en route—let’s connect and share science!
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
April 15, 2025 at 5:47 AM
Excited for an inspiring meeting in France 🇫🇷 on #cilia and #centrosomes! The German #cilia community is en route—let’s connect and share science!
Reposted by FOR5547 Primary cilia dynamics
Reposted by FOR5547 Primary cilia dynamics
Cilia has been at the center of our discussions at the spring school of our @for5547.bsky.social cilia consortium.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
March 7, 2025 at 2:29 PM
Cilia has been at the center of our discussions at the spring school of our @for5547.bsky.social cilia consortium.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
In total there were 26 trainees from across Europe, few PIs and our brilliant coordinator Christina Klausen.
Happy faces and a lot of sunshine at the start of our Spring School on #cilia dynamics! @jayccblab.bsky.social @nathaliejuya.bsky.social @mick-lab.bsky.social @wachtenlab.bsky.social Looking forward to three days of interactions with early career researchers from our cilia network partners!
March 5, 2025 at 3:10 PM
Happy faces and a lot of sunshine at the start of our Spring School on #cilia dynamics! @jayccblab.bsky.social @nathaliejuya.bsky.social @mick-lab.bsky.social @wachtenlab.bsky.social Looking forward to three days of interactions with early career researchers from our cilia network partners!
FOR5547 members @ GRC Cilia & Mucus meeting - great talk by @walenteklab.bsky.social about Foxi1 #cilia
February 19, 2025 at 6:03 PM
FOR5547 members @ GRC Cilia & Mucus meeting - great talk by @walenteklab.bsky.social about Foxi1 #cilia
Reposted by FOR5547 Primary cilia dynamics
We invite you to submit your latest research to our special issue - Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
journals.biologists.com/jcs/pages/ci...
journals.biologists.com/jcs/pages/ci...
February 6, 2025 at 10:02 AM
We invite you to submit your latest research to our special issue - Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
journals.biologists.com/jcs/pages/ci...
journals.biologists.com/jcs/pages/ci...
Reposted by FOR5547 Primary cilia dynamics
New paper! journals.plos.org/plosbiology/...
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.
February 6, 2025 at 7:40 PM
New paper! journals.plos.org/plosbiology/...
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.
Great to see our #FOR5547 members present the research performed on #cilia in our research unit and congratulations to @wachtenlab.bsky.social 🎉
Decoding cilia signaling and function by the one and only @wachtenlab.bsky.social Thanks for delivering a fantastic #FEBS national lecture at the Norwegian bioscience society winter meeting.
January 27, 2025 at 1:21 PM
Great to see our #FOR5547 members present the research performed on #cilia in our research unit and congratulations to @wachtenlab.bsky.social 🎉
Congratulations to our #FOR5547 PI @mick-lab.bsky.social for winning the Teaching Award (Preclinical) 2024 of Saarland University! 🎉🥳
January 23, 2025 at 5:16 PM
Congratulations to our #FOR5547 PI @mick-lab.bsky.social for winning the Teaching Award (Preclinical) 2024 of Saarland University! 🎉🥳
Reposted by FOR5547 Primary cilia dynamics
🚧 Work in progress for cilia 2027!
🙏 thanks to this amazing group of scientists, clinicians and patient advocates for joining the Cilia 2027 organizing committee!
🌸 Spring 2027 in Milan, more to follow
🙏 thanks to this amazing group of scientists, clinicians and patient advocates for joining the Cilia 2027 organizing committee!
🌸 Spring 2027 in Milan, more to follow
January 23, 2025 at 10:56 AM
🚧 Work in progress for cilia 2027!
🙏 thanks to this amazing group of scientists, clinicians and patient advocates for joining the Cilia 2027 organizing committee!
🌸 Spring 2027 in Milan, more to follow
🙏 thanks to this amazing group of scientists, clinicians and patient advocates for joining the Cilia 2027 organizing committee!
🌸 Spring 2027 in Milan, more to follow
Reposted by FOR5547 Primary cilia dynamics
We would like to welcome you to our second International Conference on Brown and Beige Fat
March 31st - April 02nd 2025
Top-class speakers, cutting edge research and respected experts will come together in beautiful Bonn.
Registration is open!
www.trr333.uni-bonn.de/batenergy-sy...
January 22, 2025 at 3:10 PM
We would like to welcome you to our second International Conference on Brown and Beige Fat
March 31st - April 02nd 2025
Top-class speakers, cutting edge research and respected experts will come together in beautiful Bonn.
Registration is open!
www.trr333.uni-bonn.de/batenergy-sy...
Must read from our Mercator fellow #cilia - congratulations to the whole team!
Have you ever wondered what role motile #cilia and cerebrospinal fluid (#CSF) play in brain development and physiology? If yes, please check out our latest article now published in Cell Reports and spearheaded by the newly minted Dr D'Gama www.sciencedirect.com/science/arti...
Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain
The brain uses a specialized system to transport cerebrospinal fluid (CSF), consisting of interconnected ventricles lined by motile ciliated ependymal…
www.sciencedirect.com
January 17, 2025 at 3:35 PM
Must read from our Mercator fellow #cilia - congratulations to the whole team!
Fantastic team work by our @for5547.bsky.social PIs, headed by David Mick! Check this out: www.biorxiv.org/content/10.1...
iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...
www.biorxiv.org
January 13, 2025 at 7:19 AM
Fantastic team work by our @for5547.bsky.social PIs, headed by David Mick! Check this out: www.biorxiv.org/content/10.1...
Reposted by FOR5547 Primary cilia dynamics
Calendars out- just over two weeks until our 🎉50th🥳 @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 14/01/2025 15:00-17:30- everything hot in #cilia #centrosomes free & open to all! Register to access this 🔥 series: www.eventbrite.co.uk/e/bscb-genso... /1
December 30, 2024 at 5:25 PM
Calendars out- just over two weeks until our 🎉50th🥳 @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 14/01/2025 15:00-17:30- everything hot in #cilia #centrosomes free & open to all! Register to access this 🔥 series: www.eventbrite.co.uk/e/bscb-genso... /1
Reposted by FOR5547 Primary cilia dynamics
Anyone could help with an ID?
I've been seeing this vortex of cilia inside different dinoflagellate species at different sites along the European coast. It's several layers of cilia facing into a central cavity, emerging from regularly spaces basal bodies (arrows and centrin ). #ProtistsOnSky
I've been seeing this vortex of cilia inside different dinoflagellate species at different sites along the European coast. It's several layers of cilia facing into a central cavity, emerging from regularly spaces basal bodies (arrows and centrin ). #ProtistsOnSky
January 11, 2025 at 2:27 PM
Anyone could help with an ID?
I've been seeing this vortex of cilia inside different dinoflagellate species at different sites along the European coast. It's several layers of cilia facing into a central cavity, emerging from regularly spaces basal bodies (arrows and centrin ). #ProtistsOnSky
I've been seeing this vortex of cilia inside different dinoflagellate species at different sites along the European coast. It's several layers of cilia facing into a central cavity, emerging from regularly spaces basal bodies (arrows and centrin ). #ProtistsOnSky
New paper out from our @for5547.bsky.social PIs Jay Gopalakrishnan and @nathaliejuya.bsky.social on human #brain #organoids modeling #microcephaly
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening
Nature Communications - Human brain organoids are plagued by heterogeneity and poor reproducibility, critical parameters for reliable disease modeling and drug testing. Here, the authors report on...
www.nature.com
December 20, 2024 at 11:27 AM
New paper out from our @for5547.bsky.social PIs Jay Gopalakrishnan and @nathaliejuya.bsky.social on human #brain #organoids modeling #microcephaly
www.nature.com/articles/s41...
www.nature.com/articles/s41...