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Shoa Clarke

@shoaclarke.bsky.social

750 followers 310 following 270 posts

Assistant Professor, Stanford University // Preventive cardiologist for adults & children // https://clarkelab.stanford.edu 🧬🫀💻

clarkelab.stanford.edu

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Shoa Clarke @shoaclarke.bsky.social · Nov 21

By request, here is a longer explanation of how the CardioSky feed works. I created the feed so I could have one place to see cardiology related activity on Bluesky beyond just the #CardioSky hashtag. Below are the details, some considerations, and some caveats.

bsky.app/profile/did:...

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Shoa Clarke @shoaclarke.bsky.social · 4d

Congrats, Satoshi! Your work is incredible! I feel fortunate to get to collaborate with you. Looking forward to seeing your lab grow!

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Reposted by Shoa Clarke

Satoshi Koyama @skoyama.bsky.social · 10d

Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.

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Shoa Clarke @shoaclarke.bsky.social · 6d

ENDORSE! Please can we make MOC make sense?

Harlan M. Krumholz @hmkyale.bsky.social · 6d

Physician certification should not be an ordeal; it is in vast need of improvement.
My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective.
🔗 www.jacc.org/doi/10.1016/...

Rethinking Physician Certification: A Call for a Modern, Meaningful Standard

www.jacc.org

Shoa Clarke @shoaclarke.bsky.social · 12d

🤣 Incredible

Reposted by Shoa Clarke

Vivek Bhalla, MD, FASN, FAHA @bhallaresearch.bsky.social · 17d

We are thrilled to announce that we have generously received funding for a one-year hypertension fellowship, and we are recruiting now for a candidate to start fellowship July 1, 2026 .
med.stanford.edu/hypertension/e…

-Jehan Zahid Bahrainwala
HTN Fellowship Program Director

https://med.stanford.edu/hypertension/e…

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Reposted by Shoa Clarke

Harlan M. Krumholz @hmkyale.bsky.social · 19d

Quality measurement was once a breakthrough.
But today it’s too slow, too costly, and too disconnected from daily care.

It’s time to reinvent it.

🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10....

@jaccjournals.bsky.social @yalemed.bsky.social

Computable Quality

You have to enable JavaScript in your browser's settings in order to use the eReader.

www.jacc.org

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Reposted by Shoa Clarke

Vijay G. Sankaran @bloodgenes.bsky.social · Sep 11

Congratulations to this amazing group who received the @laskerfdn.bsky.social awards!!!

www.nytimes.com/2025/09/11/h...

Major Medical Prizes Given to Cell Biology and Cystic Fibrosis Pioneers

www.nytimes.com

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Reposted by Shoa Clarke

Chad Weldy, MD, PhD @chadweldy.bsky.social · Sep 10

I am tremendously excited to share our work revealing the epigenomic landscape of single vascular cells. We discover that enhancers are not only cell type but vascular site specific and regulate the genetic drivers of disease risk. Let's dive in! 🧬👇 #epigenetics
www.embopress.org/doi/full/10....

Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci | Molecular Systems Biology

imageimageVascular sites have distinct susceptibility to disease. Here, through single cell epigenomic profiling and predictive machine learning modeling, this study revealed that regulatory enhancers are vascular site specific, providing insight ...

www.embopress.org

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Shoa Clarke @shoaclarke.bsky.social · Sep 10

Promoting fads and infusing more money into the >$6 trillion wellness industry is not how to make America healthy.

www.nytimes.com/2025/09/10/o...

Opinion | It’s Not You. It’s the Food.

www.nytimes.com

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Reposted by Shoa Clarke

James Priest @jamesrpriestmd.bsky.social · Sep 9

I’m hiring in statistical genetics—senior scientist role but it’s the skills that matter—so earlier career folks with the right experience & interest should apply!

There may also be multiple positions — so please RT & share w/ your network

cytokinetics.wd1.myworkdayjobs.com/en-US/Cytoki...

Senior Scientist I

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibi...

cytokinetics.wd1.myworkdayjobs.com

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Reposted by Shoa Clarke

Michael L. Barnett @mlbarnett.bsky.social · Sep 8

New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com!

Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??

jamanetwork.com/journals/jam...

Question Has hospital length of stay increased more for Medicare
Advantage beneficiaries than for traditional Medicare beneficiaries
since the COVID-19 pandemic?Findings In this cohort study involving more than 89 million
hospitalizations from 2017 to the third quarter of 2023, Medicare
Advantage beneficiaries experienced disproportionately greater
increases in extended hospital stays, especially among those
discharged to skilled nursing facilities.Meaning These findings suggest that the Medicare Advantage
plan design and practices may contribute to hospital discharge
delays, with implications for patient outcomes and hospital
capacity as enrollment continues to rise.

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Shoa Clarke @shoaclarke.bsky.social · Aug 30

This is a key concept that so many people in AI don't seem to understand. Hallucinations are not a bug. They are the feature. Hallucination is the fundamental way generative AI works. For AI there is no "reality" and "hallucination." Which is which is fully defined by how the user feels.

Shoa Clarke @shoaclarke.bsky.social · Aug 23

Jay will be remembered for crying, "Censorship!" when the science community rejected his unfounded claims, gaining power by bowing to Trump, and then leading the most insane scientific censorship campaign in US history.

www.wsj.com/health/scien...

The Words Scientists Are Changing to Scrub Diversity from Research Grants

Researchers are amending descriptions of their work to keep federal funding and avoid getting flagged in the Trump administration’s push against DEI.

www.wsj.com

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Reposted by Shoa Clarke

Kat Tenbarge @kattenbarge.bsky.social · Aug 18

The people dominating our political landscape, culture, and economy are just so stupid and full of shit it's almost impossible to describe

A transcription of a conversation between OpenAI CEO Sam Altman and podcast host Theo Von on Von's podcast, in an excerpt from the Atlantic article "AI is a mass-delusion event" by Charlie Warzel:

"Sam Altman: I do guess that a lot of the world gets covered in data centers over time.

Theo Von: Do you really?

Altman: But I don’t know, because maybe we put them in space. Like, maybe we build a big Dyson sphere around the solar system and say, “Hey, it actually makes no sense to put these on Earth.”

Von: Yeah.

Altman: I wish I had, like, more concrete answers for you, but, like, we’re stumbling through this."

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Shoa Clarke @shoaclarke.bsky.social · Aug 14

Some debates will never die

www.nejm.org/doi/full/10....

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline | NEJM

Whether lactated Ringer’s solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain. In an open-label, two-period, two-sequence, cross-sectional...

www.nejm.org

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Shoa Clarke @shoaclarke.bsky.social · Aug 12

“If it makes sense for adults, why wouldn’t it make sense for kids?” said Bonkowski....

This is literally the antithesis of pediatrics 🤦🏻‍♂️

[Also, it does not make sense for adults]

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Shoa Clarke @shoaclarke.bsky.social · Aug 12

Good lord, no. Why, people, why??

www.wsj.com/health/welln...

Meet the Parents Raising ‘Carnivore Babies,’ Swapping Puréed Fruit for Rib-Eye

Infants and toddlers are getting in on animal-heavy diets, gnawing on leg of lamb and pork rinds. Pediatricians and nutrition scientists are concerned—and perplexed.

www.wsj.com

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Shoa Clarke @shoaclarke.bsky.social · Aug 8

We all know exactly how this happened.

www.theverge.com/news/756444/...

OpenAI gets caught vibe graphing

An OpenAI staffer apologized for the “unintentional chart crime.”

www.theverge.com

Reposted by Shoa Clarke

Sarah J. Jackson @sjjphd.bsky.social · Aug 7

I’m not gonna QT the article baiting engagement but more posting doesn’t make a place great. Maybe people grew up & stopped wasting their time on debate bros, social media norms moved from conversation to broadcast, many explanations for fewer posts besides “people don’t actually like the platform”

Sarah J. Jackson @sjjphd.bsky.social · Aug 7

The idea that more posts = better engagement 🧐. I am old enough to remember days on Twitter when I spent all day wasting energy debating misogynists, I prob posted a hundred posts in those arguments some days. Their followers probably send me 100 violent replies. Was all that posting better? Lol no.

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Shoa Clarke @shoaclarke.bsky.social · Jul 17

100% the absolute wrong interpretation of these observations. I thought economists were supposed to understand confounding and causal inference 🤦🏻‍♂️. People do not randomly move between institutions.

Science Magazine @science.org · Jul 17

The mantra “location, location, location” isn’t just about real estate. For life scientists, more than 50% of their productivity can be attributed to the institution where they work, according to a new study. scim.ag/4kKs1YO

Large study of scientists who move their labs reveals how location drives productivity

Concentrating funding at high-powered universities can maximize output, paper argues, but may sacrifice broader benefits

scim.ag

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Shoa Clarke @shoaclarke.bsky.social · Jul 3

Science. We had a good run...

Figure showing dramatic gains in survival among children with acute lymphoblastic leukemia. Source: https://www.nejm.org/doi/full/10.1056/NEJMra1400972

Figure showing steady declines in overall cancer death rates in the United States, which are most notable when also accounting for increasing lifespan. Source: https://ourworldindata.org/data-insights/americans-are-now-one-third-less-likely-to-die-from-cancer-at-the-same-ages-as-americans-in-1990

Figure showing rapid decline in deaths due to heart disease and stroke in the United States. Source: https://data.cdc.gov/d/6rkc-nb2q

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Shoa Clarke @shoaclarke.bsky.social · Jun 21

IYKYK

derek guy @dieworkwear.bsky.social · Jun 21

Unexpected crossover. One of my favorite IG style accounts featured Dr. Keith Churchwell, a man whose style I've admired for 20 years. Dr. Churchwell's tailor is Leonard Logsdail, who made clothes for The Wolf of Wall Street and American Gangster.

IG ladiesofmadisonave

Reposted by Shoa Clarke

Randall Munroe @xkcd.com · Jun 19

David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...

The Missing 11th of the Month - David R Hagen

Personal website of David R Hagen, scientific software engineer

drhagen.com

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Shoa Clarke @shoaclarke.bsky.social · Jun 17

Really really saddened to hear of Dr. Atul Butte's passing. Atul was a passionate scientist and mentor. When I was an undergrad, he took me for coffee, and his infectious enthusiasm completely changed my trajectory. I have always and will always look up to him.

Reposted by Shoa Clarke

Eimear Kenny @eimearekenny.bsky.social · Jun 17

📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv!

Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses.
🔗 www.medrxiv.org/content/10.1...

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SPC: a SPectral Component approach to address recent population structure in genomic analysis

Population structure is a well-known confounder in statistical genetics, particularly in genome-wide association studies (GWAS), where it can lead to inflated test statistics and spurious associations...

www.medrxiv.org

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