Jase Gehring
@skyjase.bsky.social
490 followers 1.1K following 870 posts
scientist at UC Berkeley inventing advanced genomic technologies lover of molecules, user of computers https://scholar.google.com/citations?user=63ZRebIAAAAJ&hl=en
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skyjase.bsky.social
they seem skittish, but the EU just became the top global research destination due to political instability in the US. it'll stay that way for at least five years.

if the EU isn't structured in a way that can take advantage, that'd be a pretty big indictment of the EU!
skyjase.bsky.social
he actually has a good grasp on big data and ML in biology, but then he's like that's lame i'm talking about LLMs being physically and mentally better and cheaper than humans at doing science

his comments, from one year ago, are especially ironic in light of "ASL-3" restrictions on LLMs for bio use
skyjase.bsky.social
you know i'm down bad when i'm scrolling the ResearchGate forums. just completely out of my element. flailing.
skyjase.bsky.social
Using LLMs for science is like scrolling posts on some niche labrat internet forum.

and not a good one like SeqAnswers. i'm talking some dicey ResearchGate advice. some r/DIYbio. like you almost wish you hadn't read it.
skyjase.bsky.social
"I’m talking about using AI to perform, direct, and improve upon nearly everything biologists do."

"my basic prediction is that AI-enabled biology and medicine will allow us to compress the progress that human biologists would have achieved over the next 50-100 years into 5-10 years."

Dario Amodei
skyjase.bsky.social
keep the conversation away from biology and ask it in relation to something like polymer chemistry (useless for weapons, surely 🙃)

tbh it's frustrating all around.
skyjase.bsky.social
my goodness what a fear-mongering, over-the-top hype headline. really leaning into telling lies to sell newspapers
mclem.org
“In September, scientists at Stanford reported they had used A.I. to design a virus for the first time.”
Opinion | The A.I. Prompt That Could End the World
www.nytimes.com
skyjase.bsky.social
Sure but once factor in subsidies and Iowa‘s position in the presidential primary, corn is the clear winner
skyjase.bsky.social
web developers using a stochastic generative algorithm:

omg it's alive u guys. it has rights
skyjase.bsky.social
beating a dead horse, but it is just the height of hubris and ignorance to think that the only thing standing in the way of chemical and bioterrorism is access to a chatbot
skyjase.bsky.social
yup. and even worse intuition for software! not only is software the foundation of modern weapons, propaganda, terrorist and state attacks, etc... LLMs are way, way more powerful for software applications than science!

their threat model is completely backwards
skyjase.bsky.social
OpenAI launched a deepfake propaganda video generator the very same day they deactivated my account for asking basic questions about laboratory research.

LLM companies aren't serious about safety OR advancing scientific research.
skyjase.bsky.social
LLMs have been bricked for biomedical research. OpenAI deactivated my account ('weapons'). Claude won't engage

question: in the last decade, how many hospitals have been held for ransom with chemical, biological, or radiological weapons? and how many have been held for ransom by cyberattacks?
skyjase.bsky.social
it's weird that the web browser has taken over desktop but phones have been colonized by apps. are apps better for thumb-based GUIs? or gathering more user telemetry? or maybe the desktop is just a portal for search and cloud access?
skyjase.bsky.social
oh with some cute text formatting!! they coulda gone for the full plasmid-design-in-a-Word-doc annotations but i guess this is a bit more tasteful, restrained
skyjase.bsky.social
between global researchers choosing the EU over the US, Europeans doing the same, and Americans making the jump.. the EU is going to be flooded with researchers. it's a historical opportunity and Europe would do well to take full advantage
lastpositivist.bsky.social
This is probably a desired goal for the Trump regime? They have inconsistent preferences mind you so there's another sense in which this is undesired. But "drive out the intelligentsia and weaken academia" is, under this aspect, a favoured policy goal of theirs.

www.politico.eu/article/euro...
Top US researchers rush to relocate to Europe
U.S.-based applicants to a prestigious EU research scheme have increased five-fold.
www.politico.eu
skyjase.bsky.social
Haven’t seen that so far! I’m doing some side by sides on generated designs versus colabfold and esmfold, but not done yet. Would be curious how the same sequences fold using other models
Reposted by Jase Gehring
cryoempapers.bsky.social
Cryo-electron tomography reconstructs polymer in liquid film for fab-compatible lithography pubmed.ncbi.nlm.nih.gov/41027883/ #cryoem
skyjase.bsky.social
Congrats Ben! Great work
skyjase.bsky.social
the Gemini button on Chrome browser. you tell it to go away it becomes a slightly smaller button

worst demand vs capital investment of any technology in history
crushbort.bsky.social
oh hell yeah pop ups on my work computer telling me to try copilot or click “later” that then disappear before i can click the settings. definitely don’t kill the guy who put that in
skyjase.bsky.social
mesmerizing wagon-wheel effect using hi-speed camera and droplet generator. droplets enter the channel from the top, flowing counterclockwise around the bend, a mixing feature. droplet generation rate is ~1kHz, droplet size ~80 microns
skyjase.bsky.social
That server was so great. i inferred thousands of structures