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Reposted by Stephen V Mahler

Jibran Khokhar @drjkhokhar.bsky.social · 20h

Excited to share recent collaborative work led by Hayley Thorpe published in Molecular Psychiatry: Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals www.nature.com/articles/s41...

Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals - Molecular Psychiatry

Molecular Psychiatry - Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals

www.nature.com

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Stephen V Mahler @svmahler.bsky.social · 23h

To good to be true?
Not this time!
Any questions—just ask!!

UCI Center for the Study of Cannabis @ucicannabis.bsky.social · 1d

🧠 THC researchers: Get free adolescent THC brain & organ tissue from UCI ICAL Tissue Bank! No DEA license needed, shipping covered. Limited supply—first-come, first-served! 🌱🔬
📩 DM for info
IG: @uci_cannabis | X: @ucicannabis

REQUEST HERE: cannabis.uci.edu/ical/tissueb...

#CannabisResearch #THC

ICAL Tissue Bank - UCI Center for the Study of Cannabis

ICAL Tissue Bank ICAL maintains a biobank of brain and peripheral organs collected from mice and rats treated in adolescence with D9-tetrahydrocannabinol (THC) or vehicle. Both male and female…

cannabis.uci.edu

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Reposted by Stephen V Mahler

Alicia Izquierdo @aliciaizquierdo.bsky.social · 5d

🎇 Excited to finally share JL Romero Sosa’s publication! Results are from single-cell imaging in different subregions of rat frontal cortex during ✨de novo learning. Spoiler: everything is not everywhere all at once www.nature.com/articles/s41...

Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex - Nature Communications

Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.

www.nature.com

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Reposted by Stephen V Mahler

Mallar Chakravarty @mallarchak.bsky.social · 11d

Check out this great summary of our recent paper on the impact of exposure to #THC during gestation.

Thanks @douglasresearch.bsky.social !!

Orig paper here:

www.nature.com/articles/s41...

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Stephen V Mahler @svmahler.bsky.social · 11d

Welcome!

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Reposted by Stephen V Mahler

Josh Johansen @jojolab.bsky.social · 12d

Excited to announce that I'll be moving to the Univ of California Irvine @ucirvine.bsky.social next Spring!🌴

Happily, this is not goodbye to Japan as I'll continue my lab @RIKEN_CBS for some time.

Help spread the word: the new UCI lab will be hiring, DM or email ([email protected]) if interested!

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Reposted by Stephen V Mahler

Alicia Izquierdo @aliciaizquierdo.bsky.social · 15d

Too bad no mention of the Crespi Effect, dependent on basolateral amygdala. Classic 🏆 ibotenic lesion and lidocaine inactivation papers by Salinas, Packard, and McGaugh, 1993; Salinas, Parent, and McGaugh, 1996 could have been cited.
www.nature.com/articles/s41...

Stimulus-specific and adaptive value representations in the basolateral amygdala in male mice - Nature Communications

How basolateral amygdala represents the specific value of rewards remains unclear. Here the authors find that basolateral amygdala neurons assign stimulus-specific values to different rewards and rapidly re-scale these signals with changing reward context, thirst or stress, illuminating how the brain guides flexible, state-dependent choices.

www.nature.com

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Reposted by Stephen V Mahler

Drug Monkey @drugmonkey.bsky.social · 17d

The NSF GRFP is now limited to undergrads and first-year grads drugmonkey.wordpress.com/2025/09/26/t...

The NSF GRFP is now limited to undergrads and first-year grads

The solicitation for the 2025 submission dates for the NSF Graduate Research Fellowship Program is out, with the first deadline of November 10 for life-sciences disciplines. The big news is that el…

drugmonkey.wordpress.com

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Reposted by Stephen V Mahler

Tallie Z Baram @talliezee.bsky.social · 18d

Published! to NAIL human paraventricular thalamus, we imaged & aligned postmortem human thalamus labeled c calretinin. Finally a gold standard allowing mouse, rat human comparisons onlinelibrary.wiley.com/doi/10.1002/... @ted-satterthwaite.bsky.social @flagel-lab.bsky.social @mikeyassa.bsky.social l

A Combined Neuroanatomy, Ex Vivo Imaging, and Immunohistochemistry Defined MRI Mask for the Human Paraventricular Nucleus of the Thalamus

Existing definitions of the human paraventricular nucleus of the thalamus (PVT) differ between histological and MRI atlases; this study addresses this conflict by leveraging MRI and histology in the ...

onlinelibrary.wiley.com

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Reposted by Stephen V Mahler

Keri Martinowich @martinowk.bsky.social · 19d

In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.

www.bbc.com/news/article...

www.bbc.com/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

www.bbc.com

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Reposted by Stephen V Mahler

Olivia Hon @ohon.bsky.social · 20d

Some good science news for a change- MBF Bioscience is hiring! Looking for a microscopy aficionado to join our scientific support team in Williston, VT or San Diego, CA. Please share and feel free to reach out with questions. Link here: www.linkedin.com/jobs/view/43...

MBF Bioscience hiring Senior Scientific Support Specialist in Williston, VT | LinkedIn

Posted 1:11:55 PM. MBF Bioscience is seeking a Senior Scientific Support Specialist with an advanced degree and proven…See this and similar jobs on LinkedIn.

www.linkedin.com

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Reposted by Stephen V Mahler

Tallie Z Baram @talliezee.bsky.social · 20d

Just dropped! 🧠🧪how to pinpoint brain cells activated by early-life #stress then determine their #epigenomic and #transcriptional changes that govern adult behaviors. Led by @amaliaflorious.bsky.social @svmahler.bsky.social @cate-cholamine.bsky.social @thebalelab.bsky.social doi.org/10.3389/fnin...

schematic of genetic tagging of cells that respond preferentially to early-life stress, and then capturing ribosomally tethered transcripts in these same cells

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Reposted by Stephen V Mahler

Neuropsychopharmacology @npp-journal.bsky.social · Sep 9

A fresh new @npp-journal.bsky.social from @superkash.bsky.social & team is out now 🤩 👇

davidweinshenker.bsky.social @davidweinshenker.bsky.social · Sep 7

Nice paper from @superkash.bsky.social and team in @npp-journal.bsky.social comparing the contribution of CRF and GABA release from the same BNST neurons to ethanol self-administration. Tom you know I am obsessed with co-transmitter release this is really elegant work! www.nature.com/articles/s41...

Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice - Neuropsychopharmacology

Neuropsychopharmacology - Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice

www.nature.com

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Reposted by Stephen V Mahler

Neuropsychopharmacology @npp-journal.bsky.social · Sep 8

This recent study found that cannabidiol (CBD) ⬇️ alcohol dependence & withdrawal in 🐀 by normalizing BLA excitability & protecting striatal neurons.

A promising step toward innovative #AUD treatments?

Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum

Neuropsychopharmacology - Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum

www.nature.com

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Reposted by Stephen V Mahler

Tallie Z Baram @talliezee.bsky.social · Sep 8

In a packed retreat of anatomy/neurobiology an neurobiology/ behavior departnents, marcelo wood providing current state of uci neuroscience in 2025 USA 🧪🧠 @svmahler.bsky.social @ucirvinemedschool.bsky.social @ucirvine.bsky.social

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Reposted by Stephen V Mahler

Nick Bednar @nicholasbednar.bsky.social · Sep 6

One of the greatest errors in K-12 education, in my opinion, is prioritizing trigonometry and calculus over statistics. Yes, trig and calc are important for many professions. Statistics are important for literacy.

Andrew Heiss @andrew.heiss.phd · Sep 6

oh noooo

compared to last year’s results.” However, I take issue with the author’s subsequent interpretation of the most recent test scores which reflects poorly on his/her understanding of basic statistics. The differences in proficiency rates cited in throughout the article are overwhelmingly NOT STATISTICALLY SIGNIFICANT.

Using a standard p-value of 0.05, any improvement in scores must show at least a gain of five percentage points in order to be considered as statistically significant. So, for example, even the slight decline in 4th grade ISAT scores in Idaho (2024 67.1%, 2025 64.6) is not significant. Similarly, the following assertion made by the author of the article is incorrect and misleading.

“Students scoring in the advanced range of the proficient category saw a slight increase, with 23.2% scoring advanced in 2024 compared to 23.6% in 2025.” In order to have been statistically significant, 28.2% of students must have scored proficient in the language arts subtest.

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Reposted by Stephen V Mahler

Guillaume Thibault @gthibault.bsky.social · Aug 27

📣 Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up package. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack

Register HERE: lnkd.in/gSy5qpA7

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Reposted by Stephen V Mahler

Bossett @bossett.social · Aug 22

ooh they did a science to find the scientists

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky

Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

academic.oup.com

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Reposted by Stephen V Mahler

Jibran Khokhar @drjkhokhar.bsky.social · Aug 18

For those following alone on #CannabinoidGRC2025, here is the starter pack to stay on top of the latest and greatest in cannabis science go.bsky.app/JmeZk14

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Reposted by Stephen V Mahler

The New Yorker @newyorker.com · Aug 9

How Stanley Kubrick’s film “Dr. Strangelove” exposed dangers inherent in nuclear command-and-control systems.

Almost Everything in “Dr. Strangelove” Was True

How Stanley Kubrick’s film “Dr. Strangelove” exposed dangers inherent in nuclear command-and-control systems.

www.newyorker.com

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Reposted by Stephen V Mahler

Shelly Flagel @flagel-lab.bsky.social · Jul 25

Excited to have this little @npp-journal.bsky.social "hot topics" article out with my dear friend and collaborator @jbeehner.bsky.social. Even more excited for the opportunity to jump into field research and explore some of these ideas. www.nature.com/articles/s41...

Field experimentation enhances translation for behavioral neuroscience - Neuropsychopharmacology

Neuropsychopharmacology - Field experimentation enhances translation for behavioral neuroscience

www.nature.com

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Reposted by Stephen V Mahler

Alicia Izquierdo @aliciaizquierdo.bsky.social · Jul 21

5-HT-mediated depolarization of OFC PV neurons occurs via activation of 2A, not 2C, receptors. And 2A antagonism works similarly in males and females www.nature.com/articles/s41...

Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity - Scientific Reports

Scientific Reports - Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity

www.nature.com

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Reposted by Stephen V Mahler

Nate Heller @nate-h-heller.bsky.social · Jul 17

🌈🧠 The Trip Between Bedside and Bench 🌈🧠
Join us at #SfN2025 for a deep dive into cross-species research in psychedelic neuroscience!

🧬 Posters, 🎤 panels, 🔑 keynotes, 🍸 cocktails, and 🥟 tasty apps await.

RSVP, explore speaker profiles, and help spread the word:
👉 hopkinspsychedelic.org/sfn2025

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Reposted by Stephen V Mahler

Matt Wanat @mattjwanat.bsky.social · Jul 16

Ever wonder how stress and the estrous cycle affects reward learning? Well we have answers for you in our paper led by @askaneuroscientist.bsky.social published in
@npp-journal.bsky.social

And huge thanks to the NIH and NSF who supported this research.

Estrous cycle stage gates the effect of stress on reward learning

Neuropsychopharmacology - Estrous cycle stage gates the effect of stress on reward learning

nam11.safelinks.protection.outlook.com

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Reposted by Stephen V Mahler

Dr. Nikki Crowley @nicoleacrowley.bsky.social · Jul 9

Check out this NPP Hot Topic by @seemiller.bsky.social "A biological blind spot in addiction research: hormonal contraceptives and adolescent reward seeking".

Read it here: tinyurl.com/3hrbswkr

A biological blind spot in addiction research: hormonal contraceptives and adolescent reward seeking

Neuropsychopharmacology - A biological blind spot in addiction research: hormonal contraceptives and adolescent reward seeking

www.nature.com

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