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Jason Trubiano

@trubianojason.bsky.social

1.8K followers 510 following 35 posts

Prof/Director of Infectious Diseases & Immunology @austin_health. UoM Research Fellow @ID_austin @CAAR_Aus @TheDohertyInst @UniMelbMDHS #AMS #AMR #penicillinallergy #drugallergy #TID

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Jason Trubiano @trubianojason.bsky.social · Nov 12

My Top 5 Antibiotic Allergy Papers.... #IDSky #MedSky #Penicillinallergy #Antibioticallergy.

Jason Trubiano @trubianojason.bsky.social · Nov 12

My Top 5 Antibiotic Allergy Papers - #5
▶️Gadde et al. JAMA 1993; 270 (20)
▶️ A paper before its time. Skin testing for #penicillinallergy in patients with ID indication!
▶️ 7.1% + ; PPL & MDM utilisation; safety (1/128+ required adrenaline); Allergy LOSS WITH TIME.
jamanetwork.com/journals/jam...

Clinical Experience With Penicillin Skin Testing in a Large Inner-City STD Clinic

Objective. —To establish (1) the prevalence of positive penicillin skin tests among outpatients with well-defined but variable history of penicillin allergy and (2) the reproducibility, safety, a...

jamanetwork.com

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Jason Trubiano @trubianojason.bsky.social · Aug 29

Congratulations Elise Mitri from NACE, Austin Health & The Peter Doherty Institute presenting the iNAAN Trial results - > 5000 pts & 1500 inpatient #penicillinallergy DOC performed. Safe irrespective of stakeholder with significant prescribing gains. Largest inpatient penicillin allergy study 👏🎉

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Jason Trubiano @trubianojason.bsky.social · Aug 28

Is one dose enough?! Great talk from Dr Rose for the #PROSPECTOR #penicillinallergy #RCT at #EAACI HK Summer School. 6.7% increase in immune mediated reactions with prolonged oral challenge. Looking forward to #PROSPECTOR2 definitive phase III study to change practice!

Jason Trubiano @trubianojason.bsky.social · Aug 27

Excited to be at EAACI Hong Kong School 2025 Hosted by Prof Li. Can’t wait for Elise Mitri from The Peter Doherty Institute to present the #iNAAN Results - #PenicillinAllergy #delabing Global Implementation! Dr Rose will present #PROSPECTOR1 - is one dose enough to delabel penicillin allergy?!? ‼️👀

Jason Trubiano @trubianojason.bsky.social · Jul 31

Thank you @eurekaprizes.bsky.social for the opportunity and my research team Austin Health & Doherty Institute for driving the research in #antibioticallergy #EurekaPrizes

Australian Museum Eureka Prizes @eurekaprizes.bsky.social · Jul 31

Professor @trubianojason.bsky.social is a finalist in the Eureka Prize for Emerging Leader in Science.

Learn more: youtu.be/qaPw-YsXix4

#EurekaPrizes

Jason Trubiano @trubianojason.bsky.social · May 26

Can’t say no to that!

Jason Trubiano @trubianojason.bsky.social · May 26

Another validation of SULF-FAST form Canadian data about to drop! 🎤

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Jason Trubiano @trubianojason.bsky.social · Apr 13

#ESCMIDGlobal #FOMO…. Watching online the amazing @elisemitri.bsky.social and thanks to @cmicomms.bsky.social for publishing this work! Not missing another #ESCMIDGlobal!!

Angela Huttner @angelahuttner.bsky.social · Apr 13

Congrats to @elisemitri.bsky.social, @trubianojason.bsky.social et al for their great work on safely delabeling patients with #penicillinallergy. Elise presenting their prospective, pharmacist-led program live at #ESCMIDGlobal
#IDSky #PharmSky #openacess

www.cmi-comms.com/article/S295...

Elise Mitri presenting work on safely delabeling patients with penicillin allergy at the ESCMID Global conference.

Jason Trubiano @trubianojason.bsky.social · Apr 4

Hopefully can get a # going for the conference - #ASID2025 ? Get some of the proffered papers and new research out from #EMCR #IDResearch #Infectiousdiseases

Jason Trubiano @trubianojason.bsky.social · Apr 3

Follow our 🇦🇺🇳🇿 ID Society #ASID asidaud.bsky.social 🏆 Great to see you on #bsky 👏

asidaud.bsky.social

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Jason Trubiano @trubianojason.bsky.social · Apr 3

Follow our 🇦🇺🇳🇿 ID Society #ASID asidaud.bsky.social 🏆 Great to see you on #bsky 👏

asidaud.bsky.social

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Reposted by Jason Trubiano

asidaud.bsky.social @asidaud.bsky.social · Apr 2

ASID Annual Scientific Meeting kicked off yesterday in Canberra. The pre-conference workshop hosted by Therapeutic Guidelines Australia attracted over 120 attendees and was a very engaging and informative session. The formal program commences tomorrow in what will be one of the largest ASM’s.

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Jason Trubiano @trubianojason.bsky.social · Mar 27

Well done team 👏 Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing: The PREPARE Randomized Clinical Trial jamanetwork.com/journals/jam...

Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing

This pilot randomized clinical trial assesses the feasibility and safety of using a smartphone application for antibiotic allergy assessment and delabeling in anesthesiologist-led clinics among patien...

jamanetwork.com

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Jason Trubiano @trubianojason.bsky.social · Mar 26

We randomised our first patients yesterday into the #PROSPECTOR2 ⛏️ study - international superioty trail of 1 dose versus day challenge for #penicillinallergy. “Is one dose ever enough….”

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Jason Trubiano @trubianojason.bsky.social · Feb 28

Best thing about #AAAAI25 is the start of the #JPCoffeeTour! #SanDiego #DrugAllergyChat

Jason Trubiano @trubianojason.bsky.social · Jan 29

www.sciencedirect.com/science/arti... - nice review and global prevalence number!

The Global Prevalence of Reported Penicillin Allergy: A Systematic Review and Meta-Analysis

Patients labelled with penicillin allergy (PenA) often receive broader spectrum antibiotics, associated with antimicrobial resistance and poorer outco…

www.sciencedirect.com

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Reposted by Jason Trubiano

Tori Hall @victoriahall.bsky.social · Jan 16

Very proud of this hard work & team effort from all involved! Limited benefit of adjuvanted flu 💉 & 2 vs 1 dose in pts w/ MM, CLL or NHL. @ncicancer.bsky.social @petermaccc.bsky.social @benwteh.bsky.social @trubianojason.bsky.social @michyong.bsky.social @nejm.org www.nejm.org/doi/full/10....

Influenza Vaccination Strategies in Patients with Hematologic Cancer | NEJM

In this trial involving patients with hematologic cancers, the immune responses that were elicited were similar for adjuvanted-dose and standard-dose influenza vaccines.

www.nejm.org

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Reposted by Jason Trubiano

CMI Communications @cmicomms.bsky.social · Jan 7

📣 @elisemitri.bsky.social et al prospectively assessed 477 inpatients with #penicillin allergy. 166 were low-risk & underwent oral challenge: 158 (95%) delabeled. 111 (type A allergy) delabeled without challenge.
➡️ No SAE
#IDSky #MedSky
@trubianojason.bsky.social
www.cmi-comms.com/article/S295...

The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round: A prospective cohort study.

Inpatient penicillin allergy is associated with inappropriate antibiotic prescribing and adverse patient outcomes. We reviewed the long-term effectiveness, safety and antimicrobial stewardship impacts of a pharmacist-led penicillin allergy delabelling ward round.

www.cmi-comms.com

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Reposted by Jason Trubiano

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · Dec 20

🆕💫Prospective cohort study
The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round with 🌟 @trubianojason.bsky.social @cmicomms.bsky.social #idsky
www.sciencedirect.com/science/arti...

The long-term sustainability of a pharmacist-led antimicrobial stewardship penicillin allergy delabelling ward round: A prospective cohort study.

Inpatient penicillin allergy is associated with inappropriate antibiotic prescribing and adverse patient outcomes. We reviewed the long-term effective…

www.sciencedirect.com

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Jason Trubiano @trubianojason.bsky.social · Nov 24

Loved this ❤️ Talk of the #drugallergy town!

Jason Trubiano @trubianojason.bsky.social · Nov 23

1000 direct oral #penicillinallergy challenges in the prospective iNAAN study 🎉- 39 hospitals and 7 countries 😳. The largest adult penicillin challenge study! Well done @elisemitri.bsky.social 👏👏 and all collaborators! @escmid.bsky.social data coming hopefully to #ESCMIDglobal 2025!

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Reposted by Jason Trubiano

Gabriele Pollara @gpollara.bsky.social · Nov 21

🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨

We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.

Lead author @gushamilton.bsky.social

#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)

Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study

Our findings propose a causal relationship between reduced IL-6 signalling and lower risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This study suggests that IL-6 antago...

www.thelancet.com

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Reposted by Jason Trubiano

Steven Tong @steventong.bsky.social · Nov 22

The incredibly impressive Ouli Xie is presenting his PhD completion seminar on Monday Nov 25 at 12.30pm AEDT.

"The clinical, epidemiological, and evolutionary intersection between Streptococcus dysgalactiae subspecies equisimilis and Streptococcus pyogenes"

unimelb.zoom.us/j/8944229688...?

Join our Cloud HD Video Meeting

Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...

unimelb.zoom.us

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Reposted by Jason Trubiano

Sean Ong @seanong.bsky.social · Nov 21

Feels right that my 1st post here should be to share this incredible RCT, led by my PhD supervisor Nick Daneman:

www.nejm.org/doi/full/10....

Main takeaway: 7-days of abx should be the standard of care for patients with uncomplicated non-S. aureus BSI.

A deep dive 🧵:

#IDsky

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM

Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

www.nejm.org

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Reposted by Jason Trubiano

Josh Davis @gurujosh.bsky.social · Nov 21

Hi #IDSky! I’m putting together my usual top 10 ID papers of this year list again (this time will post here not in the other world).

Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!

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Jason Trubiano @trubianojason.bsky.social · Nov 22

Thought worth a share on #WAAW @ncas.bsky.social day today. A practical guide to #penicillinallergy into inpatient #AMS programs. A partner to implementation! #IDSky #MedSky
pubmed.ncbi.nlm.nih.gov/39444148/

Adult penicillin allergy programmes in Australian hospitals: a practical guide from the National Antibiotic Allergy Network - PubMed

Penicillin allergy is a significant burden on patient, prescribing and hospital outcomes. There has been increasing interest in the incorporation of penicillin allergy testing (i.e. delabelling) into ...

pubmed.ncbi.nlm.nih.gov

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Jason Trubiano @trubianojason.bsky.social · Nov 21

#WAAW kicking off at @ncas.bsky.social symposium today 🇦🇺. Looking forward to a great program and a lot of representation from team #AustinHealth #AMS #DrugAllergy

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