Niladri Sinha
@2primehydroxyl.bsky.social
Assistant Professor @ University of Utah | interested in ribosomes and translational control in health and disease
https://sinha.biochem.utah.edu
https://sinha.biochem.utah.edu
Pinned
Niladri Sinha
@2primehydroxyl.bsky.social
· Aug 21
The Sinha Lab
The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.
sinha.biochem.utah.edu
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
Reposted by Niladri Sinha
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
If you are a motivated and curious scientist eager to drive independent projects within a collaborative environment, please do not hesitate to reach out at [email protected]. Kindly re-post this opportunity amongst your professional networks.
August 29, 2025 at 3:51 PM
If you are a motivated and curious scientist eager to drive independent projects within a collaborative environment, please do not hesitate to reach out at [email protected]. Kindly re-post this opportunity amongst your professional networks.
This is a unique opportunity to lead exciting projects and play an active role in shaping the lab culture, with a chance to apply a multidisciplinary toolkit (biochemistry, proteomics, genetics, and structural biology) to address exciting questions in translational control.
August 29, 2025 at 3:51 PM
This is a unique opportunity to lead exciting projects and play an active role in shaping the lab culture, with a chance to apply a multidisciplinary toolkit (biochemistry, proteomics, genetics, and structural biology) to address exciting questions in translational control.
We have an opening for a Postdoctoral Fellow to join us in exploring fundamental questions at the interface of protein synthesis defects and stress-responsive signaling pathways. utah.peopleadmin.com/postings/187... #RNAsky
Post Doc Res Assoc
Postdoc with a primary duty consisting research-related work. Required to meet FLSA threshold to be paid on a salaried basis, otherwise employment record will convert to hourly.
utah.peopleadmin.com
August 29, 2025 at 3:51 PM
We have an opening for a Postdoctoral Fellow to join us in exploring fundamental questions at the interface of protein synthesis defects and stress-responsive signaling pathways. utah.peopleadmin.com/postings/187... #RNAsky
Thanks Michael!
August 27, 2025 at 3:02 AM
Thanks Michael!
Likewise - thanks Brenda!
August 23, 2025 at 4:04 PM
Likewise - thanks Brenda!
Thanks Charles!
August 23, 2025 at 3:56 AM
Thanks Charles!
Thanks Heather!
August 21, 2025 at 11:01 PM
Thanks Heather!
It is an honor to return to the institution where I began my scientific journey. As I embark on establishing my lab, I approach this opportunity with excitement and humility. My goal is to train the next generation of scientists, paying forward the mentorship and support that shaped my career.
August 21, 2025 at 7:09 PM
It is an honor to return to the institution where I began my scientific journey. As I embark on establishing my lab, I approach this opportunity with excitement and humility. My goal is to train the next generation of scientists, paying forward the mentorship and support that shaped my career.
I take this opportunity to thank my postdoc and PhD advisors, Rachel Green and Brenda Bass @bbass.bsky.social who took great care to train me well, to my funding agencies NIGMS and @jcchildsfund.bsky.social for supporting my work, and to my family and close friends for their unconditional support.
August 21, 2025 at 7:09 PM
I take this opportunity to thank my postdoc and PhD advisors, Rachel Green and Brenda Bass @bbass.bsky.social who took great care to train me well, to my funding agencies NIGMS and @jcchildsfund.bsky.social for supporting my work, and to my family and close friends for their unconditional support.
The lab will employ multidisciplinary approaches to study cellular responses to translation #stress and #proteotoxicity. We seek to identify quality control and signaling pathways triggered by ribotoxic stress and develop therapeutic strategies to target these pathways in #cancer and #aging cells.
August 21, 2025 at 7:09 PM
The lab will employ multidisciplinary approaches to study cellular responses to translation #stress and #proteotoxicity. We seek to identify quality control and signaling pathways triggered by ribotoxic stress and develop therapeutic strategies to target these pathways in #cancer and #aging cells.
We are hiring at all levels, so please help spread the word! #RNAsky #ribosomes #signaling #translation sinha.biochem.utah.edu/join
Join — The Sinha Lab
We welcome curiosity-driven individuals excited to make foundational discoveries aimed at understanding and combating defects in translational control and proteostasis in a dynamic, collaborative, and...
sinha.biochem.utah.edu
August 21, 2025 at 7:09 PM
We are hiring at all levels, so please help spread the word! #RNAsky #ribosomes #signaling #translation sinha.biochem.utah.edu/join
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
The Sinha Lab
The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.
sinha.biochem.utah.edu
August 21, 2025 at 7:09 PM
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
Reposted by Niladri Sinha
“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University.
www.quantamagazine.org/rna-is-the-c...
www.quantamagazine.org/rna-is-the-c...
July 18, 2025 at 8:04 PM
“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University.
www.quantamagazine.org/rna-is-the-c...
www.quantamagazine.org/rna-is-the-c...
Reposted by Niladri Sinha
We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
May 26, 2025 at 9:29 AM
We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
Reposted by Niladri Sinha
Happy to share our review on the cellular responses to RNA damage 🥂
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Cellular responses to RNA damage
RNA plays a central role in protein biosynthesis and performs diverse regulatory and
catalytic functions, making it essential for all processes of life. Like DNA, RNA
is constantly subjected to damage...
www.cell.com
February 20, 2025 at 6:37 PM
Happy to share our review on the cellular responses to RNA damage 🥂
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Reposted by Niladri Sinha
Latest work from our next door neighbors! #RNAsky #RNAbiology
Online Now: The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
To maintain translational fidelity, cells degrade decoding-incompetent ribosomes through the 18S nonfunctional rRNA decay (NRD) pathway. Coria et al. demonstrate that the concerted actions of GCN2, RNF10, and RIOK3 lead to a block in translation…
dlvr.it
February 12, 2025 at 10:49 PM
Latest work from our next door neighbors! #RNAsky #RNAbiology