adam grieve
@adamgrieve.bsky.social
Membrane protein signalling and turnover in neurons
Sir Henry Dale Fellow at School of Biochemistry, University of Bristol
grieve-lab.com
Sir Henry Dale Fellow at School of Biochemistry, University of Bristol
grieve-lab.com
Add our first pre-print to your reading list?
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
November 25, 2025 at 9:57 AM
Add our first pre-print to your reading list?
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
Reposted by adam grieve
Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...
July 10, 2025 at 6:10 PM
Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...
Reposted by adam grieve
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
ki.se/en/about-ki/...
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
ki.se
June 25, 2025 at 2:56 PM
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
ki.se/en/about-ki/...
This sounds like a fun job!
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
June 24, 2025 at 8:03 AM
This sounds like a fun job!
Reposted by adam grieve
Are you a PI of a federal grant cancelled by the Trump administration?
Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations 🔭🧪
forms.office.com/pages/respon...
Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations 🔭🧪
forms.office.com/pages/respon...
May 29, 2025 at 1:46 PM
Are you a PI of a federal grant cancelled by the Trump administration?
Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations 🔭🧪
forms.office.com/pages/respon...
Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations 🔭🧪
forms.office.com/pages/respon...
Reposted by adam grieve
Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.
May 29, 2025 at 2:39 PM
Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.
Reposted by adam grieve
🔬 Hiring: Postdoctoral Fellow
Seeking a bioinformatician/screening expert to be part of our team running genome‑wide screens, building data‑integration pipelines & validating hits in higher organisms.
🌱 2‑yr fellowship with tailored mentorship, leadership & science‑communication training
Seeking a bioinformatician/screening expert to be part of our team running genome‑wide screens, building data‑integration pipelines & validating hits in higher organisms.
🌱 2‑yr fellowship with tailored mentorship, leadership & science‑communication training
April 18, 2025 at 8:03 AM
🔬 Hiring: Postdoctoral Fellow
Seeking a bioinformatician/screening expert to be part of our team running genome‑wide screens, building data‑integration pipelines & validating hits in higher organisms.
🌱 2‑yr fellowship with tailored mentorship, leadership & science‑communication training
Seeking a bioinformatician/screening expert to be part of our team running genome‑wide screens, building data‑integration pipelines & validating hits in higher organisms.
🌱 2‑yr fellowship with tailored mentorship, leadership & science‑communication training
Reposted by adam grieve
Come and join us in solving mystery of plasma membrane proteostasis in beautiful neurons.
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
April 10, 2025 at 1:14 PM
Come and join us in solving mystery of plasma membrane proteostasis in beautiful neurons.
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
April 9, 2025 at 3:42 PM
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
Reposted by adam grieve
A fitting announcement to an outstanding scientist and friend who is dearly missed by many. journals.biologists.com/jcs/article/...
Announcing the JCS–David Stephens Prize and the 2024 winner Anja Konietzny
Over the past 25 years, Journal of Cell Science (JCS) has been awarding a prize of £1000 – ‘The JCS Prize’ – to the first author(s) of the paper that is judged by the Editors to be the best paper publ...
journals.biologists.com
April 7, 2025 at 1:29 PM
A fitting announcement to an outstanding scientist and friend who is dearly missed by many. journals.biologists.com/jcs/article/...
Reposted by adam grieve
April 9, 2025 at 8:36 AM
Reposted by adam grieve
I am recruiting a research assistant. Please send to anyone you know who is interested in gaining more lab experience in host:pathogen interactions of bacterial infections.
www.jobs.cam.ac.uk/job/50738/
www.jobs.cam.ac.uk/job/50738/
Research Assistant - Godlee Group (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant - Godlee Group (Fixed Term) in the Department of Biochemistry at the University of Cambridge.
www.jobs.cam.ac.uk
March 31, 2025 at 7:38 AM
I am recruiting a research assistant. Please send to anyone you know who is interested in gaining more lab experience in host:pathogen interactions of bacterial infections.
www.jobs.cam.ac.uk/job/50738/
www.jobs.cam.ac.uk/job/50738/
Reposted by adam grieve
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 27, 2025 at 7:45 PM
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Reposted by adam grieve
Check out our new paper with Michael Landreh, @pstansfeld.bsky.social and others in @elife.bsky.social : Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization doi.org/10.7554/eLif...
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
doi.org
March 27, 2025 at 9:31 AM
Check out our new paper with Michael Landreh, @pstansfeld.bsky.social and others in @elife.bsky.social : Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization doi.org/10.7554/eLif...
Reposted by adam grieve
Applications close today for this @uniofmanchester.bsky.social #DigitalNotebook #Metascience project, seasoned with #OpenResearch & served with helpings of #ResearchIntegrity and a side of #ResearchCulture
Full details of everything on the menu below 👇
www.jobs.manchester.ac.uk/Job/JobDetai...
Full details of everything on the menu below 👇
www.jobs.manchester.ac.uk/Job/JobDetai...
March 24, 2025 at 1:12 PM
Applications close today for this @uniofmanchester.bsky.social #DigitalNotebook #Metascience project, seasoned with #OpenResearch & served with helpings of #ResearchIntegrity and a side of #ResearchCulture
Full details of everything on the menu below 👇
www.jobs.manchester.ac.uk/Job/JobDetai...
Full details of everything on the menu below 👇
www.jobs.manchester.ac.uk/Job/JobDetai...
Thank you Ines! I had such a lovely time visiting sunny York this week, sharing our science and chatting cell bio, neuroscience and proteases. Thanks for the invite, special thanks to the one and only @yorkyeast.bsky.social for top-notch hosting!
March 23, 2025 at 12:04 PM
Thank you Ines! I had such a lovely time visiting sunny York this week, sharing our science and chatting cell bio, neuroscience and proteases. Thanks for the invite, special thanks to the one and only @yorkyeast.bsky.social for top-notch hosting!
Reposted by adam grieve
Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social
Toward single-molecule protein sequencing using nanopores
Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing
rdcu.be
March 18, 2025 at 10:18 AM
Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social
Reposted by adam grieve
Do you need some science joy in your life? Do you like neurons? Maybe glia? Molecules? Cell biology? Save the date for #NeuroBioUK25 - the venue is booked and we are excited to see you and your incredible science there on the 12th of September!
neurobiouk.sites.sheffield.ac.uk
neurobiouk.sites.sheffield.ac.uk
March 6, 2025 at 7:57 AM
Do you need some science joy in your life? Do you like neurons? Maybe glia? Molecules? Cell biology? Save the date for #NeuroBioUK25 - the venue is booked and we are excited to see you and your incredible science there on the 12th of September!
neurobiouk.sites.sheffield.ac.uk
neurobiouk.sites.sheffield.ac.uk
Reposted by adam grieve
Save the date: We're excited that the third NeuroBioUK will take place on September. Block it in your calendar to join us in York for a fun day of neurons, glia, cool science and chats!
March 6, 2025 at 9:23 AM
Save the date: We're excited that the third NeuroBioUK will take place on September. Block it in your calendar to join us in York for a fun day of neurons, glia, cool science and chats!
Reposted by adam grieve
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
Macrophages promote collagen deposition through circadian regulation of fibroblasts
Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...
www.biorxiv.org
March 5, 2025 at 8:28 AM
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
Exciting opportunity in the newly minted McMillan lab in Liverpool. Kirsty is a great scientist and a top mentor for students - if you’re looking for a PhD and are interested in trafficking and neurodegeneration, do contact her!
I have a funded PhD studentship available to start in my new lab in 2025! If you are interested in Endosomal Biology, Astrocytes and Alzheimer’s Disease have a look:
www.findaphd.com/phds/project...
Please feel free to share.
www.findaphd.com/phds/project...
Please feel free to share.
The Role of the Endosomal System in Alzheimer’s Disease. at University of Liverpool on FindAPhD.com
PhD Project - The Role of the Endosomal System in Alzheimer’s Disease. at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
December 18, 2024 at 6:29 PM
Exciting opportunity in the newly minted McMillan lab in Liverpool. Kirsty is a great scientist and a top mentor for students - if you’re looking for a PhD and are interested in trafficking and neurodegeneration, do contact her!
Reposted by adam grieve
UK Membrane Trafficking 2024
Who doesn’t like a deadline that gets brought forward?
Please register by 3rd December - King’s need longer to make the sandwiches than I previously thought!
estore.kcl.ac.uk/conferences-...
Programme coming soon!
Who doesn’t like a deadline that gets brought forward?
Please register by 3rd December - King’s need longer to make the sandwiches than I previously thought!
estore.kcl.ac.uk/conferences-...
Programme coming soon!
UK Membrane Trafficking Meeting 2024 | King's College London eStore
Registration for the 2024 UK Membrane Trafficking Meeting, held at KCL.  Registration per person, to include sandwich lunch and coffee breaks and even
estore.kcl.ac.uk
November 25, 2024 at 8:53 AM
UK Membrane Trafficking 2024
Who doesn’t like a deadline that gets brought forward?
Please register by 3rd December - King’s need longer to make the sandwiches than I previously thought!
estore.kcl.ac.uk/conferences-...
Programme coming soon!
Who doesn’t like a deadline that gets brought forward?
Please register by 3rd December - King’s need longer to make the sandwiches than I previously thought!
estore.kcl.ac.uk/conferences-...
Programme coming soon!
Amazing PhD opportunity to join an exciting new lab at Bristol Biochemistry - send your best students in Ferdos’ direction!
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
November 27, 2024 at 12:36 PM
Amazing PhD opportunity to join an exciting new lab at Bristol Biochemistry - send your best students in Ferdos’ direction!
Reposted by adam grieve
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
November 27, 2024 at 12:15 PM
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
November 15, 2024 at 5:55 PM
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c