I am excited to see our latest collaborative work in Aging Cell

doi.org/10.1111/acel...

We explored muscle–brain cross-talk and discovered that the muscle-derived cathepsin B (a myokine) plays a key role in improving behavioral and neurogenic deficits in a mouse model of Alzheimer’s disease.

Are you interested in #proteomics and #skeletalmuscle? It can be a real pain to get deep reproducible coverage. Check out our review with @adeshmukh.bsky.social We analyse some considerations including current limitations and how to potentially overcome them #myoblue @unimelbcmr.bsky.social

New publication!

We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.

www.sciencedirect.com/science/arti...

@cbmr.science @jeppekjaergaard.bsky.social

Preprint Alert
We present the most comprehensive, time-resolved atlas of the human proteomic response to acute exercise. We mapped 10,000+ proteins across plasma, saliva & urine—3,000+ changed after just one workout.
doi.org/10.1101/2025...
Explore cbmr-rmpp.shinyapps.io/exerome/

Getting to the basis of insulin resistance at the individual level via muscle biopsy and mapping the proteins
www.cell.com/cell/fulltex...

Highlighting our latest research.
Deconvoluting insulin signaling in human skeletal muscle.
www.news-medical.net/news/2025052...

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.

@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science

doi.org/10.1016/j.ce...

Excited to share another great collaborative effort — we successfully combined single muscle fiber proteomics with functional assays in the same fiber! This integrated approach allows a direct link between molecular composition and functional performance at the single cell/fiber level.

Latest from Jonas Treebak and team @cbmr.science

NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

I am happy to have contributed to this exciting work by applying our single muscle fiber proteomics workflow.

Fiber Type–Specific Adaptations to Exercise Training in Human Skeletal Muscle: Lessons From Proteome Analyses and Future Directions
onlinelibrary.wiley.com/doi/10.1111/...

Excited, share this review article with Morten Hostrup, where we discuss fiber type–specific muscle adaptations to exercise using single-fiber and pooled fiber proteomics.
Review also highlights key bioinformatics/statistical considerations!

doi.org/10.1111/sms....

@adeshmukh.bsky.social, recipient of the 2019 #EFSD/@novo-nordisk.bsky.social Future Leaders Award, explores how exercise regulates the skeletal muscle interstitial fluid #proteome, uncovering new treatments for #diabetes & #sarcopenia.

His latest study highlights LL-37’s role in muscle growth:
👇👇

💪 𝐑𝐞𝐭𝐡𝐢𝐧𝐤𝐢𝐧𝐠 𝐌𝐮𝐬𝐜𝐥𝐞: 𝐍𝐞𝐰 𝐬𝐭𝐮𝐝𝐲 𝐜𝐡𝐚𝐥𝐥𝐞𝐧𝐠𝐞𝐬 𝐨𝐥𝐝 𝐜𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬

🔬 Our current approach to dividing muscle fibers into separate types may need to be revised following new research in Nature Communications by a team of scientists, including AssocProf Atul Deshmukh.

👇

www.nature.com/articles/s41...

I am excited to share our new publication where we analyzed transcriptome and proteome of >1000 single muscle fiber. Study explore the remarkable heterogeneity beyond traditional myosin heavy chain classifications.
Huge thanks to everyone who contributed.

I am excited to share our latest publication in Science Advances!

We mapped the proteome of interstitial fluid across the leg in response to exhaustive exercise, and discovered immune cell derived peptide regulating muscle growth.

www.science.org/doi/10.1126/...

5,562 proteins were found to have tissue-specific enrichment across 32 human tissues.

◼️ The majority of them (3,088) are enriched at the protein but not RNA level.

🧠 The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.

Proteomics of body fluids like saliva offers immense potential for biomarker discovery, as saliva is easy to collect, non-invasive, and rich in secreted factors.

Using a 21-minute MS method, we identified >4500 proteins highlighting saliva's untapped potential for diagnostics.

First post on this platform.

Excited to our manuscript where we used cutting-edge proteomics to map human & bacterial proteomes in saliva, revealing signatures of #Type2Diabetes

Arricle- rdcu.be/d5U3u
Video- shorturl.at/cSUCD

I am very grateful to my collaborators.