Adrian Woolfson
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adrianwoolfson.bsky.social
Adrian Woolfson
@adrianwoolfson.bsky.social
1.4K followers 700 following 660 posts
Opinions @WSJ.com & @Science.org. Author Life Without Genes @harpercollins.bsky.social & On The Future of Species bloomsburybooksuk.bsky.social (12 Feb 2026) & @MITpress.bsky.social (17 Mar, 2026). www.adrianwoolfson.com. Founder Genyro.com
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adrianwoolfson.bsky.social
www.genengnews.com/topics/genom...
Writing the Code of Life: Synthetic Human Chromosomes on the Horizon
New international projects to develop foundational large-genome construction tools.
www.genengnews.com
January 18, 2026 at 2:59 AM
adrianwoolfson.bsky.social
An important moment in the use of personalized cancer neoantigen vaccines to prevent the onset of clinical disease

www.nature.com/articles/s41...
Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial - Nature Medicine
In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficie...
www.nature.com
January 16, 2026 at 11:31 AM
adrianwoolfson.bsky.social
www.biorxiv.org/content/10.6...
Amplified genome editing by in vivo editor production
Genome editing enzymes have vast therapeutic potential. However, achieving sufficient delivery in vivo remains a major challenge, because editing machinery is confined to the subset of transfectable c...
www.biorxiv.org
January 16, 2026 at 5:16 AM
adrianwoolfson.bsky.social
www.scientificamerican.com/article/scie...
Scientists Find Extinct Rhino DNA in Mummified Wolf Puppy’s Stomach
Scientists have sequenced the genome of the long-extinct woolly rhinoceros from remains found in the stomach of a naturally mummified Pleistocene wolf pup
www.scientificamerican.com
January 15, 2026 at 2:04 PM
adrianwoolfson.bsky.social
www.scientificamerican.com/article/jell...
Scientists Catch Jellyfish and Sea Anemones Behaving in Surprisingly Human Ways
Sea anemones and jellyfish don’t have brains, but the way their neurons behave during sleep shows some surprising similarities to humans
www.scientificamerican.com
January 15, 2026 at 1:25 PM
adrianwoolfson.bsky.social
share.google/QLne0KU5tf8I...
The Paraphrase Project: Designing defense for an era of synthetic biology
Microsoft researchers reveal a confidential research effort that explored how open-source AI tools could be used to bypass biosecurity checks—and helped create fixes now influencing global standards.
share.google
January 14, 2026 at 9:37 PM
adrianwoolfson.bsky.social
writings.stephenwolfram.com/2026/01/what...
What Is Ruliology?
Stephen Wolfram explains the science of ruliology--studying what abstract rules do--and integral applications of the science in his own work.
writings.stephenwolfram.com
January 13, 2026 at 3:35 AM
adrianwoolfson.bsky.social
news.microsoft.com/signal/artic...
Can AI learn the language of biology to reimagine medicine? | Microsoft Signal Blog | Microsoft
news.microsoft.com
January 10, 2026 at 7:01 PM
adrianwoolfson.bsky.social
www.biorxiv.org/content/10.6...
Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
www.biorxiv.org
January 10, 2026 at 3:31 AM
adrianwoolfson.bsky.social
www.nature.com/articles/s41...
An expanded registry of candidate cis-regulatory elements - Nature
The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types...
www.nature.com
January 8, 2026 at 9:12 AM
adrianwoolfson.bsky.social
AI can learn the language of sleep and use it to predict disease risk

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A multimodal sleep foundation model for disease prediction - Nature Medicine
A deep learning-based model, developed using the rich, multimodal data available from polysomnography-derived sleep recordings, performs well on common sleep analysis tasks and predicts future disease...
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January 7, 2026 at 1:26 PM
adrianwoolfson.bsky.social
www.science.org/content/arti...
Exclusive: Have scientists found Leonardo da Vinci’s DNA?
Inside the decadeslong quest to reveal the genes of a genius—and revolutionize art authentication
www.science.org
January 7, 2026 at 1:09 PM
adrianwoolfson.bsky.social
phys.org/news/2026-01...
Eye-opening research: Greenland sharks maintain vision for centuries through DNA repair mechanism
Dorota Skowronska-Krawczyk sits in her office, eyes fixed on the computer monitor in front of her. "You see it move its eye," says the UC Irvine associate professor of physiology and biophysics, point...
phys.org
January 6, 2026 at 12:32 PM
adrianwoolfson.bsky.social
academic.oup.com/synbio/artic...
Emerging trends in genome integration tools for precision engineering of diverse bacterial species
Abstract. The ability to precisely insert DNA payloads into a genome enables the comprehensive engineering of cellular phenotypes and the creation of new b
academic.oup.com
January 6, 2026 at 12:31 PM
adrianwoolfson.bsky.social
news.stanford.edu/stories/2026...
Synthetic biologists transform waste CO2 into useful chemicals
A groundbreaking new system paves the way for advances in synthetic biology and carbon recycling.
news.stanford.edu
January 6, 2026 at 8:09 AM
adrianwoolfson.bsky.social
www.techradar.com/pro/after-ne...
Atlas Data Storage aims to cram 13TB of data into a drop of water
Atlas Data Storage aims to cram 13TB of data into a drop of water
www.techradar.com
January 6, 2026 at 5:37 AM
adrianwoolfson.bsky.social
January 6, 2026 at 5:21 AM
adrianwoolfson.bsky.social
Stinkbugs harbor a fungal nursery in a structure on their hindlegs that mothers use to coat their newly laid eggs to protect them from parasitic wasps

www.science.org/doi/10.1126/...
Defensive fungal symbiosis on insect hindlegs
Dinidorid stinkbugs were reported to possess a conspicuous tympanal organ on female hindlegs. In this study, we show that this organ is specialized to retain microbial symbionts rather than to perceiv...
www.science.org
January 4, 2026 at 8:25 PM
adrianwoolfson.bsky.social
share.google/G51EHiz11LNd...
Random access and semantic search in DNA data storage enabled by Cas9 and machine-guided design - Nature Communications
CRISPR-Cas9 has potential as an efficient tool for information retrieval in DNA data storage. Here the authors present a Cas9-based random access and similarity search approach and test on DNA databas...
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January 4, 2026 at 2:18 PM
adrianwoolfson.bsky.social
www.theguardian.com/environment/...
‘They didn’t de-extinct anything’: can Colossal’s genetically engineered animals ever be the real thing?
The bioscience startup has attracted billions in investment – and a flurry of criticism, but founder tells the Guardian plans to bring back the woolly mammoth will not be derailed
www.theguardian.com
January 4, 2026 at 7:30 AM
adrianwoolfson.bsky.social
www.synbiobeta.com/read/ending-...
Ending The Waiting Game: How Ansa Biotechnologies Guarantees are Turning DNA Synthesis Into A Predictable Industry
Join SynBioBeta, the global community of biological engineers, entrepreneurs, investors, and innovators working to make biology easier to engineer.
www.synbiobeta.com
January 4, 2026 at 7:28 AM
adrianwoolfson.bsky.social
Recovery of RNA from a thylacine

www.earth.com/news/scienti...
Scientists retrieve RNA from an extinct animal, marking a first in genetics research
Researchers in Sweden recovered RNA from a 130-year-old Tasmanian tiger, allowing them to identify which genes were active in its tissues before extinction.
www.earth.com
January 3, 2026 at 7:19 PM
adrianwoolfson.bsky.social
The first dataset from the Billion Cells Project to be released publicly.

www.biorxiv.org/content/10.6...
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits
Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...
www.biorxiv.org
January 3, 2026 at 9:54 AM
adrianwoolfson.bsky.social
www.science.org/doi/10.1126/...
HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors
HLA-Shuttle enhances production of HLA class I molecules in neuroblastoma, leading to the discovery of tumor-associated antigens.
www.science.org
January 3, 2026 at 1:06 AM
adrianwoolfson.bsky.social
Sensitive measurement of base editing off-target

www.nature.com/articles/s41...
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - Nature Biotechnology
Base editor off-target effects are profiled with high precision in a tailored approach.
www.nature.com
January 2, 2026 at 9:21 PM