The mTOR protein kinase forms two multiprotein complexes, mTORC1 and mTORC2, that function in distinct signaling pathways. mTORC1 is regulated by nutrients, and mTORC2 is a central node in phosphoinos...

This study positions intermediate filaments (IFs) as functional drivers and molecular markers of glioblastoma invasion. van Bodegraven et al. reveal that vimentin expression correlates with pro-invasive markers in patients. They show that while IFs reduce glioblastoma cell deformability, they promote matrix degradation via MMP14 expression, which facilitates 3D invasion.

Nature Structural & Molecular Biology, Published online: 26 November 2025; doi:10.1038/s41594-025-01716-0Rocha-Roa et al. identify TMEM170 proteins as endoplasmic reticulum lipid scramblases that partner with bridge-like lipid transfer proteins BLTP1/Csf1 proteins to enable bulk lipid transport between organelles.

Nature Structural & Molecular Biology, Published online: 27 November 2025; doi:10.1038/s41594-025-01720-4Cells store excess fat in lipid droplets to avoid lipotoxicity and maintain homeostasis. We identified an autophagy-independent role for the autophagy lipid transfer protein ATG2A in helping direct lipids to growing lipid droplets and promoting recruitment of the enzyme DGAT2. This coordination enhances triglyceride storage, protects the endoplasmic reticulum from lipid overload and limits the misrouting of lipids into other metabolic pathways.

Under stress, cells adapt their gene expression programs through changes in transcription and translation. It is unclear how cells determine which mRNAs are translated or repressed. Zedan et al. show that the timing of mRNA production alone determines the selectivity of translation, thereby coupling the processes of transcription and translation.

Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...

imageimageDynein-2 is a motor protein essential for retrograde intraflagellar transport (IFT) on the A-tubule of ciliary doublet microtubules. Here, biochemical and cryo-ET analyses demonstrate that d...

Zhou et al. design protein-based artificial kinetochore constructs as decoys to prevent premature chromosomal separation in aged oocytes. These constructs compete with chromosomal kinetochores, reduci...

Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones t...

Ribosome recycling’s role in translational regulation remains unclear. Miluzio, Scagliola, et al. show that blocking eIF6 phosphorylation by environmental stressors delays ribosome recycling at stop codons, leading to translational reprogramming and establishing RESt. RESt is reversible, characterized by metabolic remodeling, low translation, reduced reinitiation, and NF-κB pathway activation.

Cyclic adenosine monophosphate (cAMP) signaling is a major stimulus for lipid and glucose catabolism, yet catabolic processes like these can also coordinate with lysosome-dependent degradation. Howeve...

Enveloped viruses enter cells by membrane fusion. The viral membrane fuses with a host membrane, either at the cell surface or within endocytic compartments. For endocytic entry, fusion is typically t...

Understanding how LMD-3 governs lysosomal function and reproduction in C. elegans paves the way for fertility treatments.

Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...