Alice Laigle
@alicelaigle.bsky.social
Looking for a position in science communication 🎨 or as a research assistant/bioinformatician 🧬| Currently living in🇨🇭| Interested in whatever linked to biodiversity, evolution, genomics and interactions | 🪂🧗♀️🗻 | She/her
Pinned
Alice Laigle
@alicelaigle.bsky.social
· Apr 20
Our preprint has now found a wonderful home in @molbioevol.bsky.social. Shout out to our collaborators in the Mozgova lab too 💚
New study with @petrollromy.bsky.social @borglab.bsky.social traces the evolution of epigenetic silencing in plants. Deep conservation of PRC2-mediated H3K27me3 marks across green algae suggest ancient, conserved networks of gene repression.
🔗 doi.org/10.1093/molb...
#evobio #molevol #plants
🔗 doi.org/10.1093/molb...
#evobio #molevol #plants
Super happy to see it out with all the hard work of everyone ! Such a nice story ! 🔥
Reposted by Alice Laigle
Nature research paper: Convergent genome evolution shaped the emergence of terrestrial animals
go.nature.com/4i0i61w
go.nature.com/4i0i61w
Convergent genome evolution shaped the emergence of terrestrial animals - Nature
Comparisons of 154 genomes from 21 animal phyla and outgroups have been used to reconstruct ancestral adaptation to life on land across 11 distinct terrestrialization events, revealing strong evidence for convergent genomic evolution across the animal kingdom and recurring periods of terrestrial colonization.
go.nature.com
November 13, 2025 at 9:18 AM
Nature research paper: Convergent genome evolution shaped the emergence of terrestrial animals
go.nature.com/4i0i61w
go.nature.com/4i0i61w
Reposted by Alice Laigle
🌿 3 new PhD positions in the Ton lab @PPS_UoS. Part of the ERC project '#PlantMemo', exploring how plants remember & respond to stress.
🧬 PhD 1 (UK only)👉 www.findaphd.com/phds/project...
🦠 PhD 2 (UK & EU)👉 www.findaphd.com/phds/project...
🌱 PhD 3 (UK only)👉 www.findaphd.com/phds/project...
#PhD
🧬 PhD 1 (UK only)👉 www.findaphd.com/phds/project...
🦠 PhD 2 (UK & EU)👉 www.findaphd.com/phds/project...
🌱 PhD 3 (UK only)👉 www.findaphd.com/phds/project...
#PhD
November 11, 2025 at 7:19 PM
🌿 3 new PhD positions in the Ton lab @PPS_UoS. Part of the ERC project '#PlantMemo', exploring how plants remember & respond to stress.
🧬 PhD 1 (UK only)👉 www.findaphd.com/phds/project...
🦠 PhD 2 (UK & EU)👉 www.findaphd.com/phds/project...
🌱 PhD 3 (UK only)👉 www.findaphd.com/phds/project...
#PhD
🧬 PhD 1 (UK only)👉 www.findaphd.com/phds/project...
🦠 PhD 2 (UK & EU)👉 www.findaphd.com/phds/project...
🌱 PhD 3 (UK only)👉 www.findaphd.com/phds/project...
#PhD
Some mushrooms we identified at the Society of Mycology of Neuchâtel and around (www.smne.ch).
❓how to memorise them all?
🎨 My manner is to paint them. It takes up a lot of time, but once I see them again, I know who they are!
🍄🐡 #Sciart #fungifriends #mushrooms #illustrations #watercolor
❓how to memorise them all?
🎨 My manner is to paint them. It takes up a lot of time, but once I see them again, I know who they are!
🍄🐡 #Sciart #fungifriends #mushrooms #illustrations #watercolor
November 10, 2025 at 3:26 PM
Some mushrooms we identified at the Society of Mycology of Neuchâtel and around (www.smne.ch).
❓how to memorise them all?
🎨 My manner is to paint them. It takes up a lot of time, but once I see them again, I know who they are!
🍄🐡 #Sciart #fungifriends #mushrooms #illustrations #watercolor
❓how to memorise them all?
🎨 My manner is to paint them. It takes up a lot of time, but once I see them again, I know who they are!
🍄🐡 #Sciart #fungifriends #mushrooms #illustrations #watercolor
Reposted by Alice Laigle
Want to understand how entire fungal chromosomes can be horizontally transferred?
Join us to unravel the mechanism/consequences of horizontal chromosome transfer in a fungal pathogen as part of an ERC-funded project. Postdoc/PhD positions available.
fungal-evolutionary-genetics.de/open-positio...
Join us to unravel the mechanism/consequences of horizontal chromosome transfer in a fungal pathogen as part of an ERC-funded project. Postdoc/PhD positions available.
fungal-evolutionary-genetics.de/open-positio...
Open Positions
ERC-funded project on the mechanism of horizontal transfer of entire fungal chromosomes PhD PostDoc
fungal-evolutionary-genetics.de
October 13, 2025 at 9:39 AM
Want to understand how entire fungal chromosomes can be horizontally transferred?
Join us to unravel the mechanism/consequences of horizontal chromosome transfer in a fungal pathogen as part of an ERC-funded project. Postdoc/PhD positions available.
fungal-evolutionary-genetics.de/open-positio...
Join us to unravel the mechanism/consequences of horizontal chromosome transfer in a fungal pathogen as part of an ERC-funded project. Postdoc/PhD positions available.
fungal-evolutionary-genetics.de/open-positio...
Reposted by Alice Laigle
📣 I’m excited to share two open positions in my lab @leibniz-hki.de. For this interdisciplinary project with @luziagyr.bsky.social, I’m seeking (1) an enthusiastic PhD student interested in fungal natural product research and genetic engineering, as well as (2) a technical assistant 👇🏻
October 21, 2025 at 2:48 PM
📣 I’m excited to share two open positions in my lab @leibniz-hki.de. For this interdisciplinary project with @luziagyr.bsky.social, I’m seeking (1) an enthusiastic PhD student interested in fungal natural product research and genetic engineering, as well as (2) a technical assistant 👇🏻
Reposted by Alice Laigle
🎃We are ready & excited for the new #FragileNucleosome seminar session tomorrow with @alicelaigle.bsky.social and @seungsookim.bsky.social ! How about you ?
October 21, 2025 at 2:42 PM
🎃We are ready & excited for the new #FragileNucleosome seminar session tomorrow with @alicelaigle.bsky.social and @seungsookim.bsky.social ! How about you ?
I am very excited to present you our work, which will also be very soon on biorxiv!! ✨️
👀Next Wednesday, Oct 22nd, at #FragileNucleosome seminar, we are excited to host @alicelaigle.bsky.social and @seungsookim.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
October 14, 2025 at 9:11 PM
I am very excited to present you our work, which will also be very soon on biorxiv!! ✨️
September 15, 2025 at 2:27 PM
Reposted by Alice Laigle
Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...
We are hiring! Oxford biology has three associate professorships available as we move to new state-of-the-art facilities
www.biology.ox.ac.uk
September 15, 2025 at 11:22 AM
Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...
Reposted by Alice Laigle
Our Pitt Microbiology and Molecular Genetics department in the School of Medicine is recruiting..
Microbiologists! 🧫🦠🔬🧪
Please apply to join our faculty and enjoy these views 👀 while doing great science
cfopitt.taleo.net/careersectio...
Microbiologists! 🧫🦠🔬🧪
Please apply to join our faculty and enjoy these views 👀 while doing great science
cfopitt.taleo.net/careersectio...
August 21, 2025 at 3:19 PM
Our Pitt Microbiology and Molecular Genetics department in the School of Medicine is recruiting..
Microbiologists! 🧫🦠🔬🧪
Please apply to join our faculty and enjoy these views 👀 while doing great science
cfopitt.taleo.net/careersectio...
Microbiologists! 🧫🦠🔬🧪
Please apply to join our faculty and enjoy these views 👀 while doing great science
cfopitt.taleo.net/careersectio...
Reposted by Alice Laigle
🚨 First PhD chapter is out! My work thus far, with @andy2dobson.bsky.social
We found that formerly common species have declined the fastest, on average.
📄 North American bird declines are driven by reductions in common species | Science Advances www.science.org/doi/10.1126/...
We found that formerly common species have declined the fastest, on average.
📄 North American bird declines are driven by reductions in common species | Science Advances www.science.org/doi/10.1126/...
North American bird declines are driven by reductions in common species
Declines in North American birds are driven not by rare species vanishing but by sharp losses among formerly common species.
www.science.org
July 31, 2025 at 3:18 AM
🚨 First PhD chapter is out! My work thus far, with @andy2dobson.bsky.social
We found that formerly common species have declined the fastest, on average.
📄 North American bird declines are driven by reductions in common species | Science Advances www.science.org/doi/10.1126/...
We found that formerly common species have declined the fastest, on average.
📄 North American bird declines are driven by reductions in common species | Science Advances www.science.org/doi/10.1126/...
Reposted by Alice Laigle
📣 Happy to see the journal publication 📄 of our work on Starships 🚀 in Verticillium fungi: terrific work led by @yukiyosato.bsky.social
rdcu.be/exBSp
rdcu.be/exBSp
Starship giant transposons dominate plastic genomic regions in a fungal plant pathogen and drive virulence evolution
Nature Communications - Giant transposons, known as ‘Starships’, mediate horizontal gene transfer between fungal genomes. Here, Sato et al. show that Starships occupy genome regions...
rdcu.be
July 24, 2025 at 10:40 AM
📣 Happy to see the journal publication 📄 of our work on Starships 🚀 in Verticillium fungi: terrific work led by @yukiyosato.bsky.social
rdcu.be/exBSp
rdcu.be/exBSp
Reposted by Alice Laigle
⚠️ Closing soon! 2 x Postdoctoral Research Associate roles in Infectious Disease Modelling #JobOffer #PDRA
🧪 Develop data-driven mathematical models for modelling avian influenza outbreaks in Great Britain #IDSky #EpiSky
🗓️ Application deadline 12:00 noon BST on Friday (04 July 2025)
More details👇
🧪 Develop data-driven mathematical models for modelling avian influenza outbreaks in Great Britain #IDSky #EpiSky
🗓️ Application deadline 12:00 noon BST on Friday (04 July 2025)
More details👇
1/ 📣 #JobOffer Postdoctoral Research Associate in Infectious Disease Modelling (two posts) 📣
🧪 Develop data-driven mathematical models for modelling avian influenza outbreaks in Great Britain #IDSky #EpiSky
⏳ Application deadline: 12:00 noon BST, 04 July 2025
🔗: www.maths.ox.ac.uk/node/71795
🧪 Develop data-driven mathematical models for modelling avian influenza outbreaks in Great Britain #IDSky #EpiSky
⏳ Application deadline: 12:00 noon BST, 04 July 2025
🔗: www.maths.ox.ac.uk/node/71795
Postdoctoral Research Associate in Infectious Disease Modelling | Mathematical Institute
www.maths.ox.ac.uk
July 1, 2025 at 11:44 AM
Reposted by Alice Laigle
The first paper of my PhD is now available as a preprint! 🎉
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
www.biorxiv.org
June 20, 2025 at 7:39 PM
The first paper of my PhD is now available as a preprint! 🎉
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Reposted by Alice Laigle
Biodiversity is in crisis—so let's act smarter 🌍
💧🍄 Aquatic fungi are key yet overlooked. Help us bring them into conservation & monitoring plans.
Take our quick survey (10–15 min)
🔗 forms.office.com/e/UjCrG1L8YV
#biodiversity #conservation #monitoring #aquaticfungi
💧🍄 Aquatic fungi are key yet overlooked. Help us bring them into conservation & monitoring plans.
Take our quick survey (10–15 min)
🔗 forms.office.com/e/UjCrG1L8YV
#biodiversity #conservation #monitoring #aquaticfungi
June 12, 2025 at 10:29 AM
Biodiversity is in crisis—so let's act smarter 🌍
💧🍄 Aquatic fungi are key yet overlooked. Help us bring them into conservation & monitoring plans.
Take our quick survey (10–15 min)
🔗 forms.office.com/e/UjCrG1L8YV
#biodiversity #conservation #monitoring #aquaticfungi
💧🍄 Aquatic fungi are key yet overlooked. Help us bring them into conservation & monitoring plans.
Take our quick survey (10–15 min)
🔗 forms.office.com/e/UjCrG1L8YV
#biodiversity #conservation #monitoring #aquaticfungi
Reposted by Alice Laigle
The Fungal Kingdom as a Rosetta Stone for biological discovery – a long-time Current Biology advisory board member, Joseph Heitman, introduces the special issue on ‘The Fungi’. www.cell.com/current-biol...
The Fungal Kingdom as a Rosetta Stone for biological discovery
Long-time Current Biology advisory board member, Joseph Heitman, introduces this special
issue on ‘The Fungi’.
www.cell.com
June 11, 2025 at 2:04 PM
The Fungal Kingdom as a Rosetta Stone for biological discovery – a long-time Current Biology advisory board member, Joseph Heitman, introduces the special issue on ‘The Fungi’. www.cell.com/current-biol...
Reposted by Alice Laigle
final version of our study "Dating the Bacterial Tree of Life Based on Ancient Symbiosis" doi.org/10.1093/sysb... particularly thx to haiwei luo for his guidance during my postdoc!
see sishuowang2022.wordpress.com/2025/03/01/a... for a brief summary and comparison w/ others #phylo #molecular_clock
see sishuowang2022.wordpress.com/2025/03/01/a... for a brief summary and comparison w/ others #phylo #molecular_clock
Dating the Bacterial Tree of Life Based on Ancient Symbiosis
Abstract. Obtaining a timescale for bacterial evolution is crucial to understand early life evolution but is difficult owing to the scarcity of bacterial f
doi.org
June 5, 2025 at 6:40 AM
final version of our study "Dating the Bacterial Tree of Life Based on Ancient Symbiosis" doi.org/10.1093/sysb... particularly thx to haiwei luo for his guidance during my postdoc!
see sishuowang2022.wordpress.com/2025/03/01/a... for a brief summary and comparison w/ others #phylo #molecular_clock
see sishuowang2022.wordpress.com/2025/03/01/a... for a brief summary and comparison w/ others #phylo #molecular_clock
Reposted by Alice Laigle
📣 We have a postdoc position in fungus-microbiota interactions! Apply here: jobportal.uni-koeln.de/bewerben/2197
For more details, visit: bewerbungsmanagement.uni-koeln.de/ausschreibun...
For more details, visit: bewerbungsmanagement.uni-koeln.de/ausschreibun...
bewerbungsmanagement.uni-koeln.de
June 4, 2025 at 5:34 PM
📣 We have a postdoc position in fungus-microbiota interactions! Apply here: jobportal.uni-koeln.de/bewerben/2197
For more details, visit: bewerbungsmanagement.uni-koeln.de/ausschreibun...
For more details, visit: bewerbungsmanagement.uni-koeln.de/ausschreibun...
Reposted by Alice Laigle
Latest #CDlab paper out now in Nucleus: www.tandfonline.com/doi/epdf/10....
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
June 5, 2025 at 7:35 AM
Latest #CDlab paper out now in Nucleus: www.tandfonline.com/doi/epdf/10....
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
Reposted by Alice Laigle
Starship giant transposable elements cluster by host taxonomy using k-mer-based phylogenetics. #TransposableElements #TEs #Kmer #Phylogenetics #Genomics #Bioinformatics #G3 🧬 🖥️
academic.oup.com/g3journal/ad...
academic.oup.com/g3journal/ad...
June 2, 2025 at 5:06 PM
Starship giant transposable elements cluster by host taxonomy using k-mer-based phylogenetics. #TransposableElements #TEs #Kmer #Phylogenetics #Genomics #Bioinformatics #G3 🧬 🖥️
academic.oup.com/g3journal/ad...
academic.oup.com/g3journal/ad...
Reposted by Alice Laigle
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 27, 2025 at 12:19 PM
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Reposted by Alice Laigle
stTrace: Detecting Spatial-Temporal Domains from spatial transcriptome to Trace Developmental Path https://www.biorxiv.org/content/10.1101/2025.05.19.654812v1
May 24, 2025 at 4:49 AM
stTrace: Detecting Spatial-Temporal Domains from spatial transcriptome to Trace Developmental Path https://www.biorxiv.org/content/10.1101/2025.05.19.654812v1
Reposted by Alice Laigle
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
May 19, 2025 at 2:01 PM
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
Reposted by Alice Laigle
Excited to share the first PhD preprint of @iglavincheska.bsky.social — now on bioRxiv!
We explored the 3D genome of Zymo and found:
🧬 Rabl-like conformation
🧩 Accessory chr tethered to core centromeres
🏰 Self-interacting domains and boundaries with insulator motifs
www.biorxiv.org/content/10.1...
We explored the 3D genome of Zymo and found:
🧬 Rabl-like conformation
🧩 Accessory chr tethered to core centromeres
🏰 Self-interacting domains and boundaries with insulator motifs
www.biorxiv.org/content/10.1...
May 18, 2025 at 5:24 PM
Excited to share the first PhD preprint of @iglavincheska.bsky.social — now on bioRxiv!
We explored the 3D genome of Zymo and found:
🧬 Rabl-like conformation
🧩 Accessory chr tethered to core centromeres
🏰 Self-interacting domains and boundaries with insulator motifs
www.biorxiv.org/content/10.1...
We explored the 3D genome of Zymo and found:
🧬 Rabl-like conformation
🧩 Accessory chr tethered to core centromeres
🏰 Self-interacting domains and boundaries with insulator motifs
www.biorxiv.org/content/10.1...